NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1573864425|gb|RZD53863|]
View 

MAG: translation initiation factor IF-2 subunit beta [Methanobacteriota archaeon]

Protein Classification

GCD7 family protein( domain architecture ID 10004034)

GCD7 family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
3-135 6.68e-67

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 441209  Cd Length: 133  Bit Score: 198.50  E-value: 6.68e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   3 DFDYESLLNRARDKIPQELSSSERWKLPEPDVLIEGSQTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSREDRRVLLK 82
Cdd:COG1601     1 DMDYEELLDRAYEKLPEKVGSGERFEVPEPEVRIEGNRTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIEGGRAILQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1573864425  83 GRIPPKRIREKLGNYVKTYILCGQCNAPDTSFIKEDRTTLLKCQACGATRPVK 135
Cdd:COG1601    81 GKFSPEDINALIDRYVKEYVICPECGSPDTRLVKEGRVLMLKCEACGARRPVK 133
 
Name Accession Description Interval E-value
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
3-135 6.68e-67

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 198.50  E-value: 6.68e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   3 DFDYESLLNRARDKIPQELSSSERWKLPEPDVLIEGSQTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSREDRRVLLK 82
Cdd:COG1601     1 DMDYEELLDRAYEKLPEKVGSGERFEVPEPEVRIEGNRTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIEGGRAILQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1573864425  83 GRIPPKRIREKLGNYVKTYILCGQCNAPDTSFIKEDRTTLLKCQACGATRPVK 135
Cdd:COG1601    81 GKFSPEDINALIDRYVKEYVICPECGSPDTRLVKEGRVLMLKCEACGARRPVK 133
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
1-135 4.15e-59

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 178.95  E-value: 4.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   1 MTDFDYESLLNRARDKIPQELSSSERWKLPEPDVLIEGSQTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSREDRRVL 80
Cdd:PRK03988    2 SDYYDYEELLDRAYEKLPEKVFKESRFEVPKPDVRIEGNRTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIEGGRLI 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1573864425  81 LKGRIPPKRIREKLGNYVKTYILCGQCNAPDTSFIKEDRTTLLKCQACGATRPVK 135
Cdd:PRK03988   82 LQGKFSPRVINEKIDRYVKEYVICPECGSPDTKLIKEGRIWVLKCEACGAETPVK 136
aIF-2beta TIGR00311
translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high ...
5-135 1.36e-45

translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high enough to select only archaeal members. The suggested cutoff is set to include most eukaryotic members but largely exclude the related eIF-5. [Protein synthesis, Translation factors]


Pssm-ID: 129411  Cd Length: 133  Bit Score: 144.61  E-value: 1.36e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   5 DYESLLNRARDKIPQELSSSERWKLPEPDVLIEGSQTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSREDRRVLLKGR 84
Cdd:TIGR00311   1 DYEELLERAFEQLPDKVFVRERFEIPRVSIQIEGNRTIIKNFREIAKALNRDEDHLYKYLLKELGTAGNLEGGRLILQGK 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1573864425  85 IPPKRIREKLGNYVKTYILCGQCNAPDTSFIKEDRTTLLKCQACGATRPVK 135
Cdd:TIGR00311  81 FTESLLQKRIDDYVRLYVICRECNSPDTEIIKEGRVLLLKCLACGAKHPVR 131
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
23-130 2.47e-42

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 135.72  E-value: 2.47e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425  23 SSERWKLPEPDVLIEGSQ-TIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGS-REDRRVLLKGRIPPKRIREKLGNYVKT 100
Cdd:pfam01873   5 SFYRYKMPPPQVKREGKGkTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSiDENGRLIINGKFSAKQIEDLLDKYIEE 84
                          90       100       110
                  ....*....|....*....|....*....|
gi 1573864425 101 YILCGQCNAPDTSFIKEDRTTLLKCQACGA 130
Cdd:pfam01873  85 YVLCPECGSPDTELIKENRLLFLKCEACGA 114
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
26-130 6.33e-36

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 119.27  E-value: 6.33e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   26 RWKLPEPDVLIEGS-QTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSRED-RRVLLKGRIPPKRIREKLGNYVKTYIL 103
Cdd:smart00653   3 RFKMPPPQVLREGKgKTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGkGRLIVNGRFTPKKLQDLLRRYIKEYVL 82
                           90       100
                   ....*....|....*....|....*..
gi 1573864425  104 CGQCNAPDTSFIKEDRTTLLKCQACGA 130
Cdd:smart00653  83 CPECGSPDTELIKENRLFFLKCEACGA 109
 
Name Accession Description Interval E-value
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
3-135 6.68e-67

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 198.50  E-value: 6.68e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   3 DFDYESLLNRARDKIPQELSSSERWKLPEPDVLIEGSQTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSREDRRVLLK 82
Cdd:COG1601     1 DMDYEELLDRAYEKLPEKVGSGERFEVPEPEVRIEGNRTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIEGGRAILQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1573864425  83 GRIPPKRIREKLGNYVKTYILCGQCNAPDTSFIKEDRTTLLKCQACGATRPVK 135
Cdd:COG1601    81 GKFSPEDINALIDRYVKEYVICPECGSPDTRLVKEGRVLMLKCEACGARRPVK 133
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
1-135 4.15e-59

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 178.95  E-value: 4.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   1 MTDFDYESLLNRARDKIPQELSSSERWKLPEPDVLIEGSQTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSREDRRVL 80
Cdd:PRK03988    2 SDYYDYEELLDRAYEKLPEKVFKESRFEVPKPDVRIEGNRTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIEGGRLI 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1573864425  81 LKGRIPPKRIREKLGNYVKTYILCGQCNAPDTSFIKEDRTTLLKCQACGATRPVK 135
Cdd:PRK03988   82 LQGKFSPRVINEKIDRYVKEYVICPECGSPDTKLIKEGRIWVLKCEACGAETPVK 136
PRK12336 PRK12336
translation initiation factor IF-2 subunit beta; Provisional
4-135 4.24e-56

translation initiation factor IF-2 subunit beta; Provisional


Pssm-ID: 183451 [Multi-domain]  Cd Length: 201  Bit Score: 173.59  E-value: 4.24e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   4 FDYESLLNRARDKIPQELSSSERWKLPEPDVLIEGSQTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSREDRRVLLKG 83
Cdd:PRK12336    1 MDYESLLDRAMEVLPEPTKSGERFSIPEPKIFIEGKTTILTNFGEIADALNRDPDHLMKFLQRELGTAGKIEGGRAVFNG 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1573864425  84 RIPPKRIREKLGNYVKTYILCGQCNAPDTSFIKEDRTTLLKCQACGATRPVK 135
Cdd:PRK12336   81 KFTEEDIQAAIDAYVDEYVICSECGLPDTRLVKEDRVLMLRCDACGAHRPVK 132
aIF-2beta TIGR00311
translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high ...
5-135 1.36e-45

translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high enough to select only archaeal members. The suggested cutoff is set to include most eukaryotic members but largely exclude the related eIF-5. [Protein synthesis, Translation factors]


Pssm-ID: 129411  Cd Length: 133  Bit Score: 144.61  E-value: 1.36e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   5 DYESLLNRARDKIPQELSSSERWKLPEPDVLIEGSQTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSREDRRVLLKGR 84
Cdd:TIGR00311   1 DYEELLERAFEQLPDKVFVRERFEIPRVSIQIEGNRTIIKNFREIAKALNRDEDHLYKYLLKELGTAGNLEGGRLILQGK 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1573864425  85 IPPKRIREKLGNYVKTYILCGQCNAPDTSFIKEDRTTLLKCQACGATRPVK 135
Cdd:TIGR00311  81 FTESLLQKRIDDYVRLYVICRECNSPDTEIIKEGRVLLLKCLACGAKHPVR 131
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
23-130 2.47e-42

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 135.72  E-value: 2.47e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425  23 SSERWKLPEPDVLIEGSQ-TIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGS-REDRRVLLKGRIPPKRIREKLGNYVKT 100
Cdd:pfam01873   5 SFYRYKMPPPQVKREGKGkTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSiDENGRLIINGKFSAKQIEDLLDKYIEE 84
                          90       100       110
                  ....*....|....*....|....*....|
gi 1573864425 101 YILCGQCNAPDTSFIKEDRTTLLKCQACGA 130
Cdd:pfam01873  85 YVLCPECGSPDTELIKENRLLFLKCEACGA 114
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
26-130 6.33e-36

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 119.27  E-value: 6.33e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864425   26 RWKLPEPDVLIEGS-QTIIRNFGDIIDMMDRDGNHVYHFLQNELGTSGSRED-RRVLLKGRIPPKRIREKLGNYVKTYIL 103
Cdd:smart00653   3 RFKMPPPQVLREGKgKTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGkGRLIVNGRFTPKKLQDLLRRYIKEYVL 82
                           90       100
                   ....*....|....*....|....*..
gi 1573864425  104 CGQCNAPDTSFIKEDRTTLLKCQACGA 130
Cdd:smart00653  83 CPECGSPDTELIKENRLFFLKCEACGA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH