NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1578099510|gb|RZZ67407|]
View 

multidrug efflux RND transporter permease subunit MdtB [Escherichia coli]

Protein Classification

multidrug transporter subunit MdtB( domain architecture ID 11484747)

multidrug transporter subunit MdtB is a component of the MdtABC tripartite complex that confers resistance against novobiocin and deoxycholate; MdtABC requires TolC for its function

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
1-1040 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


:

Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 2067.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510    1 MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
Cdd:PRK10503     1 MQVLPPSSTGGPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
Cdd:PRK10503    81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  161 TQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSA 240
Cdd:PRK10503   161 TQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESL 320
Cdd:PRK10503   241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  321 PKSVKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMA 400
Cdd:PRK10503   321 PKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAI 480
Cdd:PRK10503   401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKG 560
Cdd:PRK10503   481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKG 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
Cdd:PRK10503   561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  641 IARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYV 720
Cdd:PRK10503   641 IARLQTAVAKVPGVDLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQ 800
Cdd:PRK10503   721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQ 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  801 RFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
Cdd:PRK10503   801 RFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  881 LGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQA 960
Cdd:PRK10503   881 LGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA 1040
Cdd:PRK10503   961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEEA 1040
 
Name Accession Description Interval E-value
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
1-1040 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 2067.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510    1 MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
Cdd:PRK10503     1 MQVLPPSSTGGPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
Cdd:PRK10503    81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  161 TQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSA 240
Cdd:PRK10503   161 TQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESL 320
Cdd:PRK10503   241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  321 PKSVKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMA 400
Cdd:PRK10503   321 PKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAI 480
Cdd:PRK10503   401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKG 560
Cdd:PRK10503   481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKG 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
Cdd:PRK10503   561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  641 IARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYV 720
Cdd:PRK10503   641 IARLQTAVAKVPGVDLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQ 800
Cdd:PRK10503   721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQ 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  801 RFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
Cdd:PRK10503   801 RFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  881 LGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQA 960
Cdd:PRK10503   881 LGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA 1040
Cdd:PRK10503   961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEEA 1040
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
13-1024 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1424.41  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   13 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
Cdd:NF033617     1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVA 172
Cdd:NF033617    81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  173 QKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQ 252
Cdd:NF033617   161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  253 LIIAYQ-NGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSD 331
Cdd:NF033617   241 LVIKYAdNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  332 RTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDD 411
Cdd:NF033617   321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  412 AIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLT 491
Cdd:NF033617   401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  492 PMMCARMLSQESlrKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQ 571
Cdd:NF033617   481 PMMCSRLLKANE--KPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVIF 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  572 GTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVdGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKV 651
Cdd:NF033617   559 GMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGV-GGNPGDNTGFGIINLKPWDERDVSAQEIIDRLRPKLAKV 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  652 PGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLG 731
Cdd:NF033617   638 PGMDLFLFPLQDLPGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLG 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  732 ISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLD 811
Cdd:NF033617   718 ISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFN 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  812 QFPVTTISFNVPDNYSLGDAVQAIMDTEKTLnLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHP 891
Cdd:NF033617   798 QFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDP 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  892 ITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMT 971
Cdd:NF033617   877 LTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMT 956
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1578099510  972 TLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDR 1024
Cdd:NF033617   957 TLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
12-1023 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1199.04  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   12 PSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSS 91
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   92 QSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLpNPPVYSKVNPADPPIMTLAVTST--AMPMTQVEDMVET 169
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGV-QRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  170 RVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEE 249
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  250 YRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVL 329
Cdd:pfam00873  240 FEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  330 SDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVV 409
Cdd:pfam00873  320 YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  410 DDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSL 488
Cdd:pfam00873  400 DDAIVVVENIERVLeENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  489 TLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNG 568
Cdd:pfam00873  480 TLTPALCATLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  569 IIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGV--DGTNPSLNSARLQINLKPLDER---DDRVQKVIAR 643
Cdd:pfam00873  560 VFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFafSGDNNGPNSGDAFISLKPWKERpgpEKSVQALIER 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  644 LQTAVDKVPGVDLFLQPTQDLTID--TQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYVN 721
Cdd:pfam00873  640 LRKALKQIPGANVFLFQPIQLRGLgtISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVN 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  722 VDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQR 801
Cdd:pfam00873  720 IDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  802 FAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVL 881
Cdd:pfam00873  800 YGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  882 GILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQAC 961
Cdd:pfam00873  880 AALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEAC 959
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578099510  962 LLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFD 1023
Cdd:pfam00873  960 RLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
13-1028 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1133.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   13 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
Cdd:COG0841      4 SRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITST 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLpNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVA 172
Cdd:COG0841     84 SSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDV-EPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERNIK 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  173 QKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQ 252
Cdd:COG0841    163 DRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFEN 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  253 LIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDR 332
Cdd:COG0841    243 IVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVYDQ 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  333 TTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDA 412
Cdd:COG0841    323 SEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDA 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  413 IVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTP 492
Cdd:COG0841    403 IVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTLTP 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  493 MMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQG 572
Cdd:COG0841    483 ALCARLLKPHPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIV 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  573 TLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVP 652
Cdd:COG0841    563 SVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSNSGTIFVTLKPWDERDRSADEIIARLREKLAKIP 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  653 GVDLFLQPTQDltiDTQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGI 732
Cdd:COG0841    643 GARVFVFQPPA---GGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAALGV 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  733 SMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQ 812
Cdd:COG0841    720 TVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINRYNG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  813 FPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPI 892
Cdd:COG0841    800 QRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  893 TILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALaAEREQGMSPREAIYQACLLRFRPILMTT 972
Cdd:COG0841    880 IILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFAN-QLREEGMSLREAILEAARLRLRPILMTS 958
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1578099510  973 LAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALW 1028
Cdd:COG0841    959 LATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRR 1014
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
13-1025 2.58e-173

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 534.69  E-value: 2.58e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   13 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
Cdd:TIGR00915    2 AKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSS 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   93 SSG-GASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVysKVNPA-DPPIMTLAVTSTAMPMTQVE--DMVE 168
Cdd:TIGR00915   82 SDSdGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGV--RVEKAsSNFLMVIGLVSDDGSMTKEDlsDYAA 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  169 TRVAQKISQISGVGLVTLSGGQRpAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDG-PSRA-----VTLSAND 242
Cdd:TIGR00915  160 SNMVDPLSRLEGVGDVQLFGSQY-AMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGlPAVPgqqlnATIIAQT 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  243 QMQSAEEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLP 321
Cdd:TIGR00915  239 RLQTPEQFENILLkVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  322 KSVKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMAL 401
Cdd:TIGR00915  319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  402 TIATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAI 480
Cdd:TIGR00915  399 VLAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  481 LISAVVSLTLTPMMCARML----SQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVF 556
Cdd:TIGR00915  479 ALSVLVALILTPALCATMLkpieKGEHHEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVR 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  557 IPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAvQSLTSFVGVDGTNPS---LNSARLQINLKPLDER 633
Cdd:TIGR00915  559 LPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEK-ANVESVFTVNGFSFAgrgQNMGMAFIRLKDWEER 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  634 D---DRVQKVIARLQTAVDKVPgvDLFLQPTQDLTIDTQVSRTQYQFTLQA---TSLDALSTWVPELMEKLQQLPQLSDV 707
Cdd:TIGR00915  638 TgkeNSVFAIAGRATGHFMQIK--DAMVIAFVPPAILELGNATGFDFFLQDragLGHEALLQARNQLLGLAAQNPALTRV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  708 SSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDG 787
Cdd:TIGR00915  716 RPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASG 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  788 GVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKtlNLPVDITTQFQGSTLAFQSALGSTV 867
Cdd:TIGR00915  796 EMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQ--KLPPGFGFSWTGMSYEERLSGSQAP 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  868 WLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFAlAAER 947
Cdd:TIGR00915  874 ALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFA-KELM 952
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1578099510  948 EQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRL 1025
Cdd:TIGR00915  953 AQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVRRL 1030
 
Name Accession Description Interval E-value
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
1-1040 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 2067.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510    1 MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
Cdd:PRK10503     1 MQVLPPSSTGGPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
Cdd:PRK10503    81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  161 TQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSA 240
Cdd:PRK10503   161 TQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESL 320
Cdd:PRK10503   241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  321 PKSVKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMA 400
Cdd:PRK10503   321 PKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAI 480
Cdd:PRK10503   401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKG 560
Cdd:PRK10503   481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKG 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
Cdd:PRK10503   561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  641 IARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYV 720
Cdd:PRK10503   641 IARLQTAVAKVPGVDLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQ 800
Cdd:PRK10503   721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQ 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  801 RFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
Cdd:PRK10503   801 RFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  881 LGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQA 960
Cdd:PRK10503   881 LGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA 1040
Cdd:PRK10503   961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEEA 1040
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
13-1024 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1424.41  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   13 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
Cdd:NF033617     1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVA 172
Cdd:NF033617    81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  173 QKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQ 252
Cdd:NF033617   161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  253 LIIAYQ-NGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSD 331
Cdd:NF033617   241 LVIKYAdNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  332 RTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDD 411
Cdd:NF033617   321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  412 AIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLT 491
Cdd:NF033617   401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  492 PMMCARMLSQESlrKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQ 571
Cdd:NF033617   481 PMMCSRLLKANE--KPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVIF 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  572 GTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVdGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKV 651
Cdd:NF033617   559 GMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGV-GGNPGDNTGFGIINLKPWDERDVSAQEIIDRLRPKLAKV 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  652 PGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLG 731
Cdd:NF033617   638 PGMDLFLFPLQDLPGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLG 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  732 ISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLD 811
Cdd:NF033617   718 ISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFN 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  812 QFPVTTISFNVPDNYSLGDAVQAIMDTEKTLnLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHP 891
Cdd:NF033617   798 QFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDP 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  892 ITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMT 971
Cdd:NF033617   877 LTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMT 956
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1578099510  972 TLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDR 1024
Cdd:NF033617   957 TLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
12-1023 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1199.04  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   12 PSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSS 91
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   92 QSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLpNPPVYSKVNPADPPIMTLAVTST--AMPMTQVEDMVET 169
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGV-QRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  170 RVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEE 249
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  250 YRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVL 329
Cdd:pfam00873  240 FEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  330 SDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVV 409
Cdd:pfam00873  320 YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  410 DDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSL 488
Cdd:pfam00873  400 DDAIVVVENIERVLeENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  489 TLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNG 568
Cdd:pfam00873  480 TLTPALCATLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  569 IIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGV--DGTNPSLNSARLQINLKPLDER---DDRVQKVIAR 643
Cdd:pfam00873  560 VFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFafSGDNNGPNSGDAFISLKPWKERpgpEKSVQALIER 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  644 LQTAVDKVPGVDLFLQPTQDLTID--TQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYVN 721
Cdd:pfam00873  640 LRKALKQIPGANVFLFQPIQLRGLgtISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVN 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  722 VDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQR 801
Cdd:pfam00873  720 IDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  802 FAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVL 881
Cdd:pfam00873  800 YGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  882 GILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQAC 961
Cdd:pfam00873  880 AALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEAC 959
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578099510  962 LLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFD 1023
Cdd:pfam00873  960 RLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
13-1028 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1133.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   13 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
Cdd:COG0841      4 SRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITST 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLpNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVA 172
Cdd:COG0841     84 SSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDV-EPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERNIK 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  173 QKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQ 252
Cdd:COG0841    163 DRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFEN 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  253 LIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDR 332
Cdd:COG0841    243 IVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVYDQ 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  333 TTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDA 412
Cdd:COG0841    323 SEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDA 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  413 IVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTP 492
Cdd:COG0841    403 IVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTLTP 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  493 MMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQG 572
Cdd:COG0841    483 ALCARLLKPHPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIV 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  573 TLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVP 652
Cdd:COG0841    563 SVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSNSGTIFVTLKPWDERDRSADEIIARLREKLAKIP 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  653 GVDLFLQPTQDltiDTQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGI 732
Cdd:COG0841    643 GARVFVFQPPA---GGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAALGV 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  733 SMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQ 812
Cdd:COG0841    720 TVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINRYNG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  813 FPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPI 892
Cdd:COG0841    800 QRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  893 TILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALaAEREQGMSPREAIYQACLLRFRPILMTT 972
Cdd:COG0841    880 IILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFAN-QLREEGMSLREAILEAARLRLRPILMTS 958
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1578099510  973 LAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALW 1028
Cdd:COG0841    959 LATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRR 1014
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
15-1025 0e+00

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 1057.41  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   15 LFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSS 94
Cdd:PRK10614     6 LFIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSS 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   95 GGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQK 174
Cdd:PRK10614    86 LGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGQLYDFASTQLAQT 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  175 ISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLI 254
Cdd:PRK10614   166 ISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLI 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  255 IAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTT 334
Cdd:PRK10614   246 IHYNNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIAQDRSP 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  335 NIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIV 414
Cdd:PRK10614   326 TIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIV 405
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  415 VIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMM 494
Cdd:PRK10614   406 VLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLTLTPMM 485
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  495 CARMLSQESLRKQNRfSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTL 574
Cdd:PRK10614   486 CAWLLKSSKPREQKR-LRGFGRMLVALQQGYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPKTFFPEQDTGRLMGFI 564
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  575 QAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTnpslNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGV 654
Cdd:PRK10614   565 QADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRV----NSGMMFITLKPLSERSETAQQVIDRLRVKLAKEPGA 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  655 DLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISM 734
Cdd:PRK10614   641 NLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  735 ADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFP 814
Cdd:PRK10614   721 QAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  815 VTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITI 894
Cdd:PRK10614   801 ASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVRGSFAGTAQVFQETMNSQLILILAAIATVYIVLGILYESYVHPLTI 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  895 LSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLA 974
Cdd:PRK10614   881 LSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTAQEAIFQACLLRFRPIMMTTLA 960
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1578099510  975 ALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRL 1025
Cdd:PRK10614   961 ALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL 1011
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
13-1025 2.58e-173

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 534.69  E-value: 2.58e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   13 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
Cdd:TIGR00915    2 AKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSS 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   93 SSG-GASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVysKVNPA-DPPIMTLAVTSTAMPMTQVE--DMVE 168
Cdd:TIGR00915   82 SDSdGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGV--RVEKAsSNFLMVIGLVSDDGSMTKEDlsDYAA 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  169 TRVAQKISQISGVGLVTLSGGQRpAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDG-PSRA-----VTLSAND 242
Cdd:TIGR00915  160 SNMVDPLSRLEGVGDVQLFGSQY-AMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGlPAVPgqqlnATIIAQT 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  243 QMQSAEEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLP 321
Cdd:TIGR00915  239 RLQTPEQFENILLkVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  322 KSVKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMAL 401
Cdd:TIGR00915  319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  402 TIATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAI 480
Cdd:TIGR00915  399 VLAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  481 LISAVVSLTLTPMMCARML----SQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVF 556
Cdd:TIGR00915  479 ALSVLVALILTPALCATMLkpieKGEHHEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVR 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  557 IPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAvQSLTSFVGVDGTNPS---LNSARLQINLKPLDER 633
Cdd:TIGR00915  559 LPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEK-ANVESVFTVNGFSFAgrgQNMGMAFIRLKDWEER 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  634 D---DRVQKVIARLQTAVDKVPgvDLFLQPTQDLTIDTQVSRTQYQFTLQA---TSLDALSTWVPELMEKLQQLPQLSDV 707
Cdd:TIGR00915  638 TgkeNSVFAIAGRATGHFMQIK--DAMVIAFVPPAILELGNATGFDFFLQDragLGHEALLQARNQLLGLAAQNPALTRV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  708 SSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDG 787
Cdd:TIGR00915  716 RPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASG 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  788 GVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKtlNLPVDITTQFQGSTLAFQSALGSTV 867
Cdd:TIGR00915  796 EMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQ--KLPPGFGFSWTGMSYEERLSGSQAP 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  868 WLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFAlAAER 947
Cdd:TIGR00915  874 ALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFA-KELM 952
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1578099510  948 EQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRL 1025
Cdd:TIGR00915  953 AQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVRRL 1030
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
14-1024 1.15e-141

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 451.02  E-value: 1.15e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   14 RLFIMrpvattLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQS 93
Cdd:COG3696     13 RLLVL------LLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVRSIS 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   94 SGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDlpnppvyskVNPA-DPP------IMTLAVTSTAMPMTQVE-- 164
Cdd:COG3696     87 RFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAG---------VTPElGPIstglgeIYQYTLESDPGKYSLMElr 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  165 DMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQM 244
Cdd:COG3696    158 TLQDWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLI 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  245 QSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSwLGA--WANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPK 322
Cdd:COG3696    238 RSLEDIENIVVKTRNGTPVLLRDVAEVRIGPAPR-RGAatLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPE 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  323 SVKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALT 402
Cdd:COG3696    317 GVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLA 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  403 IATGFVVDDAIVVIENISRYIEK------GEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITL 476
Cdd:COG3696    397 IDFGIIVDGAVVMVENILRRLEEnraagtPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMALTV 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  477 AVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRasekmfdRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVF 556
Cdd:COG3696    477 IFALLGALLLSLTLVPVLASLLLRGKVPEKENPLVR-------WLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPR 549
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  557 IPKGFFPVQDNG--IIQGTLqaPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGV--DGTNP-SLNSARLQINLKPLD 631
Cdd:COG3696    550 LGSEFLPELDEGdlLVMATL--PPGISLEESVELGQQVERILKSFPEVESVVSRTGRaeDATDPmGVNMSETFVILKPRS 627
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  632 E-RDDR-VQKVIARLQTAVDKVPGVDL-FLQPTQDlTIDTQVS--RTQYQFTLQATSLDALSTWVPELMEKLQQLPQLSD 706
Cdd:COG3696    628 EwRSGRtKEELIAEMREALEQIPGVNFnFSQPIQM-RVDELLSgvRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAAD 706
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  707 VSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQY--RVVLEHNTENTPglAALDTIRLTS 784
Cdd:COG3696    707 VQVERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFdiVVRLPEELRDDP--EAIRNLPIPT 784
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  785 SDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVpDNYSLGDAVQAIMDT-EKTLNLPVDITTQFQGSTLAFQSAL 863
Cdd:COG3696    785 PSGAQVPLSQVADIEVVEGPNQISRENGRRRIVVQANV-RGRDLGSFVAEAQAKvAEQVKLPPGYYIEWGGQFENLQRAT 863
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  864 GSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSEL--------------DVIaiigiillig 929
Cdd:COG3696    864 ARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLsvsagvgfialfgvAVL---------- 933
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  930 ivkkNAIMMIDFALAAeREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQV 1009
Cdd:COG3696    934 ----NGVVLVSYINQL-RAEGLDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTL 1008
                         1050
                   ....*....|....*
gi 1578099510 1010 LTLFTTPVIYLLFDR 1024
Cdd:COG3696   1009 LTLLVLPALYLLFGR 1023
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
15-1024 5.85e-136

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 435.80  E-value: 5.85e-136
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   15 LFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSS 94
Cdd:PRK09579     6 PFIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSR 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   95 GGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPpVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQK 174
Cdd:PRK09579    86 QNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDP-VLSKEAADASALMYISFYSEEMSNPQITDYLSRVIQPK 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  175 ISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLI 254
Cdd:PRK09579   165 LATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAFAAIP 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  255 IAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTT 334
Cdd:PRK09579   245 VKTSGDSRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSIAYDATL 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  335 NIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIV 414
Cdd:PRK09579   325 FIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVDDAIV 404
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  415 VIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMM 494
Cdd:PRK09579   405 VVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVALTLSPMM 484
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  495 CARMLSQEslRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTL 574
Cdd:PRK09579   485 CALLLRHE--ENPSGLAHRLDRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLLKFTQSELAPEEDQGIIFMMS 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  575 QAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSarlqINLKPLDERDDRVQKVIARLQTAVDKVPGV 654
Cdd:PRK09579   563 SSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNGVQSGIGG----FLLKPWNERERTQMELLPLVQAKLEEIPGL 638
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  655 DLFLQPTQDLTIDTQvsRTQYQFTLQ-ATSLDALSTWVPELMEKLQQLPQLSDVSSDWQ-DKGLVAyVNVDRDSASRLGI 732
Cdd:PRK09579   639 QIFGFNLPSLPGTGE--GLPFQFVINtANDYESLLQVAQRVKQRAQESGKFAFLDIDLAfDKPEVV-VDIDRAKAAQMGV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  733 SMADVDNALYNAFGQRLISTIYTQANQYRVV--LEHNTENTPGLaaLDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHL 810
Cdd:PRK09579   716 SMQDLGGTLATLLGEGEINRFTIDGRSYKVIaqVERPYRDNPGW--LNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQF 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  811 DQFPVTTISfNVPdNYSLGDAVQAIMDTEKTlNLPVDITTQFQGSTLAFQSAlGSTVWLIVAAVVAM-YIVLGILYESFI 889
Cdd:PRK09579   794 QQLNSAIIS-GFP-IVSMGEAIETVQQIARE-EAPEGFAFDYAGASRQYVQE-GSALWVTFGLALAIiFLVLAAQFESFR 869
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  890 HPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPIL 969
Cdd:PRK09579   870 DPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQLRHEQGLSRREAIEEAAAIRLRPVL 949
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1578099510  970 MTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDR 1024
Cdd:PRK09579   950 MTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLLAK 1004
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
13-1024 2.16e-127

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 413.46  E-value: 2.16e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   13 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
Cdd:PRK10555     2 ANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQ 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   93 SSG-GASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKvNPADPPIMTLAVTST--AMPMTQVEDMVET 169
Cdd:PRK10555    82 SSGtGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVR-KTGDTNILTIAFVSTdgSMDKQDIADYVAS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  170 RVAQKISQISGVGLVTLSGGQRpAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDG----PSRAV--TLSANDQ 243
Cdd:PRK10555   161 NIQDPLSRVNGVGDIDAYGSQY-SMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGGtpsvDKQALnaTINAQSL 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  244 MQSAEEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPK 322
Cdd:PRK10555   240 LQTPEQFRDITLrVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPH 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  323 SVKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALT 402
Cdd:PRK10555   320 GLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  403 IATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAIL 481
Cdd:PRK10555   400 LAIGLLVDDAIVVVENVERIMsEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMV 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  482 ISAVVSLTLTPMMCARML---SQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHP--WLTLSVALSTLLLsvllWVF 556
Cdd:PRK10555   480 LSVLVAMILTPALCATLLkplKKGEHHGQKGFFGWFNRMFNRNAERYEKGVAKILHRSlrWILIYVLLLGGMV----FLF 555
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  557 I--PKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPA--VQSLTSFVGVDGTNPSLNSARLQINLKPLDE 632
Cdd:PRK10555   556 LrlPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFTHEKdnVMSVFATVGSGPGGNGQNVARMFIRLKDWDE 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  633 RDDRVQK---VIARLQTAVDKVPGVDLFlqPTQDLTIDTQVSRTQYQFTLQ---ATSLDALSTWVPELMEKLQQLPQLSD 706
Cdd:PRK10555   636 RDSKTGTsfaIIERATKAFNKIKEARVI--ASSPPAISGLGSSAGFDMELQdhaGAGHDALMAARNQLLALAAKNPELTR 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  707 VSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLIS---------TIYTQAN-QYRVVlehntentPGLAA 776
Cdd:PRK10555   714 VRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNdfmdrgrvkKVYVQAAaPYRML--------PDDIN 785
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  777 LDTIRltSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAvqaiMDTEKTL--NLPVDITTQFQG 854
Cdd:PRK10555   786 LWYVR--NKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTA----MDIMESLvkQLPNGFGLEWTA 859
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  855 STLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKN 934
Cdd:PRK10555   860 MSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKN 939
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  935 AIMMIDFAlAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFT 1014
Cdd:PRK10555   940 AILIVEFA-NEMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAIFF 1018
                         1050
                   ....*....|
gi 1578099510 1015 TPVIYLLFDR 1024
Cdd:PRK10555  1019 VPLFFVLVRR 1028
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
13-1025 1.66e-125

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 408.09  E-value: 1.66e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   13 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
Cdd:PRK09577     2 ARFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSAT 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKvNPADPPIMTLAVTSTAMPMTQVE--DMVETR 170
Cdd:PRK09577    82 SSAGQASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIQVE-KAADNIQLIVSLTSDDGRLTGVElgEYASAN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  171 VAQKISQISGVGLVTLSGGQRpAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSL------DGPSRAVTLSANDQM 244
Cdd:PRK09577   161 VLQALRRVEGVGKVQFWGAEY-AMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIgrsavpDSAPIAATVFADAPL 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  245 QSAEEYRQLIIAYQ-NGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKS 323
Cdd:PRK09577   240 KTPEDFGAIALRARaDGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPG 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  324 VKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTI 403
Cdd:PRK09577   320 VKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVL 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  404 ATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILI 482
Cdd:PRK09577   400 AIGILVDDAIVVVENVERLMvEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGF 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  483 SAVVSLTLTPMMCARMLSQESLRKQNR--FSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKG 560
Cdd:PRK09577   480 SAFLALSLTPALCATLLKPVDGDHHEKrgFFGWFNRFVARSTQRYATRVGAILKRPLRWLVVYGALTAAAALLFTRLPTA 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVD--GTNPslNSARLQINLKPLDER---DD 635
Cdd:PRK09577   560 FLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNlyGEGP--NGGMIFVTLKDWKERkaaRD 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  636 RVQKVIARLQTAVDKVPGVDLF---LQPTQDLTidtqvSRTQYQFTLQ---ATSLDALSTWVPELMEKLQQLPQLSDVSS 709
Cdd:PRK09577   638 HVQAIVARINERFAGTPNTTVFamnSPALPDLG-----STSGFDFRLQdrgGLGYAAFVAAREQLLAEGAKDPALTDLMF 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  710 DWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGV 789
Cdd:PRK09577   713 AGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQGEM 792
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  790 VPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTlnLPVDITTQFQGSTLAFQSALGSTVWL 869
Cdd:PRK09577   793 VPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAAT--LPAGIGYAWSGQSFEERLSGAQAPML 870
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  870 IVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFA--LAAer 947
Cdd:PRK09577   871 FALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAkdLVA-- 948
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1578099510  948 eQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRL 1025
Cdd:PRK09577   949 -QRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPLFFVVVGRL 1025
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
13-1039 7.51e-115

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 379.63  E-value: 7.51e-115
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   13 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
Cdd:PRK15127     2 PNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSN 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   93 S-SGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVySKVNPADPPIMTLAVTSTAMPMTQ--VEDMVET 169
Cdd:PRK15127    82 SdSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGV-SVEKSSSSFLMVVGVINTDGTMTQedISDYVAA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  170 RVAQKISQISGVGLVTLSGGQRpAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDG--PSRAVTLSAN----DQ 243
Cdd:PRK15127   161 NMKDPISRTSGVGDVQLFGSQY-AMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGtpPVKGQQLNASiiaqTR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  244 MQSAEEYRQLIIAY-QNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPK 322
Cdd:PRK15127   240 LTSTEEFGKILLKVnQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPS 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  323 SVKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALT 402
Cdd:PRK15127   320 GLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  403 IATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAIL 481
Cdd:PRK15127   400 LAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMA 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  482 ISAVVSLTLTPMMCARMLSQ----ESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFI 557
Cdd:PRK15127   480 LSVLVALILTPALCATMLKPiakgDHGEGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAYLFVRL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  558 PKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVIL--QDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDER-- 633
Cdd:PRK15127   560 PSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLtkEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRpg 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  634 -DDRVQKVIARLQTAVDKVPgvDLFLQPTQDLTIDTQVSRTQYQFTL--QAT-SLDALSTWVPELMEKLQQLPQ-LSDVS 708
Cdd:PRK15127   640 eENKVEAITMRATRAFSQIK--DAMVFAFNLPAIVELGTATGFDFELidQAGlGHEKLTQARNQLLGEAAKHPDmLVGVR 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  709 SDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGG 788
Cdd:PRK15127   718 PNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQ 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  789 VVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVqAIMDtEKTLNLPVDITTQFQGstLAFQSALG--ST 866
Cdd:PRK15127   798 MVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAM-ELME-ELASKLPTGVGYDWTG--MSYQERLSgnQA 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  867 VWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAE 946
Cdd:PRK15127   874 PALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLM 953
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  947 REQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRla 1026
Cdd:PRK15127   954 DKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRR-- 1031
                         1050
                   ....*....|...
gi 1578099510 1027 lwtksRFARHEEE 1039
Cdd:PRK15127  1032 -----RFSRKNED 1039
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
25-1024 5.69e-89

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 308.23  E-value: 5.69e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510   25 LLMVAILLAGIIG---YRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVIT 101
Cdd:TIGR00914   15 LVLLATLVMAILGiwsYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLSRYGLSQVT 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  102 LQFQLTLPLDVAEQEVQAAINAATNLLPSDlpnppvyskVNPADPPIMT----------LAVTSTAMPMTQVEDMVETRV 171
Cdd:TIGR00914   95 VIFKDGTDLYFARQLVNERLQQARDNLPEG---------VSPEMGPISTglgeiflytvEAEEGARKKDGGAYTLTDLRT 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  172 AQ------KISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQ 245
Cdd:TIGR00914  166 IQdwiirpQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRAPGQVQ 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  246 SAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVK 325
Cdd:TIGR00914  246 SMDDIRNIVIATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTLPEGVE 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  326 VTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALtiAT 405
Cdd:TIGR00914  326 IVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGAL--DF 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  406 GFVVDDAIVVIENISRYIEKGEKPLAAALK----------GAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAIT 475
Cdd:TIGR00914  404 GLIVDGAVVIVENAHRRLAEAQHHHGRQLTlkerlhevfaASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFT 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  476 LAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRasekmfdRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWV 555
Cdd:TIGR00914  484 VVLALAGAMILSLTFVPAAVALFIRGKVAEKENRLMR-------VLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWIAS 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  556 FIPKGFFPVQDNG-IIQGTLQAPqSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVD--GTNPS-LNSARLQINLKPLD 631
Cdd:TIGR00914  557 RVGGEFIPSLNEGdLAYQALRIP-GTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAeiATDPMpPNASDTYIILKPES 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  632 ERDDRVQ---KVIARLQTAVDKVPG-VDLFLQPTQdLTIDTQVS--RTQYQFTLQATSLDALSTWVPELMEKLQQLPQLS 705
Cdd:TIGR00914  636 QWPEGKKtkeDLIEEIQEATVRIPGnNYEFTQPIQ-MRFNELISgvRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  706 DVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVL---EHNTENTPGLAALdTIRL 782
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIrlpESLRESPQALRQL-PIPL 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  783 TSSDGGV---VPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNySLG----DAVQAIMDTEKtlnLPVDITTQFQGS 855
Cdd:TIGR00914  794 PLSEDARkqfIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGR-DLGsfvdDAKKAIAEQVK---LPPGYWITWGGQ 869
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  856 TLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNA 935
Cdd:TIGR00914  870 FEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNG 949
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  936 IMMIDFaLAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTT 1015
Cdd:TIGR00914  950 LVMISF-IRKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVL 1028

                   ....*....
gi 1578099510 1016 PVIYLLFDR 1024
Cdd:TIGR00914 1029 PALYRLVHR 1037
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
289-543 1.60e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 84.53  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  289 AIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSD---RTTNIRASVNDTQFELMMAIALVVMIIYLFLRNI 365
Cdd:COG1033    163 LIVVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFpvlRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  366 PATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTII 445
Cdd:COG1033    243 RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREALRKLGPPVL 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  446 SLTFSLIAVLIPLLFMgDIvgRLFREFAITLAVAILISAVVSLTLTPMmcarMLSQESLRKQNRFSRASEKMFDRIIAAY 525
Cdd:COG1033    323 LTSLTTAIGFLSLLFS-DI--PPIRDFGIVAAIGVLLAFLTSLTLLPA----LLSLLPRPKPKTRRLKKPPELGRLLAKL 395
                          250
                   ....*....|....*...
gi 1578099510  526 GRglaKVLNHPWLTLSVA 543
Cdd:COG1033    396 AR---FVLRRPKVILVVA 410
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
290-492 6.11e-15

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 79.52  E-value: 6.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  290 IVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVNDTQFE-LMMAIALVVMIIYLFLRNIPAT 368
Cdd:COG1033    553 VTVRLKDLDSEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRsLLLALLLIFLLLLLAFRSLRLG 632
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  369 IIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLT 448
Cdd:COG1033    633 LISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTS 712
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1578099510  449 FSLIAVLIPLLFmGDIVGrlFREFAITLAVAILISAVVSLTLTP 492
Cdd:COG1033    713 LTLAAGFGVLLF-SSFPP--LADFGLLLALGLLVALLAALLLLP 753
SecD COG0342
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular ...
319-506 2.26e-07

Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440111 [Multi-domain]  Cd Length: 434  Bit Score: 54.35  E-value: 2.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  319 SLPksVKVTVLSDRT-------TNIRASVndtqFELMMAIALVVMIIYLFLRnipatiIPGFAVPLSLIG----TFAVMV 387
Cdd:COG0342    248 ALP--APLEIVEERTvgptlgaDSIEKGL----IAGLIGLLLVALFMLLYYR------LPGLVANIALALnvvlLLGVLS 315
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  388 FLDFsinNLTL-----MALTIATGfvVDDAIVVIENISRYIEKGeKPLAAALkgagEIGF-----TIIS--LTfSLIAVL 455
Cdd:COG0342    316 LLGA---TLTLpgiagIILTIGMA--VDANVLIFERIREELRAG-RSLRAAI----EAGFkrafsTILDanVT-TLIAAV 384
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1578099510  456 IpLLFMGdiVGRLfREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRK 506
Cdd:COG0342    385 V-LFVLG--TGPV-KGFAVTLILGILISMFTAVPVTRPLLNLLLGRRRLKK 431
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
303-496 7.99e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 52.29  E-value: 7.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  303 ISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVN-DTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIG 381
Cdd:pfam03176  103 DESVAAVRDAVEQAPPPEGLKAYLTGPAATVADLRDAGDrDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGA 182
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  382 TFAVMVFL----DFSINNLT---LMALTIATGfvVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIislTFSLIAV 454
Cdd:pfam03176  183 AQGLVAILahilGIGLSTFAlnlLVVLLIAVG--TDYALFLVSRYREELRAGEDREEAVIRAVRGTGKVV---TAAGLTV 257
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1578099510  455 LIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCA 496
Cdd:pfam03176  258 AIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLA 299
2A0604s01 TIGR00916
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ...
283-488 1.21e-06

protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273336 [Multi-domain]  Cd Length: 192  Bit Score: 49.95  E-value: 1.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  283 WANKEQAIVMNVQRQPGANIIStADSIRQMLPQLTESLpksvkvtvlsdrttnIRASVndtqfeLMMAIALVVMIIYLFL 362
Cdd:TIGR00916    9 FADFAANIGKPAIVLDNAKVIS-APVVGTVGPTLGGEL---------------IKAGI------IALLIGLVLVLLYMLL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  363 RNIPATIIPGFAVPLS-LIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGE-KPLAAALkgagEI 440
Cdd:TIGR00916   67 RYEWRGAIAAIAALVHdVILILGVLSLFGATLTLPGIAGLLTIIGYSVDDTVVIFDRIREELRKYKgRTFREAI----NL 142
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1578099510  441 GF------TIISLTFSLIAVLIPLLFMGDIVgrlfREFAITLAVAILISAVVSL 488
Cdd:TIGR00916  143 GInqtlsrIIDTNVTTLLAVLALYVFGGGAI----KGFALTLGIGVIAGTYSSI 192
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
305-543 5.42e-06

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 50.53  E-value: 5.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  305 TADSIRQMLPQLTESLPKSVKVTV---LSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIG 381
Cdd:COG2409    130 AAEAVDALRDAVAAAPAPGLTVYVtgpAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGV 209
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  382 TFAVMVFL-------DFSINNLTLMALTIATgfvvDDAIVVIeniSRY---IEKGEKPLAA---ALKGAGEI----GFTI 444
Cdd:COG2409    210 ALGLLALLaaftdvsSFAPNLLTMLGLGVGI----DYALFLV---SRYreeLRAGEDREEAvarAVATAGRAvlfsGLTV 282
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  445 IsltfslIAvLIPLLFMGDivgRLFREFAITLAVAILISAVVSLTLTPMMCA----RMLSQeSLRKQNRFSRASEKMFDR 520
Cdd:COG2409    283 A------IA-LLGLLLAGL---PFLRSMGPAAAIGVAVAVLAALTLLPALLAllgrRVFWP-RRPRRRRAAAPESGFWRR 351
                          250       260
                   ....*....|....*....|...
gi 1578099510  521 IIAAygrglakVLNHPWLTLSVA 543
Cdd:COG2409    352 LARA-------VVRRPVPVLVAA 367
secD PRK05812
preprotein translocase subunit SecD; Reviewed
319-514 9.88e-06

preprotein translocase subunit SecD; Reviewed


Pssm-ID: 235615 [Multi-domain]  Cd Length: 462  Bit Score: 49.45  E-value: 9.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  319 SLPksVKVTVLSDRT-------TNIRASVndtqFELMMAIALVV--MIIY--LFlrnipaTIIPGFAVPLSLIGTFAVMV 387
Cdd:PRK05812   274 ALP--APLEIVEERTigpslgaDSIRAGL----IAGLIGLALVLlfMILYyrLF------GLIANIALVANLVLILAVLS 341
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  388 FLDFSinnLTL-----MALTIatGFVVDdAIVVI-ENISRYIEKGEKPLAAAlkgagEIGF-----TIIS--LTfSLIAV 454
Cdd:PRK05812   342 LLGAT---LTLpgiagIVLTI--GMAVD-ANVLIfERIREELREGRSLRSAI-----EAGFkrafsTILDsnIT-TLIAA 409
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  455 LIpLLFMGdiVGrLFREFAITLAVAILISAVVSLTLTpmmcaRMLSQESLRKQNRFSRAS 514
Cdd:PRK05812   410 II-LYALG--TG-PVKGFAVTLGIGILTSMFTAITVT-----RALVNLLYGRRKRLKKLS 460
secD TIGR01129
protein-export membrane protein SecD; Members of this family are highly variable in length ...
305-491 1.00e-05

protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273456 [Multi-domain]  Cd Length: 397  Bit Score: 49.21  E-value: 1.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  305 TADSIRQMLPQL-TESLPksVKVTVLSDRTT-------NIRASVNDTqfelmmAIALVVMIIYLFLRNIPATIIPGFAVP 376
Cdd:TIGR01129  210 TAEEANDLALVLrSGALP--APLQILEERTIgpslgadSIEAGIKAG------LIGLVLVLVFMILYYRLFGLIAAIALV 281
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  377 LSLIGTFAVMVFLDFSinnLTL-----MALTIatGFVVDDAIVVIENISRYIEKGEKPLAAAlkgagEIGF-----TIIS 446
Cdd:TIGR01129  282 INIVLILAILSAFGAT---LTLpgiagLILTI--GMAVDANVLIYERIKEELRLGKSVRQAI-----EAGFerafsTIFD 351
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1578099510  447 --LTfSLIAVLIPLLF-MGDIVGrlfreFAITLAVAILISAVVSLTLT 491
Cdd:TIGR01129  352 anIT-TLIAALILYVFgTGPVKG-----FAVTLAIGIIASLFTALVFT 393
PRK12911 PRK12911
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
343-491 6.01e-04

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 171815 [Multi-domain]  Cd Length: 1403  Bit Score: 44.08  E-value: 6.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  343 TQFELMMAIALVVMIIYLFLRNIPATIIPGFAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENIsry 422
Cdd:PRK12911   909 TQGIISVCLGLAVLIVLMSVYYRFGGVIASGAVLLNLLLIWAALQYLDAPLTLSGLAGIVLAMGMAVDANVLVFERI--- 985
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1578099510  423 ieKGEKPLAAALKGAGEIG----FTII---SLTFSLIAVLIPLLFMGDIVGrlfreFAITLAVAILISAVVSLTLT 491
Cdd:PRK12911   986 --REEYLLSRSLSESVEAGykkaFSAIfdsNLTTILASALLLMLDTGPIKG-----FALTLIIGIFSSMFTALFMT 1054
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
824-1026 2.45e-03

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 41.77  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  824 DNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLpTAGV 903
Cdd:COG1033    178 DRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVV-LLAV 256
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  904 GALLALL-IAGSELDVIAiigiilligivkkNAIMMIDFALA------------AEREQGMSPREAIYQACLLRFRPILM 970
Cdd:COG1033    257 IWTLGLMgLLGIPLSPLT-------------ILVPPLLLAIGidygihllnryrEERRKGLDKREALREALRKLGPPVLL 323
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1578099510  971 TTLaallgalplmlSTGVG------AELR--RPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLA 1026
Cdd:COG1033    324 TSL-----------TTAIGflsllfSDIPpiRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPK 376
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
319-511 3.02e-03

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 41.76  E-value: 3.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  319 SLPksVKVTVLSDRTtnIRASVNDTQFElMMAIALVVMIIYLFLRNIPATIIPGF----AVPLSLIGTFAVMVFLDFSIN 394
Cdd:PRK13024   243 ALP--APLKIIESRS--VGPTLGQDAID-AGIIAGIIGFALIFLFMLVYYGLPGLianiALLLYIFLTLGALSSLGAVLT 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578099510  395 NLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTII--SLTfSLIAVLIplLFM---GDIvgrlf 469
Cdd:PRK13024   318 LPGIAGLVLGIGMAVDANVLIFERIKEELRKGKSLKKAFKKGFKNAFSTILdsNIT-TLIAAAI--LFFfgtGPV----- 389
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1578099510  470 REFAITLAVAILISAVVSLTLTpmmcaRMLSQESLRKQNRFS 511
Cdd:PRK13024   390 KGFATTLIIGILASLFTAVFLT-----RLLLELLVKRGDKKP 426
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH