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Conserved domains on  [gi|1570058799|gb|RYP54479|]
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hypothetical protein DL768_000785 [Monosporascus sp. mg162]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
65-433 2.31e-86

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17327:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 406  Bit Score: 271.81  E-value: 2.31e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRIsRPSLYIACAMMLWGLTSTLSGNVHN 144
Cdd:cd17327    15 FLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRF-PPSKWLSVFIVLWGLLTLLTAAVKN 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnMQGTLGHAAWRWLFWIE 224
Cdd:cd17327    94 FGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFK-ILGVGGLAGWRWLFIIE 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAFILPDLPHNSRGFTDEERQVAQLRMVEDvgeaDVDAEGQGV-FDGLIMAVKDPKIYLMMI-TFTAYVV 302
Cdd:cd17327   173 GLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRAN----QTGKGDQKFkWKQIKEAFKDPRTWLLFLfFFCSQIT 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 303 GLSFNAFFPTLTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGF-VISMSTLNTAARYV 381
Cdd:cd17327   249 NNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSiILLAAPNPPGAYFA 328
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1570058799 382 ALFLQASSYAGFIVFYSWISSSFpRPPAKRAVAIAMINAFSQLGNVAGSYVW 433
Cdd:cd17327   329 AYILGGGSYAGFPILLSWISSNC-AGYTKRATVLAIMLIFYNVGNIVAPQIF 379
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
65-433 2.31e-86

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 271.81  E-value: 2.31e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRIsRPSLYIACAMMLWGLTSTLSGNVHN 144
Cdd:cd17327    15 FLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRF-PPSKWLSVFIVLWGLLTLLTAAVKN 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnMQGTLGHAAWRWLFWIE 224
Cdd:cd17327    94 FGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFK-ILGVGGLAGWRWLFIIE 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAFILPDLPHNSRGFTDEERQVAQLRMVEDvgeaDVDAEGQGV-FDGLIMAVKDPKIYLMMI-TFTAYVV 302
Cdd:cd17327   173 GLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRAN----QTGKGDQKFkWKQIKEAFKDPRTWLLFLfFFCSQIT 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 303 GLSFNAFFPTLTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGF-VISMSTLNTAARYV 381
Cdd:cd17327   249 NNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSiILLAAPNPPGAYFA 328
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1570058799 382 ALFLQASSYAGFIVFYSWISSSFpRPPAKRAVAIAMINAFSQLGNVAGSYVW 433
Cdd:cd17327   329 AYILGGGSYAGFPILLSWISSNC-AGYTKRATVLAIMLIFYNVGNIVAPQIF 379
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
65-462 5.89e-41

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 150.79  E-value: 5.89e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLRgLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLyIACAMMLWGLTSTLSGNVHN 144
Cdd:COG2271    20 FLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV-LAIGLLLWGLATLLFGFATS 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtlgHAAWRWLFWIE 224
Cdd:COG2271    98 FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA-------AFGWRAAFLIL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAfilpdlphnsrgftdeerqvaqlrmvedvgeadvdaegqgvfdglimavkdpkIYLMMITFTAYVVGL 304
Cdd:COG2271   171 GLPGLLLALLRF-----------------------------------------------------WLLALAYFLVYFALY 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 305 SFNAFFPT-LTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKF-WHITGPIIGGLVGFVISMSTLNTAARYVA 382
Cdd:COG2271   198 GFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPSPALAIAL 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 383 LFL-QASSYAGFIVFYSWISSSFprPPAKRAVAIAMINAFSQLGNVAGSYVWG--LKSNGYRQSYGIVTAMFGLTILGCL 459
Cdd:COG2271   278 LFLaGFGLGGAFGLLWALAAELF--PKKARGTASGLVNTFGFLGGALGPLLVGylLDATGYQAAFLLLAALALLAALLAL 355

                  ...
gi 1570058799 460 WFR 462
Cdd:COG2271   356 LLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
65-430 1.41e-30

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 121.76  E-value: 1.41e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIaCAMMLWGLTSTLSGNVHN 144
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL-IGLLLFALGLLLLLFASS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtlgHAAWRWLFWIE 224
Cdd:pfam07690  85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-------LFGWRAAFLIL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAFILPDlphnsrgftdeerqvaqlrmVEDVGEADVDAEGQGVFDGLIMAVKDPKIYLMMITFTAYVVGL 304
Cdd:pfam07690 158 AILSLLAAVLLLLPRPP--------------------PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFF 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 305 SFNAFFPTLTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKF--WHITGPIIGGLVGFVISMSTLNTAARYVA 382
Cdd:pfam07690 218 GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrlLLALLLLILAALGLLLLSLTLSSLWLLLA 297
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1570058799 383 LFLQASSYAG-FIVFYSWISSSFprPPAKRAVAIAMINAFSQLGNVAGS 430
Cdd:pfam07690 298 LLLLGFGFGLvFPALNALVSDLA--PKEERGTASGLYNTAGSLGGALGP 344
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
68-440 1.30e-08

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 57.00  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  68 YLDRNNIAAArLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISrPSLYIACAMMLWGLTSTLSGNVHNFAG 147
Cdd:TIGR00881   8 YLVRKNFALA-MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSN-PRVFLPIGLILCAIVNLFFGFSTSLWV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 148 MVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSNMQGtlghaaWRWLFWIEGAA 227
Cdd:TIGR00881  86 MAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYS------WHWVFIVPGII 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 228 TMTVAIMAAFILPDLPHnSRGFTDEErqvaQLRMVEDVGEADVDAEGQGVFDGLIMAV-KDPKI-YLMMITFTAYVVGLS 305
Cdd:TIGR00881 160 AIIVSLICFLLLRDSPQ-SCGLPPAE----EMPNEEPDGDAEKKEEELTKKQIFLQYVlLNKVLwYISLGYVFVYVVRTG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 306 FNAFFPT-LTETLGFE-YVATLLMSSPPWAfSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGFVISMSTLNTAARY--- 380
Cdd:TIGR00881 235 ILDWSPLyLTQEKGFSkEKASWAFTLYELG-GLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPlmd 313
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1570058799 381 -VALFLQASSYAGFIVFYSWISSSFPrPPAKRAVAIAMINAFSQLGNVAGSYVWGLKSNGY 440
Cdd:TIGR00881 314 lICLFALGFLVYGPQMLIGVIASELA-PKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGF 373
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
74-258 4.01e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 46.11  E-value: 4.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  74 IAAARLRglqDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIAcAMMLWGLTSTLSGNVHNFAGMVAVRF 153
Cdd:PRK11551   36 VAAPRMA---QEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIV-SVALFGLFSLATAQAWDFPSLLVARL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 154 FLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGagVLSNmqgtlGHAAWRWLFWIEGAATMTVAI 233
Cdd:PRK11551  112 LTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIG--VLAA-----GDAAWRHIFYVGGVGPLLLVP 184
                         170       180
                  ....*....|....*....|....*
gi 1570058799 234 MAAFILPDlphnSRGFTDEERQVAQ 258
Cdd:PRK11551  185 LLMRWLPE----SRAFAQAAGAGKQ 205
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
65-433 2.31e-86

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 271.81  E-value: 2.31e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRIsRPSLYIACAMMLWGLTSTLSGNVHN 144
Cdd:cd17327    15 FLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRF-PPSKWLSVFIVLWGLLTLLTAAVKN 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnMQGTLGHAAWRWLFWIE 224
Cdd:cd17327    94 FGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFK-ILGVGGLAGWRWLFIIE 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAFILPDLPHNSRGFTDEERQVAQLRMVEDvgeaDVDAEGQGV-FDGLIMAVKDPKIYLMMI-TFTAYVV 302
Cdd:cd17327   173 GLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRAN----QTGKGDQKFkWKQIKEAFKDPRTWLLFLfFFCSQIT 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 303 GLSFNAFFPTLTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGF-VISMSTLNTAARYV 381
Cdd:cd17327   249 NNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSiILLAAPNPPGAYFA 328
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1570058799 382 ALFLQASSYAGFIVFYSWISSSFpRPPAKRAVAIAMINAFSQLGNVAGSYVW 433
Cdd:cd17327   329 AYILGGGSYAGFPILLSWISSNC-AGYTKRATVLAIMLIFYNVGNIVAPQIF 379
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
65-463 1.00e-46

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 166.21  E-value: 1.00e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLRgLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISrPSLYIACAMMLWGLTSTLSGNVHN 144
Cdd:cd17319    13 VINYLDRVNISVAAPT-IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFG-ARKVLAVSMLLWSLFTALTGFATS 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVlsnmqgtLGHAAWRWLFWIE 224
Cdd:cd17319    91 LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL-------LLLFGWRWAFIIE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAFILPDLphnsrgftdeerqvaqlrmvedvgeadvdaegqgvfdglimavkdpkIYLMMITFTAYVVGL 304
Cdd:cd17319   164 GLLGLLLAVLWWFYLRQV-----------------------------------------------WGLALGYFGINYALY 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 305 SFNAFFPT-LTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDR--TQEKFWHITGPIIGGLVGFVISMSTLNTAARYV 381
Cdd:cd17319   197 GLLTWLPTyLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVI 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 382 ALFL-QASSYAGFIVFYSWISSSFPRppAKRAVAIAMINAFSQLGNVAGSYVWG-LKSNGYRQSYGIVTAMFGLTILGCL 459
Cdd:cd17319   277 LLSLaGFGIGAASPVFWSLPADLLPG--EAAATAGGLINSGGNLGGFVAPLLIGyLVDATGSYTAAFLFLAAVALLAALL 354

                  ....
gi 1570058799 460 WFRV 463
Cdd:cd17319   355 VLLL 358
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
65-462 5.89e-41

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 150.79  E-value: 5.89e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLRgLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLyIACAMMLWGLTSTLSGNVHN 144
Cdd:COG2271    20 FLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV-LAIGLLLWGLATLLFGFATS 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtlgHAAWRWLFWIE 224
Cdd:COG2271    98 FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA-------AFGWRAAFLIL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAfilpdlphnsrgftdeerqvaqlrmvedvgeadvdaegqgvfdglimavkdpkIYLMMITFTAYVVGL 304
Cdd:COG2271   171 GLPGLLLALLRF-----------------------------------------------------WLLALAYFLVYFALY 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 305 SFNAFFPT-LTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKF-WHITGPIIGGLVGFVISMSTLNTAARYVA 382
Cdd:COG2271   198 GFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPSPALAIAL 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 383 LFL-QASSYAGFIVFYSWISSSFprPPAKRAVAIAMINAFSQLGNVAGSYVWG--LKSNGYRQSYGIVTAMFGLTILGCL 459
Cdd:COG2271   278 LFLaGFGLGGAFGLLWALAAELF--PKKARGTASGLVNTFGFLGGALGPLLVGylLDATGYQAAFLLLAALALLAALLAL 355

                  ...
gi 1570058799 460 WFR 462
Cdd:COG2271   356 LLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
65-430 1.41e-30

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 121.76  E-value: 1.41e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIaCAMMLWGLTSTLSGNVHN 144
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL-IGLLLFALGLLLLLFASS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtlgHAAWRWLFWIE 224
Cdd:pfam07690  85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-------LFGWRAAFLIL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAFILPDlphnsrgftdeerqvaqlrmVEDVGEADVDAEGQGVFDGLIMAVKDPKIYLMMITFTAYVVGL 304
Cdd:pfam07690 158 AILSLLAAVLLLLPRPP--------------------PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFF 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 305 SFNAFFPTLTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKF--WHITGPIIGGLVGFVISMSTLNTAARYVA 382
Cdd:pfam07690 218 GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrlLLALLLLILAALGLLLLSLTLSSLWLLLA 297
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1570058799 383 LFLQASSYAG-FIVFYSWISSSFprPPAKRAVAIAMINAFSQLGNVAGS 430
Cdd:pfam07690 298 LLLLGFGFGLvFPALNALVSDLA--PKEERGTASGLYNTAGSLGGALGP 344
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
65-463 1.70e-25

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 108.04  E-value: 1.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLRgLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISrPSLYIACAMMLWGLTSTLSGNVHN 144
Cdd:COG2223    15 FLAFGVWYLWSVLAPP-LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFG-PRRVLLIGLLLLGIGLLLLALAVS 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVlsnmqgtLGHAAWRWLFWIE 224
Cdd:COG2223    93 YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL-------IAAFGWRNAFLIL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAFILPDLPhnsrgftdeerqvaqlrmvedvgeADVDAEGQGVFDGLIMAVKDPKIYLMMIT-FTAYVVG 303
Cdd:COG2223   166 GILLLVVAVLAWLFLRDPP------------------------AGAAAAAKASLRDQLEALRDPRFWLLSLLyFGTFGSF 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 304 LSFNAFFPT-LTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGFVISMSTLNTAARYVA 382
Cdd:COG2223   222 IGFSSWLPPyLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVL 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 383 LFLQASSY-AGFIVFYSWISSSFprPPAKRAVAIAMINAFSQLGNVAGSYVWGL---KSNGYRQSYGIVTAMFGLTILGC 458
Cdd:COG2223   302 FLLLGLALgGGNGAVFALVPDIF--PTKNAGAVYGLVGAAGGLGGFLGPLLFGAlldATGSYTAAFLVFAVLALVALVLT 379

                  ....*
gi 1570058799 459 LWFRV 463
Cdd:COG2223   380 LLLYR 384
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
65-459 4.07e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 104.05  E-value: 4.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAArLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIACaMMLWGLTSTLSGNVHN 144
Cdd:cd06174     6 FLTGLARGLISPL-LPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLG-LLLFALGALLFAFAPS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 145 FAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtLGHAAWRWLFWIE 224
Cdd:cd06174    84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS-----SLGFGWRAVFLIA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 225 GAATMTVAIMAAFILPDLPHNSRGFTDEERQVAQLRmvedvgeadvdaegqgvfdGLIMAVKDPKI-YLMMITFTAYVVG 303
Cdd:cd06174   159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLK-------------------LLKRVLKNPGLwLLLLAIFLVNLAY 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 304 LSFNAFFPT-LTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRT-QEKFWHITGPIIGGLVGFVISMSTLNTAARYV 381
Cdd:cd06174   220 YSFSTLLPLfLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 382 ALFLQASSYAGFIVFYSWISSSFprPPAKRAVAIAMINAFSQLGNVAGSYVWGLKSN---GYRQSYGIVTAMFGLTILGC 458
Cdd:cd06174   300 LLLLGFGLGGLLPLSFALIAELF--PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAatfGLTGAFLVLAVLLLLAAILL 377

                  .
gi 1570058799 459 L 459
Cdd:cd06174   378 L 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
82-428 2.19e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 89.26  E-value: 2.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  82 LQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIACaMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAA 161
Cdd:COG2814    36 IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG-LLLFALGSLLCALAPSLWLLLAARFLQGLGAGA 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 162 FLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtlgHAAWRWLFWIEGAATMTVAIMAAFILPD 241
Cdd:COG2814   115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-------LFGWRWVFLVNAVLALLALLLLLRLLPE 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 242 -LPHNSRGFTDEERQVAQLRMVedvgeadvdaegqgvfdglimavkdpkIYLMMITFTAYVVGLSFNAFFPT-LTETLGF 319
Cdd:COG2814   188 sRPAARARLRGSLRELLRRPRL---------------------------LLLLLLAFLLGFGFFALFTYLPLyLQEVLGL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 320 EYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGFVISMSTLNTAARYVALFLQASSYAGFIVFYSW 399
Cdd:COG2814   241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
                         330       340
                  ....*....|....*....|....*....
gi 1570058799 400 ISSSFprPPAKRAVAIAMINAFSQLGNVA 428
Cdd:COG2814   321 VAELA--PPEARGRASGLYNSAFFLGGPL 347
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
72-462 2.78e-14

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 74.51  E-value: 2.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  72 NNIAAARLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRI-SRPSLYIACAMMLWGLtsTLSGNVHNFAGMVA 150
Cdd:COG0738    24 TALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFgYKRGLLLGLLLMALGL--LLFALAPSYPLLLL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 151 VRFFLGF----VEAAFLPGALLIQSKWYTRReLTMRNAIlfcgniisNAFSALIGAGVLSNMQGTLGHAAWRWLFWIEGA 226
Cdd:COG0738   102 ALFLLGLglglLDVAANPYVAALGPETAASR-LNLLHAF--------FSLGALLGPLLGGLLILLGLSLSWHLPYLILAV 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 227 ATMTVAIMAAFI-LPDLphnsrgftdeerqvaqlrmvedvgeADVDAEGQGVFDGLIMAVKDPKIYLMMITFTAYVVG-L 304
Cdd:COG0738   173 LLLLLALLFLRSkLPEI-------------------------EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAeG 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 305 SFNAFFPT-LTETLGF-EYVATLLMSSpPWAFSCIICLVNAWHSDR-TQEKFwhITGPIIGGLVGFVISMSTLNTAARYV 381
Cdd:COG0738   228 AIGDWLPLyLKDVLGLsEATAALGLSL-FWGGMTIGRFLGGFLLKRfGPVRL--LRLSALLAAVGLLLALLAPGPWLALI 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 382 ALFLQASSYA-GFIVFYSWISSSFPRPPAKravAIAMINAFSQLGNVAGSYVWGL--KSNGYRQSYGIVTAMFGLTILGC 458
Cdd:COG0738   305 GLALVGLGLSlMFPTIFSLALDGLGKRTAA---AVSAVLIMGIVGGAIGPPLIGFlaDAFGLRAAFLVPLVCYLLILLLA 381

                  ....
gi 1570058799 459 LWFR 462
Cdd:COG0738   382 LALK 385
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
85-462 1.24e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 66.06  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  85 DLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIAcAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAAFLP 164
Cdd:cd17325    25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLL-GLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 165 GALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGaGVLSnmqgtlGHAAWRWLFWIEGAATMTVAIMAAFILPDLPH 244
Cdd:cd17325   104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG-GLLA------DALGYRAPFLVCAALALLALVLALLLLPEPRP 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 245 NSRgftdeerqvaqlrmvedvgeaDVDAEGQGVFDGLIMAVKDPKIYLMMITFTAYVVGLS-FNAFFPT-LTETLGFEYV 322
Cdd:cd17325   177 PPN---------------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGaLEPFLPLyAAELGGLSPA 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 323 ATLLMSSPPWAFSCIICLVNAWHSDRTQEKfwhitGPIIGGLVGFVISMSTLNTAARYVALFLqASSYAGFIVFYSWISS 402
Cdd:cd17325   236 QIGLLFGAQGLASALSQPPAGKLSDRIGRK-----PLILIGLLLSAVALLLLPLATSFWLLLL-LLALLGLGLGLVFPAT 309
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1570058799 403 ----SFPRPPAKRAVAIAMINAFSQLGNVAGSYVWGL--KSNGYRQSYGIVTAMFGLTILGCLWFR 462
Cdd:cd17325   310 lallADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFlyDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
57-461 1.28e-11

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 66.49  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  57 LISMLTPEMLNYLDRNNIAAArLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLyIACAMMLWGLTS 136
Cdd:cd17328     1 VAVLFLINLLNYMDRFTIAGV-LPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWI-LAVGILIWSAAT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 137 TLSGNVHNFAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILfcgNIISNAFSALiGAGVLSNMQGTLGHaa 216
Cdd:cd17328    79 LLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVF---YFAIPLGSGL-GYVVGGLVAQATGG-- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 217 WRWLFWIEGAATMTVAIMAAFILPDLPhnsRGFTDEERQVAQLRmvedvgeadvdaegQGVFDGLIMAVKDPKIYLMMIT 296
Cdd:cd17328   153 WRWAFRVTGVLGVLLAILLLLFVREPP---RGAAEGGVMAKSTA--------------TSFLADLKALAKNPSFILSTLG 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 297 FTAYV-VGLSFNAFFPTLtETLGFEyVATLLMSSPPWAFSCIIC-------LVNAWHSDRTQEKFWHiTGPIIGG----- 363
Cdd:cd17328   216 FTAVSfVTGALAFWAPTF-FLRAFG-VGDLSSADVGLIFGAITCiagvlgvLLGGILADRLRRKTPR-ADPLVCAvglla 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 364 ---LVGFVISMSTLNTAARYVALFLqassyAGFIVFYSWISSSF----PRPPAKRAVAIAMINAFSQ-LGNVAGSYVWGL 435
Cdd:cd17328   293 aapFLFLALVLALSNLLLAWVLLFL-----GEFLLSLNWAPVFAillyVVIPTRRSTASAIQILLSHlLGDAGSPYLIGL 367
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1570058799 436 KSNGYRQS------------YGIVTAMFGLTILGCLWF 461
Cdd:cd17328   368 ISDLLRQNkdsplaeaaslqYALLLCSFVLVLGGFFFL 405
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
82-341 3.08e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 61.37  E-value: 3.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  82 LQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIACaMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAA 161
Cdd:COG0477    40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG-LLLFGLASLLCGLAPSPELLIAARALQGIGAGG 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 162 FLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtlgHAAWRWLFWIeGAATMTVAIMAAFILPD 241
Cdd:COG0477   119 LMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA-------ALGWRWIFLI-NAPLGLLALVLRLRLPE 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 242 lphnSRGFTDEERQVAQLRMVEDVGEADVDAEGQGVFDGLIMAVKDPKIYLMMITFTAYVVGLSFNAFFPTLTETLGFEY 321
Cdd:COG0477   191 ----SRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLL 266
                         250       260
                  ....*....|....*....|
gi 1570058799 322 VATLLMSSPPWAFSCIICLV 341
Cdd:COG0477   267 LLLLLLALLLALLLLLLLLL 286
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
82-435 1.02e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 60.26  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  82 LQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIAcAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAA 161
Cdd:cd17324    25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLV-LLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 162 FLPGALLIQSkwytrrELTMRNAIlfcGNIISNAFSALIGAGVLSNMQGTL--GHAAWRWLFWIEGAATMTVAIMAAFIL 239
Cdd:cd17324   104 FWAIAAAYAA------DLVPPEKR---GRAIGLVFSGLTLGLVLGRPLGGLlgQLLGWRAAFLAIAVLALLAALLLWRLL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 240 PDLPHNSRGftdeerqvaqlrmvedvgeadvdaeGQGVFDGLIMAVKDPKIYLMMITftayvVGLSFNAFFptltetLGF 319
Cdd:cd17324   175 PSLPPKKPG-------------------------SLGLLSSLLLLLRNPRLRLAYLI-----TFLLFGGFF------ALY 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 320 EYVATLLMSSP-------PWAFSC--IICLVNAWHSDRTQEKFWHITGPIIGGL---VGFVISMSTLNTAARYVALFLQ- 386
Cdd:cd17324   219 TYLAPFLTDVPgfsssaiIGLLLLfgVAGVVGSPLAGRLADRGGRRALLIALLLlaaALLLLTLLGPSPLLLLVGLVLWg 298
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1570058799 387 ASSYAGFIVFYSWISSsfpRPPAKRAVAIAMINAFSQLGNVAGSYVWGL 435
Cdd:cd17324   299 LGFFAAHSALQTRVLR---LAPEARGLASSLYLAAYNLGGALGAALGGL 344
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
82-244 1.84e-09

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 59.57  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  82 LQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIACAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAA 161
Cdd:cd17341    25 IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGAN 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 162 FLPGALLIqSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSNMQGTLGHAAWRWLFWIEGAATMTVAIMAAFILPD 241
Cdd:cd17341   105 FASGQPWA-SFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDD 183

                  ...
gi 1570058799 242 LPH 244
Cdd:cd17341   184 LPT 186
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
68-440 1.30e-08

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 57.00  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  68 YLDRNNIAAArLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISrPSLYIACAMMLWGLTSTLSGNVHNFAG 147
Cdd:TIGR00881   8 YLVRKNFALA-MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSN-PRVFLPIGLILCAIVNLFFGFSTSLWV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 148 MVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSNMQGtlghaaWRWLFWIEGAA 227
Cdd:TIGR00881  86 MAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYS------WHWVFIVPGII 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 228 TMTVAIMAAFILPDLPHnSRGFTDEErqvaQLRMVEDVGEADVDAEGQGVFDGLIMAV-KDPKI-YLMMITFTAYVVGLS 305
Cdd:TIGR00881 160 AIIVSLICFLLLRDSPQ-SCGLPPAE----EMPNEEPDGDAEKKEEELTKKQIFLQYVlLNKVLwYISLGYVFVYVVRTG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 306 FNAFFPT-LTETLGFE-YVATLLMSSPPWAfSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGFVISMSTLNTAARY--- 380
Cdd:TIGR00881 235 ILDWSPLyLTQEKGFSkEKASWAFTLYELG-GLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPlmd 313
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1570058799 381 -VALFLQASSYAGFIVFYSWISSSFPrPPAKRAVAIAMINAFSQLGNVAGSYVWGLKSNGY 440
Cdd:TIGR00881 314 lICLFALGFLVYGPQMLIGVIASELA-PKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGF 373
2_A_01_02 TIGR00880
Multidrug resistance protein;
98-241 8.40e-08

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 51.11  E-value: 8.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  98 SILYVGYILMQV----PSNMLINRISRPSLYIaCAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAAFLPGALLIQSKW 173
Cdd:TIGR00880   1 GLLLAGYALGQLiyspLSGLLTDRFGRKPVLL-VGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADI 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1570058799 174 YTRRELTMRNAILFCGNIISNAFSALIGaGVLSNMQGtlghaaWRWLFWIEGAATMTVAIMAAFILPD 241
Cdd:TIGR00880  80 YPPEERGVALGLMSAGIALGPLLGPPLG-GVLAQFLG------WRAPFLFLAILALAAFILLAFLLPE 140
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
65-240 9.88e-08

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 54.10  E-value: 9.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  65 MLNYLDRNNIAAARLrGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLyIACAMMLWGLTSTLSGNV-- 142
Cdd:cd17380     9 CICYADRVNMPIAIV-PMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKV-LLLAVALWSLATLLTPLLay 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 143 HNFAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtlgHAAWRWLFW 222
Cdd:cd17380    87 SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE-------YYGWPSVFY 159
                         170
                  ....*....|....*....
gi 1570058799 223 IEGAATMT-VAIMAAFILP 240
Cdd:cd17380   160 FFGLLGLLwALVWLIYLPP 178
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
82-435 1.23e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 53.73  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  82 LQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISR-----PSLYIAcammlwGLTSTLSGNVHNFAGMVAVRFFLG 156
Cdd:cd17474    25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRkkvllPGLLLF------GIGGLLCGLSDSFALLLAGRALQG 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 157 FVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGagvlsnmqGTLGHAAWRWLFWIEGAAtMTVAIMAA 236
Cdd:cd17474    99 IGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG--------GLLAAISWRYPFFLLAAL-IPVAFLAI 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 237 FILPDLPHNsrgftdeerqvaqlrmvedvgeaDVDAEGQGVFDGLIMAVKDPKIYLMMITFTAYVVGL-SFNAFFPTLTE 315
Cdd:cd17474   170 LFLLPEPKE-----------------------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYfAFLTYLPFLLE 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 316 TL-GFEYVATLLMSSPPWAFSCIICLVNAwhsdRTQEKFWHITGPIIGGLVGFVISMstlntaaryvALFLQASSYAGFI 394
Cdd:cd17474   227 LLyGISPIIIGLLFAGWSVLLALGSLFVG----RLLKKRFGARRILVIGLLLYALSL----------LLLGFVPSLALLL 292
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1570058799 395 VFYSWIS----SSFP---------RPPAKRAVAIAMINAFSQLGNVAGSYVWGL 435
Cdd:cd17474   293 IAIVLFGlglgLNLPllttlvtelAPEEERGTASSLYNFVRFLGQAVGPLLFGL 346
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
68-243 3.18e-07

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 52.63  E-value: 3.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  68 YLDRNNIAAARlRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRiSRPSLYIACAMMLWGLTSTLSGNV----H 143
Cdd:cd17345    16 YLVRNNFSLAQ-PYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDR-SNPKRFLAIGLILSAIINILIGFVpsatS 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 144 NFAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRREltmRNAILFCGNIISNAFSALIGAGVLSNMqGTLGHAAWRWLFWI 223
Cdd:cd17345    94 SVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKE---RGTWTSIWNISHNVGGGLVGPLAGLGL-AIFGDGWWRGAFIF 169
                         170       180
                  ....*....|....*....|
gi 1570058799 224 EGAATMTVAIMAAFILPDLP 243
Cdd:cd17345   170 PAIIAIIVAVIVLFLGKDTP 189
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
85-459 5.48e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.45  E-value: 5.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  85 DLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIACaMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAAFLP 164
Cdd:cd17316    30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILT-LLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYP 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 165 GA-LLIQSKWYTRRELTMRnAILFCGNIISNAFSALIGAGVLSNMQGTLGhaaWRWLFWIEGAAtmtvAIMAAFILPDLp 243
Cdd:cd17316   109 GAsTYVAEFAPSKRRGFAL-GLLQSGWALGALLAALVASLLIPLLSGDWG---WRILFLIGALP----ALLALLLRRRT- 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 244 hnsrgftdeerqvaqlrmvedvgeadvdaegqgvfdglimavkdpkIYLMMITFTAYVVGLSFNAFFPT-LTETLGFEYV 322
Cdd:cd17316   180 ----------------------------------------------LLLILLWFFISFGYYGLTTFLPTyLQTVLGLSPA 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 323 ATLLMSSPPWAFSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGFVISMSTLNTAARYVALF--LQASSYAGFIVFYSWI 400
Cdd:cd17316   214 TSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLfiLSFFVGGVWGALYAYL 293
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1570058799 401 SSSFprPPAKRAVAIAMINAFSQLGNVAGSYVWGLkSNGYRQSYGIVTAMFGLTILGCL 459
Cdd:cd17316   294 AELF--PTEVRATGVGLSYNLGRLGGGGAPPLIAL-LLASTGGTGVPALILALLAIVAL 349
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
82-235 8.06e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.05  E-value: 8.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  82 LQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLyIACAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAA 161
Cdd:cd17365    25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRV-LLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGA 103
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1570058799 162 FLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtlgHAAWRWLFWIEGAATMTVAIMA 235
Cdd:cd17365   104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIP-------AFGWRSVFLLGGVPPLILLPLL 170
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
82-456 1.76e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 50.31  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  82 LQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISrPSLYIACAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAA 161
Cdd:cd17475    22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFG-ERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGS 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 162 FLPGALLIQSKWYTRRELTM----RNAILfcgniisnAFSALIGAGVLSNMQGTLGhaaWRWLFWIEGAATMTVAIMAAF 237
Cdd:cd17475   101 VQPGGGRAIMRWFPPRERGLamgiRQTGV--------PLGGALAAALLPPLALHYG---WRAAFVVAGLVSILAAVLFWL 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 238 ILPDLPhnsrgftdeerqvaqlrmvedvgEADVDAEGQGVFDGLIMAV-KDPKIYLMMITFTAYVVG-LSFNAFFPT-LT 314
Cdd:cd17475   170 FYREPP-----------------------AASAATESASTLLRSLKEVlRNRDVWLIAIAGALLVAPqFALLTFLLLfLH 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 315 ETLGFeyvaTLLMSSppWAFSCIICL------VNAWHSDRTQE----KFWHITGpIIGGLVGFVISMSTLNTAARYVALF 384
Cdd:cd17475   227 DHLGL----SVVAAG--ALLAVAQLGgalgriGLGRVSDRVFGgrrrPVLVITA-AIAAAALLVLSLLSPGTPLWLLVLL 299
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1570058799 385 LQASSYAGFI---VFYSWISSSFPRPPAKRAVAIAMinAFSQLGNVAGSYVWGL---KSNGYRQSYGIVTAMFGLTIL 456
Cdd:cd17475   300 LILLGLFAIGwngLYLTLVAESAGPEQAGTALGLAN--TINFIGIAIGPPLFGLlvdATHSYAPAWLALALLLVLAAL 375
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
68-243 8.36e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 48.04  E-value: 8.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  68 YLDRNNIAAArLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISrPSLYIACAMMLWGLTSTLSGNVHNFAG 147
Cdd:cd17312    16 YVCRKNFSVA-KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSN-IRRFMSAGLLLSALANIFMGFSTSLWF 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 148 MVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSNMQgtlghaaWRWLFWIEGAA 227
Cdd:cd17312    94 FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG-------WRAAFLVPGIV 166
                         170
                  ....*....|....*.
gi 1570058799 228 TMTVAIMAAFILPDLP 243
Cdd:cd17312   167 GLVVAIILFFFLRDSP 182
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
97-226 2.48e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 46.46  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  97 LSILYVGYILMQVPSNMLINRISrpslyiACAMMLWGL--TSTLS-----GNVHNFAGMVAVRFFLGFVEAAFLPGALLI 169
Cdd:cd17318    62 LSSFFYGYILTQIPGGYLAEKYG------AKRVLGYSIliTALLTlltplAARGGYGALIVLRILQGLAQGVTFPAMHAL 135
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1570058799 170 QSKWYTRRELTMRNAILFCGNIISNAFSALIGaGVLSNmqgTLGhaaWRWLFWIEGA 226
Cdd:cd17318   136 WAKWAPPLERSRLTSIAYSGSQFGTVIAMPLS-GFLCE---SLG---WPSIFYIFGG 185
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
74-258 4.01e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 46.11  E-value: 4.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  74 IAAARLRglqDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIAcAMMLWGLTSTLSGNVHNFAGMVAVRF 153
Cdd:PRK11551   36 VAAPRMA---QEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIV-SVALFGLFSLATAQAWDFPSLLVARL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 154 FLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGagVLSNmqgtlGHAAWRWLFWIEGAATMTVAI 233
Cdd:PRK11551  112 LTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIG--VLAA-----GDAAWRHIFYVGGVGPLLLVP 184
                         170       180
                  ....*....|....*....|....*
gi 1570058799 234 MAAFILPDlphnSRGFTDEERQVAQ 258
Cdd:PRK11551  185 LLMRWLPE----SRAFAQAAGAGKQ 205
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
114-240 7.25e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.87  E-value: 7.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 114 LINRISRPSLYIAcAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIIS 193
Cdd:cd17503    54 LADRFGTRRLFLT-ALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLA 132
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1570058799 194 NAFSALIGaGVLSNmqgtlgHAAWRWLFWIegaaTMTVAIMAAFILP 240
Cdd:cd17503   133 PAIGPTLG-GWLTD------NLSWRWIFYI----NLPIGILALLLAP 168
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
292-461 7.64e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 7.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 292 LMMITFTAYVVGLSFNAFFPTLTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGFVISM 371
Cdd:COG2271    15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 372 STlNTAARYVALFLQASSYAG-FIVFYSWISSSFprPPAKRAVAIAMINAFSQLGNVAGSYV--WGLKSNGYRQSYGIVT 448
Cdd:COG2271    95 AT-SFWQLLLLRFLLGLGEAGfFPAALKLIAEWF--PPKERGRALGIFNAGGPLGGALAPPLlgWLLAAFGWRAAFLILG 171
                         170
                  ....*....|...
gi 1570058799 449 AMFGLTILGCLWF 461
Cdd:COG2271   172 LPGLLLALLRFWL 184
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
120-240 1.15e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 44.49  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 120 RPSLYIACaMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAAFL-PGALLIqSKWYTRRELTMRNAILFCGNIISNAFSA 198
Cdd:cd17323    63 RRPVYLVS-LFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLaIGAGTI-ADLFTPEERGKAMGVYSLGPLLGPALGP 140
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1570058799 199 LIGaGVLSNMQGtlghaaWRWLFWIEGAATMTVAIMAAFILP 240
Cdd:cd17323   141 IIG-GFITQSLG------WRWIFWFLAIISGFCLILIFLFLP 175
PLN00028 PLN00028
nitrate transmembrane transporter; Provisional
125-244 1.22e-04

nitrate transmembrane transporter; Provisional


Pssm-ID: 177665 [Multi-domain]  Cd Length: 476  Bit Score: 44.53  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 125 IACA--MMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAAFLPGALliqskWYTRreltmrnaiLFCGNII--SNAFSA-- 198
Cdd:PLN00028  102 YGSAflLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQY-----WMST---------MFNGKIVgtANGIAAgw 167
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1570058799 199 -LIGAGV----------LSNMQGTLGHAAWRWLFWIEGAATMTVAIMAAFILPDLPH 244
Cdd:PLN00028  168 gNLGGGVtqllmplvfpLIKDAGAPSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPD 224
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
98-461 1.31e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.12  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  98 SILYVGYILMQVPSNMLINRISRPSLYIaCAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAAFLPGALLIqSKWYTRR 177
Cdd:cd17489    38 GLFTLAALLARPFAGRLLDRFGRKRLLL-IGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATL-VADIIPP 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 178 ELTMRNAILFCgniISNAFSALIGAGVLSNMQGTLGHaawRWLFWIeGAATMTVAIMAAFILPDLPHnsrgftdeerqva 257
Cdd:cd17489   116 SRRGEGIGYYG---LATTLAMALGPALGLFLYQHLGF---AVLFIV-AAVLALLALLLVFLVKDPPP------------- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 258 qlrmvedvgeadVDAEGQGVFDGLIMAVKDPKIYL-MMITFTAYVVGLSFNAFFPTLTETLGFEYVATLLMSSPpwAFSC 336
Cdd:cd17489   176 ------------VAAEEAEAGTRAFRRLVEKKVLPpALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYA--IALL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 337 IICLVNAWHSDRTQEKFWHITGPIIGGLVGFVISMSTLNTAARYVALFLQASSYAGFIVFYSWISSSFprPPAKRAVAIA 416
Cdd:cd17489   242 LSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV--PPHRRGAANG 319
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1570058799 417 MINAFSQLGNVAGSYVWGL--KSNGYRQSYgIVTAMFGLTILGCLWF 461
Cdd:cd17489   320 TFFIFFDLGIGLGGLLLGLvaELFGYRAMF-LLAAVVVLLALVLYIF 365
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
82-245 1.47e-04

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 43.83  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  82 LQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIACAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAA 161
Cdd:TIGR00886  28 IKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSVLLLIRLFIGIAGGS 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 162 FLPGALLIqSKWYTRRELTMRNAILFCGNIISNAFSALIG---AGVLSNMQGTLGHAAWRWLFWIEGAAT-MTVAIMAAF 237
Cdd:TIGR00886 108 FASCMPWI-SFFFPKKIQGTALGLAAGWGNMGGGVAQFVMppiIGSLIFGGGQPAHLAWGWAFVIVPAGIlLLPALLIFF 186

                  ....*...
gi 1570058799 238 ILPDLPHN 245
Cdd:TIGR00886 187 VGADTPPG 194
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
74-434 4.24e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 42.73  E-value: 4.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  74 IAAARLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIACaMMLWGLTSTLSGNVHNFAGMVAVRF 153
Cdd:TIGR00895  35 AMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWS-ILLFSVFTLLCALATNVTQLLILRF 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 154 FLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSNMqgtlghaAWRWLFWIEGAATMTVAI 233
Cdd:TIGR00895 114 LAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF-------GWRSLFYVGGIAPLLLLL 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 234 MAAFILPD--------LPHNSRGFTDEERQVAQLRMVEDVGEADVDAEGQGVFDGLIMAVKDPKIylMMITFTAYVVGLS 305
Cdd:TIGR00895 187 LLMRFLPEsidflvskRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARI--TVLLWLLYFMLLV 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 306 ----FNAFFPTLTETLGF---EYVATLLMSSPPWAFSCIIClvnAWHSDRTQEKfwHIT-GPIIGGLVGFVI-SMSTLNT 376
Cdd:TIGR00895 265 gvyfLTNWLPKLMVELGFslsLAATGGALFNFGGVIGSIIF---GWLADRLGPR--VTAlLLLLGAVFAVLVgSTLFSPT 339
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1570058799 377 AARYVALFLQASSYAGFIVFYSWISSSFprPPAKRAVAIAMINAFSQLGNVAGSYVWG 434
Cdd:TIGR00895 340 LLLLLGAIAGFFVNGGQSGLYALMALFY--PTAIRATGVGWAIGIGRLGAIIGPILAG 395
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
85-462 5.66e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.22  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  85 DLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSL----YIACAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEA 160
Cdd:cd06173    28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLlilaDLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 161 AFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGaGVLsnmqgtLGHAAWRWLFWIEGAATMTVAIMAAFILP 240
Cdd:cd06173   108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALG-GLL------VALLGPGGAFAINALSFLLSALLLLFIRR 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 241 DLPHNSRgftdeerqvaqlrmvedvgeADVDAEGQGVFDGLIMAVKDPKI-YLMMITFTAYVVGLSFNAFFPTLT-ETLG 318
Cdd:cd06173   181 PPPAAPG--------------------ESSSLLLRDLREGLRYLRRSPLLrLLLLALALFALLGGALTVLLPLLAkEVLG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 319 FEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKFWHITGPIIGGLVGFVISMSTLNTAArYVALFLQASSYAGF-IVFY 397
Cdd:cd06173   241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLL-LAALFLLGLAGGLFnVPLN 319
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1570058799 398 SWISSSFPrpPAKRAVAIAMINAFSQLGNVAGSYVWGLKSNGYRQSYGIVTAMFGLTILGCLWFR 462
Cdd:cd06173   320 TLLQLRVP--DELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
82-459 3.35e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.85  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  82 LQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLyIACAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAA 161
Cdd:cd17478    22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYL-LPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 162 FLPGALLIQSKWYT-RRELTMrnAILFCGNIISNAFSALIGAGVLSNmqgtLGHAAWRWLFWIegaatmtVAIMAAFILp 240
Cdd:cd17478   101 FHPEGARLASQAAGgRRGLAM--SIFSVGGNLGFALGPLIAAALVAL----FGGLGLLILLII-------PGLAVALLL- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 241 dlphnsrgftdeerqvaqLRMVEDVGEADVDAEGQGVFDGLIMAVKDPKIYLMMITFTAYVVGLSFNAFFPTLTETLGFE 320
Cdd:cd17478   167 ------------------LRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYS 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 321 YV-ATLLMSSppWAFSCII-CLVNAWHSDRTQEKFWhITGPIIGGLVGFVISMSTlNTAARYVALFLqassyAGFIVFys 398
Cdd:cd17478   229 LVfAGLLLSL--FLFAGAIgTLIGGPLSDRFGRRRV-IIASLLLAAPFLLLFLLT-PGIWSYILLVL-----AGFLLF-- 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1570058799 399 wisSSFP--------RPPAKRAVAIAMINAFSQLGNVAGSYVWGLksngYRQSYGIVTAMFGLTILGCL 459
Cdd:cd17478   298 ---ASFPvtvvlaqeLLPGNVGLASGLMMGLSFGLGGIGAPVLGA----LADAFGLESVLLILALLPLL 359
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
74-223 4.38e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.46  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  74 IAAARLRGLQDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIAcAMMLWGLTSTLSGNVHNFAGMVAVRF 153
Cdd:cd17321    14 IVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLI-GLALFGLASLLCALAPSLAFLIAARA 92
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 154 FLGFVEAAFLPGALLIQSKWYTRRELTMRNAILFCGNIISNAFSALIGAGVLSnmqgtlgHAAWRWLFWI 223
Cdd:cd17321    93 LQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE-------LFGWRWIFLI 155
MFS_1 pfam07690
Major Facilitator Superfamily;
295-462 4.51e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.32  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 295 ITFTAYVVGLSFNAFFPTLTETLGFEY-----VATLLMSSPPWAFSCIICLVNAWhSDRTQEKFWHITGpIIGGLVGFVI 369
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLgisptEIGLLLTLFSLGYALAQPLAGRL-SDRFGRRRVLLIG-LLLFALGLLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 370 SMSTLNTAARYVALFLQASSYAGFI-VFYSWISSSFPrpPAKRAVAIAMINAFSQLGNVAGSYVWGL--KSNGYRQSYGI 446
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFpAALALIADWFP--PEERGRALGLVSAGFGLGAALGPLLGGLlaSLFGWRAAFLI 156
                         170
                  ....*....|....*.
gi 1570058799 447 VTAMFGLTILGCLWFR 462
Cdd:pfam07690 157 LAILSLLAAVLLLLPR 172
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
83-238 6.20e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 6.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799  83 QDDLQLDDTQYSTCLSILYVGYILMQVPSNMLINRISRPSLYIACaMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAAF 162
Cdd:cd06173   236 KEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG-ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 163 LPGAL-LIQSK---WYTRRELTMRNAILFCGNIISNAFSALIGAgvlsnmqgtlgHAAWRWLFWIEGAATMTVAIMAAFI 238
Cdd:cd06173   315 NVPLNtLLQLRvpdELRGRVFSVYNALNSGAMPLGALLAGLLAD-----------ALGLSAVFLLAGALLLLAALLLLLL 383
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
113-248 7.31e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 113 MLINRISRPSLYIAcAMMLWGLTSTLSGNVHNFAGMVAVRFFLGFVEAAFLPGALLIQSKWYTRREltmRNAILFcgniI 192
Cdd:cd17473    57 WLADRFGRKRLLIA-GLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEE---RAKMLG----L 128
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1570058799 193 SNAFSALiGAGVLSNMQGTLGHAAWRWLFWIEGAAtMTVAIMAAFILPDLPHNSRG 248
Cdd:cd17473   129 QSAAMSL-GGVVFLLLGGALAEIGWRAPFLVYLLA-LPVLILVLLFLPEPARKSKS 182
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
292-463 8.02e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.42  E-value: 8.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 292 LMMITFTAYVVGLSFNAFFPTLTETLGFEYVATLLMSSPPWAFSCIICLVNAWHSDRTQEKFwhitgPIIGGLVGFVISM 371
Cdd:COG2814    15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR-----VLLLGLLLFALGS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570058799 372 STLNTAARYVAL----FLQASSYAGFI-VFYSWISSSFPrpPAKRAVAIAMINAFSQLGNVAGSYVWGLKSN--GYRQSY 444
Cdd:COG2814    90 LLCALAPSLWLLlaarFLQGLGAGALFpAALALIADLVP--PERRGRALGLLGAGLGLGPALGPLLGGLLADlfGWRWVF 167
                         170
                  ....*....|....*....
gi 1570058799 445 gIVTAMFGLTILGCLWFRV 463
Cdd:COG2814   168 -LVNAVLALLALLLLLRLL 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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