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Conserved domains on  [gi|1037128421|emb|SBT03248|]
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Sensory transduction protein regX3 (fragment) [Candidatus Accumulibacter aalborgensis]

Protein Classification

winged helix-turn-helix domain-containing protein( domain architecture ID 10086760)

winged helix-turn-helix (wHTH) domain-containing protein binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0006355
PubMed:  9199401|11934608|10679470|10473770|15808743
SCOP:  3001179

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 48-137 1.24e-42

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


:

Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 135.68  E-value: 1.24e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  48 LRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPSPNqPEFI 127
Cdd:cd00383     1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPE-PRLI 79

                          90
                  ....*....|
gi 1037128421 128 LTVWGVGYKF 137
Cdd:cd00383    80 KTVRGVGYRL 89
 
Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 48-137 1.24e-42

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 135.68  E-value: 1.24e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  48 LRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPSPNqPEFI 127
Cdd:cd00383     1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPE-PRLI 79

                          90
                  ....*....|
gi 1037128421 128 LTVWGVGYKF 137
Cdd:cd00383    80 KTVRGVGYRL 89
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
61-137 6.08e-37

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 121.08  E-value: 6.08e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1037128421  61 GKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPSPNQPEFILTVWGVGYKF 137
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 61-137 3.71e-35

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 116.50  E-value: 3.71e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1037128421   61 GKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPSPNqPEFILTVWGVGYKF 137
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDDGD-PRLIETVRGVGYRL 76
orf27 CHL00148
Ycf27; Reviewed
 24-138 9.38e-30

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 107.49  E-value: 9.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVD--HLSRPSDEGKVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSG 101
Cdd:CHL00148  118 RSVLRRTNkkSFSSKIPNSSIIRIGFLKIDLNKKQVYKNNERIRLTGMEFSLLELLISKSGEIFSRATILKEVWGYTPER 197

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1037128421 102 YEHT--VNAHINRLRAKIEPSPNQPEFILTVWGVGYKFR 138
Cdd:CHL00148  198 HIDTrvVDVHISRLRAKLEDDPSNPDLILTARGTGYLFQ 236
resp_regPieR NF041209
two component system response regulator PieR;
24-137 1.19e-28

two component system response regulator PieR;


Pssm-ID: 469113 [Multi-domain]  Cd Length: 231  Bit Score: 104.66  E-value: 1.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVDHLSRPSD---EGKVLDSGPLRVDVGRRQVTLAGKPVD-LTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSH 99
Cdd:NF041209  112 KAVSRRKNSASDDTEnneDTHILETTYFKISKRTREIFYQDEPLEaLTPKEFDLLYFLMEHPRQVFSREQLLERVWGYQF 191

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1037128421 100 SGYEHTVNAHINRLRAKIepSPNQPEFILTVWGVGYKF 137
Cdd:NF041209  192 YGDERTVDVHIKRLRKKI--ATEEHLFLHTIWGVGYKF 227
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
46-137 5.11e-28

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 99.21  E-value: 5.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  46 GPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGyEHTVNAHINRLRAKIEPSPNQPE 125
Cdd:COG3710     6 GDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVS-DNSLTQAISRLRKALGDDGLEPR 84

                          90
                  ....*....|..
gi 1037128421 126 FILTVWGVGYKF 137
Cdd:COG3710    85 LIRTVPRRGYRL 96
 
Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 48-137 1.24e-42

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 135.68  E-value: 1.24e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  48 LRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPSPNqPEFI 127
Cdd:cd00383     1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPE-PRLI 79

                          90
                  ....*....|
gi 1037128421 128 LTVWGVGYKF 137
Cdd:cd00383    80 KTVRGVGYRL 89
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
61-137 6.08e-37

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 121.08  E-value: 6.08e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1037128421  61 GKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPSPNQPEFILTVWGVGYKF 137
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 61-137 3.71e-35

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 116.50  E-value: 3.71e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1037128421   61 GKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPSPNqPEFILTVWGVGYKF 137
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDDGD-PRLIETVRGVGYRL 76
orf27 CHL00148
Ycf27; Reviewed
 24-138 9.38e-30

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 107.49  E-value: 9.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVD--HLSRPSDEGKVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSG 101
Cdd:CHL00148  118 RSVLRRTNkkSFSSKIPNSSIIRIGFLKIDLNKKQVYKNNERIRLTGMEFSLLELLISKSGEIFSRATILKEVWGYTPER 197

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1037128421 102 YEHT--VNAHINRLRAKIEPSPNQPEFILTVWGVGYKFR 138
Cdd:CHL00148  198 HIDTrvVDVHISRLRAKLEDDPSNPDLILTARGTGYLFQ 236
resp_regPieR NF041209
two component system response regulator PieR;
24-137 1.19e-28

two component system response regulator PieR;


Pssm-ID: 469113 [Multi-domain]  Cd Length: 231  Bit Score: 104.66  E-value: 1.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVDHLSRPSD---EGKVLDSGPLRVDVGRRQVTLAGKPVD-LTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSH 99
Cdd:NF041209  112 KAVSRRKNSASDDTEnneDTHILETTYFKISKRTREIFYQDEPLEaLTPKEFDLLYFLMEHPRQVFSREQLLERVWGYQF 191

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1037128421 100 SGYEHTVNAHINRLRAKIepSPNQPEFILTVWGVGYKF 137
Cdd:NF041209  192 YGDERTVDVHIKRLRKKI--ATEEHLFLHTIWGVGYKF 227
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
46-137 5.11e-28

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 99.21  E-value: 5.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  46 GPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGyEHTVNAHINRLRAKIEPSPNQPE 125
Cdd:COG3710     6 GDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVS-DNSLTQAISRLRKALGDDGLEPR 84

                          90
                  ....*....|..
gi 1037128421 126 FILTVWGVGYKF 137
Cdd:COG3710    85 LIRTVPRRGYRL 96
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 24-121 3.09e-27

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 100.03  E-value: 3.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVdhlsrpsdEGKVLDSGPLrVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYsHSGYE 103
Cdd:COG0745   114 RALLRRR--------AAEVLRVGDL-LDLAAREVTRDGEPVELTPKEFRLLELLMRNPGRVVSREQLLEEVWGY-DYGDD 183

                          90
                  ....*....|....*...
gi 1037128421 104 HTVNAHINRLRAKIEPSP 121
Cdd:COG0745   184 RTVDVHISRLRKKLEDDL 201
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 24-138 8.35e-24

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 91.95  E-value: 8.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVDHLSRPSDegkVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYE 103
Cdd:PRK11083  116 RTILRRVKKFAAPSP---VIRIGHFELDEPAARISYFGTPLTLTRYEFLLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYD 192

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1037128421 104 HTVNAHINRLRAKIEPSPNQPEFILTVWGVGYKFR 138
Cdd:PRK11083  193 RTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLR 227
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 24-136 8.48e-24

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 92.06  E-value: 8.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVdhlSRPSDEGKVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYE 103
Cdd:PRK10710  122 KTILRRC---KPQRELQQQDAESPLIIDESRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTD 198

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1037128421 104 HTVNAHINRLRAKIEPSPNQPEFILTVWGVGYK 136
Cdd:PRK10710  199 RTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYR 231
ompR PRK09468
osmolarity response regulator; Provisional
 24-137 1.13e-20

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 83.87  E-value: 1.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRR--VDHLSRPSDEGKVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSG 101
Cdd:PRK09468  118 RAVLRRqaPELPGAPSQEEEVIAFGKFKLNLGTRELFRGDEPMPLTTGEFAVLKALVSHPREPLSRDKLMNLARGREYSA 197

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1037128421 102 YEHTVNAHINRLRAKIEPSPNQPEFILTVWGVGYKF 137
Cdd:PRK09468  198 MERSIDVQISRLRRLIEEDPAHPRYIQTVWGLGYVF 233
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 24-137 4.58e-16

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 71.37  E-value: 4.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRvdhLSRPSDEGKVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYE 103
Cdd:PRK10529  113 RVALRR---HSATPAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHS 189

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1037128421 104 HTVNAHINRLRAKIEPSPNQPEFILTVWGVGYKF 137
Cdd:PRK10529  190 HYLRIYMGHLRQKLEQDPARPRHFITETGIGYRF 223
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
24-137 8.90e-16

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 70.90  E-value: 8.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVDhlsrPSDEGKVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYE 103
Cdd:PRK10161  117 KAVMRRIS----PMAVEEVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVED 192

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1037128421 104 HTVNAHINRLRAKIEPSpNQPEFILTVWGVGYKF 137
Cdd:PRK10161  193 RTVDVHIRRLRKALEPG-GHDRMVQTVRGTGYRF 225
PRK11173 PRK11173
two-component response regulator; Provisional
 50-137 2.55e-15

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 69.66  E-value: 2.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  50 VDVGRRQ-VTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPSPNQPEFIL 128
Cdd:PRK11173  144 LDINSRSlISPDGEQYKLPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIA 223


                  ....*....
gi 1037128421 129 TVWGVGYKF 137
Cdd:PRK11173  224 TIHGEGYRF 232
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 41-137 2.87e-15

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 69.67  E-value: 2.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  41 KVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPS 120
Cdd:PRK10701  137 KALHFGTLTIDPVNRQVTLAGEEISLSTADFDLLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLDN 216

                          90
                  ....*....|....*..
gi 1037128421 121 PNQPEFILTVWGVGYKF 137
Cdd:PRK10701  217 AAEPYRIKTVRNKGYLF 233
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 24-135 1.21e-14

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 67.64  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVDHLSrPSDEGKVLDsgpLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYE 103
Cdd:PRK09836  113 RTLLRRGAAVI-IESQFQVAD---LMVDLVSRKVTRSGTRITLTSKEFTLLEFFLRHQGEVLPRSLIASQVWDMNFDSDT 188

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1037128421 104 HTVNAHINRLRAKIEpSPNQPEFILTVWGVGY 135
Cdd:PRK09836  189 NAIDVAVKRLRGKID-NDFEPKLIQTVRGVGY 219
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 54-137 3.64e-13

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 64.06  E-value: 3.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  54 RRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEPSPNQPEFILTVWGV 133
Cdd:PRK13856  144 RRLISEAGGEVKLTAGEFNLLVAFLEKPRDVLSREQLLIASRVREEEVYDRSIDVLILRLRRKLEQDPANPQLIKTARGA 223


                  ....
gi 1037128421 134 GYKF 137
Cdd:PRK13856  224 GYFF 227
PRK11517 PRK11517
DNA-binding response regulator HprR;
48-138 3.89e-13

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 63.76  E-value: 3.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  48 LRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEpSPNQPEFI 127
Cdd:PRK11517  130 LRMDSVSQSVSRDNISITLTRKEFQLLWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVD-DPFPEKLI 208

                          90
                  ....*....|.
gi 1037128421 128 LTVWGVGYKFR 138
Cdd:PRK11517  209 ATIRGMGYSFV 219
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
24-135 1.71e-12

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 62.13  E-value: 1.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRvdhlSRPSDEGKVLDSGP-------LRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWG 96
Cdd:PRK10955  112 RAILRR----SHWSEQQQNNDNGSptlevdaLSLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLG 187

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1037128421  97 YSHSGYEHTVNAHINRLRAKI-EPSPNQPEFiLTVWGVGY 135
Cdd:PRK10955  188 KRLTPFDRAIDMHISNLRRKLpDRKDGHPWF-KTLRGRGY 226
PRK10766 PRK10766
two-component system response regulator TorR;
51-119 4.57e-11

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 58.13  E-value: 4.57e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1037128421  51 DVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEP 119
Cdd:PRK10766  145 NVSRRTLERNGEPIKLTKAEYELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRHKLNP 213
PRK10643 PRK10643
two-component system response regulator PmrA;
24-135 2.00e-10

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 56.20  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  24 RAIFRRVDHLSRpsdegKVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYE 103
Cdd:PRK10643  113 RALIRRHQGQGE-----NELQVGNLTLNLGRQQVWLDGQELILTPKEFALLSRLMLKAGSPVHREILYQDIYNWDDEPSS 187

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1037128421 104 HTVNAHINRLRAKIEPSPnqpefILTVWGVGY 135
Cdd:PRK10643  188 NTLEVHIHNLRDKVGKDR-----IRTVRGFGY 214
PRK10336 PRK10336
two-component system response regulator QseB;
43-139 4.87e-10

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 55.29  E-value: 4.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  43 LDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIepspn 122
Cdd:PRK10336  127 LRHGNVMLDPGKRIATLAGEPLTLKPKEFALLELLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKL----- 201

                          90
                  ....*....|....*..
gi 1037128421 123 QPEFILTVWGVGYKFRD 139
Cdd:PRK10336  202 GSDFIRTVHGIGYTLGE 218
PRK10816 PRK10816
two-component system response regulator PhoP;
47-137 6.53e-09

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 52.05  E-value: 6.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  47 PLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGYEHTVNAHINRLRAKIEpSPNQPEF 126
Cdd:PRK10816  131 PFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQ-AQYPQEV 209

                          90
                  ....*....|.
gi 1037128421 127 ILTVWGVGYKF 137
Cdd:PRK10816  210 ITTVRGQGYRF 220
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
 55-136 4.59e-08

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 50.43  E-value: 4.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  55 RQVTLAGKPVDLtakefdlLLHFAEHPGRVFSRAQLLDKVWgyshSGYE---HTVNAHINRLRaKI--EPSPNQPEFILT 129
Cdd:PRK10153   25 REVTLEPRLIDL-------LVFFAQHSGEVLSRDELIDHVW----DRAIvtdHVVTQSISELR-KSlkDGREDNPEYIVT 92


                  ....*..
gi 1037128421 130 VWGVGYK 136
Cdd:PRK10153   93 VPKRGYK 99
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
62-137 8.58e-05

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 40.99  E-value: 8.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1037128421  62 KPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSHSGyEHTVNAHINRLRaKIEPSPNQPEFILTVWGVGYKF 137
Cdd:PRK12370   32 KKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVN-EESLTRCIYALR-RILSEDKEHRYIETLYGQGYRF 105
DnrI COG3629
DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain ...
 46-138 1.23e-03

DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain [Transcription];


Pssm-ID: 442847 [Multi-domain]  Cd Length: 244  Bit Score: 37.51  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  46 GPLRVDVGRRQVTLAGkpvdltAKEFDLLLHFAEHPGRVFSRAQLLDKVWGYSH-SGYEHTVNAHINRLRAKIEPSPnqP 124
Cdd:COG3629     8 GPLEVRVDGRPVPLGG------PKQRALLAYLALRAGRPVSRDRLADLLWGDDPpASARANLRTYVSRLRRALGPAG--G 79

                          90
                  ....*....|....
gi 1037128421 125 EFILTVwGVGYKFR 138
Cdd:COG3629    80 DLLVTR-GGGYRLD 92
PRK07239 PRK07239
bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated
 30-138 1.50e-03

bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated


Pssm-ID: 235981 [Multi-domain]  Cd Length: 381  Bit Score: 37.27  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037128421  30 VDHLsrPSDEGKVLDSGPLRVDVGRRQVTLAGKPVDLTAKEFDLLLHFAEHPGRVFSRAQLLDKVWGysHSGYEHTVNAH 109
Cdd:PRK07239  273 TEEL--PLRRARTLRAAGHVLEIRGHAVVVDGEVKPLSPAPMALLRALAARPGRVVSREDLLAALPG--GGTDEHAVETA 348

                          90       100
                  ....*....|....*....|....*....
gi 1037128421 110 INRLRAkiepSPNQPEFILTVWGVGYKFR 138
Cdd:PRK07239  349 VARLRT----ALGDPKLVQTVVKRGYRLA 373
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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