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Conserved domains on  [gi|1564158774|gb|RXM69165|]
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HesB-like protein [Clostridium tetani]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HesB_rel_seleno TIGR01911
HesB-like selenoprotein; This model represents a family of small proteins related to HesB and ...
 1-92 7.29e-47

HesB-like selenoprotein; This model represents a family of small proteins related to HesB and its close homologs, which are likely to be invovlved in iron-sulfur cluster assembly (See TIGR00049 and pfam01521). Several members are selenoproteins, with a TGA codon and Sec residue that aligns to the conserved Cys of the HesB domain. A variable Cys/Ser/Gly-rich C-terminal region is not included in the seed alignment and model. [Unknown function, General]


:

Pssm-ID: 188182  Cd Length: 92  Bit Score: 145.39  E-value: 7.29e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1564158774   1 MNIVTMSDIAYEEFLDFLKENGVENNVLRIHLAGMGCSGPVFNLIIDEEKPNDEIVKIHDVTFLIDKNLISQFGGFVIEC 80
Cdd:TIGR01911   1 MKKVVMSDEAYEEFLDFLKKNNQDNNVVRIYFEGFGUGGPKFGIAIAEPNENDELIYINDFTFYIDPNLIDQFLGFNITL 80

                          90
                  ....*....|..
gi 1564158774  81 AEENGLAGFSLE 92
Cdd:TIGR01911  81 REENFGKGLKLE 92
 
Name Accession Description Interval E-value
HesB_rel_seleno TIGR01911
HesB-like selenoprotein; This model represents a family of small proteins related to HesB and ...
 1-92 7.29e-47

HesB-like selenoprotein; This model represents a family of small proteins related to HesB and its close homologs, which are likely to be invovlved in iron-sulfur cluster assembly (See TIGR00049 and pfam01521). Several members are selenoproteins, with a TGA codon and Sec residue that aligns to the conserved Cys of the HesB domain. A variable Cys/Ser/Gly-rich C-terminal region is not included in the seed alignment and model. [Unknown function, General]


Pssm-ID: 188182  Cd Length: 92  Bit Score: 145.39  E-value: 7.29e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1564158774   1 MNIVTMSDIAYEEFLDFLKENGVENNVLRIHLAGMGCSGPVFNLIIDEEKPNDEIVKIHDVTFLIDKNLISQFGGFVIEC 80
Cdd:TIGR01911   1 MKKVVMSDEAYEEFLDFLKKNNQDNNVVRIYFEGFGUGGPKFGIAIAEPNENDELIYINDFTFYIDPNLIDQFLGFNITL 80

                          90
                  ....*....|..
gi 1564158774  81 AEENGLAGFSLE 92
Cdd:TIGR01911  81 REENFGKGLKLE 92
IscA_HesB_Se NF038090
IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, ...
 4-104 7.19e-14

IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, are homologous to proteins of iron-sulfur cluster biosynthesis such as IscA, and belong to the broader set of HesB-related proteins.


Pssm-ID: 411672  Cd Length: 99  Bit Score: 61.96  E-value: 7.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1564158774   4 VTMSDIAYEEFLDFLKENGVENNVlRIHLAGMGCSGPVFNLIIDEEKPNDEIVKIHDVTFLIDKNLISQFGGFVIECAEE 83
Cdd:NF038090    2 LEVTDLASRKLKEYFADKKIDSPI-RVFLNQGGUAGPSLGLALDEPKENDEVFEQDGLTFVIDKELLEQCGPIKVDFIDC 80

                          90       100
                  ....*....|....*....|.
gi 1564158774  84 NGlaGFSLEPIVKPDTGGCST 104
Cdd:NF038090   81 RS--GFSITSSMPLGGGGCGS 99
IscA COG0316
Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein ...
 4-67 2.62e-08

Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440085 [Multi-domain]  Cd Length: 107  Bit Score: 47.84  E-value: 2.62e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1564158774   4 VTMSDIAYEEFLDFLKENGVENNVLRIHLAGMGCSGPVFNLIIDEE-KPNDEIVKIHDVTFLIDK 67
Cdd:COG0316     2 ITLTDAAAKRIKRLLAKEGNPGLGLRVGVKGGGCSGFSYGLDFDDEpNEDDLVFEQDGVKVVVDP 66
 
Name Accession Description Interval E-value
HesB_rel_seleno TIGR01911
HesB-like selenoprotein; This model represents a family of small proteins related to HesB and ...
 1-92 7.29e-47

HesB-like selenoprotein; This model represents a family of small proteins related to HesB and its close homologs, which are likely to be invovlved in iron-sulfur cluster assembly (See TIGR00049 and pfam01521). Several members are selenoproteins, with a TGA codon and Sec residue that aligns to the conserved Cys of the HesB domain. A variable Cys/Ser/Gly-rich C-terminal region is not included in the seed alignment and model. [Unknown function, General]


Pssm-ID: 188182  Cd Length: 92  Bit Score: 145.39  E-value: 7.29e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1564158774   1 MNIVTMSDIAYEEFLDFLKENGVENNVLRIHLAGMGCSGPVFNLIIDEEKPNDEIVKIHDVTFLIDKNLISQFGGFVIEC 80
Cdd:TIGR01911   1 MKKVVMSDEAYEEFLDFLKKNNQDNNVVRIYFEGFGUGGPKFGIAIAEPNENDELIYINDFTFYIDPNLIDQFLGFNITL 80

                          90
                  ....*....|..
gi 1564158774  81 AEENGLAGFSLE 92
Cdd:TIGR01911  81 REENFGKGLKLE 92
IscA_HesB_Se NF038090
IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, ...
 4-104 7.19e-14

IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, are homologous to proteins of iron-sulfur cluster biosynthesis such as IscA, and belong to the broader set of HesB-related proteins.


Pssm-ID: 411672  Cd Length: 99  Bit Score: 61.96  E-value: 7.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1564158774   4 VTMSDIAYEEFLDFLKENGVENNVlRIHLAGMGCSGPVFNLIIDEEKPNDEIVKIHDVTFLIDKNLISQFGGFVIECAEE 83
Cdd:NF038090    2 LEVTDLASRKLKEYFADKKIDSPI-RVFLNQGGUAGPSLGLALDEPKENDEVFEQDGLTFVIDKELLEQCGPIKVDFIDC 80

                          90       100
                  ....*....|....*....|.
gi 1564158774  84 NGlaGFSLEPIVKPDTGGCST 104
Cdd:NF038090   81 RS--GFSITSSMPLGGGGCGS 99
IscA COG0316
Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein ...
 4-67 2.62e-08

Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440085 [Multi-domain]  Cd Length: 107  Bit Score: 47.84  E-value: 2.62e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1564158774   4 VTMSDIAYEEFLDFLKENGVENNVLRIHLAGMGCSGPVFNLIIDEE-KPNDEIVKIHDVTFLIDK 67
Cdd:COG0316     2 ITLTDAAAKRIKRLLAKEGNPGLGLRVGVKGGGCSGFSYGLDFDDEpNEDDLVFEQDGVKVVVDP 66
TIGR00049 TIGR00049
Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be ...
 5-89 1.11e-05

Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 272875 [Multi-domain]  Cd Length: 105  Bit Score: 40.64  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1564158774   5 TMSDIAYEEFLDFLKENGVENNVLRIHLAGMGCSGPVFNLIIDEEK-PNDEIVKIHDVTFLIDKNLISQFGGFVIECAEE 83
Cdd:TIGR00049   1 TLTDSAAKRIKALLAGEGEPNLGLRVGVKGGGCSGLQYGLEFDDEPnEDDEVFEQDGVKVVVDPKSLPYLDGSEIDYVEE 80


                  ....*.
gi 1564158774  84 NGLAGF 89
Cdd:TIGR00049  81 LLGSGF 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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