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Conserved domains on  [gi|1563131594|gb|RXK11428|]
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tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE [Halarcobacter bivalviorum]

Protein Classification

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE( domain architecture ID 10002738)

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB

Gene Symbol:  tsaE
Gene Ontology:  GO:0002949|GO:0005524
PubMed:  36362385

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 24-133 2.88e-33

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440565  Cd Length: 146  Bit Score: 113.65  E-value: 2.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563131594  24 NCIVILRGDLASGKTTFVKHFVKKLGLDDEVTSPTFSLQSIYSN---RVFHYDVYN-KSLQEFISLGLLEEFEKEGIHFV 99
Cdd:COG0802    21 GDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYELgrlPLYHFDLYRlEDPEELEDLGLEEYLDGDGVCLI 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1563131594 100 EWGdEKLEELLKSygfEVFVLNIKK-EDDKRQYTI 133
Cdd:COG0802   101 EWP-ERIEGLLPE---DDLEITIEYlGEDGRRITL 131
 
Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 24-133 2.88e-33

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 113.65  E-value: 2.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563131594  24 NCIVILRGDLASGKTTFVKHFVKKLGLDDEVTSPTFSLQSIYSN---RVFHYDVYN-KSLQEFISLGLLEEFEKEGIHFV 99
Cdd:COG0802    21 GDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYELgrlPLYHFDLYRlEDPEELEDLGLEEYLDGDGVCLI 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1563131594 100 EWGdEKLEELLKSygfEVFVLNIKK-EDDKRQYTI 133
Cdd:COG0802   101 EWP-ERIEGLLPE---DDLEITIEYlGEDGRRITL 131
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
 23-110 8.85e-31

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 106.75  E-value: 8.85e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563131594  23 NNCIVILRGDLASGKTTFVKHFVKKLGLDDEVTSPTFSLQSIYSNR---VFHYDVYN-KSLQEFISLGLLEEFEKEGIHF 98
Cdd:pfam02367  20 PGDVILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEYEGGglpLYHFDLYRlEDPEELEDLGLEDYFDGDGVCL 99

                          90
                  ....*....|..
gi 1563131594  99 VEWGdEKLEELL 110
Cdd:pfam02367 100 IEWP-ERIEELL 110
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
 16-134 7.96e-29

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 102.14  E-value: 7.96e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563131594  16 SLTQKRDNNCIVILRGDLASGKTTFVKHFVKKLGLDDEVTSPTFSLQSIYSN---RVFHYDVYN-KSLQEFISLGLLEEF 91
Cdd:TIGR00150  14 AFAKPLDFGTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEYNEgnlMVYHFDLYRlADPEELELMGLEDYF 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1563131594  92 EKEGIHFVEWGDEKLEELLKSYgfevFVLNIKKEDDKRQYTIN 134
Cdd:TIGR00150  94 EGDGICLVEWPEEGLEILPDYD----LQIKIDYVGDGREIELT 132
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
16-101 4.22e-12

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 59.39  E-value: 4.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563131594  16 SLTQKRDNNCIVILRGDLASGKTTFVKHFVKKLGLDDEVTSPTFSLQSIYS---NRVFHYDVYNKS-LQEFISLGLLEEF 91
Cdd:PRK10646   20 RVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTldnLMVYHFDLYRLAdPEELEFMGIRDYF 99

                          90
                  ....*....|
gi 1563131594  92 EKEGIHFVEW 101
Cdd:PRK10646  100 ANDAICLVEW 109
 
Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 24-133 2.88e-33

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 113.65  E-value: 2.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563131594  24 NCIVILRGDLASGKTTFVKHFVKKLGLDDEVTSPTFSLQSIYSN---RVFHYDVYN-KSLQEFISLGLLEEFEKEGIHFV 99
Cdd:COG0802    21 GDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYELgrlPLYHFDLYRlEDPEELEDLGLEEYLDGDGVCLI 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1563131594 100 EWGdEKLEELLKSygfEVFVLNIKK-EDDKRQYTI 133
Cdd:COG0802   101 EWP-ERIEGLLPE---DDLEITIEYlGEDGRRITL 131
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
 23-110 8.85e-31

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 106.75  E-value: 8.85e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563131594  23 NNCIVILRGDLASGKTTFVKHFVKKLGLDDEVTSPTFSLQSIYSNR---VFHYDVYN-KSLQEFISLGLLEEFEKEGIHF 98
Cdd:pfam02367  20 PGDVILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEYEGGglpLYHFDLYRlEDPEELEDLGLEDYFDGDGVCL 99

                          90
                  ....*....|..
gi 1563131594  99 VEWGdEKLEELL 110
Cdd:pfam02367 100 IEWP-ERIEELL 110
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
 16-134 7.96e-29

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 102.14  E-value: 7.96e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563131594  16 SLTQKRDNNCIVILRGDLASGKTTFVKHFVKKLGLDDEVTSPTFSLQSIYSN---RVFHYDVYN-KSLQEFISLGLLEEF 91
Cdd:TIGR00150  14 AFAKPLDFGTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEYNEgnlMVYHFDLYRlADPEELELMGLEDYF 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1563131594  92 EKEGIHFVEWGDEKLEELLKSYgfevFVLNIKKEDDKRQYTIN 134
Cdd:TIGR00150  94 EGDGICLVEWPEEGLEILPDYD----LQIKIDYVGDGREIELT 132
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
16-101 4.22e-12

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 59.39  E-value: 4.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563131594  16 SLTQKRDNNCIVILRGDLASGKTTFVKHFVKKLGLDDEVTSPTFSLQSIYS---NRVFHYDVYNKS-LQEFISLGLLEEF 91
Cdd:PRK10646   20 RVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTldnLMVYHFDLYRLAdPEELEFMGIRDYF 99

                          90
                  ....*....|
gi 1563131594  92 EKEGIHFVEW 101
Cdd:PRK10646  100 ANDAICLVEW 109
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 26-75 6.28e-03

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 35.09  E-value: 6.28e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1563131594  26 IVILRGDLASGKTTFVKHFVKKLGL--DDEVTSPTFSLQSIYSNRVFHYDVY 75
Cdd:COG4088     6 LLILTGPPGSGKTTFAKALAQRLYAegIAVALLHSDDFRRFLVNESFPKETY 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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