NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1577845508|gb|RZX86212|]
View 

pyrimidine utilization protein A [Escherichia coli]

Protein Classification

pyrimidine utilization protein A( domain architecture ID 10022703)

pyrimidine utilization protein A catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RutA TIGR03612
pyrimidine utilization protein A; This protein is observed in operons extremely similar to ...
 1-355 0e+00

pyrimidine utilization protein A; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the luciferase family defined by pfam00296 and is likely a FMN-dependent monoxygenase. [Unknown function, Enzymes of unknown specificity]


:

Pssm-ID: 163355  Cd Length: 355  Bit Score: 763.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508   1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80
Cdd:TIGR03612   1 MDIGVFIPIGNNGWLISENAPQYMPSFELNKAIVQKAEQYGFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKS 160
Cdd:TIGR03612  81 IKLYATAATLTLPPAIVARMASTIDSISNGRFGVNLVTGWQKPEYSQMGLWPGDEYFADRYEYLAEYVQVLRELWETGVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 161 DFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVL 240
Cdd:TIGR03612 161 DFKGEFFQMDDCRVSPRPQAEMKIICAGQSDAGMAFSAQYADYNFCFGKGVNTPTAFAPTAARLLAAAEKTGRDVGSYVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 241 FMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVAS 320
Cdd:TIGR03612 241 FMVIADETDEAARAKWEHYKDGADEEALAWLTLQGAKDTKSGADTNVRQMADPTSAVNINMGTLVGSYETVARMLDEVAE 320

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1577845508 321 VPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHL 355
Cdd:TIGR03612 321 VPGTGGVLLTFDDFLEGVEDFGTRIQPLMTSRAHV 355
 
Name Accession Description Interval E-value
RutA TIGR03612
pyrimidine utilization protein A; This protein is observed in operons extremely similar to ...
 1-355 0e+00

pyrimidine utilization protein A; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the luciferase family defined by pfam00296 and is likely a FMN-dependent monoxygenase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 163355  Cd Length: 355  Bit Score: 763.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508   1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80
Cdd:TIGR03612   1 MDIGVFIPIGNNGWLISENAPQYMPSFELNKAIVQKAEQYGFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKS 160
Cdd:TIGR03612  81 IKLYATAATLTLPPAIVARMASTIDSISNGRFGVNLVTGWQKPEYSQMGLWPGDEYFADRYEYLAEYVQVLRELWETGVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 161 DFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVL 240
Cdd:TIGR03612 161 DFKGEFFQMDDCRVSPRPQAEMKIICAGQSDAGMAFSAQYADYNFCFGKGVNTPTAFAPTAARLLAAAEKTGRDVGSYVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 241 FMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVAS 320
Cdd:TIGR03612 241 FMVIADETDEAARAKWEHYKDGADEEALAWLTLQGAKDTKSGADTNVRQMADPTSAVNINMGTLVGSYETVARMLDEVAE 320

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1577845508 321 VPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHL 355
Cdd:TIGR03612 321 VPGTGGVLLTFDDFLEGVEDFGTRIQPLMTSRAHV 355
Alkanesulfonate_monoxygenase cd01094
Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the ...
 1-258 2.12e-80

Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).


Pssm-ID: 238527 [Multi-domain]  Cd Length: 244  Bit Score: 245.65  E-value: 2.12e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508   1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMiklrgfggkteFWDHNLESFTLMAGLAAVTSR 80
Cdd:cd01094     1 LEFGWFIPNVSGGWSLSTPPRGRPWDFEYNRQIAQAAEELGFDGALSP-----------TGSSGPDGWTVAAALAAATER 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDyfsRRYDYLTEYVQVLRDLW-GTGK 159
Cdd:cd01094    70 LKFLVAIRPGLIAPTVAARQAATLDHISGGRLGLNVVTGGDPAELRMDGDFLDHD---ERYARADEFLEVLRRLWtSDEP 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 160 SDFKGDF--FTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGkgvNTPTAFAPTAARMKQAAEQTGRDVGS 237
Cdd:cd01094   147 FDFEGKFyrFKNAFLRPKPPQQPHPPIYFGGSSEAAIEFAARHADVYFTWG---EPPAQVAEAIARVRAAAAAAGRDVRF 223

                         250       260
                  ....*....|....*....|.
gi 1577845508 238 YVLFMVIADETDDAARAKWEH 258
Cdd:cd01094   224 GIRLHVIVRDTEEEAWAYADR 244
SsuD COG2141
Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase ...
 37-350 4.50e-59

Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) [Coenzyme transport and metabolism, General function prediction only]; Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441744 [Multi-domain]  Cd Length: 301  Bit Score: 192.84  E-value: 4.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  37 AEHYHFDFALSMIKLRGFGGktefwdHNLESFTLMAGLAAVTSRIQIYATAATLTL-PPAIVARMAATIDSISGGRFGVN 115
Cdd:COG2141     1 AERLGFDRVWVADHHFPPGG------ASPDPWVLLAALAAATSRIRLGTGVVVLPLrHPLVVAEQFATLDHLSGGRLDLG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 116 LVTGWQKPEYEQMGIwpgddYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQP----SVPmkVICAGQSD 191
Cdd:COG2141    75 VGRGWGPDEFAAFGL-----DHDERYERFEEALEVLRRLWTGEPVTFEGEFFTVEGARLVPRPvqgpHPP--IWIAGSSP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 192 AGMAFSAQYADFNFCFGkgvNTPTAFAPTAARMKQAAEQTGRDVGS---YVLFMVIADETDDAARakwehykagadEEAL 268
Cdd:COG2141   148 AGARLAARLGDGVFTAG---GTPEELAEAIAAYREAAAAAGRDPDDlrvSVGLHVIVAETDEEAR-----------ERAR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 269 SWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTF-----DDFLSGIETFGE 343
Cdd:COG2141   214 PYLRALLALPRGRPPEEAEEGLTVREDLLELLGAALVGTPEQVAERLEELAEAAGVDEFLLQFpgldpEDRLRSLELFAE 293


                  ....*..
gi 1577845508 344 RIQPLMQ 350
Cdd:COG2141   294 EVLPLLR 300
Bac_luciferase pfam00296
Luciferase-like monooxygenase;
1-320 5.00e-49

Luciferase-like monooxygenase;


Pssm-ID: 425589 [Multi-domain]  Cd Length: 313  Bit Score: 167.15  E-value: 5.00e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508   1 MKIGVFVPIGNNGWListHAPQymPTFELNKAIVQKAEHYHFDFALSmiklrgfggkTEFW--DHNLESFTLMAGLAAVT 78
Cdd:pfam00296   1 MEFGVFLPTRNGGGL---GAGS--ESLRYLVELARAAEELGFDGVWL----------AEHHggPGGPDPFVVLAALAAAT 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  79 SRIQIYATAATL-TLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIwpgddYFSRRYDYLTEYVQVLRDLWGT 157
Cdd:pfam00296  66 SRIRLGTAVVPLpTRHPAVLAEQAATLDHLSGGRFDLGLGTGGPAVEFRRFGV-----DHDERYARLREFLEVLRRLWRG 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 158 GKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFgkGVNTPTAFAPTAARMKQAAEQTGRDVGS 237
Cdd:pfam00296 141 EPVDFEGEFFTLDGAFLLPRPVQGIPVWVAASSPAMLELAARHADGLLLW--GFAPPAAAAELIERVRAGAAEAGRDPAD 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 238 ---YVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDT----NVRQMADPTSAVNINMGTLVGSYAS 310
Cdd:pfam00296 219 irvGASLTVIVADTEEEARAEARALIAGLPFYRMDSEGAGRLAEAREIGEEydagDWAGAADAVPDELVRAFALVGTPEQ 298

                         330
                  ....*....|
gi 1577845508 311 VARMLDEVAS 320
Cdd:pfam00296 299 VAERLAAYAE 308
PRK00719 PRK00719
alkanesulfonate monooxygenase; Provisional
 72-273 2.85e-16

alkanesulfonate monooxygenase; Provisional


Pssm-ID: 234821 [Multi-domain]  Cd Length: 378  Bit Score: 79.23  E-value: 2.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  72 AGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEqmgiwpGDDYF---SRRYDYLTEYV 148
Cdd:PRK00719   61 ASLIPVTQRLKFLVALRPGLMSPTVAARMAATLDRLSNGRLLINLVTGGDPAELA------GDGLFldhDERYEASAEFL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 149 QVLRDLWGTGKSDFKGDFFTMNDCRV------SPQPSVPMkvicAGQSDAGMAFSAQYADFNFCFGKgvnTPTAFAPTAA 222
Cdd:PRK00719  135 RIWRRLLEGETVDFEGKHIQVKGAKLlfppvqQPYPPLYF----GGSSDAAQELAAEQVDLYLTWGE---PPAQVKEKIE 207

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1577845508 223 RMKQAAEQTGRDVGSYVLFMVIADETDDAArakWEhykagADEEALSWLTE 273
Cdd:PRK00719  208 QVRAKAAAHGRKVRFGIRLHVIVRETNEEA---WQ-----AAERLISHLDD 250
 
Name Accession Description Interval E-value
RutA TIGR03612
pyrimidine utilization protein A; This protein is observed in operons extremely similar to ...
 1-355 0e+00

pyrimidine utilization protein A; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the luciferase family defined by pfam00296 and is likely a FMN-dependent monoxygenase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 163355  Cd Length: 355  Bit Score: 763.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508   1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80
Cdd:TIGR03612   1 MDIGVFIPIGNNGWLISENAPQYMPSFELNKAIVQKAEQYGFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKS 160
Cdd:TIGR03612  81 IKLYATAATLTLPPAIVARMASTIDSISNGRFGVNLVTGWQKPEYSQMGLWPGDEYFADRYEYLAEYVQVLRELWETGVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 161 DFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVL 240
Cdd:TIGR03612 161 DFKGEFFQMDDCRVSPRPQAEMKIICAGQSDAGMAFSAQYADYNFCFGKGVNTPTAFAPTAARLLAAAEKTGRDVGSYVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 241 FMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVAS 320
Cdd:TIGR03612 241 FMVIADETDEAARAKWEHYKDGADEEALAWLTLQGAKDTKSGADTNVRQMADPTSAVNINMGTLVGSYETVARMLDEVAE 320

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1577845508 321 VPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHL 355
Cdd:TIGR03612 321 VPGTGGVLLTFDDFLEGVEDFGTRIQPLMTSRAHV 355
Alkanesulfonate_monoxygenase cd01094
Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the ...
 1-258 2.12e-80

Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).


Pssm-ID: 238527 [Multi-domain]  Cd Length: 244  Bit Score: 245.65  E-value: 2.12e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508   1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMiklrgfggkteFWDHNLESFTLMAGLAAVTSR 80
Cdd:cd01094     1 LEFGWFIPNVSGGWSLSTPPRGRPWDFEYNRQIAQAAEELGFDGALSP-----------TGSSGPDGWTVAAALAAATER 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDyfsRRYDYLTEYVQVLRDLW-GTGK 159
Cdd:cd01094    70 LKFLVAIRPGLIAPTVAARQAATLDHISGGRLGLNVVTGGDPAELRMDGDFLDHD---ERYARADEFLEVLRRLWtSDEP 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 160 SDFKGDF--FTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGkgvNTPTAFAPTAARMKQAAEQTGRDVGS 237
Cdd:cd01094   147 FDFEGKFyrFKNAFLRPKPPQQPHPPIYFGGSSEAAIEFAARHADVYFTWG---EPPAQVAEAIARVRAAAAAAGRDVRF 223

                         250       260
                  ....*....|....*....|.
gi 1577845508 238 YVLFMVIADETDDAARAKWEH 258
Cdd:cd01094   224 GIRLHVIVRDTEEEAWAYADR 244
SsuD COG2141
Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase ...
 37-350 4.50e-59

Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) [Coenzyme transport and metabolism, General function prediction only]; Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441744 [Multi-domain]  Cd Length: 301  Bit Score: 192.84  E-value: 4.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  37 AEHYHFDFALSMIKLRGFGGktefwdHNLESFTLMAGLAAVTSRIQIYATAATLTL-PPAIVARMAATIDSISGGRFGVN 115
Cdd:COG2141     1 AERLGFDRVWVADHHFPPGG------ASPDPWVLLAALAAATSRIRLGTGVVVLPLrHPLVVAEQFATLDHLSGGRLDLG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 116 LVTGWQKPEYEQMGIwpgddYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQP----SVPmkVICAGQSD 191
Cdd:COG2141    75 VGRGWGPDEFAAFGL-----DHDERYERFEEALEVLRRLWTGEPVTFEGEFFTVEGARLVPRPvqgpHPP--IWIAGSSP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 192 AGMAFSAQYADFNFCFGkgvNTPTAFAPTAARMKQAAEQTGRDVGS---YVLFMVIADETDDAARakwehykagadEEAL 268
Cdd:COG2141   148 AGARLAARLGDGVFTAG---GTPEELAEAIAAYREAAAAAGRDPDDlrvSVGLHVIVAETDEEAR-----------ERAR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 269 SWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTF-----DDFLSGIETFGE 343
Cdd:COG2141   214 PYLRALLALPRGRPPEEAEEGLTVREDLLELLGAALVGTPEQVAERLEELAEAAGVDEFLLQFpgldpEDRLRSLELFAE 293


                  ....*..
gi 1577845508 344 RIQPLMQ 350
Cdd:COG2141   294 EVLPLLR 300
Bac_luciferase pfam00296
Luciferase-like monooxygenase;
1-320 5.00e-49

Luciferase-like monooxygenase;


Pssm-ID: 425589 [Multi-domain]  Cd Length: 313  Bit Score: 167.15  E-value: 5.00e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508   1 MKIGVFVPIGNNGWListHAPQymPTFELNKAIVQKAEHYHFDFALSmiklrgfggkTEFW--DHNLESFTLMAGLAAVT 78
Cdd:pfam00296   1 MEFGVFLPTRNGGGL---GAGS--ESLRYLVELARAAEELGFDGVWL----------AEHHggPGGPDPFVVLAALAAAT 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  79 SRIQIYATAATL-TLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIwpgddYFSRRYDYLTEYVQVLRDLWGT 157
Cdd:pfam00296  66 SRIRLGTAVVPLpTRHPAVLAEQAATLDHLSGGRFDLGLGTGGPAVEFRRFGV-----DHDERYARLREFLEVLRRLWRG 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 158 GKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFgkGVNTPTAFAPTAARMKQAAEQTGRDVGS 237
Cdd:pfam00296 141 EPVDFEGEFFTLDGAFLLPRPVQGIPVWVAASSPAMLELAARHADGLLLW--GFAPPAAAAELIERVRAGAAEAGRDPAD 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 238 ---YVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDT----NVRQMADPTSAVNINMGTLVGSYAS 310
Cdd:pfam00296 219 irvGASLTVIVADTEEEARAEARALIAGLPFYRMDSEGAGRLAEAREIGEEydagDWAGAADAVPDELVRAFALVGTPEQ 298

                         330
                  ....*....|
gi 1577845508 311 VARMLDEVAS 320
Cdd:pfam00296 299 VAERLAAYAE 308
F420_Rv1855c TIGR03560
probable F420-dependent oxidoreductase, Rv1855c family; Coenzyme F420 has a limited ...
 65-234 6.66e-27

probable F420-dependent oxidoreductase, Rv1855c family; Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274648 [Multi-domain]  Cd Length: 227  Bit Score: 106.25  E-value: 6.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  65 LESFTLMAGLAAVTSRIQIYA--TAATLTLPpAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDdyFSRRYD 142
Cdd:TIGR03560  50 LEAWTTLAGLARETSRIRLGTlvTGVTYRHP-GLLAKMVATVDVLSGGRAELGLGAGWYEREHRAYGIPFPP--LAERFE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 143 YLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMK---VICAGQSDAGMAFSAQYAD-FNFCFGkgvnTPTAFA 218
Cdd:TIGR03560 127 RLEEALQIITGMWSGEGVTFDGRHYRLADAIALPKPLQRPHppiLIGGGGEKRTLRLAARYADeFNLVFG----PPDELA 202

                         170
                  ....*....|....*.
gi 1577845508 219 PTAARMKQAAEQTGRD 234
Cdd:TIGR03560 203 HKFEVLRAHCEAAGRD 218
F420_Rv2161c TIGR03619
probable F420-dependent oxidoreductase, Rv2161c family; Coenzyme F420 has a limited ...
 56-265 1.01e-24

probable F420-dependent oxidoreductase, Rv2161c family; Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274680 [Multi-domain]  Cd Length: 246  Bit Score: 100.79  E-value: 1.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  56 GKTEFWDHNLESFTLMAGLAAVTSRIQIyATAATLtLP---PAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGiwp 132
Cdd:TIGR03619  35 GGGDAPDRTLDPFVALAFAAAVTSRLRL-GTGVLV-LPqrdPLLLAKQAATLDLLSGGRLRLGVGVGWLREEFRALG--- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 133 GDdyFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVI-CAGQSDAGMAFSAQYADFNFCFGKGV 211
Cdd:TIGR03619 110 VD--FDERGRLLDEAIEALRALWTQDPVSFHGEFVDFDPAVVRPKPVQRPPPIwIGGNSEAALRRAARLGDGWMPFGPPV 187

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1577845508 212 ntpTAFAPTAARMKQAAEQTGRDVGS--YVLFMVIADETDDAARAKWEHY-KAGADE 265
Cdd:TIGR03619 188 ---DRLAAAVARLRDLAAAAGRDPDAveVVLVRTDPDGDADADAEDLAAYaDLGVTR 241
Nitrilotriacetate_monoxgenase cd01095
nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin ...
 1-236 4.39e-24

nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2.


Pssm-ID: 238528 [Multi-domain]  Cd Length: 358  Bit Score: 101.24  E-value: 4.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508   1 MKIGVFVPignnGWLISTHAPQYMPT------FELNKAIVQKAEHYHFDFA-----LSMIKLRGFGGKTEFwdhnlESFT 69
Cdd:cd01095     1 LHLGAFLH----GAGHHAAAWRHPAPpdasidFDHYVRLARTAERAKFDAVfladgLAIRALSRPHPVARL-----EPLT 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  70 LMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIwpgDDYFSR--RYDYLTEY 147
Cdd:cd01095    72 LLAALAAVTERIGLVATASTTYNEPYHLARRFASLDHISGGRAGWNVVTSANPGEARNFGR---DEHPEHdeRYARAEEF 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 148 VQVLRDLWGTGKSD---------------------FKGDFFtmndcRVSPQPSVPMK-----VIC-AGQSDAGMAFSAQY 200
Cdd:cd01095   149 VEVVKGLWDSWEDDalvrdkasgrfadpakvhpldHVGDHF-----GVRGPLNGPRSpqgrpVIVqAGSSEAGREFAARH 223

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1577845508 201 ADFNFcfgKGVNTPTAFAPTAARMKQAAEQTGRDVG 236
Cdd:cd01095   224 AEAVF---TAQQTLEEAQAFYADVKARAAAAGRLDP 256
PRK00719 PRK00719
alkanesulfonate monooxygenase; Provisional
 72-273 2.85e-16

alkanesulfonate monooxygenase; Provisional


Pssm-ID: 234821 [Multi-domain]  Cd Length: 378  Bit Score: 79.23  E-value: 2.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  72 AGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEqmgiwpGDDYF---SRRYDYLTEYV 148
Cdd:PRK00719   61 ASLIPVTQRLKFLVALRPGLMSPTVAARMAATLDRLSNGRLLINLVTGGDPAELA------GDGLFldhDERYEASAEFL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 149 QVLRDLWGTGKSDFKGDFFTMNDCRV------SPQPSVPMkvicAGQSDAGMAFSAQYADFNFCFGKgvnTPTAFAPTAA 222
Cdd:PRK00719  135 RIWRRLLEGETVDFEGKHIQVKGAKLlfppvqQPYPPLYF----GGSSDAAQELAAEQVDLYLTWGE---PPAQVKEKIE 207

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1577845508 223 RMKQAAEQTGRDVGSYVLFMVIADETDDAArakWEhykagADEEALSWLTE 273
Cdd:PRK00719  208 QVRAKAAAHGRKVRFGIRLHVIVRETNEEA---WQ-----AAERLISHLDD 250
F420_G6P_family TIGR03557
F420-dependent oxidoreductase, G6PDH family; Members of this protein family include ...
 69-254 4.38e-16

F420-dependent oxidoreductase, G6PDH family; Members of this protein family include F420-dependent glucose-6-phosphate dehydrogenases (TIGR03554) and related proteins. All members of this family come from species that synthesize coenzyme F420, with the exception of those that belong to TIGR03885, a clade within this family in which cofactor binding may instead be directed to FMN. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274645  Cd Length: 316  Bit Score: 77.81  E-value: 4.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  69 TLMAGLAAVTSRIQI--YATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDyfsRRYDYLTE 146
Cdd:TIGR03557  51 SVLGALAQATERLPLttAVTCPTMRYHPAIVAQAAATSAVLSDGRFTLGLGSGENLNEHVVGDGWPSVD---VRLEMLRE 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 147 YVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFcfgkgvntptAFAPTAARMKQ 226
Cdd:TIGR03557 128 AVEIIRELWQGGYVDHRGKHYTVDSARLYDLPEEPPPIGVSAFGPRAVRLAARIGDGLI----------ATEPDADLVEA 197

                         170       180
                  ....*....|....*....|....*...
gi 1577845508 227 AAEQTGRDVGSYVLFMVIADETDDAARA 254
Cdd:TIGR03557 198 FREAGGGGKPVQGQVPVCWDPDEDAAVK 225
PRK02271 PRK02271
methylenetetrahydromethanopterin reductase; Provisional
 34-253 3.50e-07

methylenetetrahydromethanopterin reductase; Provisional


Pssm-ID: 235022 [Multi-domain]  Cd Length: 325  Bit Score: 51.48  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508  34 VQKAEHYHFDFAlsmiklrgfggktefW--DH--NLESFTLMAGLAAVTSRIQIyATAAT--LTLPPAIVARMAATIDSI 107
Cdd:PRK02271   20 AKLAEDNGFDYA---------------WitDHynNRDVYMTLAAIAAATDTIKL-GPGVTnpYTRHPAITASAIATLDEI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 108 SGGR--FGV---------NLVTGWQKPeyeqmgiwpgddyfSRRydyLTEYVQVLRDLWGTGKSDFKGDFFTMNDC-RVS 175
Cdd:PRK02271   84 SGGRavLGIgpgdkatldALGIEWEKP--------------LRT---VKEAIEVIRKLWAGERVEHDGTFKAAGAKlNVK 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 176 PQP-SVPMKVicAGQSDAGMAFSAQYADfnfcfGKGVNT--PTAFAPTAARMKQAAEQTGR-----DVGSYVLFMViaDE 247
Cdd:PRK02271  147 PVQgEIPIYM--GAQGPKMLELAGEIAD-----GVLINAsnPKDFEWAVPLIKKGAEEAGKsrgefDVAAYASVSV--DK 217


                  ....*.
gi 1577845508 248 TDDAAR 253
Cdd:PRK02271  218 DEDKAR 223
Tetrahydromethanopterin_reductase cd01097
N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5, ...
 102-268 1.56e-06

N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420.


Pssm-ID: 238530 [Multi-domain]  Cd Length: 202  Bit Score: 48.16  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 102 ATIDSISGGRFGVNLVTGWQKPEYEQMGIWPgdDYFSRRYDYLTEYVQVLRDLWGTGKSDFkGDFFTMNDCRVS--PQPS 179
Cdd:cd01097    34 VSLDALSGGRFILGLGAGGPEVEEGWGGPWF--KPPARRREELEAIRRLRALRRGDPVGED-GRFLGTRSAALPppPRGE 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577845508 180 VPmkVICAGQSDAGMAFSAQYADfnfcfgkGVNTPTAFAPTAARMKQAAEQTGRDVGSyvlfmVIADETDDAARAKwEHY 259
Cdd:cd01097   111 IP--IYIGALGPKMLELAGEIAD-------GWLPVAAPPELYEAALPAVREGAAAAGR-----VVGDPDDVAEALR-RYR 175


                  ....*....
gi 1577845508 260 KAGADEEAL 268
Cdd:cd01097   176 EAGVTEVVL 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH