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Conserved domains on  [gi|1562648001|gb|RXH88383|]
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hypothetical protein DVH24_042454 [Malus domestica]

Protein Classification

MATE family efflux transporter( domain architecture ID 8282)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_like super family cl09326
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 110-371 1.05e-57

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


The actual alignment was detected with superfamily member cd13136:

Pssm-ID: 447704 [Multi-domain]  Cd Length: 424  Bit Score: 197.40  E-value: 1.05e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 110 RMKEIAVFTGPATGLWLCGPLMSLIDTVIIGQ-GSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQ 188
Cdd:cd13136     1 LHREILALALPAILSNITVPLLGLVDTAVVGHlGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 189 HQISILLFDGLASGFLMLSFTRFFGSWALTAFtgSKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKA 268
Cdd:cd13136    81 ALLVRALLLALAIGLLLILLQSPLLALALLLL--GASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 269 LAVASAVNGVGDVLLCSFLGYGIAGAAWATMVSQVVAGYMMTEALNKKGY---NAYVISVPSSKELLTVLGLAAPVLIKM 345
Cdd:cd13136   159 QIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRllgKSLSRRLPSKAALKRLFKLNRDIFIRT 238

                         250       260
                  ....*....|....*....|....*.
gi 1562648001 346 ISKVAFYSLLVCFATSMGTNTMVAHQ 371
Cdd:cd13136   239 LALLAAFLFFTALAARLGDVILAANQ 264
 
Name Accession Description Interval E-value
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 110-371 1.05e-57

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 197.40  E-value: 1.05e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 110 RMKEIAVFTGPATGLWLCGPLMSLIDTVIIGQ-GSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQ 188
Cdd:cd13136     1 LHREILALALPAILSNITVPLLGLVDTAVVGHlGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 189 HQISILLFDGLASGFLMLSFTRFFGSWALTAFtgSKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKA 268
Cdd:cd13136    81 ALLVRALLLALAIGLLLILLQSPLLALALLLL--GASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 269 LAVASAVNGVGDVLLCSFLGYGIAGAAWATMVSQVVAGYMMTEALNKKGY---NAYVISVPSSKELLTVLGLAAPVLIKM 345
Cdd:cd13136   159 QIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRllgKSLSRRLPSKAALKRLFKLNRDIFIRT 238

                         250       260
                  ....*....|....*....|....*.
gi 1562648001 346 ISKVAFYSLLVCFATSMGTNTMVAHQ 371
Cdd:cd13136   239 LALLAAFLFFTALAARLGDVILAANQ 264
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
111-372 2.31e-28

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 116.78  E-value: 2.31e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 111 MKEIAVFTGPATGLWLCGPLMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQ 190
Cdd:COG0534     7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 191 ISILLFDGLASGFLMLSFTRFFGSWALTAFTGSknADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALA 270
Cdd:COG0534    87 LGQALLLALLLGLLLTLLGLLFAPPLLRLLGAD--PEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIML 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 271 VASAVNGVGDVLLCSFLGYGIAGAAWATMVSQVV-AGYMMTEALNKKGYNAYVIS--VPSSKELLTVLGLAAPVLIKMIS 347
Cdd:COG0534   165 IGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVsALLLLYYLFRKRSLLRLRLRdlRPDRKILKRILRIGLPAGLQQLA 244

                         250       260
                  ....*....|....*....|....*
gi 1562648001 348 KVAFYSLLVCFATSMGTNTMVAHQY 372
Cdd:COG0534   245 ESLGFLVLNALVARLGTAAVAAYGI 269
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 129-371 1.41e-19

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 90.00  E-value: 1.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 129 PLMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGFLMLSF 208
Cdd:TIGR00797  10 PLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLLV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 209 TRFFGSWALTAFTGSKnaDIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLL--CSF 286
Cdd:TIGR00797  90 GYFFIDPLLSLMGADG--EVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNYILifGKF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 287 LGYGIAGAAWATMVSQVVA-----GYMMTEalnKKGYNAYVISVPSSKELL-TVLGLAAPVLIKMISKVAFYSLLVCFAT 360
Cdd:TIGR00797 168 GFLGIVGAALATVISYWLMfllllYYIKKA---KKIGLKWEGLLKPDWEVLkRLLKLGLPIAFRVILESLSFALLALLVA 244

                         250
                  ....*....|.
gi 1562648001 361 SMGTNTMVAHQ 371
Cdd:TIGR00797 245 RLGSIALAAHQ 255
PRK10367 PRK10367
DNA-damage-inducible SOS response protein; Provisional
 129-304 1.77e-09

DNA-damage-inducible SOS response protein; Provisional


Pssm-ID: 182413 [Multi-domain]  Cd Length: 441  Bit Score: 59.75  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 129 PLMSLIDTVIIGQ-GSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGFLMLS 207
Cdd:PRK10367   26 PLLGLVDTAVIGHlDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQALARALVQPLLLALGAGALIAL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 208 FTRFFGSWALTAFTGSknADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLLCSFL 287
Cdd:PRK10367  106 LRTPLIDLALHIVGGS--EAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVVGNILNIVLDLWLVMGL 183

                         170
                  ....*....|....*..
gi 1562648001 288 GYGIAGAAWATMVSQVV 304
Cdd:PRK10367  184 HMNVQGAALATVIAEYA 200
MatE pfam01554
MatE; The MatE domain
 130-282 1.44e-06

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 48.33  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 130 LMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGFLMLSFT 209
Cdd:pfam01554  11 LYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLV 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1562648001 210 RFFGSWALTAFTGSKnaDIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVL 282
Cdd:pfam01554  91 LLFSEPILSLFGQDE--EVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNYL 161
 
Name Accession Description Interval E-value
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 110-371 1.05e-57

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 197.40  E-value: 1.05e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 110 RMKEIAVFTGPATGLWLCGPLMSLIDTVIIGQ-GSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQ 188
Cdd:cd13136     1 LHREILALALPAILSNITVPLLGLVDTAVVGHlGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 189 HQISILLFDGLASGFLMLSFTRFFGSWALTAFtgSKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKA 268
Cdd:cd13136    81 ALLVRALLLALAIGLLLILLQSPLLALALLLL--GASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 269 LAVASAVNGVGDVLLCSFLGYGIAGAAWATMVSQVVAGYMMTEALNKKGY---NAYVISVPSSKELLTVLGLAAPVLIKM 345
Cdd:cd13136   159 QIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRllgKSLSRRLPSKAALKRLFKLNRDIFIRT 238

                         250       260
                  ....*....|....*....|....*.
gi 1562648001 346 ISKVAFYSLLVCFATSMGTNTMVAHQ 371
Cdd:cd13136   239 LALLAAFLFFTALAARLGDVILAANQ 264
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
111-372 2.31e-28

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 116.78  E-value: 2.31e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 111 MKEIAVFTGPATGLWLCGPLMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQ 190
Cdd:COG0534     7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 191 ISILLFDGLASGFLMLSFTRFFGSWALTAFTGSknADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALA 270
Cdd:COG0534    87 LGQALLLALLLGLLLTLLGLLFAPPLLRLLGAD--PEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIML 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 271 VASAVNGVGDVLLCSFLGYGIAGAAWATMVSQVV-AGYMMTEALNKKGYNAYVIS--VPSSKELLTVLGLAAPVLIKMIS 347
Cdd:COG0534   165 IGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVsALLLLYYLFRKRSLLRLRLRdlRPDRKILKRILRIGLPAGLQQLA 244

                         250       260
                  ....*....|....*....|....*
gi 1562648001 348 KVAFYSLLVCFATSMGTNTMVAHQY 372
Cdd:COG0534   245 ESLGFLVLNALVARLGTAAVAAYGI 269
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 129-371 1.41e-19

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 90.00  E-value: 1.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 129 PLMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGFLMLSF 208
Cdd:TIGR00797  10 PLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLLV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 209 TRFFGSWALTAFTGSKnaDIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLL--CSF 286
Cdd:TIGR00797  90 GYFFIDPLLSLMGADG--EVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNYILifGKF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 287 LGYGIAGAAWATMVSQVVA-----GYMMTEalnKKGYNAYVISVPSSKELL-TVLGLAAPVLIKMISKVAFYSLLVCFAT 360
Cdd:TIGR00797 168 GFLGIVGAALATVISYWLMfllllYYIKKA---KKIGLKWEGLLKPDWEVLkRLLKLGLPIAFRVILESLSFALLALLVA 244

                         250
                  ....*....|.
gi 1562648001 361 SMGTNTMVAHQ 371
Cdd:TIGR00797 245 RLGSIALAAHQ 255
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 130-371 4.05e-19

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 89.49  E-value: 4.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 130 LMSLIDTVIIGQGSSIELAALGpgtvmcdYMSYVFMF-------LSIATSNMVATALARRDKSEVQHQISILLFDGLASG 202
Cdd:cd13137    19 LVGLVDVFMVGRLGAEAIAAVG-------LATQVLWLllvlnmaLGTGTVALVSQSYGAGDYERARRALGQSLLLALLLS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 203 FLMLSFTRFFGSWALTAFTGSknADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVL 282
Cdd:cd13137    92 LPLALLGLLFAEPLLRLLGAD--PEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLDYV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 283 L----CSFLGYGIAGAAWATMVSQVVAGYMMTEALNKKGYNAYV---ISVPSSKELLTVLGLAAPVLIKMISKVAFYSLL 355
Cdd:cd13137   170 LifglWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKIsfkGFRLDRKIIKKLLRIGLPAGLEQLLRSLGFLVL 249

                         250
                  ....*....|....*.
gi 1562648001 356 VCFATSMGTNTMVAHQ 371
Cdd:cd13137   250 LAIVASYGTAALAAYQ 265
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 130-369 1.27e-16

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 82.12  E-value: 1.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 130 LMSLIDTVIIGQ-GSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGF----L 204
Cdd:cd13138    21 LYNLVDLLIVGQfLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIvltiL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 205 MLSFTRFFGSWALTaftgskNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLLC 284
Cdd:cd13138   101 GLLFAPPILRLMNT------PAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVLNIILDLLFI 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 285 SFLGYGIAGAAWATMVSQVV-AGYMMTEALNKKGYNAYVIS--VPSSKELLTVLGLAAPVLIKMISkVAFYSLLVC-FAT 360
Cdd:cd13138   175 AVFHMGVAGAALATVIAQAIsVLLALYYLRKKKLPFKLSLKdfRFDKEILKEILKIGLPSALQQSL-VSISFLIINsIVN 253


                  ....*....
gi 1562648001 361 SMGTNTMVA 369
Cdd:cd13138   254 SYGVVASAA 262
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 109-364 2.13e-12

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 69.09  E-value: 2.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 109 NRMKEIAVFTGPATGLWLCGPLMSLIDTVIIGQGSSIELAALGPGTVmcdyMSYVFMFLSIATSNMVATALARRDKSEVQ 188
Cdd:cd13133     2 GGYREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGV----LYFAILMLFFGLSSGVQVFVAQYNGAGRY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 189 HQISILLFDG----LASGFLMLSFTRFFGSWALTAFTGSknADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWG 264
Cdd:cd13133    78 SRIGRVLWQGlyfsLLLAPLLALLSALAAPLLFLLLGHS--PEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRV 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 265 PLKALAVASAVNGVGDVLLC----SFLGYGIAGAAWATMVSQVVA----GYMMTEALNKKGYNAYVISVPSSKELLTVLG 336
Cdd:cd13133   156 VMVANLVMVVVNIVLDYALIfgklGFPAMGIAGAAIATVIAEAVSllffLLLLFRRKNRRRFGLRRAWRFDRELLRRILR 235

                         250       260
                  ....*....|....*....|....*...
gi 1562648001 337 LAAPVLIKMISKVAFYSLLVCFATSMGT 364
Cdd:cd13133   236 LGLPSGLQFFLDVGAFTVFFLLIGRLGT 263
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 126-306 2.28e-12

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 68.89  E-value: 2.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 126 LCGPLMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGFLM 205
Cdd:cd12082     9 LLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 206 LSFTRFFGSWALTAFTGskNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLLCS 285
Cdd:cd12082    89 AALLLFFSPLILSLLGA--EEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIF 166

                         170       180
                  ....*....|....*....|....
gi 1562648001 286 FLG---YGIAGAAWATMVSQVVAG 306
Cdd:cd12082   167 GLGppeLGIAGAALATVISYVIGA 190
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 130-372 2.79e-11

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 65.60  E-value: 2.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 130 LMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGFLMLSFT 209
Cdd:cd13134    21 LLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 210 RFFGSWALTAFtgSKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLL----CS 285
Cdd:cd13134   101 LFFGAELLRLM--GLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVGNYLLifgwFG 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 286 FLGYGIAGAAWATMVSQVVA-GYMMTEAL-NKKGYNAYVISVPSSKELL-TVLGLAAPVLIKMISKVAFYSLLVCFATSM 362
Cdd:cd13134   179 LPKLGVAGVAISTVISRAVGlVLLFILLFrKLKIRFRLKDLRPFPKKLLkKILKIGLPSAGEELSYNLSQTVITAFIARL 258

                         250
                  ....*....|
gi 1562648001 363 GTNTMVAHQY 372
Cdd:cd13134   259 GTAALAARTY 268
MATE_NorM_like cd13131
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ...
 130-371 5.72e-11

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.


Pssm-ID: 240536 [Multi-domain]  Cd Length: 435  Bit Score: 64.44  E-value: 5.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 130 LMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQI-SILLFDGLASGFLMLSF 208
Cdd:cd13131    21 AMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVrQGLWLALLLSLPLMLLL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 209 trFFGSWALTAFtgSKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLLCS--- 285
Cdd:cd13131   101 --WLAPPILPLM--GQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLNYVLIFgkf 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 286 -FLGYGIAGAAWATMVSQ-VVAGYMMTEALNKKGYNAYVISV----PSSKELLTVLGLAAPVLIKMISKVAFYSLLVCFA 359
Cdd:cd13131   177 gLPALGGAGAGLATAIVYwLMFLALAFYIRRHKRFRRYRLFArfwrPDWARLKELLRLGLPIGLTIFFEVSLFAAVALLM 256

                         250
                  ....*....|..
gi 1562648001 360 TSMGTNTMVAHQ 371
Cdd:cd13131   257 GRLGTTVLAAHQ 268
MATE_like_1 cd13140
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 132-370 3.96e-10

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240545 [Multi-domain]  Cd Length: 435  Bit Score: 61.77  E-value: 3.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 132 SLIDTVIIGQGSSIELAALGPGTvMCDYMSYVFMFLS-IATSNMVATALARRDKSEVQHQISILLFDGLASGFLMLSFTR 210
Cdd:cd13140    25 NLTDMFWVGRLGSDAVAAVGTAG-FFVWLAYALALLSkIGAQVKVSQSIGAKDEKEARKYARNALQLNLLLGILYGLLLL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 211 FFGSwALTAFTGSKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLLC----SF 286
Cdd:cd13140   104 LFAK-PLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVLNIILDPLLIfgfgPF 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 287 LGYGIAGAAWATMVSQVVAGYMMTEALNKKGY---NAYVISVPSSKELLTVLGLAAPvlikmiskVAFYSLLVCFaTSMG 363
Cdd:cd13140   183 PALGVAGAALATVLAQAIVFLLFLYALKKKKGlflKIRILKRPDRKYIKEILKLGLP--------VALQSILFAL-ISMI 253


                  ....*..
gi 1562648001 364 TNTMVAH 370
Cdd:cd13140   254 LARIIAS 260
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
108-306 4.12e-10

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 61.70  E-value: 4.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 108 WNRMKEIAVFTGPATGLWLCGPLMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEV 187
Cdd:COG0534   225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 188 QHQISILLFDGLASGFLMLSFTRFFGSWALTAFTgsKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLK 267
Cdd:COG0534   305 RRAARLALLLALGIGLLLALLLFLFPEPIIGLFT--DDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMI 382

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1562648001 268 ALAVASAVNGVGDVLLCSFLGYGIAGAAWATMVSQVVAG 306
Cdd:COG0534   383 ISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRA 421
PRK10367 PRK10367
DNA-damage-inducible SOS response protein; Provisional
 129-304 1.77e-09

DNA-damage-inducible SOS response protein; Provisional


Pssm-ID: 182413 [Multi-domain]  Cd Length: 441  Bit Score: 59.75  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 129 PLMSLIDTVIIGQ-GSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGFLMLS 207
Cdd:PRK10367   26 PLLGLVDTAVIGHlDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQALARALVQPLLLALGAGALIAL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 208 FTRFFGSWALTAFTGSknADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLLCSFL 287
Cdd:PRK10367  106 LRTPLIDLALHIVGGS--EAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVVGNILNIVLDLWLVMGL 183

                         170
                  ....*....|....*..
gi 1562648001 288 GYGIAGAAWATMVSQVV 304
Cdd:PRK10367  184 HMNVQGAALATVIAEYA 200
MATE_SpoVB_like cd13124
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ...
 103-316 5.25e-07

Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240529 [Multi-domain]  Cd Length: 434  Bit Score: 52.08  E-value: 5.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 103 ESQNLWNRMKEIAVFTGPATGLWLCGPLMSLIDTVII-------GQGSSIELAALGPGTVMcdYMSYVFMFLSIATS--- 172
Cdd:cd13124   215 SKISTKEILKELLSYAIPITLSSLILPLLQLIDSFTVprrlqaaGLSESEATALYGILTGR--AQPLVQLPTVIATAlst 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 173 ---NMVATALARRDKSEVQHQIS----ILLFDGLASGFLMLSFTR-----FFGSwaltaftgsknadiiHAANTYVQIrg 240
Cdd:cd13124   293 slvPAISEAYAKGDKKELRRRINqalrLTLLIGLPAAVGLAVLAEpintlLFGD---------------SEGGLILQI-- 355

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1562648001 241 LAWPALLVGWVAQSASL--GMKDSWGPLKALAVASAVNGVGDVLLCSFLGygIAGAAWATMVSQVVAGYMMTEALNKK 316
Cdd:cd13124   356 LAPSILFLSLQQVTAAIlqGLGKVKIPVINLLIGLLVKIVLNYVLIPIFG--IYGAAIATVIGFLVAALLNLRALKKL 431
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 124-306 1.14e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 51.04  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 124 LWLCGPLMS---------LIDTVIIGQGSSIELAALgpgTVMcdyMSYVFMFLSIATSNMVA-TALA-----RRDKSEVQ 188
Cdd:cd13142    14 LKLAWPIIVsnllqvaynLADTFWLGRLGADAVAAP---SIS---WPLIFLFISLGGGLTVAgTALVaqytgAGDYDKAN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 189 HQIS-ILLFDGLASgfLMLSFTRFFGSWALTAFTGSKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLK 267
Cdd:cd13142    88 KVAGqTFSFVIILS--LILAVLGYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMK 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1562648001 268 ALAVASAVNGVGDVLL----CSFLGYGIAGAAWATMVSQVVAG 306
Cdd:cd13142   166 IMFGSVLLNVILDPLLifgiGPFPGLGVAGAALATVISRGIAA 208
MatE pfam01554
MatE; The MatE domain
 130-282 1.44e-06

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 48.33  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 130 LMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGFLMLSFT 209
Cdd:pfam01554  11 LYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLV 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1562648001 210 RFFGSWALTAFTGSKnaDIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVL 282
Cdd:pfam01554  91 LLFSEPILSLFGQDE--EVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNYL 161
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 132-369 1.80e-06

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 50.20  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 132 SLIDTVIIGQG-SSIELAALGpgtvmcdyMSYVFMFLSIATSNMVAT--------ALARRDKSEVQHQISILLFDGLASG 202
Cdd:cd13143    24 NIVDGIFVGHGvGALALAAVN--------LVFPIIMLLMALGLMIGVggaslisrRLGAGDREKANRIFSTALLLSLILG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 203 FLMLSFTRFFGSWALTAFTGSknADIIHAANTYVQIRGLAWPALLVGWVAQ-------SASLGMKdswgplkALAVASAV 275
Cdd:cd13143    96 LLLTILGLLFLDPLLRLLGAS--GELLPYAVDYLRIILLGAPFTILSSVLNnllraegKPKLAML-------GMLIGAVL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 276 NGVGDVLLCSFLGYGIAGAAWATMVSQVVAGYMMTEALNKKGYNAYVIS---VPSSKELLTVLGLAAPVLIKMISKVAFY 352
Cdd:cd13143   167 NIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLlrfKLSLKIIKEILALGFPSFLMQLSSSVVT 246

                         250
                  ....*....|....*..
gi 1562648001 353 SLLVCFATSMGTNTMVA 369
Cdd:cd13143   247 IVLNLTLLGYGGDIGVA 263
MATE_like_4 cd13144
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 130-317 9.77e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240549 [Multi-domain]  Cd Length: 434  Bit Score: 48.00  E-value: 9.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 130 LMSLIDTVIIGQGSSIELAALGpgtvMCDYMSYVFMFLSIATSNMVATALARR----DKSEVQHQISILLFDGLASGFLM 205
Cdd:cd13144    26 LYNIVDSIFVARLGENALTAVS----LAFPIQNLMIAVAVGTGVGVNALLSRSlgekDQKEANKAANNGLLLALLSYLLF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 206 LSFTRFFGSWALTAFTgsKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLL-- 283
Cdd:cd13144   102 LLLGLFGVKPFFRLFT--DDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINIILDPILif 179

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1562648001 284 --CSFLGYGIAGAAWATMVSQVVAGYMMTEALNKKG 317
Cdd:cd13144   180 glFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKN 215
SpoVB COG5841
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ...
 111-316 2.32e-05

Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444543 [Multi-domain]  Cd Length: 532  Bit Score: 47.08  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 111 MKEIAVFTGPATGLWLCGPLMSLIDTVII-------GQGSSIELAALGPGTVMcdYMSYVFMFLSIATS------NMVAT 177
Cdd:COG5841   232 LKELLRIAIPITLSSLVLPLFQLIDSFTVprrlqaaGLSASEATSLYGILSGM--AQPLVNLPTVLATAlatslvPAISE 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 178 ALARRDKSEVQHQIS----ILLFDGLASGFLMLSFTR-----FFGSwaltaftgsknadiiHAANTYVQIrgLAWPALLV 248
Cdd:COG5841   310 AFAKKDRKLVRRRINqalrLTLLIGLPAAVGLAVLAEpintlLFGN---------------PEGGGILAI--LAPSAIFL 372

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 249 GWVAQSASL--GMKDSWGPLKALAVASAVNGVGDVLLCSFLGygIAGAAWATMVSQVVAGYMMTEALNKK 316
Cdd:COG5841   373 SLQQVTTGIlqGLGKQKIPVINLLIGLLVKIILNYLLVPLFG--IYGAALATVIGYLVAAILNLAALKKY 440
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 108-310 3.72e-05

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 46.16  E-value: 3.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 108 WNRMKEIAVFTGPATGLWLCGPLMSLIDTVIIGQ-GSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSE 186
Cdd:cd12082   215 LELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAfGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDR 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 187 V-QHQISILLFDGLASGFLMLSFTrFFGSWALTAFTgsKNADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGP 265
Cdd:cd12082   295 ArRITWVALLIGLLIGAVLGLLIL-LFPEPILSLFT--NDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKS 371

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1562648001 266 LKALAVASAVNGVGDVLLCSFLGYGIAGAAWATMVSQVVAGYMMT 310
Cdd:cd12082   372 LIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLL 416
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 114-305 6.85e-05

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 44.94  E-value: 6.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 114 IAVFTGPATGLWLCGPLMSLIDTVIIGQ-GSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQIS 192
Cdd:COG2244   175 VLKYSLPLLLSGLLGLLLTNLDRLLLGAlLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 193 ILLFDGLASGFLMLSFTRFFGSWALTAFTGSKnadiIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAVA 272
Cdd:COG2244   255 KALRLLLLLGLPLALGLALLAPPLLSLLFGPE----YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIG 330

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1562648001 273 SAVNGVGDVLLcsFLGYGIAGAAWATMVSQVVA 305
Cdd:COG2244   331 AVLNLVLNLLL--IPRYGLVGAAIATLLSYLVL 361
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 111-371 8.26e-04

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 41.79  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 111 MKEIAVFTGPATGLWLCGPLMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMF-LSIATSNMVATALARRDKSEV-- 187
Cdd:cd13132     2 AKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLgLASALDTLCGQAFGAKNYKLVgv 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 188 --QHQISILLfdgLASGFLMLSFtrFFGSWALTAFtgSKNADIIHAANTYVqiRGLAwPALLVGWVAQSASLGMKdSWGP 265
Cdd:cd13132    82 ylQRALVILL---LCCVPISLLW--LNTEPILLLL--GQDPEIARLAGEYL--RWLI-PGLFAYALFEPLKRYLQ-AQGI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 266 LKALAVASAVNGVGDVLLCSFL----GYGIAGAAWATMVSQ-----VVAGYMMTEALNKKGYnaYVISVPSSKELLTVLG 336
Cdd:cd13132   151 VLPLVYISLVALLLNILLNYLLvfvlGLGFIGAALATSISYwlivvLLLLYIFFSKGHKATW--GGFSREAFRGWGPFLK 228

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1562648001 337 LAAPVLIKMISKVAFYSLLVCFATSMGTNTMVAHQ 371
Cdd:cd13132   229 LAIPSALMLCLEWWAFEILVLLAGLLPGTVALAAQ 263
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 112-305 3.55e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 39.98  E-value: 3.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 112 KEIAVFTGPATGLWLCGPLMSLIDTVIIGQGSSIELAALGPGTVMCDYMSYVFMFLSIATSNMVATALARRDKSEVQHQI 191
Cdd:cd13149     9 RHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 192 SILLFDGLASGFLMLSFTRFFGSWALTAFTGSknADIIHAANTYVQIRGLAWPALLVGWVAQSASLGMKDSWGPLKALAV 271
Cdd:cd13149    89 TDSLILSLLLSVIVSLLGLFTIPPLFSLLGAS--GEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLG 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1562648001 272 ASAVNGVGDVLLcsFLGY------GIAGAAWATMVSQVVA 305
Cdd:cd13149   167 AALVNVILDPIL--IFGFgpipgmGIAGAAIATVISRALG 204
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 108-310 4.05e-03

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 39.45  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 108 WNRMKEIAVFTGPATGLWLCGPLMSLIDTVIIGQgssielaALGPGTV----MCDYMSYVFMFLSIATSNMVATALAR-- 181
Cdd:cd13128   202 LKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGY-------FLGDAAVgiynAAYRIAELLLFIPSAISTALFPRISEly 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 182 -RDKSEVQHQISILLFDGLASGFLMLSFTRFFGSWALTAFTGSKNADiihaANTYVQIrgLAWPALLVGWVAQSASL--G 258
Cdd:cd13128   275 kNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP----AALVLQI--LAWGFLFIFLNGIFGSIlqA 348

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1562648001 259 MKDSWGPLKALAVASAVNGVGDVLLCSFlgYGIAGAAWATMVSQVVAGYMMT 310
Cdd:cd13128   349 IGKQKLTLKILLIGALLNVILNLLLIPK--YGIIGAAIATLISEFIIFILLL 398
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 160-288 6.69e-03

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 39.08  E-value: 6.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562648001 160 MSYVFMFLSIATSNMVATALARRDKSEVQHQISILLFDGLASGFLMLSFTRFFGSWALTAFTgsKNADIIHAANTYVQIR 239
Cdd:cd13136   273 SSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGGEPIIRLFT--DDPAVLALAATYLPWL 350

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1562648001 240 GLAWPALLVGWVAQSASLGMKDSWGPLKALAVASAVNGVGDVLLCSFLG 288
Cdd:cd13136   351 ALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLLVPLWG 399
MATE_MJ0709_like cd13147
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ...
 258-309 8.14e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240552 [Multi-domain]  Cd Length: 441  Bit Score: 38.68  E-value: 8.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1562648001 258 GMKDSWGPLKALAVASAVNGVGDVLLCSFLGYGIAGAAWATMVSQVVAGYMM 309
Cdd:cd13147   152 GEGDTKRAMYAMVAGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVL 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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