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Conserved domains on  [gi|1573060030|gb|RZC43218|]
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U3 small nucleolar RNA-associated protein 15 -like protein, partial [Asbolus verrucosus]

Protein Classification

U3 small nucleolar RNA-associated protein 15( domain architecture ID 11456900)

U3 small nucleolar RNA-associated protein 15 is involved in nucleolar processing of pre-18S ribosomal RNA

Gene Ontology:  GO:0042274|GO:0006364|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 339-487 2.08e-50

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


:

Pssm-ID: 462782  Cd Length: 146  Bit Score: 168.82  E-value: 2.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 339 NLHQPVVDVIVPQFDQEKETKYDKCLRKFEYSKALDCVLVSYVanKTPQVTVSVIQELIKRRALQKAFIGRNAKSVIQIL 418
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPGV--KSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 419 RFFIRNVTETRFTKILIDAANIFIDTYeeSPVLMDS-EVRNLLINLTQLLREEVELADEMVALQGAMRML 487
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIY--GSVLGQSpELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-315 5.99e-44

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 5.99e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  39 GPIDYIDFSPVEPHYFAVTCSVRVQVYNPTTKLVVKNLSRFRENAYGATFRSDGRLLCAGGEETNVKLFDLSTKNLLRLF 118
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 119 KGHGAPVHRTYFI-EGKpQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNpliPD--IILSGGYDNFVKMYDTR 195
Cdd:COG2319   159 TGHSGAVTSVAFSpDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLA 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 196 TDQMVLNVN-HGSPVESLLFLPSGGIFLSAG--GTeIKIWDTiAGGKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHV 272
Cdd:COG2319   235 TGKLLRTLTgHSGSVRSVAFSPDGRLLASGSadGT-VRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1573060030 273 KIYDINTFKVVHTLD-YPNAVLSLGVSKNDDTIVAGLVDGLVAI 315
Cdd:COG2319   313 RLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 339-487 2.08e-50

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 168.82  E-value: 2.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 339 NLHQPVVDVIVPQFDQEKETKYDKCLRKFEYSKALDCVLVSYVanKTPQVTVSVIQELIKRRALQKAFIGRNAKSVIQIL 418
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPGV--KSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 419 RFFIRNVTETRFTKILIDAANIFIDTYeeSPVLMDS-EVRNLLINLTQLLREEVELADEMVALQGAMRML 487
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIY--GSVLGQSpELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-315 5.99e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 5.99e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  39 GPIDYIDFSPVEPHYFAVTCSVRVQVYNPTTKLVVKNLSRFRENAYGATFRSDGRLLCAGGEETNVKLFDLSTKNLLRLF 118
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 119 KGHGAPVHRTYFI-EGKpQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNpliPD--IILSGGYDNFVKMYDTR 195
Cdd:COG2319   159 TGHSGAVTSVAFSpDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLA 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 196 TDQMVLNVN-HGSPVESLLFLPSGGIFLSAG--GTeIKIWDTiAGGKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHV 272
Cdd:COG2319   235 TGKLLRTLTgHSGSVRSVAFSPDGRLLASGSadGT-VRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1573060030 273 KIYDINTFKVVHTLD-YPNAVLSLGVSKNDDTIVAGLVDGLVAI 315
Cdd:COG2319   313 RLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-315 6.23e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.03  E-value: 6.23e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  88 FRSDGRLLCAGGEETNVKLFDLSTKNLLRLFKGHGAPVHRTYFIEGKPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYV 167
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 168 RAGATNPLIPdIILSGGYDNFVKMYDTRTDQMVLNVN-HGSPVESLLFLPSGGiFLSAGGTE--IKIWDtIAGGKLLGSI 244
Cdd:cd00200    97 SSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDgtIKLWD-LRTGKCVATL 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1573060030 245 SQHHKTITCLRLASNNKRLLSGSLDRHVKIYDINTFKVVHTLDY-PNAVLSLGVSKNDDTIVAGLVDGLVAI 315
Cdd:cd00200   174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRV 245
WD40 pfam00400
WD domain, G-beta repeat;
238-276 8.19e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 8.19e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1573060030 238 GKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHVKIYD 276
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-276 1.07e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.07e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1573060030  238 GKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHVKIYD 276
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 134-307 1.36e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 134 KPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNPLIPDIILSGGYDNFVKMYDTRTDQMVLNVNHGSPVESLL 213
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQ 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 214 FLPSGGIFLSAGGTEIKI-WDTIAGGKL-LGSISQHHKTITCLRLAsNNKRLLSGSLDRHVKIYD-------INTFKVVH 284
Cdd:PLN00181  625 FPSESGRSLAFGSADHKVyYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmsisgINETPLHS 703

                         170       180
                  ....*....|....*....|...
gi 1573060030 285 TLDYPNAVLSLGVSKNDDTIVAG 307
Cdd:PLN00181  704 FMGHTNVKNFVGLSVSDGYIATG 726
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 339-487 2.08e-50

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 168.82  E-value: 2.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 339 NLHQPVVDVIVPQFDQEKETKYDKCLRKFEYSKALDCVLVSYVanKTPQVTVSVIQELIKRRALQKAFIGRNAKSVIQIL 418
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPGV--KSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 419 RFFIRNVTETRFTKILIDAANIFIDTYeeSPVLMDS-EVRNLLINLTQLLREEVELADEMVALQGAMRML 487
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIY--GSVLGQSpELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-315 5.99e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 5.99e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  39 GPIDYIDFSPVEPHYFAVTCSVRVQVYNPTTKLVVKNLSRFRENAYGATFRSDGRLLCAGGEETNVKLFDLSTKNLLRLF 118
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 119 KGHGAPVHRTYFI-EGKpQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNpliPD--IILSGGYDNFVKMYDTR 195
Cdd:COG2319   159 TGHSGAVTSVAFSpDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLA 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 196 TDQMVLNVN-HGSPVESLLFLPSGGIFLSAG--GTeIKIWDTiAGGKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHV 272
Cdd:COG2319   235 TGKLLRTLTgHSGSVRSVAFSPDGRLLASGSadGT-VRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1573060030 273 KIYDINTFKVVHTLD-YPNAVLSLGVSKNDDTIVAGLVDGLVAI 315
Cdd:COG2319   313 RLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
39-315 2.98e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 2.98e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  39 GPIDYIDFSPVEpHYFAVTCSVR-VQVYNPTTKLVVKNLSRFRENAYGATFRSDGRLLCAGGEETNVKLFDLSTKNLLRL 117
Cdd:COG2319   121 GAVRSVAFSPDG-KTLASGSADGtVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 118 FKGHGAPVHRTYFI-EGKpQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNPlipD--IILSGGYDNFVKMYDT 194
Cdd:COG2319   200 LTGHTGAVRSVAFSpDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP---DgrLLASGSADGTVRLWDL 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 195 RTDQMVLNVN-HGSPVESLLFLPSGGIFLSAG--GTeIKIWDtIAGGKLLGSISQHHKTITCLRLASNNKRLLSGSLDRH 271
Cdd:COG2319   276 ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSddGT-VRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1573060030 272 VKIYDINTFKVVHTL-DYPNAVLSLGVSKNDDTIVAGLVDGLVAI 315
Cdd:COG2319   354 VRLWDLATGELLRTLtGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-315 6.23e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.03  E-value: 6.23e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  88 FRSDGRLLCAGGEETNVKLFDLSTKNLLRLFKGHGAPVHRTYFIEGKPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYV 167
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 168 RAGATNPLIPdIILSGGYDNFVKMYDTRTDQMVLNVN-HGSPVESLLFLPSGGiFLSAGGTE--IKIWDtIAGGKLLGSI 244
Cdd:cd00200    97 SSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDgtIKLWD-LRTGKCVATL 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1573060030 245 SQHHKTITCLRLASNNKRLLSGSLDRHVKIYDINTFKVVHTLDY-PNAVLSLGVSKNDDTIVAGLVDGLVAI 315
Cdd:cd00200   174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 44-315 5.53e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.24  E-value: 5.53e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  44 IDFSPVEPHYfaVTCSV--RVQVYNPTTKLVVKNLSRFRENAYGATFRSDGRLLCAGGEETNVKLFDLSTKNLLRLFKGH 121
Cdd:cd00200    15 VAFSPDGKLL--ATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 122 GAPVHRTYFIEGKPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNPlIPDIILSGGYDNFVKMYDTRTDQMVL 201
Cdd:cd00200    93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 202 N-VNHGSPVESLLFLPSGGIFLSAGG-TEIKIWDtIAGGKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHVKIYDINT 279
Cdd:cd00200   172 TlTGHTGEVNSVAFSPDGEKLLSSSSdGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1573060030 280 FKVVHTLD-YPNAVLSLGVSKNDDTIVAGLVDGLVAI 315
Cdd:cd00200   251 GECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
59-315 3.53e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 3.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  59 SVRVQVYNPTTKLVVKNLSRFRENAYGATFRSDGRLLCAGGEETNVKLFDLSTKNLLRLFKGHGAPVHRTYFIEGKPQIV 138
Cdd:COG2319    57 DLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 139 SFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGAtnpLIPD--IILSGGYDNFVKMYDTRTDQMVLNVN-HGSPVESLLFL 215
Cdd:COG2319   137 SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA---FSPDgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFS 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 216 PSGGIFLSAGG-TEIKIWDtIAGGKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHVKIYDINTFKVVHTLD-YPNAVL 293
Cdd:COG2319   214 PDGKLLASGSAdGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVN 292

                         250       260
                  ....*....|....*....|..
gi 1573060030 294 SLGVSKNDDTIVAGLVDGLVAI 315
Cdd:COG2319   293 SVAFSPDGKLLASGSDDGTVRL 314
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-276 4.40e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.54  E-value: 4.40e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  39 GPIDYIDFSPVEpHYFAVTCSVR-VQVYNPTTKLVVKNLSRFRENAYGATFRSDGRLLCAGGEETNVKLFDLSTKNLLRL 117
Cdd:cd00200    52 GPVRDVAASADG-TYLASGSSDKtIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 118 FKGHGAPVHRTYFIEGKPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNPLIPDIILSGGyDNFVKMYDTRTD 197
Cdd:cd00200   131 LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTG 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 198 QMV-LNVNHGSPVESLLFLPSGGIFLSAG--GTeIKIWDTiAGGKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHVKI 274
Cdd:cd00200   210 KCLgTLRGHENGVNSVAFSPDGYLLASGSedGT-IRVWDL-RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                  ..
gi 1573060030 275 YD 276
Cdd:cd00200   288 WD 289
WD40 COG2319
WD40 repeat [General function prediction only];
61-279 2.16e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 2.16e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  61 RVQVYNPTTKLVVKNLSRFRENAYGATFRSDGRLLCAGGEETNVKLFDLSTKNLLRLFKGHGAPVHRTYFIEGKPQIVSF 140
Cdd:COG2319   185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 141 SDDKNVKIWDIPTEKNVISYSEHGDYVRAGAtnpLIPD--IILSGGYDNFVKMYDTRTDQMVLNVN-HGSPVESLLFLPS 217
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHSGGVNSVA---FSPDgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPD 341

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1573060030 218 GGIFLSAG--GTeIKIWDtIAGGKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHVKIYDINT 279
Cdd:COG2319   342 GKTLASGSddGT-VRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
76-315 8.44e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 8.44e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  76 LSRFRENAYGATFRSDGRLLCAGGEETNVKLFDLSTKNLLRLFKGHGAPVHRTYFIEGKPQIVSFSDDKNVKIWDIPTEK 155
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 156 NVISYSEHGDYVRAGATNPlipD--IILSGGYDNFVKMYDTRTDQMVLNVN-HGSPVESLLFLPSGGIFLSAG--GTeIK 230
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSP---DgkTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSddGT-VR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 231 IWDtIAGGKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHVKIYDINTFKVVHTLD-YPNAVLSLGVSKNDDTIVAGLV 309
Cdd:COG2319   188 LWD-LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSA 266


                  ....*.
gi 1573060030 310 DGLVAI 315
Cdd:COG2319   267 DGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 114-315 1.90e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 1.90e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 114 LLRLFKGHGAPVHRTYFIEGKPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATnplIPDI--ILSGGYDNFVKM 191
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADGtyLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 192 YDTRTDQMVLNVN-HGSPVESLLFLPSGGIFLSAGG-TEIKIWDTIAgGKLLGSISQHHKTITCLRLASNNKRLLSGSLD 269
Cdd:cd00200    78 WDLETGECVRTLTgHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQD 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1573060030 270 RHVKIYDINTFKVVHTL-DYPNAVLSLGVSKNDDTIVAGLVDGLVAI 315
Cdd:cd00200   157 GTIKLWDLRTGKCVATLtGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
88-315 3.65e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.00  E-value: 3.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  88 FRSDGRLLCAGGEETNVKLFDLSTKNLLRLFKGHGAPVHRTYFIEGKPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYV 167
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 168 RAGATNPLiPDIILSGGYDNFVKMYDTRTDQMVLNVN-HGSPVESLLFLPSGGIFLSAGG-TEIKIWDtIAGGKLLGSIS 245
Cdd:COG2319    82 LSVAFSPD-GRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSAdGTVRLWD-LATGKLLRTLT 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1573060030 246 QHHKTITCLRLASNNKRLLSGSLDRHVKIYDINTFKVVHTLD-YPNAVLSLGVSKNDDTIVAGLVDGLVAI 315
Cdd:COG2319   160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRL 230
WD40 COG2319
WD40 repeat [General function prediction only];
29-196 5.02e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 5.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030  29 LGTPVLIKEF----GPIDYIDFSPVEPHYFAVTCSVRVQVYNPTTKLVVKNLSRFRENAYGATFRSDGRLLCAGGEETNV 104
Cdd:COG2319   233 LATGKLLRTLtghsGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 105 KLFDLSTKNLLRLFKGHGAPVHRTYFIEGKPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNpliPD--IILS 182
Cdd:COG2319   313 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS---PDgrTLAS 389

                         170
                  ....*....|....
gi 1573060030 183 GGYDNFVKMYDTRT 196
Cdd:COG2319   390 GSADGTVRLWDLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
238-276 8.19e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 8.19e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1573060030 238 GKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHVKIYD 276
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-276 1.07e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.07e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1573060030  238 GKLLGSISQHHKTITCLRLASNNKRLLSGSLDRHVKIYD 276
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 134-307 1.36e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 134 KPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNPLIPDIILSGGYDNFVKMYDTRTDQMVLNVNHGSPVESLL 213
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQ 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 214 FLPSGGIFLSAGGTEIKI-WDTIAGGKL-LGSISQHHKTITCLRLAsNNKRLLSGSLDRHVKIYD-------INTFKVVH 284
Cdd:PLN00181  625 FPSESGRSLAFGSADHKVyYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmsisgINETPLHS 703

                         170       180
                  ....*....|....*....|...
gi 1573060030 285 TLDYPNAVLSLGVSKNDDTIVAG 307
Cdd:PLN00181  704 FMGHTNVKNFVGLSVSDGYIATG 726
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 111-150 1.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1573060030  111 TKNLLRLFKGHGAPVHRTYFIEGKPQIVSFSDDKNVKIWD 150
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
122-304 2.25e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.76  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 122 GAPVHRTYFIEGKPQIVSFSDDKNVKIWDIPTEKNVISYSEHGDYVRAGATNPLIPD---IILSGGYDNFVKMYDTRTDQ 198
Cdd:COG3391    22 AVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADgrrLYVANSGSGRVSVIDLATGK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573060030 199 MVLNVNHGSPVESLLFLPSGG-IFLSAGGT-EIKIWDTiAGGKLLGSISQHhKTITCLRLASNNKRLLSGSLDRH----- 271
Cdd:COG3391   102 VVATIPVGGGPRGLAVDPDGGrLYVADSGNgRVSVIDT-ATGKVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNtvsvi 179

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1573060030 272 VKIYDINTFKVVHTLDYPNAVLSLGVSKNDDTI 304
Cdd:COG3391   180 VSVIDTATGKVVATIPVGGGPVGVAVSPDGRRL 212
WD40 pfam00400
WD domain, G-beta repeat;
112-150 4.19e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1573060030 112 KNLLRLFKGHGAPVHRTYFIEGKPQIVSFSDDKNVKIWD 150
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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