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Conserved domains on  [gi|1573864356|gb|RZD53796|]
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MAG: hypothetical protein CXT67_02680 [Methanobacteriota archaeon]

Protein Classification

C1 domain-containing protein( domain architecture ID 10033252)

C1 (protein kinase C conserved region 1) domain-containing protein similar to Caenorhabditis elegans phorbol-ester/DAG-type domain-containing protein

Gene Ontology:  GO:0005515|GO:0019992
PubMed:  15817391|16861033

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MJ0795 super family cl27848
S-layer protein MJ0795, predicted component of type IV pili-like system [General function ...
 4-247 2.30e-04

S-layer protein MJ0795, predicted component of type IV pili-like system [General function prediction only];


The actual alignment was detected with superfamily member COG1361:

Pssm-ID: 440972 [Multi-domain]  Cd Length: 409  Bit Score: 43.92  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356   4 DIILRVLGNPTNVTPGQSSSATFEIENNGNGP-EHAMLIVEGiPSTWEYHIEVGATELSGP-ISLSPSY---ENNHIA-- 76
Cdd:COG1361   137 RFEVVSVTSPDSLTPGDTGTLTLTIKNTGTGTaKNVTVTLTS-PSGDLTDLEPGPRPATNVvVVLSSPVspvGSNSVAlg 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356  77 ------QVQIIFT---PPSGEEGNLEIDIDISvvpSEGTDLNPSDNSHSFSVRTNRvtKPVLSMSTNVLDVRTDSMHLVT 147
Cdd:COG1361   216 tlepgeSATFTFKvdvSEDAEPGPYPLPLTVT---YRDEDGDTYSDTVTIGVYVAP--KADFEVENVESTITAGETVTIT 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356 148 LGVLNDGNAVDGSMRIRIVADTLLPGITSTLSnggaslhlsqwmdLG-MPPQQNKELQWLITVSSDLPVGTRVIfSVVFE 226
Cdd:COG1361   291 ITVTNTGNETAKNVVARLSADDPLSSLDDEAF-------------IGdLAPGESATVTFTVSASSDATPGTYPI-TVTIR 356

                         250       260
                  ....*....|....*....|.
gi 1573864356 227 ASDDiQGNSQtINETLILTIT 247
Cdd:COG1361   357 YDDD-DGNTQ-LSDTITVPVE 375
C1 cd00029
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ...
 604-643 6.38e-04

protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.


:

Pssm-ID: 410341  Cd Length: 50  Bit Score: 37.88  E-value: 6.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1573864356 604 VNCAYCDR-ILSHTDQWFECPDCGIYSHTQCREgqQVCSRC 643
Cdd:cd00029    12 TFCDVCGKlIWGLFKQGLKCSDCGLVCHKKCLD--KAPSPC 50
 
Name Accession Description Interval E-value
MJ0795 COG1361
S-layer protein MJ0795, predicted component of type IV pili-like system [General function ...
 4-247 2.30e-04

S-layer protein MJ0795, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 440972 [Multi-domain]  Cd Length: 409  Bit Score: 43.92  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356   4 DIILRVLGNPTNVTPGQSSSATFEIENNGNGP-EHAMLIVEGiPSTWEYHIEVGATELSGP-ISLSPSY---ENNHIA-- 76
Cdd:COG1361   137 RFEVVSVTSPDSLTPGDTGTLTLTIKNTGTGTaKNVTVTLTS-PSGDLTDLEPGPRPATNVvVVLSSPVspvGSNSVAlg 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356  77 ------QVQIIFT---PPSGEEGNLEIDIDISvvpSEGTDLNPSDNSHSFSVRTNRvtKPVLSMSTNVLDVRTDSMHLVT 147
Cdd:COG1361   216 tlepgeSATFTFKvdvSEDAEPGPYPLPLTVT---YRDEDGDTYSDTVTIGVYVAP--KADFEVENVESTITAGETVTIT 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356 148 LGVLNDGNAVDGSMRIRIVADTLLPGITSTLSnggaslhlsqwmdLG-MPPQQNKELQWLITVSSDLPVGTRVIfSVVFE 226
Cdd:COG1361   291 ITVTNTGNETAKNVVARLSADDPLSSLDDEAF-------------IGdLAPGESATVTFTVSASSDATPGTYPI-TVTIR 356

                         250       260
                  ....*....|....*....|.
gi 1573864356 227 ASDDiQGNSQtINETLILTIT 247
Cdd:COG1361   357 YDDD-DGNTQ-LSDTITVPVE 375
C1 cd00029
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ...
 604-643 6.38e-04

protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.


Pssm-ID: 410341  Cd Length: 50  Bit Score: 37.88  E-value: 6.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1573864356 604 VNCAYCDR-ILSHTDQWFECPDCGIYSHTQCREgqQVCSRC 643
Cdd:cd00029    12 TFCDVCGKlIWGLFKQGLKCSDCGLVCHKKCLD--KAPSPC 50
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 604-633 2.24e-03

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 36.29  E-value: 2.24e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1573864356  604 VNCAYCDRILSHTD-QWFECPDCGIYSHTQC 633
Cdd:smart00109  12 TFCCVCRKSIWGSFkQGLRCSECKVKCHKKC 42
 
Name Accession Description Interval E-value
MJ0795 COG1361
S-layer protein MJ0795, predicted component of type IV pili-like system [General function ...
 4-247 2.30e-04

S-layer protein MJ0795, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 440972 [Multi-domain]  Cd Length: 409  Bit Score: 43.92  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356   4 DIILRVLGNPTNVTPGQSSSATFEIENNGNGP-EHAMLIVEGiPSTWEYHIEVGATELSGP-ISLSPSY---ENNHIA-- 76
Cdd:COG1361   137 RFEVVSVTSPDSLTPGDTGTLTLTIKNTGTGTaKNVTVTLTS-PSGDLTDLEPGPRPATNVvVVLSSPVspvGSNSVAlg 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356  77 ------QVQIIFT---PPSGEEGNLEIDIDISvvpSEGTDLNPSDNSHSFSVRTNRvtKPVLSMSTNVLDVRTDSMHLVT 147
Cdd:COG1361   216 tlepgeSATFTFKvdvSEDAEPGPYPLPLTVT---YRDEDGDTYSDTVTIGVYVAP--KADFEVENVESTITAGETVTIT 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356 148 LGVLNDGNAVDGSMRIRIVADTLLPGITSTLSnggaslhlsqwmdLG-MPPQQNKELQWLITVSSDLPVGTRVIfSVVFE 226
Cdd:COG1361   291 ITVTNTGNETAKNVVARLSADDPLSSLDDEAF-------------IGdLAPGESATVTFTVSASSDATPGTYPI-TVTIR 356

                         250       260
                  ....*....|....*....|.
gi 1573864356 227 ASDDiQGNSQtINETLILTIT 247
Cdd:COG1361   357 YDDD-DGNTQ-LSDTITVPVE 375
MJ0795 COG1361
S-layer protein MJ0795, predicted component of type IV pili-like system [General function ...
 4-268 5.26e-04

S-layer protein MJ0795, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 440972 [Multi-domain]  Cd Length: 409  Bit Score: 42.76  E-value: 5.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356   4 DIILRVLGNPTnVTPGQSSSATFEIENNGNGPEHAmLIVEGIPStweYHIEVGATELSGPISLSPSYEnnhiAQVQIIFT 83
Cdd:COG1361    25 DLSVTVSDSNE-VAPGEEVTLTVTITNDGTLTARN-VTVELEGD---YPFEVKSGEQSVGGSLPPGQS----VTVTFTVT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356  84 -PPSGEEGNLEIDIDISVvpsegtDLNPSDNSHSFSVRTN-RVT-KPVLSMS--TNVLDVRTDSMHLVTLGVLNDGNAVD 158
Cdd:COG1361    96 vPEDAEPGTYPIPVTVSY------SYGYTDRTETETYTVTvKVEgEPRFEVVsvTSPDSLTPGDTGTLTLTIKNTGTGTA 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864356 159 GSMRIRIVADTL----LPGITSTLSNggASLHLSQWMDLG---------MPPQQNKELQWLITVSSDLPVGTRVI-FSVV 224
Cdd:COG1361   170 KNVTVTLTSPSGdltdLEPGPRPATN--VVVVLSSPVSPVgsnsvalgtLEPGESATFTFKVDVSEDAEPGPYPLpLTVT 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1573864356 225 FeasDDIQGNSQTINETLILTITSHRELNFENTLSQIpelYPGQ 268
Cdd:COG1361   248 Y---RDEDGDTYSDTVTIGVYVAPKADFEVENVESTI---TAGE 285
C1 cd00029
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ...
 604-643 6.38e-04

protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.


Pssm-ID: 410341  Cd Length: 50  Bit Score: 37.88  E-value: 6.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1573864356 604 VNCAYCDR-ILSHTDQWFECPDCGIYSHTQCREgqQVCSRC 643
Cdd:cd00029    12 TFCDVCGKlIWGLFKQGLKCSDCGLVCHKKCLD--KAPSPC 50
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 604-633 2.24e-03

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 36.29  E-value: 2.24e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1573864356  604 VNCAYCDRILSHTD-QWFECPDCGIYSHTQC 633
Cdd:smart00109  12 TFCCVCRKSIWGSFkQGLRCSECKVKCHKKC 42
C1_AKAP13 cd20878
protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) ...
 602-642 6.89e-03

protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins; AKAP-13, also called AKAP-Lbc, breast cancer nuclear receptor-binding auxiliary protein (Brx-1), guanine nucleotide exchange factor Lbc, human thyroid-anchoring protein 31, lymphoid blast crisis oncogene (LBC oncogene), non-oncogenic Rho GTPase-specific GTP exchange factor, protein kinase A-anchoring protein 13 (PRKA13), or p47, is a scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors (GPCRs). It activates RhoA in response to GPCR signaling via its function as a Rho guanine nucleotide exchange factor. It may also activate other Rho family members. AKAP-13 plays a role in cell growth, cell development and actin fiber formation. Its Rho-GEF activity is regulated by protein kinase A (PKA), through binding and phosphorylation. Alternative splicing of this gene in humans has at least 3 transcript variants encoding different isoforms (i.e. proto-/onco-Lymphoid blast crisis, Lbc and breast cancer nuclear receptor-binding auxiliary protein, and Brx) that contain a C1 domain followed by a dbl oncogene homology (DH) domain and a PH domain which are required for full transforming activity. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410428  Cd Length: 60  Bit Score: 35.40  E-value: 6.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1573864356 602 PQVNCAYCDRILSHTDQwFECPDCGIYSHTQCREGQQVCSR 642
Cdd:cd20878    17 GPTQCYHCSKPLNTKDA-FLCANCNVQVHKGCRESLPVCAK 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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