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Conserved domains on  [gi|1576222018|gb|RZL16817|]
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ArsR family transcriptional regulator, partial [Hymenobacter sp.]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-95 7.23e-23

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 84.56  E-value: 7.23e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576222018   6 TEDQQQLARLAKALAHPARVAIIQFLASKQTCIsGDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNTELIN 85
Cdd:COG0640     4 TKELEELAELFKALADPTRLRILRLLAEGELCV-GELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82

                          90
                  ....*....|
gi 1576222018  86 KVHQQFTAFF 95
Cdd:COG0640    83 ELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-95 7.23e-23

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 84.56  E-value: 7.23e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576222018   6 TEDQQQLARLAKALAHPARVAIIQFLASKQTCIsGDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNTELIN 85
Cdd:COG0640     4 TKELEELAELFKALADPTRLRILRLLAEGELCV-GELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82

                          90
                  ....*....|
gi 1576222018  86 KVHQQFTAFF 95
Cdd:COG0640    83 ELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 12-87 1.29e-17

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 70.95  E-value: 1.29e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1576222018  12 LARLAKALAHPARVAIIQFLASKQTCIsGDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNTELINKV 87
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCV-CELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 16-80 7.36e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 63.86  E-value: 7.36e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1576222018  16 AKALAHPARVAIIQFLASKQTCISgDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLN 80
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVS-ELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 17-81 2.10e-11

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 55.11  E-value: 2.10e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1576222018  17 KALAHPARVAIIQFLASKQ-TciSGDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNT 81
Cdd:NF033789    3 KALSDPTRREILELLKEGDmT--AGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNT 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 13-69 5.88e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 53.31  E-value: 5.88e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1576222018  13 ARLAKALAHPARVAIIQFLASKQTCISGDIAAELPLSRTTVSQHLQELKALDLIRGE 69
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVV 57
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
27-91 1.04e-10

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 52.98  E-value: 1.04e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1576222018   27 IIQFLASKQTCISgDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNTELINKVHQQF 91
Cdd:smart00418   2 ILKLLAEGELCVC-ELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-95 7.23e-23

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 84.56  E-value: 7.23e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576222018   6 TEDQQQLARLAKALAHPARVAIIQFLASKQTCIsGDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNTELIN 85
Cdd:COG0640     4 TKELEELAELFKALADPTRLRILRLLAEGELCV-GELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82

                          90
                  ....*....|
gi 1576222018  86 KVHQQFTAFF 95
Cdd:COG0640    83 ELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 12-87 1.29e-17

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 70.95  E-value: 1.29e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1576222018  12 LARLAKALAHPARVAIIQFLASKQTCIsGDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNTELINKV 87
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCV-CELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 16-80 7.36e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 63.86  E-value: 7.36e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1576222018  16 AKALAHPARVAIIQFLASKQTCISgDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLN 80
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVS-ELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
5-82 9.57e-13

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 60.28  E-value: 9.57e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1576222018   5 FTEDQQqlaRLAKALAHPARVAIIQFLASKQTCISGDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNTE 82
Cdd:COG3398    83 YSEEEK---KILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
6-69 1.21e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 58.82  E-value: 1.21e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1576222018   6 TEDQQQLARLAKALAHPARVAIIQFLASKQTCISgDIAAELPLSRTTVSQHLQELKALDLIRGE 69
Cdd:COG4189     3 VLDDEESLEVLKALASETRLRILRLLAEEPLNVN-ELAEALGLPKSTVSYHIRKLEEAGLIRTE 65
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 17-81 2.10e-11

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 55.11  E-value: 2.10e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1576222018  17 KALAHPARVAIIQFLASKQ-TciSGDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNT 81
Cdd:NF033789    3 KALSDPTRREILELLKEGDmT--AGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNT 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 13-69 5.88e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 53.31  E-value: 5.88e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1576222018  13 ARLAKALAHPARVAIIQFLASKQTCISGDIAAELPLSRTTVSQHLQELKALDLIRGE 69
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVV 57
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
27-91 1.04e-10

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 52.98  E-value: 1.04e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1576222018   27 IIQFLASKQTCISgDIAAELPLSRTTVSQHLQELKALDLIRGEIDGLTVCYCLNTELINKVHQQF 91
Cdd:smart00418   2 ILKLLAEGELCVC-ELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 21-66 6.51e-08

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 45.13  E-value: 6.51e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1576222018  21 HPARVAIIQFLASKQTCISgDIAAELPLSRTTVSQHLQELKALDLI 66
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVC-ELAEELGLSQSTVSHHLKKLREAGLV 45
BirA COG1654
Biotin operon repressor [Transcription];
21-63 4.45e-05

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 40.74  E-value: 4.45e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1576222018  21 HPARVAIIQFLASKQtCISG-DIAAELPLSRTTVSQHLQELKAL 63
Cdd:COG1654     3 SSTRLKLLRLLADGE-FHSGeELAEELGVSRAAVWKHIKALREL 45
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 22-67 2.20e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 36.41  E-value: 2.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1576222018  22 PARVAIIQFLASKQTCISGDIAAELPLSRTTVSQHLQELKALDLIR 67
Cdd:pfam12802   5 PAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVE 50
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 26-63 3.04e-04

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 35.87  E-value: 3.04e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1576222018  26 AIIQFLASKQTCISG-DIAAELPLSRTTVSQHLQELKAL 63
Cdd:pfam08279   2 QILQLLLEARGPISGqELAEKLGVSRRTIRRDIKILEEL 40
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
18-67 8.37e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.82  E-value: 8.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1576222018  18 ALAHPARVAIIQFLASKQTCISGDIAAELPLSRTTVSQHLQELKALDLIR 67
Cdd:COG2345     9 ALADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE 58
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 13-67 8.25e-03

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 32.43  E-value: 8.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1576222018  13 ARLAKAL---AHPARVAIIQFLASKQtcisgDIAAELPLSRTTVSQHLQELKALDLIR 67
Cdd:pfam13545   1 QRLARFLlelAARDGGGRIDLPLTQE-----DLADLLGTTRETVSRVLSELRREGLIE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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