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Conserved domains on  [gi|1550449143|gb|RVR09724|]
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sensor histidine kinase [Sinorhizobium meliloti]

Protein Classification

sensor histidine kinase( domain architecture ID 11454343)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0007165|GO:0004673|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
8-119 2.86e-35

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 121.17  E-value: 2.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   8 FIFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGL 87
Cdd:COG2205   125 LVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGL 204

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1550449143  88 SLVRAVADLHGGQIFL-SDNRTGLVCTVSFPVA 119
Cdd:COG2205   205 AIVKRIVEAHGGTIWVeSEPGGGTTFTVTLPLA 237
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
8-119 2.86e-35

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 121.17  E-value: 2.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   8 FIFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGL 87
Cdd:COG2205   125 LVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGL 204

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1550449143  88 SLVRAVADLHGGQIFL-SDNRTGLVCTVSFPVA 119
Cdd:COG2205   205 AIVKRIVEAHGGTIWVeSEPGGGTTFTVTLPLA 237
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 11-116 3.13e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 104.80  E-value: 3.13e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVkLIVCANGLGIPAAERTKVFGRFYRLDKTLGsPGTELGLSLV 90
Cdd:cd16940     9 GDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDGQNY-GGSGLGLSIV 86

                          90       100
                  ....*....|....*....|....*..
gi 1550449143  91 RAVADLHGGQIFLSDNRT-GLVCTVSF 116
Cdd:cd16940    87 KRIVELHGGQIFLGNAQGgGLEAWVRL 113
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 11-119 1.06e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 95.41  E-value: 1.06e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGS-PGTELGLSL 89
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKiGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1550449143   90 VRAVADLHGGQI-FLSDNRTGLVCTVSFPVA 119
Cdd:smart00387  81 VKKLVELHGGEIsVESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 11-119 1.22e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 85.11  E-value: 1.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDaEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSpGTELGLSLV 90
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG-GTGLGLSIV 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 1550449143  91 RAVADLHGGQIFL-SDNRTGLVCTVSFPVA 119
Cdd:pfam02518  79 RKLVELLGGTITVeSEPGGGTTVTLTLPLA 108
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 3-117 1.52e-19

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 82.82  E-value: 1.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   3 LQSSGFIFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLD--KTLGS 80
Cdd:TIGR01386 341 VEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDpaRSNSG 420

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1550449143  81 PGTELGLSLVRAVADLHGGQIFLS--DNRTGLvcTVSFP 117
Cdd:TIGR01386 421 EGTGLGLAIVRSIMEAHGGRASAEspDGKTRF--ILRFP 457
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 11-119 6.00e-19

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 81.04  E-value: 6.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSP-GTELGLSL 89
Cdd:PRK11100  364 GDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLPRPANGRkSTGLGLAF 443

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1550449143  90 VRAVADLHGGQIFLsDNRT--GLVCTVSFPVA 119
Cdd:PRK11100  444 VREVARLHGGEVTL-RNRPegGVLATLTLPRH 474
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
8-119 2.86e-35

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 121.17  E-value: 2.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   8 FIFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGL 87
Cdd:COG2205   125 LVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGL 204

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1550449143  88 SLVRAVADLHGGQIFL-SDNRTGLVCTVSFPVA 119
Cdd:COG2205   205 AIVKRIVEAHGGTIWVeSEPGGGTTFTVTLPLA 237
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
9-119 1.34e-33

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 119.24  E-value: 1.34e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGLS 88
Cdd:COG0642   217 VRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLA 296

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1550449143  89 LVRAVADLHGGQIFLSDNR-TGLVCTVSFPVA 119
Cdd:COG0642   297 IVKRIVELHGGTIEVESEPgKGTTFTVTLPLA 328
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
8-119 2.66e-31

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 114.26  E-value: 2.66e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   8 FIFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDK--TLGSPGTEL 85
Cdd:COG5002   274 LVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKsrSRETGGTGL 353

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1550449143  86 GLSLVRAVADLHGGQIFL-SDNRTGLVCTVSFPVA 119
Cdd:COG5002   354 GLAIVKHIVEAHGGRIWVeSEPGKGTTFTITLPLA 388
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 11-116 3.13e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 104.80  E-value: 3.13e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVkLIVCANGLGIPAAERTKVFGRFYRLDKTLGsPGTELGLSLV 90
Cdd:cd16940     9 GDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDGQNY-GGSGLGLSIV 86

                          90       100
                  ....*....|....*....|....*..
gi 1550449143  91 RAVADLHGGQIFLSDNRT-GLVCTVSF 116
Cdd:cd16940    87 KRIVELHGGQIFLGNAQGgGLEAWVRL 113
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 16-116 8.84e-27

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 95.36  E-value: 8.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  16 VKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGLSLVRAVAD 95
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80

                          90       100
                  ....*....|....*....|..
gi 1550449143  96 LHGGQIFL-SDNRTGLVCTVSF 116
Cdd:cd00075    81 AHGGRITVeSEPGGGTTFTVTL 102
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 11-119 1.06e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 95.41  E-value: 1.06e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGS-PGTELGLSL 89
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKiGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1550449143   90 VRAVADLHGGQI-FLSDNRTGLVCTVSFPVA 119
Cdd:smart00387  81 VKKLVELHGGEIsVESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 11-119 1.22e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 85.11  E-value: 1.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDaEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSpGTELGLSLV 90
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG-GTGLGLSIV 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 1550449143  91 RAVADLHGGQIFL-SDNRTGLVCTVSFPVA 119
Cdd:pfam02518  79 RKLVELLGGTITVeSEPGGGTTVTLTLPLA 108
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 9-119 2.33e-20

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 84.63  E-value: 2.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYrldkTLGSPGTELGLS 88
Cdd:COG5000   311 VLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF----TTKPKGTGLGLA 386

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1550449143  89 LVRAVADLHGGQIFLSDNR-TGLVCTVSFPVA 119
Cdd:COG5000   387 IVKKIVEEHGGTIELESRPgGGTTFTIRLPLA 418
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 3-117 1.52e-19

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 82.82  E-value: 1.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   3 LQSSGFIFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLD--KTLGS 80
Cdd:TIGR01386 341 VEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDpaRSNSG 420

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1550449143  81 PGTELGLSLVRAVADLHGGQIFLS--DNRTGLvcTVSFP 117
Cdd:TIGR01386 421 EGTGLGLAIVRSIMEAHGGRASAEspDGKTRF--ILRFP 457
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 11-119 6.00e-19

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 81.04  E-value: 6.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSP-GTELGLSL 89
Cdd:PRK11100  364 GDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLPRPANGRkSTGLGLAF 443

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1550449143  90 VRAVADLHGGQIFLsDNRT--GLVCTVSFPVA 119
Cdd:PRK11100  444 VREVARLHGGEVTL-RNRPegGVLATLTLPRH 474
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 9-101 7.96e-19

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 80.60  E-value: 7.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCG--PAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELG 86
Cdd:COG4251   388 VRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIG 467

                          90
                  ....*....|....*
gi 1550449143  87 LSLVRAVADLHGGQI 101
Cdd:COG4251   468 LAIVKKIVERHGGRI 482
PRK09303 PRK09303
histidine kinase;
9-101 9.03e-19

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 80.00  E-value: 9.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGPAVELT-LSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGL 87
Cdd:PRK09303  266 VYADQERIRQVLLNLLDNAIKYTPEGGTITLSmLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGL 345

                          90
                  ....*....|....
gi 1550449143  88 SLVRAVADLHGGQI 101
Cdd:PRK09303  346 SVCRRIVRVHYGQI 359
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 22-118 1.27e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 72.08  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  22 NLLTNATRHtpCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLD--KTLGSPGTELGLSLVRAVADLHGG 99
Cdd:cd16939     7 NLLRNALRY--AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDpsRDRATGGFGLGLAIVHRVALWHGG 84

                          90       100
                  ....*....|....*....|
gi 1550449143 100 QIFLSDNRTGLVC-TVSFPV 118
Cdd:cd16939    85 HVECDDSELGGACfRLTWPR 104
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
11-123 3.66e-17

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 75.39  E-value: 3.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGspGTELGLSLV 90
Cdd:PRK10755  243 GDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYG--GIGLGLSIV 320

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1550449143  91 RAVADLHGGQIFLSD--NRTGLVCTVSFPVAVGSS 123
Cdd:PRK10755  321 SRITQLHHGQFFLQNrqERSGTRAWVWLPKAQNVA 355
PRK10490 PRK10490
sensor protein KdpD; Provisional
 8-112 1.58e-16

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 74.30  E-value: 1.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   8 FIFGDADLVKQLCVNLLTNATRHTpcGPAVELTLSS--DAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTEL 85
Cdd:PRK10490  771 LIHVDGPLFERVLINLLENAVKYA--GAQAEIGIDAhvEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGL 848

                          90       100
                  ....*....|....*....|....*..
gi 1550449143  86 GLSLVRAVADLHGGQIFLSDNRTGLVC 112
Cdd:PRK10490  849 GLAICRAIVEVHGGTIWAENRPEGGAC 875
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
9-117 2.04e-16

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 74.04  E-value: 2.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLD--KTLGSPGTELG 86
Cdd:PRK09835  369 VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDpsRQRKGEGSGIG 448

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1550449143  87 LSLVRAVADLHGGQIFLSDNRTGLVCTVSFP 117
Cdd:PRK09835  449 LAIVKSIVVAHKGTVAVTSDARGTRFVISLP 479
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 12-117 4.49e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 68.26  E-value: 4.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  12 DADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLD--KTLGSPGTELGLSL 89
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVEssRNRASGGSGLGLAI 80

                          90       100
                  ....*....|....*....|....*....
gi 1550449143  90 VRAVADLHGGQI-FLSDNRTGLVCTVSFP 117
Cdd:cd16946    81 CHNIALAHGGTIsAEHSPLGGLRLVLTLP 109
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 12-109 1.16e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 67.10  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  12 DADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDK-TLGSPGTELGLSLV 90
Cdd:cd16945     1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRpHSGQKSTGLGLAFV 80

                          90
                  ....*....|....*....
gi 1550449143  91 RAVADLHGGQIFLSdNRTG 109
Cdd:cd16945    81 QEVAQLHGGRITLR-NRPD 98
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 12-109 3.21e-15

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 66.36  E-value: 3.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  12 DADLVKQLCVNLLTNATRHTPCGPAVELTLS-SDAEWVKLIVCANGLGIPAAERTKVFGRFYRL--DKTLGSPGTELGLS 88
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGdgSSTRAHGGTGLGLS 80

                          90       100
                  ....*....|....*....|.
gi 1550449143  89 LVRAVADLHGGQIFLSDNRTG 109
Cdd:cd16925    81 IVKEFVELHGGTVTVSDAPGG 101
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 22-117 3.50e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 65.81  E-value: 3.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  22 NLLTNATRHTPcgPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLD--KTLGSPGTELGLSLVRAVADLHGG 99
Cdd:cd16949     7 NVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDsaRDRESGGTGLGLAIAERAIEQHGG 84

                          90
                  ....*....|....*....
gi 1550449143 100 QIFLSDN-RTGLVCTVSFP 117
Cdd:cd16949    85 KIKASNRkPGGLRVRIWLP 103
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 22-117 5.79e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 65.49  E-value: 5.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  22 NLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGLSLVRAVADLHGGQI 101
Cdd:cd16923     7 NLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIELHGGSA 86

                          90
                  ....*....|....*.
gi 1550449143 102 FLSDNRTGLVCTVSFP 117
Cdd:cd16923    87 SAEYDDNHDLFKVRLP 102
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 16-109 2.48e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 63.62  E-value: 2.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  16 VKQLCVNLLTNATRHTpcGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGLSLVRAVAD 95
Cdd:cd16950     1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78

                          90
                  ....*....|....
gi 1550449143  96 LHGGQIFLSdNRTG 109
Cdd:cd16950    79 AHGGSLTLA-NRAG 91
PRK10604 PRK10604
sensor protein RstB; Provisional
 8-103 3.36e-14

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 67.32  E-value: 3.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   8 FIFGDADLVKQLCVNLLTNATRHtpCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLG--SPGTEL 85
Cdd:PRK10604  312 YGALDMRLMERVLDNLLNNALRY--AHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDraTGGCGL 389

                          90
                  ....*....|....*...
gi 1550449143  86 GLSLVRAVADLHGGQIFL 103
Cdd:PRK10604  390 GLAIVHSIALAMGGSVNC 407
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 9-119 3.81e-14

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 67.13  E-value: 3.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNAtRH---TPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYrLDKTLGSpGTEL 85
Cdd:COG4191   250 VLGDPGQLEQVLLNLLINA-IDameEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF-TTKPVGK-GTGL 326

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1550449143  86 GLSLVRAVADLHGGQIFLSDNR-TGLVCTVSFPVA 119
Cdd:COG4191   327 GLSISYGIVEKHGGRIEVESEPgGGTTFTITLPLA 361
PRK10337 PRK10337
sensor protein QseC; Provisional
 11-115 8.98e-14

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 66.21  E-value: 8.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAewvkLIVCANGLGIPAAERTKVFGRFYRldktlgSPGTE-----L 85
Cdd:PRK10337  348 GQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN----FTVRDNGPGVTPEALARIGERFYR------PPGQEatgsgL 417

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1550449143  86 GLSLVRAVADLHGGQIFLSDNRT-GLVCTVS 115
Cdd:PRK10337  418 GLSIVRRIAKLHGMNVSFGNAPEgGFEAKVS 448
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 14-112 9.33e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 63.03  E-value: 9.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  14 DLVkQLCVNLLTNATRHtpCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTlgSPGTELGLSLVRAV 93
Cdd:cd16954    37 DLM-ELLGNLLDNACKW--CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQ--RPGQGLGLAIAKEI 111

                          90
                  ....*....|....*....
gi 1550449143  94 ADLHGGQIFLSDNRTGLVC 112
Cdd:cd16954   112 VEQYGGELSLSDSPLGGAR 130
envZ PRK09467
osmolarity sensor protein; Provisional
 16-119 3.11e-13

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 64.55  E-value: 3.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  16 VKQLCVNLLTNATRHTpcGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGLSLVRAVAD 95
Cdd:PRK09467  332 IKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVD 409

                          90       100
                  ....*....|....*....|....*.
gi 1550449143  96 LHGGQIFLSdNRT--GLVCTVSFPVA 119
Cdd:PRK09467  410 QHNGKVELG-NSEegGLSARAWLPLT 434
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 16-103 3.69e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 60.80  E-value: 3.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  16 VKQLCVNLLTNAT--RHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELGLSLVRAV 93
Cdd:cd16921     1 LGQVLTNLLGNAIkfRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80

                          90
                  ....*....|
gi 1550449143  94 ADLHGGQIFL 103
Cdd:cd16921    81 IERHGGRIWL 90
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 12-117 1.54e-12

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 62.56  E-value: 1.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  12 DADLVKQLCvNLLTNATRHTPCGPA----VELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRldkTLGSPGTELGL 87
Cdd:COG3290   279 DTDLVTILG-NLLDNAIEAVEKLPEeerrVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS---TKLGEGRGLGL 354

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1550449143  88 SLVRAVADLHGGQI-FLSDNRTGLVCTVSFP 117
Cdd:COG3290   355 ALVKQIVEKYGGTIeVESEEGEGTVFTVRLP 385
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 12-109 3.74e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 58.24  E-value: 3.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  12 DADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPG-TELGLSLV 90
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIA 80

                          90
                  ....*....|....*....
gi 1550449143  91 RAVADLHGGQIFLSDNRTG 109
Cdd:cd16975    81 KNLVEKHGGSLIIENSQKG 99
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
9-118 2.64e-11

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 59.26  E-value: 2.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLD--KTLGSPGTELG 86
Cdd:PRK10549  346 VFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEgsRNRASGGSGLG 425

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1550449143  87 LSLVRAVADLHGGQIFLSDNRTGLV-CTVSFPV 118
Cdd:PRK10549  426 LAICLNIVEAHNGRIIAAHSPFGGVsITVELPL 458
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
9-119 7.06e-11

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 57.93  E-value: 7.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSD----------AEWVKLIVCANGLGIPAAERTKVF-----GRfyr 73
Cdd:COG3852   238 VLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVErqvtlgglrpRLYVRIEVIDNGPGIPEEILDRIFepfftTK--- 314

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1550449143  74 lDKtlgspGTELGLSLVRAVADLHGGQI-FLSDNRTGLVCTVSFPVA 119
Cdd:COG3852   315 -EK-----GTGLGLAIVQKIVEQHGGTIeVESEPGKGTTFRIYLPLE 355
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 16-117 4.32e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 52.78  E-value: 4.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  16 VKQLCVNLLTN---ATRHTPCGPAvELTLS---SDAEWVKLIVCANGLGIPAAERTKVFGRFYrldkTLGSPGTELGLSL 89
Cdd:cd16920     1 IQQVLINLVRNgieAMSEGGCERR-ELTIRtspADDRAVTISVKDTGPGIAEEVAGQLFDPFY----TTKSEGLGMGLSI 75

                          90       100
                  ....*....|....*....|....*....
gi 1550449143  90 VRAVADLHGGQIFLSDNRTGLVC-TVSFP 117
Cdd:cd16920    76 CRSIIEAHGGRLSVESPAGGGATfQFTLP 104
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 22-109 6.03e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 52.29  E-value: 6.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  22 NLLTN---ATRHTPCGPA-VELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYrldKTLGSPGTELGLSLVRAVADLH 97
Cdd:cd16915     7 NLIDNaldALAATGAPNKqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV---STKGQGERGIGLALVRQSVERL 83

                          90
                  ....*....|..
gi 1550449143  98 GGQIFLSDNRTG 109
Cdd:cd16915    84 GGSITVESEPGG 95
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 16-101 1.23e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 51.72  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  16 VKQLCVNLLTNATRHTPCGpAVELTLSSDAE-----WVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSP--GTELGLS 88
Cdd:cd16922     1 LRQILLNLLGNAIKFTEEG-EVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKygGTGLGLA 79

                          90
                  ....*....|...
gi 1550449143  89 LVRAVADLHGGQI 101
Cdd:cd16922    80 ISKKLVELMGGDI 92
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
9-123 3.49e-09

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 53.05  E-value: 3.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGPAVELT--LSSDAEwVKLIVCANGLGIPAAERTKVFGRFYrldkTLGSPGTELG 86
Cdd:PRK11360  494 IWADPELLKQVLLNILINAVQAISARGKIRIRtwQYSDGQ-VAVSIEDNGCGIDPELLKKIFDPFF----TTKAKGTGLG 568

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1550449143  87 LSLVRAVADLHGGQIFL-SDNRTGLVCTVSFPVAVGSS 123
Cdd:PRK11360  569 LALSQRIINAHGGDIEVeSEPGVGTTFTLYLPINPQGN 606
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 1-114 4.63e-09

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 52.77  E-value: 4.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   1 MNLQSSGFIFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAErtKVFGRFYrldkTLGS 80
Cdd:COG4192   529 LHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVD--KLFTPFT----TTKE 602

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1550449143  81 PGTELGLSLVRAVADLHGGQIFLSDNRTGLVCTV 114
Cdd:COG4192   603 VGLGLGLSICRSIMQQFGGDLYLASTLERGAMVI 636
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 8-118 4.97e-09

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 52.81  E-value: 4.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   8 FIFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYrldkTLGSPGTELGL 87
Cdd:COG5805   388 FIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF----TTKEKGTGLGL 463

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1550449143  88 SLVRAVADLHGGQI-FLSDNRTGLVCTVSFPV 118
Cdd:COG5805   464 MVSYKIIENHNGTIdIDSKVGKGTTFTITLPL 495
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
9-91 5.80e-09

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 52.32  E-value: 5.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLG--SPGTELG 86
Cdd:PRK11006  311 VFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSrqTGGSGLG 390


                  ....*
gi 1550449143  87 LSLVR 91
Cdd:PRK11006  391 LAIVK 395
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 12-112 5.80e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 50.23  E-value: 5.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  12 DADLVKQLCVNLLTNAT---RHTPCGPA-VELTLSSDAEW-VKLIVCANGLGIPAAERTKVFGRFYrldkTLGSPGTELG 86
Cdd:cd16944     1 DTTQISQVLTNILKNAAeaiEGRPSDVGeVRIRVEADQDGrIVLIVCDNGKGFPREMRHRATEPYV----TTRPKGTGLG 76

                          90       100
                  ....*....|....*....|....*.
gi 1550449143  87 LSLVRAVADLHGGQIFLSDNRTGLVC 112
Cdd:cd16944    77 LAIVKKIMEEHGGRISLSNREAGGAC 102
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 19-119 7.59e-09

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 52.21  E-value: 7.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  19 LCVN-LLTNATRH----TPCGPaVELTLSSDAEWVKLIVCANGLGIPAaertkvfgrfyrlDKTLGSPGTeLGLSLVRAV 93
Cdd:COG3920   402 LILNeLVTNALKHaflsGEGGR-IRVSWRREDGRLRLTVSDNGVGLPE-------------DVDPPARKG-LGLRLIRAL 466

                          90       100
                  ....*....|....*....|....*.
gi 1550449143  94 ADLHGGQIFLsDNRTGLVCTVSFPVA 119
Cdd:COG3920   467 VRQLGGTLEL-DRPEGTRVRITFPLA 491
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
12-120 1.04e-08

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 51.71  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  12 DADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYrldkTLGSPGTELGLSLVR 91
Cdd:PRK10364  345 DPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF----TTKAEGTGLGLAVVH 420

                          90       100       110
                  ....*....|....*....|....*....|
gi 1550449143  92 AVADLHGGQIFL-SDNRTGLVCTVSFPVAV 120
Cdd:PRK10364  421 NIVEQHGGTIQVaSQEGKGATFTLWLPVNI 450
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 22-104 1.78e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 48.74  E-value: 1.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  22 NLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGS--PGTELGLSLVRAVADLHGG 99
Cdd:cd16952     7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRntGGTGLGLAIVKHVMSRHDA 86


                  ....*
gi 1550449143 100 QIFLS 104
Cdd:cd16952    87 RLLIA 91
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 11-104 2.77e-08

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 50.67  E-value: 2.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVkLIVCANGLGIPAAERTKVFGRFYRLDKTLGspGTELGLSLV 90
Cdd:PRK11466  557 GDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQWL-VEVEDSGCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTIS 633

                          90
                  ....*....|....
gi 1550449143  91 RAVADLHGGQIFLS 104
Cdd:PRK11466  634 SRLAQAMGGELSAT 647
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
22-109 4.67e-08

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 50.02  E-value: 4.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  22 NLLTNATRHtpCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDkTLgSPGTELGLSLVRAVADLHGGQI 101
Cdd:PRK10815  385 NVLDNACKY--CLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRAD-TL-RPGQGLGLSVAREITEQYEGKI 460


                  ....*...
gi 1550449143 102 FLSDNRTG 109
Cdd:PRK10815  461 SAGDSPLG 468
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 11-104 5.91e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 47.89  E-value: 5.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  11 GDADLVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGS--PGTELGLS 88
Cdd:cd16947    16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSakQGNGLGLT 95

                          90
                  ....*....|....*.
gi 1550449143  89 LVRAVADLHGGQIFLS 104
Cdd:cd16947    96 ITKRLAESMGGSIYVN 111
PRK15347 PRK15347
two component system sensor kinase;
12-104 1.25e-07

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 48.87  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  12 DADLVKQLCVNLLTNATRHTPCGpAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGspGTELGLSLVR 91
Cdd:PRK15347  510 DSLRLRQILVNLLGNAVKFTETG-GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ--GTGLGLTIAS 586

                          90
                  ....*....|...
gi 1550449143  92 AVADLHGGQIFLS 104
Cdd:PRK15347  587 SLAKMMGGELTLF 599
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
8-109 3.23e-07

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 47.62  E-value: 3.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   8 FIFGDADLVKQLCVNLLTNATRHTpcGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLD--KTLGSPGTEL 85
Cdd:PRK09470  346 PINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDeaRDRESGGTGL 423

                          90       100
                  ....*....|....*....|....
gi 1550449143  86 GLSLVRAVADLHGGQIFLSDNRTG 109
Cdd:PRK09470  424 GLAIVENAIQQHRGWVKAEDSPLG 447
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 15-101 8.53e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 44.34  E-value: 8.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  15 LVKQLCVNLLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRlDKTLGSpGTELGLSLVRAVA 94
Cdd:cd16943     3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-TKPVGE-GTGLGLSLSYRII 80


                  ....*..
gi 1550449143  95 DLHGGQI 101
Cdd:cd16943    81 QKHGGTI 87
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 8-120 2.79e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 44.93  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   8 FIFGDADLVKQLCVNLLTNATRHTPCGpAVELTLSSDAEWVKLI-VCANGLGIPAAERTKVFGRFYRL-DKTLGSP--GT 83
Cdd:PRK11091  391 KVITDGTRLRQILWNLISNAVKFTQQG-GVTVRVRYEEGDMLTFeVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPatGT 469

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1550449143  84 ELGLSLVRAVADLHGGQIFL-SDNRTGLVCTVSFPVAV 120
Cdd:PRK11091  470 GIGLAVSKRLAQAMGGDITVtSEEGKGSCFTLTIHAPA 507
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 9-122 2.95e-06

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 44.58  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGpaVELTLSS---DAEWVKLIVCANGLGIPAaertkvfgrfYRLDKtLGSP---- 81
Cdd:COG5809   373 ILGDENQLKQVFINLLKNAIEAMPEG--GNITIETkaeDDDKVVISVTDEGCGIPE----------ERLKK-LGEPfytt 439

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1550449143  82 ---GTELGLSLVRAVADLHGGQI-FLSDNRTGLVCTVSFPVAVGS 122
Cdd:COG5809   440 kekGTGLGLMVSYKIIEEHGGKItVESEVGKGTTFSITLPIKLSE 484
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 16-103 1.17e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 41.29  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  16 VKQLCVNLLTNA--TRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRlDKTLGSpGTELGLSLVRAV 93
Cdd:cd16976     1 IQQVLMNLLQNAldAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-TKPVGK-GTGLGLSISYGI 78

                          90
                  ....*....|
gi 1550449143  94 ADLHGGQIFL 103
Cdd:cd16976    79 VEEHGGRLSV 88
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 18-108 1.18e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 41.40  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  18 QLCVNLLTNATRHTPCGPA-VELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTE--LGLSLVRAVA 94
Cdd:cd16953     3 QVLRNLIGNAISFSPPDTGrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHsgLGLSISRQII 82

                          90
                  ....*....|....
gi 1550449143  95 DLHGGqIFLSDNRT 108
Cdd:cd16953    83 EAHGG-ISVAENHN 95
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 23-117 3.58e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 39.96  E-value: 3.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  23 LLTNATRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFY-----RLDKTlgspGTELGLSLVRAVADLH 97
Cdd:cd16948    13 IVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgengRNFQE----STGMGLYLVKKLCDKL 88

                          90       100
                  ....*....|....*....|.
gi 1550449143  98 GGQIFL-SDNRTGLVCTVSFP 117
Cdd:cd16948    89 GHKIDVeSEVGEGTTFTITFP 109
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
18-95 8.64e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 39.13  E-value: 8.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  18 QLCVN-LLTNATRHTPCGPA---VELTLSSDAEWVKLIVCANGLGIPAAERTKVfgrfYRLDKTLGspgteLGLSLVRAV 93
Cdd:COG2172    36 VLAVSeAVTNAVRHAYGGDPdgpVEVELELDPDGLEIEVRDEGPGFDPEDLPDP----YSTLAEGG-----RGLFLIRRL 106


                  ..
gi 1550449143  94 AD 95
Cdd:COG2172   107 MD 108
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
12-120 1.11e-04

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 40.49  E-value: 1.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   12 DADLVKQLCVNLLTNATRHTPCGpAVELTLS-----SDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSPGTELG 86
Cdd:PRK09959   825 DPQAFKQVLSNLLSNALKFTTEG-AVKITTSlghidDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLG 903

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1550449143   87 LSLVRA-VADLHGGQIFLSDNRTGLVCTVSFPVAV 120
Cdd:PRK09959   904 LMICKElIKNMQGDLSLESHPGIGTTFTITIPVEI 938
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 21-103 2.62e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 37.74  E-value: 2.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  21 VNLLTNATRHTPCGPAVELTLSSD---------------AEWVKLIVCANGLGIPAAERTKVFGRFYRlDKTLGSpGTEL 85
Cdd:cd16919     6 LNLAVNARDAMPEGGRLTIETSNQrvdadyalnyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFFT-TKEVGK-GTGL 83

                          90
                  ....*....|....*...
gi 1550449143  86 GLSLVRAVADLHGGQIFL 103
Cdd:cd16919    84 GLSMVYGFVKQSGGHLRI 101
HATPase_TopVIB-like cd16933
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
 35-99 4.69e-04

Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.


Pssm-ID: 340410 [Multi-domain]  Cd Length: 203  Bit Score: 38.10  E-value: 4.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1550449143  35 PAVELTLSS-DAEWVKLIVCANGLGIPAAERTKVFGRF-----YRLDKTLGSPGteLGLSLVRAVADLHGG 99
Cdd:cd16933    42 PDIKVEIEEiGKDHYKVIVEDNGPGIPEEQIPKVFGKVlygskYHNKQSRGQQG--LGISAAVLYSQMTTG 110
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
9-87 1.01e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 37.65  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143   9 IFGDADLVKQLCVNLLTNATRHTPCGPAVeLTLSSDAEWVKLIVCANGLGIPAAERTKVFGRFYRLDKTLGSP--GTELG 86
Cdd:PRK10841  556 LNGDPMRLQQVISNLLSNAIKFTDTGCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNfqGTGLG 634


                  .
gi 1550449143  87 L 87
Cdd:PRK10841  635 L 635
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
23-119 1.53e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 36.91  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  23 LLTNATRHTPCGpAVELTLSSDAEWVKLIVCANGLGIPAAERtkvfgrfyrldktlgsPGTELGLSLVRAVADLHGGQI- 101
Cdd:COG4585   170 ALTNALKHAGAT-RVTVTLEVDDGELTLTVRDDGVGFDPEAA----------------PGGGLGLRGMRERAEALGGTLt 232

                          90
                  ....*....|....*...
gi 1550449143 102 FLSDNRTGLVCTVSFPVA 119
Cdd:COG4585   233 IGSAPGGGTRVRATLPLA 250
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 18-101 7.30e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 33.91  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  18 QLCVNLLTNATRHTPcGPAVELTLSSDAEW------------VKLIVCANGLGIPAAERTKVFGRFYrldkTLGSPGTEL 85
Cdd:cd16918     3 QVFLNLVRNAAQALA-GSGGEIILRTRTQRqvtlghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMV----SGRENGTGL 77

                          90
                  ....*....|....*.
gi 1550449143  86 GLSLVRAVADLHGGQI 101
Cdd:cd16918    78 GLAIAQNIVSQHGGVI 93
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 22-106 7.69e-03

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 34.81  E-value: 7.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550449143  22 NLLTNA----TRHTPCGPAVELTLSSDAEWVKLIVCANGLGIPAAERTKVF--GRFYRLDKtlgsPGTE-LGLSLVRAVA 94
Cdd:PRK15053  439 NLLDNAfeasLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFeqGVSTRADE----PGEHgIGLYLIASYV 514

                          90
                  ....*....|..
gi 1550449143  95 DLHGGQIFLSDN 106
Cdd:PRK15053  515 TRCGGVITLEDN 526
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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