NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1573864727|gb|RZD54160|]
View 

MAG: methylated-DNA--[protein]-cysteine S-methyltransferase [Methanobacteriota archaeon]

Protein Classification

methylated-DNA--[protein]-cysteine S-methyltransferase( domain architecture ID 11417447)

methylated-DNA--[protein]-cysteine S-methyltransferase is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA; it repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme

CATH:  3.30.160.70|1.10.10.10
EC:  2.1.1.63
Gene Ontology:  GO:0003908|GO:0003677|GO:0046872|GO:0006281|GO:0032259
PubMed:  17500045|17485252
SCOP:  4000565|4000678

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AdaB COG0350
DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, ...
 1-151 8.16e-48

DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair];


:

Pssm-ID: 440119 [Multi-domain]  Cd Length: 163  Bit Score: 152.33  E-value: 8.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727   1 MMARDCILTPLGPIFVKASTNGLTEVGWGEKNPS----------TEENPHLAAAREWFRAYFSGESQILP-ELDSsRLTG 69
Cdd:COG0350     1 TIRYAIFDTPLGPLLIAATDRGLCALSFGDDREEallarfpaalREDPPLLAEAARQLDAYFAGERKDFDlPLDL-RGTP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  70 FQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLLEH 149
Cdd:COG0350    80 FQRRVWEALR-KIPYGETVTYGELARAIGRPKAARAVGSACGANPIPIIIPCHRVIGADGSLGGYA--GGLERKRALLEL 156


                  ..
gi 1573864727 150 EG 151
Cdd:COG0350   157 EG 158
 
Name Accession Description Interval E-value
AdaB COG0350
DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, ...
 1-151 8.16e-48

DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair];


Pssm-ID: 440119 [Multi-domain]  Cd Length: 163  Bit Score: 152.33  E-value: 8.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727   1 MMARDCILTPLGPIFVKASTNGLTEVGWGEKNPS----------TEENPHLAAAREWFRAYFSGESQILP-ELDSsRLTG 69
Cdd:COG0350     1 TIRYAIFDTPLGPLLIAATDRGLCALSFGDDREEallarfpaalREDPPLLAEAARQLDAYFAGERKDFDlPLDL-RGTP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  70 FQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLLEH 149
Cdd:COG0350    80 FQRRVWEALR-KIPYGETVTYGELARAIGRPKAARAVGSACGANPIPIIIPCHRVIGADGSLGGYA--GGLERKRALLEL 156


                  ..
gi 1573864727 150 EG 151
Cdd:COG0350   157 EG 158
ATase cd06445
The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT ...
 70-151 2.77e-33

The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases are specific for repair of guanines with O6-alkyl adducts, however human ATase is not limited to O6-methylguanine, repairing many other adducts at the O6-position of guanine as well. ATase is widely distributed among species. Most ATases have N- and C-terminal domains. The C-terminal domain contains the conserved active-site cysteine motif (PCHR), the O6-alkylguanine binding channel, and the helix-turn-helix (HTH) DNA-binding motif. The active site is located near the recognition helix of the HTH motif. While the C-terminal domain of ATase contains residues that are necessary for DNA binding and alkyl transfer, the function of the N-terminal domain is still unknown. Removal of the N-terminal domain abolishes the activity of the C-terminal domain, suggesting an important structural role for the N-terminal domain in orienting the C-terminal domain for proper catalysis. Some ATase C-terminal domain homologs are either single-domain proteins that lack an N-terminal domain, or have a tryptophan substituted in place of the acceptor cysteine (i.e. the motif PCHR is replaced by PWHR). ATase null mutant mice are viable, fertile, and have a normal lifespan.


Pssm-ID: 119438 [Multi-domain]  Cd Length: 79  Bit Score: 112.57  E-value: 2.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  70 FQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLLEH 149
Cdd:cd06445     1 FQRRVWEALR-QIPYGEVTTYGQIAKLAGTPKAARAVGSALARNPIPILIPCHRVVRSDGGLGGYR--GGLERKRELLEL 77


                  ..
gi 1573864727 150 EG 151
Cdd:cd06445    78 EG 79
DNA_binding_1 pfam01035
6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal ...
 70-151 7.96e-33

6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases.


Pssm-ID: 460036  Cd Length: 81  Bit Score: 111.30  E-value: 7.96e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  70 FQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLLEH 149
Cdd:pfam01035   2 FQRRVWEALR-QIPYGKTTTYGEIAKLLGRPKAARAVGNALGANPIPIIVPCHRVVGSDGSLGGYA--GGLERKRALLEL 78


                  ..
gi 1573864727 150 EG 151
Cdd:pfam01035  79 EG 80
ogt TIGR00589
O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are ...
 68-150 3.73e-25

O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273157  Cd Length: 80  Bit Score: 91.99  E-value: 3.73e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  68 TGFQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLL 147
Cdd:TIGR00589   1 TPFQQKVWKALR-TIPYGETKSYGQLAKAIGNPKAARAVGGANGRNPLAILVPCHRVVGKNGTLTGYG--GGLERKEFLL 77


                  ...
gi 1573864727 148 EHE 150
Cdd:TIGR00589  78 EHE 80
PRK00901 PRK00901
methylated-DNA--protein-cysteine methyltransferase; Provisional
 1-151 4.16e-21

methylated-DNA--protein-cysteine methyltransferase; Provisional


Pssm-ID: 234860 [Multi-domain]  Cd Length: 155  Bit Score: 83.95  E-value: 4.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727   1 MMARDCILTPLGPIFVKASTNGLTEVGWGE----KNPSTEENPHLAAAREWFRAYFSGESQ-----ILPELdssrlTGFQ 71
Cdd:PRK00901    1 MNNIYFYETPIGKIGIAENGTAITHLCFGEdkipKDVTILETDLLKEANKQLEEYFEGKRKkfdlpLAPQG-----TEFQ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  72 KRTLDALVGqTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLLEHEG 151
Cdd:PRK00901   76 KKVWKALQE-IPYGETRSYKEIAVNIGNPKACRAVGLANNKNPIPIFIPCHRVIGANGKLVGYA--GGLDIKEKLLKLEK 152
 
Name Accession Description Interval E-value
AdaB COG0350
DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, ...
 1-151 8.16e-48

DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair];


Pssm-ID: 440119 [Multi-domain]  Cd Length: 163  Bit Score: 152.33  E-value: 8.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727   1 MMARDCILTPLGPIFVKASTNGLTEVGWGEKNPS----------TEENPHLAAAREWFRAYFSGESQILP-ELDSsRLTG 69
Cdd:COG0350     1 TIRYAIFDTPLGPLLIAATDRGLCALSFGDDREEallarfpaalREDPPLLAEAARQLDAYFAGERKDFDlPLDL-RGTP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  70 FQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLLEH 149
Cdd:COG0350    80 FQRRVWEALR-KIPYGETVTYGELARAIGRPKAARAVGSACGANPIPIIIPCHRVIGADGSLGGYA--GGLERKRALLEL 156


                  ..
gi 1573864727 150 EG 151
Cdd:COG0350   157 EG 158
ATase cd06445
The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT ...
 70-151 2.77e-33

The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases are specific for repair of guanines with O6-alkyl adducts, however human ATase is not limited to O6-methylguanine, repairing many other adducts at the O6-position of guanine as well. ATase is widely distributed among species. Most ATases have N- and C-terminal domains. The C-terminal domain contains the conserved active-site cysteine motif (PCHR), the O6-alkylguanine binding channel, and the helix-turn-helix (HTH) DNA-binding motif. The active site is located near the recognition helix of the HTH motif. While the C-terminal domain of ATase contains residues that are necessary for DNA binding and alkyl transfer, the function of the N-terminal domain is still unknown. Removal of the N-terminal domain abolishes the activity of the C-terminal domain, suggesting an important structural role for the N-terminal domain in orienting the C-terminal domain for proper catalysis. Some ATase C-terminal domain homologs are either single-domain proteins that lack an N-terminal domain, or have a tryptophan substituted in place of the acceptor cysteine (i.e. the motif PCHR is replaced by PWHR). ATase null mutant mice are viable, fertile, and have a normal lifespan.


Pssm-ID: 119438 [Multi-domain]  Cd Length: 79  Bit Score: 112.57  E-value: 2.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  70 FQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLLEH 149
Cdd:cd06445     1 FQRRVWEALR-QIPYGEVTTYGQIAKLAGTPKAARAVGSALARNPIPILIPCHRVVRSDGGLGGYR--GGLERKRELLEL 77


                  ..
gi 1573864727 150 EG 151
Cdd:cd06445    78 EG 79
DNA_binding_1 pfam01035
6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal ...
 70-151 7.96e-33

6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases.


Pssm-ID: 460036  Cd Length: 81  Bit Score: 111.30  E-value: 7.96e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  70 FQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLLEH 149
Cdd:pfam01035   2 FQRRVWEALR-QIPYGKTTTYGEIAKLLGRPKAARAVGNALGANPIPIIVPCHRVVGSDGSLGGYA--GGLERKRALLEL 78


                  ..
gi 1573864727 150 EG 151
Cdd:pfam01035  79 EG 80
ogt TIGR00589
O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are ...
 68-150 3.73e-25

O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273157  Cd Length: 80  Bit Score: 91.99  E-value: 3.73e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  68 TGFQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLL 147
Cdd:TIGR00589   1 TPFQQKVWKALR-TIPYGETKSYGQLAKAIGNPKAARAVGGANGRNPLAILVPCHRVVGKNGTLTGYG--GGLERKEFLL 77


                  ...
gi 1573864727 148 EHE 150
Cdd:TIGR00589  78 EHE 80
Atl1 COG3695
Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like ...
 85-159 4.05e-23

Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain [Transcription];


Pssm-ID: 442910  Cd Length: 104  Bit Score: 87.55  E-value: 4.05e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1573864727  85 GKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIgSYSGLGGQATKIRLLEHEGHSFDEAGR 159
Cdd:COG3695    20 GRVATYGDIAALAGLPRGARQVGRALRALPEGSDLPWHRVVNADGRL-SPGHAGGAEEQRELLEAEGVPVVDDGR 93
PRK00901 PRK00901
methylated-DNA--protein-cysteine methyltransferase; Provisional
 1-151 4.16e-21

methylated-DNA--protein-cysteine methyltransferase; Provisional


Pssm-ID: 234860 [Multi-domain]  Cd Length: 155  Bit Score: 83.95  E-value: 4.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727   1 MMARDCILTPLGPIFVKASTNGLTEVGWGE----KNPSTEENPHLAAAREWFRAYFSGESQ-----ILPELdssrlTGFQ 71
Cdd:PRK00901    1 MNNIYFYETPIGKIGIAENGTAITHLCFGEdkipKDVTILETDLLKEANKQLEEYFEGKRKkfdlpLAPQG-----TEFQ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  72 KRTLDALVGqTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLLEHEG 151
Cdd:PRK00901   76 KKVWKALQE-IPYGETRSYKEIAVNIGNPKACRAVGLANNKNPIPIFIPCHRVIGANGKLVGYA--GGLDIKEKLLKLEK 152
PRK10286 PRK10286
methylated-DNA--[protein]-cysteine S-methyltransferase;
5-152 1.37e-17

methylated-DNA--[protein]-cysteine S-methyltransferase;


Pssm-ID: 182355 [Multi-domain]  Cd Length: 171  Bit Score: 75.29  E-value: 1.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727   5 DCILTPLGPIFVKASTN-GLTEVGWGEKNPSTEENPHLAAAREWF---------------RAYFSGESQILPELDSSRL- 67
Cdd:PRK10286    7 EKIATPLGPLWVICDEQfRLRAVEWEEYSERMVQLLDIHYRKEGYerisatnpgglsdklRDYFAGNLSIIDTLPTATGg 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  68 TGFQKRTLDALvGQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYSglGGQATKIRLL 147
Cdd:PRK10286   87 TPFQREVWQTL-RTIPCGQVMHYGQLAEQLGRPGAARAVGAANGSNPISIVVPCHRVIGRNGTMTGYA--GGVQRKEWLL 163


                  ....*
gi 1573864727 148 EHEGH 152
Cdd:PRK10286  164 RHEGY 168
PRK03887 PRK03887
methylated-DNA--protein-cysteine methyltransferase; Provisional
 59-151 2.63e-16

methylated-DNA--protein-cysteine methyltransferase; Provisional


Pssm-ID: 167628 [Multi-domain]  Cd Length: 175  Bit Score: 71.69  E-value: 2.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  59 LPELDSSRLTGFQKRTLDALVGQTHFGKVVSYGELAELAGSkgASRAVGSVMAMNPWPLLVPCHRVVRSDRmIGSYSglG 138
Cdd:PRK03887   82 LEELSFEGLTPFERKVYEWLTKNVKRGEVITYGELAKALNT--SPRAVGGAMKRNPYPIIVPCHRVVGRKN-PGLYT--P 156

                          90
                  ....*....|...
gi 1573864727 139 GQATKIRLLEHEG 151
Cdd:PRK03887  157 KPEYKKFLLEVEG 169
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
66-150 7.74e-12

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 61.73  E-value: 7.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  66 RLTGFQKRTLDALVgQTHFGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDrmiGSYSGLG-GQATKI 144
Cdd:PRK15435  267 RGTAFQQQVWQALR-TIPCGETVSYQQLANAIGKPKAVRAVASACAANKLAIVIPCHRVVRGD---GALSGYRwGVSRKA 342


                  ....*.
gi 1573864727 145 RLLEHE 150
Cdd:PRK15435  343 QLLRRE 348
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 9-159 4.00e-10

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 56.99  E-value: 4.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727   9 TPLGPIFVKASTNGLTEVGWGEKNPSTEE--------------NPHLAAAREWFRAYFSGESQILPELDSSRLTGFQKRT 74
Cdd:COG2169   197 CSLGLLLVAASARGVCAILLGDDPEALLRdlqdrfpaaeliggDAAFEQLVAEVVGFVEGPLLGLDLPLDLRGTAFQQRV 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573864727  75 LDALVGQTHfGKVVSYGELAELAGSKGASRAVGSVMAMNPWPLLVPCHRVVRSDRMIGSYsgLGGQATKIRLLEHEGHSF 154
Cdd:COG2169   277 WQALRAIPA-GETASYAEIAARIGAPKAVRAVAAACAANQLAVAIPCHRVVRADGALSGY--RWGVERKRALLEREAAAA 353


                  ....*
gi 1573864727 155 DEAGR 159
Cdd:COG2169   354 AAAAA 358
Methyltransf_1N pfam02870
6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; This entry represents the ...
 9-58 4.93e-04

6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; This entry represents the N-terminal ribonuclease-like domain associated with 6-O-methylguanine DNA methyltransferase activity. The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase (also known as O-6-methylguanine-DNA-alkyltransferase)


Pssm-ID: 397139 [Multi-domain]  Cd Length: 77  Bit Score: 36.96  E-value: 4.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1573864727   9 TPLGPIFVKASTNGLTEVGWGEKN-----------PSTEENPHLAAAREWFRAYFSGESQI 58
Cdd:pfam02870   9 SPLGRLLLAGDERGLTAIDFLDKDyalrkelpkvlPQPELLPALALLVQALEEYFAGELKP 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH