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Conserved domains on  [gi|1560507144|gb|RXB89395|]
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transposase [Escherichia coli]

Protein Classification

nuclease/transposase family protein( domain architecture ID 1563233)

PD-(D/E)XK nuclease/transposase family protein similar to the recombination-promoting nuclease RpnA, which is a low activity DNA endonuclease active on single- and double-stranded DNA, but not RNA, with little sequence specificity

EC:  3.1.21.-
PubMed:  28096446

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RpnC super family cl35003
Recombination-promoting DNA endonuclease RpnC/YadD [Replication, recombination and repair];
2-69 5.97e-10

Recombination-promoting DNA endonuclease RpnC/YadD [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG5464:

Pssm-ID: 444215 [Multi-domain]  Cd Length: 301  Bit Score: 52.66  E-value: 5.97e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1560507144   2 EIKTRRETRQTLAQWFEEKGFQKGFQKGYK---EGLR--KVRLAQRLLSK--GMSREDVAEMATLSLTEVDKLIN 69
Cdd:COG5464   223 LIDELKETIMTIYQELLQEGREEGRQEGREgrqEGRQegKLELALRLLKRrfGLPLELIARITGLSLEQLEALGE 297
 
Name Accession Description Interval E-value
RpnC COG5464
Recombination-promoting DNA endonuclease RpnC/YadD [Replication, recombination and repair];
2-69 5.97e-10

Recombination-promoting DNA endonuclease RpnC/YadD [Replication, recombination and repair];


Pssm-ID: 444215 [Multi-domain]  Cd Length: 301  Bit Score: 52.66  E-value: 5.97e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1560507144   2 EIKTRRETRQTLAQWFEEKGFQKGFQKGYK---EGLR--KVRLAQRLLSK--GMSREDVAEMATLSLTEVDKLIN 69
Cdd:COG5464   223 LIDELKETIMTIYQELLQEGREEGRQEGREgrqEGRQegKLELALRLLKRrfGLPLELIARITGLSLEQLEALGE 297
T_den_put_tspse TIGR01784
conserved hypothetical protein (putative transposase or invertase); Several lines of evidence ...
2-67 1.29e-09

conserved hypothetical protein (putative transposase or invertase); Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.


Pssm-ID: 273806 [Multi-domain]  Cd Length: 270  Bit Score: 51.63  E-value: 1.29e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1560507144   2 EIKTRRETRQTLAQWFEEKGFQKGFQKGYKEGlrKVRLAQRLLSKGMSREDVAEMATLSLTEVDKL 67
Cdd:TIGR01784 207 ELYEQREKYMTDAISAEEEGKEEGIEEGILEA--KLETAKKLLKNGLTLEQVAEATGLSVEELEEI 270
 
Name Accession Description Interval E-value
RpnC COG5464
Recombination-promoting DNA endonuclease RpnC/YadD [Replication, recombination and repair];
2-69 5.97e-10

Recombination-promoting DNA endonuclease RpnC/YadD [Replication, recombination and repair];


Pssm-ID: 444215 [Multi-domain]  Cd Length: 301  Bit Score: 52.66  E-value: 5.97e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1560507144   2 EIKTRRETRQTLAQWFEEKGFQKGFQKGYK---EGLR--KVRLAQRLLSK--GMSREDVAEMATLSLTEVDKLIN 69
Cdd:COG5464   223 LIDELKETIMTIYQELLQEGREEGRQEGREgrqEGRQegKLELALRLLKRrfGLPLELIARITGLSLEQLEALGE 297
T_den_put_tspse TIGR01784
conserved hypothetical protein (putative transposase or invertase); Several lines of evidence ...
2-67 1.29e-09

conserved hypothetical protein (putative transposase or invertase); Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.


Pssm-ID: 273806 [Multi-domain]  Cd Length: 270  Bit Score: 51.63  E-value: 1.29e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1560507144   2 EIKTRRETRQTLAQWFEEKGFQKGFQKGYKEGlrKVRLAQRLLSKGMSREDVAEMATLSLTEVDKL 67
Cdd:TIGR01784 207 ELYEQREKYMTDAISAEEEGKEEGIEEGILEA--KLETAKKLLKNGLTLEQVAEATGLSVEELEEI 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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