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Conserved domains on  [gi|1550430273|gb|RVQ92007|]
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urease subunit beta [Sinorhizobium meliloti]

Protein Classification

urease subunit beta( domain architecture ID 10793751)

urease subunit beta (UreB) is a component of the urease enzyme complex that catalyzes the hydrolysis of urea into carbon dioxide and ammonia

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ureB PRK13203
urease subunit beta; Reviewed
 1-101 1.33e-71

urease subunit beta; Reviewed


:

Pssm-ID: 237303  Cd Length: 102  Bit Score: 207.76  E-value: 1.33e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:PRK13203    1 MIPGEYITADGEIELNAGRETVTLTVANTGDRPIQVGSHYHFFEVNPALSFDREAARGMRLNIPAGTAVRFEPGQTREVE 80

                          90       100
                  ....*....|....*....|.
gi 1550430273  81 LIPLSGKREVFGFRQQVMGKL 101
Cdd:PRK13203   81 LVPLAGARRVYGFRGKVMGKL 101
 
Name Accession Description Interval E-value
ureB PRK13203
urease subunit beta; Reviewed
 1-101 1.33e-71

urease subunit beta; Reviewed


Pssm-ID: 237303  Cd Length: 102  Bit Score: 207.76  E-value: 1.33e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:PRK13203    1 MIPGEYITADGEIELNAGRETVTLTVANTGDRPIQVGSHYHFFEVNPALSFDREAARGMRLNIPAGTAVRFEPGQTREVE 80

                          90       100
                  ....*....|....*....|.
gi 1550430273  81 LIPLSGKREVFGFRQQVMGKL 101
Cdd:PRK13203   81 LVPLAGARRVYGFRGKVMGKL 101
UreB COG0832
Urease beta subunit [Amino acid transport and metabolism];
4-101 1.28e-69

Urease beta subunit [Amino acid transport and metabolism];


Pssm-ID: 440594  Cd Length: 101  Bit Score: 202.60  E-value: 1.28e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   4 GEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVTLIP 83
Cdd:COG0832     1 GEIIVADGDIELNAGRETITLTVANTGDRPIQVGSHYHFFEVNPALEFDREAARGMRLDIPAGTAVRFEPGQTREVELVP 80

                          90
                  ....*....|....*...
gi 1550430273  84 LSGKREVFGFRQQVMGKL 101
Cdd:COG0832    81 IGGARRVYGFNGLVNGPL 98
Urease_beta pfam00699
Urease beta subunit; This subunit is known as alpha in Heliobacter.
 3-100 1.04e-66

Urease beta subunit; This subunit is known as alpha in Heliobacter.


Pssm-ID: 459909  Cd Length: 98  Bit Score: 195.29  E-value: 1.04e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   3 PGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVTLI 82
Cdd:pfam00699   1 PGEIITGDGDIELNAGRETITLTVTNTGDRPIQVGSHYHFFEVNPALEFDREAAYGMRLDIPAGTAVRFEPGDTKTVTLV 80

                          90
                  ....*....|....*...
gi 1550430273  83 PLSGKREVFGFRQQVMGK 100
Cdd:pfam00699  81 PIGGARVVYGFNGLVNGP 98
Urease_beta cd00407
Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis ...
 1-101 8.89e-61

Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of external and internally-generated urea as a nitrogen source. The enzyme consists of three subunits, alpha, beta and gamma, which can exist as separate proteins or can be fused on a single protein chain. The alpha-beta-gamma heterotrimer forms multimers, mainly trimers. The large alpha subunit is the catalytic domain containing an active site with a bi-nickel center complexed by a carbamylated lysine. The beta and gamma subunits play a role in subunit association to form the higher order trimers.


Pssm-ID: 238238  Cd Length: 101  Bit Score: 180.41  E-value: 8.89e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:cd00407     1 MIPGEIILKEGDIELNAGREAVTLKVKNTGDRPIQVGSHYHFFEVNPALKFDREKAYGMRLDIPAGTAVRFEPGEEKEVE 80

                          90       100
                  ....*....|....*....|.
gi 1550430273  81 LIPLSGKREVFGFRQQVMGKL 101
Cdd:cd00407    81 LVPIGGKRRVYGFNGLVNGPL 101
urease_beta TIGR00192
urease, beta subunit; In a number of species, including B.subtilis, Synechocystis, and ...
 1-101 9.70e-47

urease, beta subunit; In a number of species, including B.subtilis, Synechocystis, and Haemophilus influenzae, urease subunits beta and gamma are encoded as separate polypeptides. In Helicobacter pylori UreA and in the fission yeast Schizosaccharomyces pombe, beta subunit-like sequence follows gamma subunit-like sequence in a single chain; the fission yeast protein contains additional C-terminal regions. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 129296  Cd Length: 101  Bit Score: 144.97  E-value: 9.70e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:TIGR00192   1 MIPGELQLAEGDITINEGRKTVSVKVKNTGDRPIQVGSHFHFFEVNRALDFDRELAFGMRLDIPSGTAVRFEPGEEKSVE 80

                          90       100
                  ....*....|....*....|.
gi 1550430273  81 LIPLSGKREVFGFRQQVMGKL 101
Cdd:TIGR00192  81 LVAIGGNRRIYGFNGLVDGQL 101
 
Name Accession Description Interval E-value
ureB PRK13203
urease subunit beta; Reviewed
 1-101 1.33e-71

urease subunit beta; Reviewed


Pssm-ID: 237303  Cd Length: 102  Bit Score: 207.76  E-value: 1.33e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:PRK13203    1 MIPGEYITADGEIELNAGRETVTLTVANTGDRPIQVGSHYHFFEVNPALSFDREAARGMRLNIPAGTAVRFEPGQTREVE 80

                          90       100
                  ....*....|....*....|.
gi 1550430273  81 LIPLSGKREVFGFRQQVMGKL 101
Cdd:PRK13203   81 LVPLAGARRVYGFRGKVMGKL 101
UreB COG0832
Urease beta subunit [Amino acid transport and metabolism];
4-101 1.28e-69

Urease beta subunit [Amino acid transport and metabolism];


Pssm-ID: 440594  Cd Length: 101  Bit Score: 202.60  E-value: 1.28e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   4 GEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVTLIP 83
Cdd:COG0832     1 GEIIVADGDIELNAGRETITLTVANTGDRPIQVGSHYHFFEVNPALEFDREAARGMRLDIPAGTAVRFEPGQTREVELVP 80

                          90
                  ....*....|....*...
gi 1550430273  84 LSGKREVFGFRQQVMGKL 101
Cdd:COG0832    81 IGGARRVYGFNGLVNGPL 98
Urease_beta pfam00699
Urease beta subunit; This subunit is known as alpha in Heliobacter.
 3-100 1.04e-66

Urease beta subunit; This subunit is known as alpha in Heliobacter.


Pssm-ID: 459909  Cd Length: 98  Bit Score: 195.29  E-value: 1.04e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   3 PGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVTLI 82
Cdd:pfam00699   1 PGEIITGDGDIELNAGRETITLTVTNTGDRPIQVGSHYHFFEVNPALEFDREAAYGMRLDIPAGTAVRFEPGDTKTVTLV 80

                          90
                  ....*....|....*...
gi 1550430273  83 PLSGKREVFGFRQQVMGK 100
Cdd:pfam00699  81 PIGGARVVYGFNGLVNGP 98
Urease_beta cd00407
Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis ...
 1-101 8.89e-61

Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of external and internally-generated urea as a nitrogen source. The enzyme consists of three subunits, alpha, beta and gamma, which can exist as separate proteins or can be fused on a single protein chain. The alpha-beta-gamma heterotrimer forms multimers, mainly trimers. The large alpha subunit is the catalytic domain containing an active site with a bi-nickel center complexed by a carbamylated lysine. The beta and gamma subunits play a role in subunit association to form the higher order trimers.


Pssm-ID: 238238  Cd Length: 101  Bit Score: 180.41  E-value: 8.89e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:cd00407     1 MIPGEIILKEGDIELNAGREAVTLKVKNTGDRPIQVGSHYHFFEVNPALKFDREKAYGMRLDIPAGTAVRFEPGEEKEVE 80

                          90       100
                  ....*....|....*....|.
gi 1550430273  81 LIPLSGKREVFGFRQQVMGKL 101
Cdd:cd00407    81 LVPIGGKRRVYGFNGLVNGPL 101
PRK13192 PRK13192
bifunctional urease subunit gamma/beta; Reviewed
 2-99 3.20e-48

bifunctional urease subunit gamma/beta; Reviewed


Pssm-ID: 183886 [Multi-domain]  Cd Length: 208  Bit Score: 152.44  E-value: 3.20e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   2 IPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVTL 81
Cdd:PRK13192  111 YPGEILPGDGEIELNAGRPAVTLDVTNTGDRPIQVGSHFHFFEVNRALRFDRAAAYGMRLDIPAGTAVRFEPGETKEVRL 190

                          90
                  ....*....|....*...
gi 1550430273  82 IPLSGKREVFGFRQQVMG 99
Cdd:PRK13192  191 VPIGGARVVIGFNGLTNG 208
urease_beta TIGR00192
urease, beta subunit; In a number of species, including B.subtilis, Synechocystis, and ...
 1-101 9.70e-47

urease, beta subunit; In a number of species, including B.subtilis, Synechocystis, and Haemophilus influenzae, urease subunits beta and gamma are encoded as separate polypeptides. In Helicobacter pylori UreA and in the fission yeast Schizosaccharomyces pombe, beta subunit-like sequence follows gamma subunit-like sequence in a single chain; the fission yeast protein contains additional C-terminal regions. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 129296  Cd Length: 101  Bit Score: 144.97  E-value: 9.70e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:TIGR00192   1 MIPGELQLAEGDITINEGRKTVSVKVKNTGDRPIQVGSHFHFFEVNRALDFDRELAFGMRLDIPSGTAVRFEPGEEKSVE 80

                          90       100
                  ....*....|....*....|.
gi 1550430273  81 LIPLSGKREVFGFRQQVMGKL 101
Cdd:TIGR00192  81 LVAIGGNRRIYGFNGLVDGQL 101
ureB PRK13201
urease subunit beta; Reviewed
 1-101 6.21e-42

urease subunit beta; Reviewed


Pssm-ID: 237302 [Multi-domain]  Cd Length: 136  Bit Score: 134.19  E-value: 6.21e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:PRK13201    1 MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKHLDIPAGAAVRFEPGDKKEVQ 80

                          90       100
                  ....*....|....*....|.
gi 1550430273  81 LIPLSGKREVFGFRQQVMGKL 101
Cdd:PRK13201   81 LVEYAGKRKIFGFRGMVNGPI 101
PRK13986 PRK13986
urease subunit beta;
3-93 1.38e-40

urease subunit beta;


Pssm-ID: 184439 [Multi-domain]  Cd Length: 225  Bit Score: 133.41  E-value: 1.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   3 PGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVTLI 82
Cdd:PRK13986  108 PGELFLKDEDITINAGKKAVSVKVKNVGDRPVQVGSHFHFFEVNRCLEFDREKAFGKRLDIASGTAVRFEPGEEKSVELI 187

                          90
                  ....*....|.
gi 1550430273  83 PLSGKREVFGF 93
Cdd:PRK13986  188 DIGGNRRIFGF 198
PLN02303 PLN02303
urease
 1-92 5.59e-39

urease


Pssm-ID: 215172 [Multi-domain]  Cd Length: 837  Bit Score: 137.19  E-value: 5.59e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:PLN02303  131 PIPGEIITGDGSIIINAGRKAVKLKVTNTGDRPIQVGSHYHFIETNPYLVFDRRKAYGMRLNIPAGTAVRFEPGETKTVT 210

                          90
                  ....*....|..
gi 1550430273  81 LIPLSGKREVFG 92
Cdd:PLN02303  211 LVSIGGNKVIRG 222
ureB PRK13205
urease subunit beta; Reviewed
 1-101 4.03e-35

urease subunit beta; Reviewed


Pssm-ID: 106174 [Multi-domain]  Cd Length: 162  Bit Score: 117.60  E-value: 4.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVT 80
Cdd:PRK13205    1 MIPGEYILSSESLTGNVGREAKTIEIINTGDRPVQIGSHFHFAEVNPSISFDRSEGYGFRLDIPSGTAVRLEPGDARTVN 80

                          90       100
                  ....*....|....*....|.
gi 1550430273  81 LIPLSGKREVFGFRQQVMGKL 101
Cdd:PRK13205   81 LVAIGGDRIVAGFRDLVDGPL 101
ureB PRK13204
urease subunit beta; Reviewed
 4-99 6.35e-33

urease subunit beta; Reviewed


Pssm-ID: 171902 [Multi-domain]  Cd Length: 159  Bit Score: 111.79  E-value: 6.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   4 GEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVTLIP 83
Cdd:PRK13204   27 GGYVLAKDPIEINQGRPRTTLTVRNTGDRPIQIGSHFHFFEVNRYLEFDRSKAFGLRLDIPANTAVRFEPGDEKEVTLVP 106

                          90
                  ....*....|....*.
gi 1550430273  84 LSGKREVFGFRQQVMG 99
Cdd:PRK13204  107 FAGKRFIFGFNNLVDG 122
ureB PRK13198
urease subunit beta; Reviewed
 4-99 1.73e-32

urease subunit beta; Reviewed


Pssm-ID: 171897 [Multi-domain]  Cd Length: 158  Bit Score: 110.93  E-value: 1.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   4 GEIIAAAGEIELNAGLETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQVTLIP 83
Cdd:PRK13198   32 GGLVLAETPITFNENKPVTKVKVRNTGDRPIQVGSHFHFFEVNRALEFDRAAAYGKRLNISSTTAIRFEPGDETEVPLIP 111

                          90
                  ....*....|....*.
gi 1550430273  84 LSGKREVFGFRQQVMG 99
Cdd:PRK13198  112 FGGKQTLYGFNNLVDG 127
ureB PRK13202
urease subunit beta; Reviewed
 1-101 6.34e-32

urease subunit beta; Reviewed


Pssm-ID: 106171  Cd Length: 104  Bit Score: 107.86  E-value: 6.34e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550430273   1 MIPGEIIAAAGEIELNAG-LETVSIEVANSGDRPVQVGSHYHFAETNPGLIFDRDAARGKRLDIPAGTAVRFEPGQTRQV 79
Cdd:PRK13202    1 MIPGEIFYGSGDIEMNAAaLSRLQMRIINAGDRPVQVGSHVHLPQANRALSFDRATAHGYRLDIPAATAVRFEPGIPQIV 80

                          90       100
                  ....*....|....*....|..
gi 1550430273  80 TLIPLSGKREVFGFRQQVMGKL 101
Cdd:PRK13202   81 GLVPLGGRREVPGLTLNPPGRL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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