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Conserved domains on  [gi|1029879998|emb|SBC16755|]
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fic/DOC family protein [Staphylococcus aureus]

Protein Classification

Fic family protein( domain architecture ID 11459786)

Fic (Filamentation induced by cAMP) family protein similar to Shewanella oneidensis adenosine monophosphate-protein transferase SoFic, which mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins

Gene Ontology:  GO:0005524|GO:0000287|GO:0042803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3177 COG3177
Fic family protein [Transcription];
17-261 5.31e-32

Fic family protein [Transcription];


:

Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 119.79  E-value: 5.31e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998  17 NVRDIRAIYDKLVSNEINEQDKLdGElFRKNFVGVhdgstnKYIHVGLQPEtKIVEYIGEMLTFLKYFDAPQPF-KIMAS 95
Cdd:COG3177    93 TEELILELHRILLKGLRGEDKEP-GE-YRTGQVGI------GAVYVPPPPE-EVPELMEELLDWLNEEDELHPLiKAAIA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998  96 HYMFEYIHPFYDGNGRVGRFIIAKLLSDY-YDNYTALTFSYVINRNKSKYYKAFMTASNHlncGDLTEFIDTMLELLIAG 174
Cdd:COG3177   164 HYQFETIHPFADGNGRTGRLLMNLLLLRAgLLSQPLLPLSRIIEEDRDEYYDALEAVRET---GDLTPWIEFFLEAILEA 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998 175 QERILDelipKMDATEKLTLYLTSHYKKIDYEFLYllsmdklfgnKRNRLTLIDLENILGVGRVKINNTIKKFG--NYLV 252
Cdd:COG3177   241 AEEALA----LLERLLELARGRLNERQRKLLELLF----------ENPVLTASELAELLGVSRRTARRDLKDLVelGILE 306

                         250
                  ....*....|
gi 1029879998 253 KIKS-RPTIY 261
Cdd:COG3177   307 KVGGgRNTRY 316
 
Name Accession Description Interval E-value
COG3177 COG3177
Fic family protein [Transcription];
17-261 5.31e-32

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 119.79  E-value: 5.31e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998  17 NVRDIRAIYDKLVSNEINEQDKLdGElFRKNFVGVhdgstnKYIHVGLQPEtKIVEYIGEMLTFLKYFDAPQPF-KIMAS 95
Cdd:COG3177    93 TEELILELHRILLKGLRGEDKEP-GE-YRTGQVGI------GAVYVPPPPE-EVPELMEELLDWLNEEDELHPLiKAAIA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998  96 HYMFEYIHPFYDGNGRVGRFIIAKLLSDY-YDNYTALTFSYVINRNKSKYYKAFMTASNHlncGDLTEFIDTMLELLIAG 174
Cdd:COG3177   164 HYQFETIHPFADGNGRTGRLLMNLLLLRAgLLSQPLLPLSRIIEEDRDEYYDALEAVRET---GDLTPWIEFFLEAILEA 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998 175 QERILDelipKMDATEKLTLYLTSHYKKIDYEFLYllsmdklfgnKRNRLTLIDLENILGVGRVKINNTIKKFG--NYLV 252
Cdd:COG3177   241 AEEALA----LLERLLELARGRLNERQRKLLELLF----------ENPVLTASELAELLGVSRRTARRDLKDLVelGILE 306

                         250
                  ....*....|
gi 1029879998 253 KIKS-RPTIY 261
Cdd:COG3177   307 KVGGgRNTRY 316
Fic pfam02661
Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and ...
 17-121 3.12e-14

Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.


Pssm-ID: 426907  Cd Length: 94  Bit Score: 66.72  E-value: 3.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998  17 NVRDIRAIYDKLVsneineQDKLDGELFRKNFVgvhdgsTNKYIHVGLQPEtKIVEYIGEMLTFLKYFDAPQPFKIMASH 96
Cdd:pfam02661   3 DLEDLLALHRLLI------ERHGGAGGARDVNV------SGLLESALARPE-QIPFGLEELLLYPDLDREHPLEKAAALH 69

                          90       100
                  ....*....|....*....|....*
gi 1029879998  97 YMFEYIHPFYDGNGRVGRFIIAKLL 121
Cdd:pfam02661  70 FGFAKIHPFRDGNGRTARLLANLFL 94
 
Name Accession Description Interval E-value
COG3177 COG3177
Fic family protein [Transcription];
17-261 5.31e-32

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 119.79  E-value: 5.31e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998  17 NVRDIRAIYDKLVSNEINEQDKLdGElFRKNFVGVhdgstnKYIHVGLQPEtKIVEYIGEMLTFLKYFDAPQPF-KIMAS 95
Cdd:COG3177    93 TEELILELHRILLKGLRGEDKEP-GE-YRTGQVGI------GAVYVPPPPE-EVPELMEELLDWLNEEDELHPLiKAAIA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998  96 HYMFEYIHPFYDGNGRVGRFIIAKLLSDY-YDNYTALTFSYVINRNKSKYYKAFMTASNHlncGDLTEFIDTMLELLIAG 174
Cdd:COG3177   164 HYQFETIHPFADGNGRTGRLLMNLLLLRAgLLSQPLLPLSRIIEEDRDEYYDALEAVRET---GDLTPWIEFFLEAILEA 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998 175 QERILDelipKMDATEKLTLYLTSHYKKIDYEFLYllsmdklfgnKRNRLTLIDLENILGVGRVKINNTIKKFG--NYLV 252
Cdd:COG3177   241 AEEALA----LLERLLELARGRLNERQRKLLELLF----------ENPVLTASELAELLGVSRRTARRDLKDLVelGILE 306

                         250
                  ....*....|
gi 1029879998 253 KIKS-RPTIY 261
Cdd:COG3177   307 KVGGgRNTRY 316
Fic pfam02661
Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and ...
 17-121 3.12e-14

Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.


Pssm-ID: 426907  Cd Length: 94  Bit Score: 66.72  E-value: 3.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998  17 NVRDIRAIYDKLVsneineQDKLDGELFRKNFVgvhdgsTNKYIHVGLQPEtKIVEYIGEMLTFLKYFDAPQPFKIMASH 96
Cdd:pfam02661   3 DLEDLLALHRLLI------ERHGGAGGARDVNV------SGLLESALARPE-QIPFGLEELLLYPDLDREHPLEKAAALH 69

                          90       100
                  ....*....|....*....|....*
gi 1029879998  97 YMFEYIHPFYDGNGRVGRFIIAKLL 121
Cdd:pfam02661  70 FGFAKIHPFRDGNGRTARLLANLFL 94
FIDO COG2184
Fido, protein-threonine AMPylation domain [Signal transduction mechanisms];
79-165 2.01e-03

Fido, protein-threonine AMPylation domain [Signal transduction mechanisms];


Pssm-ID: 441787 [Multi-domain]  Cd Length: 196  Bit Score: 38.37  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1029879998  79 TFLKYFDAPQPFKIMAsHYMFE--YIHPFYDGNGRVGRFIIAKLLSDY-YDnytaLTFSYVinrNKSKYYKAfMTASNHL 155
Cdd:COG2184   107 NYLRGLDREEFAERLA-RFHGElnVIHPFREGNGRTQRLFFDQLARQAgYP----LDWSRV---DKEEYLEA-LIAADNG 177

                          90
                  ....*....|
gi 1029879998 156 NCGDLTEFID 165
Cdd:COG2184   178 DYSPLKALFR 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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