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Conserved domains on  [gi|1560336861|gb|RXA25289|]
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ISC system 2Fe-2S type ferredoxin [Escherichia coli]

Protein Classification

ISC system 2Fe-2S type ferredoxin( domain architecture ID 10797691)

ISC system 2Fe-2S type ferredoxin is an iron-sulfur protein that transfers electrons in a wide variety of metabolic reactions, and is associated with and essential to the ISC system

CATH:  3.10.20.30
Gene Ontology:  GO:0016226|GO:0051536|GO:0046872|GO:0009055
SCOP:  3000113

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 2.94e-68

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


:

Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 200.02  E-value: 2.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861   2 PKIVILPHQELCPDGAVLEANSGETILDAALRNGIEIEHACEKSCACTTCHCIVREGFDSLPESSEQEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1560336861  82 ESRLSCQARVTDEDLVVEIPRYTINHAREH 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 2.94e-68

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 200.02  E-value: 2.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861   2 PKIVILPHQELCPDGAVLEANSGETILDAALRNGIEIEHACEKSCACTTCHCIVREGFDSLPESSEQEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1560336861  82 ESRLSCQARVTDEDLVVEIPRYTINHAREH 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-108 1.88e-26

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 94.40  E-value: 1.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  14 PDGA--VLEANSGETILDAALRNGIEIEHACEKSCACTTCHCIV--REGFDSLPESSEQEDDMLDKAWGLEPESRLSCQA 89
Cdd:PLN02593    8 KDGEerTVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQV 87

                          90       100
                  ....*....|....*....|.
gi 1560336861  90 RVTDE--DLVVEIPRYTINHA 108
Cdd:PLN02593   88 IAKPEldGMRLALPAATRNFA 108
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 2.60e-25

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 90.68  E-value: 2.60e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861   1 MPKIVILPHqelcpdGAVLEANSGETILDAALRNGIEIEHACEkSCACTTCHCIVREGfdslpESSEQEDDMLDkAWGLE 80
Cdd:COG0633     1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCR-SGACGTCHVRVLEG-----EVDHREEDALS-DEERA 67

                          90       100
                  ....*....|....*....|.
gi 1560336861  81 PESRLSCQARVTDeDLVVEIP 101
Cdd:COG0633    68 AGSRLACQARPTS-DLVVELP 87
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 2.41e-17

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 70.50  E-value: 2.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  14 PDGAVLEANSGETILDAALRNGIEIEHACEKScACTTCHCIVREGFDslpessEQEDDMLDKAWGLEPESRLSCQARVTD 93
Cdd:cd00207     7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEGEV------DQSDPSLLDEEEAEGGYVLACQTRVTD 79


                  ....*.
gi 1560336861  94 eDLVVE 99
Cdd:cd00207    80 -GLVIE 84
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
11-92 2.52e-11

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 54.84  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  11 ELCPDGAVLEANSGET-ILDAALRNGIEIEHACEKSCaCTTCHCIVREGFDsLPESSEQEDDMLDKAWGLepesrLSCQA 89
Cdd:pfam00111   2 TINGKGVTIEVPDGETtLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGED-QSDQSFLEDDELAAGYVV-----LACQT 74


                  ...
gi 1560336861  90 RVT 92
Cdd:pfam00111  75 YPK 77
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 2.94e-68

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 200.02  E-value: 2.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861   2 PKIVILPHQELCPDGAVLEANSGETILDAALRNGIEIEHACEKSCACTTCHCIVREGFDSLPESSEQEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1560336861  82 ESRLSCQARVTDEDLVVEIPRYTINHAREH 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-108 1.88e-26

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 94.40  E-value: 1.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  14 PDGA--VLEANSGETILDAALRNGIEIEHACEKSCACTTCHCIV--REGFDSLPESSEQEDDMLDKAWGLEPESRLSCQA 89
Cdd:PLN02593    8 KDGEerTVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQV 87

                          90       100
                  ....*....|....*....|.
gi 1560336861  90 RVTDE--DLVVEIPRYTINHA 108
Cdd:PLN02593   88 IAKPEldGMRLALPAATRNFA 108
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 2.60e-25

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 90.68  E-value: 2.60e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861   1 MPKIVILPHqelcpdGAVLEANSGETILDAALRNGIEIEHACEkSCACTTCHCIVREGfdslpESSEQEDDMLDkAWGLE 80
Cdd:COG0633     1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCR-SGACGTCHVRVLEG-----EVDHREEDALS-DEERA 67

                          90       100
                  ....*....|....*....|.
gi 1560336861  81 PESRLSCQARVTDeDLVVEIP 101
Cdd:COG0633    68 AGSRLACQARPTS-DLVVELP 87
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 2.41e-17

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 70.50  E-value: 2.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  14 PDGAVLEANSGETILDAALRNGIEIEHACEKScACTTCHCIVREGFDslpessEQEDDMLDKAWGLEPESRLSCQARVTD 93
Cdd:cd00207     7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEGEV------DQSDPSLLDEEEAEGGYVLACQTRVTD 79


                  ....*.
gi 1560336861  94 eDLVVE 99
Cdd:cd00207    80 -GLVIE 84
NqrF COG2871
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and ...
 14-101 6.05e-16

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 442118 [Multi-domain]  Cd Length: 396  Bit Score: 71.82  E-value: 6.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  14 PDGAVLEANSGETILDAALRNGIEIEHACEKSCACTTCHCIVREG-FDSLPES----SEQEddmLDKAWglepesRLSCQ 88
Cdd:COG2871    41 GDGKEIEVEEGQTLLDALLRQGIFLPSACGGGGTCGQCKVKVLEGgGDILPTEtfhlSDRE---RKEGY------RLACQ 111

                          90
                  ....*....|...
gi 1560336861  89 ARVtDEDLVVEIP 101
Cdd:COG2871   112 VKV-KSDMEIEVP 123
COG3894 COG3894
Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain ...
 1-101 8.47e-15

Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain [Function unknown];


Pssm-ID: 443101 [Multi-domain]  Cd Length: 621  Bit Score: 68.68  E-value: 8.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861   1 MPKIVILPHqelcpdGAVLEANSGETILDAALRNGIEIEHACEKSCACTTCHCIVREGFDSLPESSEQEddmLDKAWGLE 80
Cdd:COG3894     3 KVKVTFLPS------GKRVEVEAGTTLLDAAREAGVDIDAPCGGRGTCGKCKVKVEEGEFSPVTEEERR---LLSPEELA 73

                          90       100
                  ....*....|....*....|.
gi 1560336861  81 PESRLSCQARVTdEDLVVEIP 101
Cdd:COG3894    74 EGYRLACQARVL-GDLVVEVP 93
PRK07609 PRK07609
CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated
 14-104 1.41e-12

CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated


Pssm-ID: 181058 [Multi-domain]  Cd Length: 339  Bit Score: 62.20  E-value: 1.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  14 PDGAVLEANSGETILDAALRNGIEIEHACeKSCACTTCHCIVREGFDSLPESSEQEDDMLDKAWGLEpesrLSCQARvTD 93
Cdd:PRK07609    9 PSGRQFTAEPDETILDAALRQGIHLPYGC-KNGACGSCKGRLLEGEVEQGPHQASALSGEERAAGEA----LTCCAK-PL 82

                          90
                  ....*....|.
gi 1560336861  94 EDLVVEIPRYT 104
Cdd:PRK07609   83 SDLVLEAREVP 93
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
11-92 2.52e-11

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 54.84  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  11 ELCPDGAVLEANSGET-ILDAALRNGIEIEHACEKSCaCTTCHCIVREGFDsLPESSEQEDDMLDKAWGLepesrLSCQA 89
Cdd:pfam00111   2 TINGKGVTIEVPDGETtLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGED-QSDQSFLEDDELAAGYVV-----LACQT 74


                  ...
gi 1560336861  90 RVT 92
Cdd:pfam00111  75 YPK 77
PTZ00490 PTZ00490
Ferredoxin superfamily; Provisional
 36-106 2.57e-11

Ferredoxin superfamily; Provisional


Pssm-ID: 185668  Cd Length: 143  Bit Score: 56.41  E-value: 2.57e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1560336861  36 IEIEHACEKSCACTTCHCIVREG-FDSLPESSEQEDDMLDKAWGLEPESRLSCQARVTDE--DLVVEIPRYTIN 106
Cdd:PTZ00490   68 LDVEGTCNGCMQCATCHVYLSAAsFKKLGGPSEEEEDVLAKALDVKETSRLACQVDLTPEmdGLEVELPSYVTN 141
PRK05713 PRK05713
iron-sulfur-binding ferredoxin reductase;
11-100 1.51e-05

iron-sulfur-binding ferredoxin reductase;


Pssm-ID: 235575 [Multi-domain]  Cd Length: 312  Bit Score: 42.02  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  11 ELCPDGAVLEANSGETILDAALRNGIEIEHACEK-SCACTTCHCIVREGFDSLPESSEQEDDmlDKAWglepesRLSCQA 89
Cdd:PRK05713    3 ELRVGERRWSVPAGSNLLDALNAAGVAVPYSCRAgSCHACLVRCLQGEPEDALPEALAAEKR--EQGW------RLACQC 74

                          90
                  ....*....|.
gi 1560336861  90 RVtDEDLVVEI 100
Cdd:PRK05713   75 RV-VGDLRVEV 84
PTZ00038 PTZ00038
ferredoxin; Provisional
 14-79 3.84e-05

ferredoxin; Provisional


Pssm-ID: 240237 [Multi-domain]  Cd Length: 191  Bit Score: 40.59  E-value: 3.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1560336861  14 PDG-AVLEANSGETILDAALRNGIEIEHACeKSCACTTCHCIVREGFDSLPESSEQEDDMLDKAWGL 79
Cdd:PTZ00038  103 PDGeKVIECDEDEYILDAAERQGVELPYSC-RGGSCSTCAAKLLEGEVDNEDQSYLDDEQLKKGYCL 168
PRK08493 PRK08493
NADH-quinone oxidoreductase subunit G;
15-53 1.18e-04

NADH-quinone oxidoreductase subunit G;


Pssm-ID: 236277 [Multi-domain]  Cd Length: 819  Bit Score: 39.69  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1560336861  15 DGAVLEANSGETILDAALRNGIEIEHACEKSCACTTCHC 53
Cdd:PRK08493    7 NGKECEAQEGEYILNVARRNGIFIPAICYLSGCSPTLAC 45
antC PRK11872
anthranilate 1,2-dioxygenase electron transfer component AntC;
22-91 3.63e-04

anthranilate 1,2-dioxygenase electron transfer component AntC;


Pssm-ID: 183350 [Multi-domain]  Cd Length: 340  Bit Score: 38.19  E-value: 3.63e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1560336861  22 NSGETILDAALRNGIEIEHACEKScACTTCH--CivregfdslpESSEQEDDMLDK----AWGLEPESRLSCQARV 91
Cdd:PRK11872   20 GKDELLLDAALRNGINLPLDCREG-VCGTCQgrC----------ESGIYSQDYVDEdalsERDLAQRKMLACQTRV 84
petF CHL00134
ferredoxin; Validated
 17-94 3.16e-03

ferredoxin; Validated


Pssm-ID: 177056 [Multi-domain]  Cd Length: 99  Bit Score: 34.31  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560336861  17 AVLEANSGETILDAALRNGIEIEHACeKSCACTTCHCIVREGFDSLPESSEQEDDMLDKAWGLE----PESRLSCQARVT 92
Cdd:CHL00134   17 VTIDCPDDVYILDAAEEQGIDLPYSC-RAGACSTCAGKVTEGTVDQSDQSFLDDDQLEAGFVLTcvayPTSDCTILTHQE 95


                  ..
gi 1560336861  93 DE 94
Cdd:CHL00134   96 EE 97
Fer2_4 pfam13510
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
 15-42 5.06e-03

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.


Pssm-ID: 433268 [Multi-domain]  Cd Length: 82  Bit Score: 33.28  E-value: 5.06e-03
                          10        20
                  ....*....|....*....|....*...
gi 1560336861  15 DGAVLEANSGETILDAALRNGIEIEHAC 42
Cdd:pfam13510   9 DGRPVTAPEGDTIAAALLANGVRVPRSC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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