|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
4-383 |
2.26e-114 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 339.20 E-value: 2.26e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 4 LLTGLYFAQGLPFGFFTQAIPVLLRDAGLSLTAISLTSFLYLPWGLKFLWAPAVDR-----IGTRRQWLLATQLGSAGVA 78
Cdd:cd17485 1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRyglprLGRRRSWLLPTQLGLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 79 FALAATDLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVL 158
Cdd:cd17485 81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 159 LITLGGLILLCTVPVVVLARDESSDGGPrlGHRPTEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDAG 238
Cdd:cd17485 161 LLSLAALYLLLLLPVLFLRELELPQQPP--ASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 239 LTLHQIALVSGALSSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLY--VAAALGIGGGAMVISATVLEHVFGGA 316
Cdd:cd17485 239 FSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYtlLALGGSGLNWVLLLASLALLHLVGGM 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1089117791 317 ALVALCTLMMDACERDDAGADYTLLASAVVATQGLAGFAGAAVGDVLGYSAAFTIGMVLSGLGCAVL 383
Cdd:cd17485 319 ITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLL 385
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
8-385 |
6.01e-60 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 199.36 E-value: 6.01e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 8 LYFAQGLPFGFFTQAIPVLLRDAGLSLTAISLTSFLYLPWGLKFLWAPAVDRIGT-----RRQWLLATQLGSAGVAFALA 82
Cdd:cd17486 4 LGFASGLPYLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDRYSTpflgrRRGWILLTQILLMAALIALA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 83 ATDLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVLLITL 162
Cdd:cd17486 84 FLDPFTNLVLSALLFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVYLIM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 163 GGLILLCTVPVVVLARDESSDGGPRLGHRPTEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDAGLTLH 242
Cdd:cd17486 164 AALMGPGILATLFAPEPPRTDPPANSLSETVVAFFAPFKDFFGQPGALLILAFILLYKLGDAMLGAMATPFLLDLGFTKT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 243 QIALVSGALSSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLYVAAALGIGGGAMVISATVLEHVFGGAALVALC 322
Cdd:cd17486 244 EIGAVYKTVGLIATIVGGLLGGFLMSRLGLKRSLWLFGILQALSNLGFIYLAHAGPNLTLLVAAVAVENFGGGLGTTAFV 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1089117791 323 TLMMDACERDDAGADYTLLASAVVATQGLAGFAGAAVGDVLGYSAAFTIGMVLSGLGCAVLVR 385
Cdd:cd17486 324 AYLMSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEALGWTGFFLLTTLAAIPGLLLLLK 386
|
|
| sider_RhtX_FptX |
TIGR02718 |
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ... |
1-385 |
1.84e-37 |
|
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 131765 Cd Length: 390 Bit Score: 140.03 E-value: 1.84e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 1 MLLLLTGLYFAQGLPFGFFTQAIPVLLRDAGLSLTAISLTSFLYLPWGLKFLWAPAVD-----RIGTRRQWLLATQLGSA 75
Cdd:TIGR02718 2 LVITLGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDnwwswRLGRRRSWVLPMQCLVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 76 GVAFALAATDLT-GSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGG 154
Cdd:TIGR02718 82 ACLASLALVGPDvAGAGWAVGLLACASLASATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKFG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 155 WRVLLITLGGLILLCTVPVVVLARDESSDGGPRLGHRpteglgTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFL 234
Cdd:TIGR02718 162 QRPAFLLVACVPLASLVCVLWLKDRAVASPEAPLARR------ASLFRFFRRPLAWSLLALALLSAMTAVSGFGLSKLYL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 235 HDAGLTLHQIALVSGALSSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLYVAAALG--IGGGAMVISATVLEHV 312
Cdd:TIGR02718 236 VDAGWPLEWIGRLGMAGGAVTVLLGCGGGAWLVRRAGLWRTFILGVGLAGSLALLWFAQAAFwlAPGIAVAWSCSAFGSL 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1089117791 313 FGGAALVALCTLMMD-ACERDDAGADYTLLASAVVATQGLAGFAGAAVGDVLGYSAAFTIGMVLSGLGCAVLVR 385
Cdd:TIGR02718 316 ITGITSVAIYTAFMRfAGDGDQAGTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAILLAVR 389
|
|
| ampG |
PRK11902 |
muropeptide transporter; Reviewed |
8-343 |
1.40e-24 |
|
muropeptide transporter; Reviewed
Pssm-ID: 183369 [Multi-domain] Cd Length: 402 Bit Score: 104.16 E-value: 1.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 8 LYFAQGLPFGFFTQAIPVLLRDAGLSLTAISLTSFLYLPWGLKFLWAPAVDR-----IGTRRQWLLATQLGSAGVAFALA 82
Cdd:PRK11902 7 LGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRytpplLGRRRGWLLLTQVGLAASIAAMA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 83 ATDLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEG-GWRVLLIT 161
Cdd:PRK11902 87 FCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLADRVlGWGNTYLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 162 LGGLILLCTVPVVVLARDESSDGGPRlghrpteGLGTAWWHRLR----RPGVIPLIGLLAAYKFGNAMASSISGPFL-HD 236
Cdd:PRK11902 167 MAGLMLAGALTTLWAPEPEVPARPPR-------SLGEAVVGPLRdffsRRGAWALLLLIVLYKLGDAFAGSLSTTFLiRG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 237 AGLTLHQIALVSGALSSAGALAGSALGGWLAFRYG-RRSALLFGGVSQTLAVGLYVAAALGIGGGAMVISATVlEHVFGG 315
Cdd:PRK11902 240 AGFSAGEVGIVNKTLGLAATIVGALAGGTLMVRLGlYRSLMLFGVLQAVSNLGYWVLAVTPKHLWTMALAIGI-ENLCGG 318
|
330 340
....*....|....*....|....*...
gi 1089117791 316 AALVALCTLMMDACERDDAGADYTLLAS 343
Cdd:PRK11902 319 MGTAAFVALLMALCNRSFSATQYALLSA 346
|
|
| ampG |
PRK11010 |
muropeptide MFS transporter AmpG; |
2-345 |
3.12e-18 |
|
muropeptide MFS transporter AmpG;
Pssm-ID: 182898 [Multi-domain] Cd Length: 491 Bit Score: 86.24 E-value: 3.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 2 LLLLTGlyFAQGLPFGFFTQAIPVLLRDAGLSLTAISLTSFLYLPWGLKFLWAPAVDR-----IGTRRQWLLATQLGSAG 76
Cdd:PRK11010 16 ILLILG--FASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRytppfLGRRRGWLLATQLLLLV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 77 VAFALAATDLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEG-GW 155
Cdd:PRK11010 94 AIAAMGFLEPGTQLRWLAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLAMLVSGGLALWLADRYlGW 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 156 RVLLITLGGLILLCTVPVVVLARDESSDGGPRLGH-------RPTEGLGTAWwhrlrrpgvipLIGLLAA-YKFGNAMAS 227
Cdd:PRK11010 174 QGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEqavvaplRDFFGRNNAW-----------LILLLIVlYKLGDAFAM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 228 SISGPFL-HDAGLTLHQIALVSGALSSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLYVAAALGIGGGAMVISA 306
Cdd:PRK11010 243 SLTTTFLiRGVGFDAGEVGLVNKTLGLLATIVGALYGGILMQRLSLFRALMIFGILQGVSNAGYWLLSITDKNLYSMGAA 322
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1089117791 307 TVLEHVFGGAALVALCTLMMDACERDDAGADYTLLA--SAV 345
Cdd:PRK11010 323 VFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSalSAV 363
|
|
| Acatn |
pfam13000 |
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ... |
4-132 |
6.71e-14 |
|
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pssm-ID: 372424 [Multi-domain] Cd Length: 543 Bit Score: 73.16 E-value: 6.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 4 LLTGLYFAQGLPFGFFTQAIPVLLRDAG--LSLTAISLTSFLYLPWGLKFLWAPAVD-----RIGTRRQWLLATQLGSAG 76
Cdd:pfam13000 3 LLVALYFLQGIPVGLAFGTIPFLLKSMAkeTSFTSLGIFSMATYPYSLKILWSPIVDsiyskKIGRRRSWIIPVQLVSGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 77 VAFALAATDLTG------------------------SLRWLFVAIAainLLSATQDVATDGLAVRLLGPRERGLGNGIQT 132
Cdd:pfam13000 83 MLIILGYCISKGlifpgvddafhgrlskgvlnvnitTLTWYFGILV---FLCATQDIAVDGWALTILSKQSLSYASTAQT 159
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
5-384 |
1.62e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 71.30 E-value: 1.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 5 LTGLYFAQGLPFGFFTQAIPVLLRDAGLSLTAISL--TSFLYLPWGLKFLWAPAVDRIGtRRQWLLATQLGSAGVAFALA 82
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLlfALFSLGYALLQPLAGLLADRFG-RRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 83 atdLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGG--GGLLWIYAEGGWRVLLI 160
Cdd:cd06174 80 ---FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPllGGILASSLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 161 TLGGLILLCTVPVVVLARDESSDGGPRLGHRPTEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDAGLT 240
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 241 LHQIALVSGALSSAGALAGSALGGWLA-FRYGRRSALLFGGVSQTLAVGLYVAAALGIGGGAMVISAtvleHVFGGAALV 319
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSdRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLL----GFGLGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1089117791 320 ALCTLMMDACERDDAGADYTLLASAVVATQGLAGFAGAAVGD-VLGYSAAFTIGMVLSGLGCAVLV 384
Cdd:cd06174 313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
5-357 |
1.15e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 65.52 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 5 LTGLYFAQGLPFGFFTQAIPVLLRDA-GLSLTAISL--TSFLYLPWGLKFLWAPAVDRIGTRRQWLLATQLGSAGVAFAL 81
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLllTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 82 AATdltgSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVLLIT 161
Cdd:pfam07690 81 FAS----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 162 LGGLILLCTVPVVVLARDESSDGGPRLGHRPTEGLGTawWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDAGLTL 241
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA--WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 242 HQIALVSGaLSSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLYVAAALGIGGGAMVISATVLEhVFGGAALVAL 321
Cdd:pfam07690 235 LLAGLLLG-LGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLG-FGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|....*.
gi 1089117791 322 CTLMMDACERDDAGAdytlLASAVVATQGLAGFAGA 357
Cdd:pfam07690 313 NALVSDLAPKEERGT----ASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-344 |
1.19e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 62.30 E-value: 1.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 2 LLLLTGLYFAQGLPFGFFTQAIPVLLRDAGLSLTAISLTSFLY-LPWGL-KFLWAPAVDRIGtRRQWLLATQLGSAGVAF 79
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYlLGAALgAPLAGRLADRFG-RRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 80 ALAatdLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVLL 159
Cdd:COG2814 91 LCA---LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 160 ITLGGLILLCTVPVVVLArdessdggPRLGHRPTEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHD-AG 238
Cdd:COG2814 168 LVNAVLALLALLLLLRLL--------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 239 LTLHQIALVsGALSSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLYvaaaLGIGGGAMVISATVLEHVFGGAAL 318
Cdd:COG2814 240 LSASAAGLL-LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL----ALAGSLWLLLLALFLLGFGFGLLF 314
|
330 340
....*....|....*....|....*.
gi 1089117791 319 VALCTLMMDACERDDAGADYTLLASA 344
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-385 |
8.38e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.94 E-value: 8.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 2 LLLLTGLYFAQGLPFGFFTQAIPVLLRDAGLSLTAISLTSFLY-LPWGLKFLWAPAVDRIGTRRQWLLATQLGSAGVAFA 80
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFfLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 81 LAATDLTGSLRW--LFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVL 158
Cdd:cd06173 81 LALLALLGSLSLwlLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 159 LITLGGLILLCTVPVVVLARDESSDGGPRLGHRPTEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDAG 238
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 239 LTLHQIALVSGALsSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLYvaaaLGIGGGAMVISATVLEHVFGGAAL 318
Cdd:cd06173 241 GGAAGYGLLLAAF-GVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL----GLSPSLWLLLAALFLLGLAGGLFN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1089117791 319 VALCTLMMDACERDDAGADYTLLASAVVATQGLAGFAGAAVGDVLGYSAAFTIGMVLSGLGCAVLVR 385
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
23-387 |
8.52e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 8.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 23 IPVLLRDAGLSLTAISLTSFLYLPWGL--KFLWAPAVDRIGTRRqwllATQLGSAGVAFALAATDLTGSLRWLFVAIAAI 100
Cdd:cd17325 19 LPLYAESLGASVAQIGLIVAAYALAQLlfSPPAGRLSDRFGRKR----LLLLGLLLLAVSTLLFAFATSYWQLLLARFLQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 101 NLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGG--GGLLwiYAEGGWRVLLITLGGLILLCTVPVVVLAR 178
Cdd:cd17325 95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPllGGLL--ADALGYRAPFLVCAALALLALVLALLLLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 179 DESSdgGPRLGHRPTEGLGTAWWHRLRRPGVIPLIGLLaaykFGNAMASSISGPFL-----HDAGLTLHQIALVSGALSS 253
Cdd:cd17325 173 EPRP--PPNKRAVSAARLRSGLRLLLRDRRLLALFLAI----FVLAFAFGALEPFLplyaaELGGLSPAQIGLLFGAQGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 254 AGALAgSALGGWLAFRYGRRSALLFGGVSQTLAVGLYvaaaLGIGGGAMVISATVLEHVFGGAALVALCTLMMDACERDD 333
Cdd:cd17325 247 ASALS-QPPAGKLSDRIGRKPLILIGLLLSAVALLLL----PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1089117791 334 AGADYTLLASAVVATQGLAGFAGAAVGDVLGYSAAFTIGMVLSGLGCAVLVRGL 387
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-395 |
1.75e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.12 E-value: 1.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 35 TAISLTSFLYLPWGLkflwapAVDRIGTRRQWLLATQLGSAGVAFALAATDLTgslrWLFVAIAAINLLSATQDVATDGL 114
Cdd:COG2223 48 IPVLVGALLRIPLGF------LVDRFGPRRVLLIGLLLLGIGLLLLALAVSYW----LLLLLGLLLGIGGGGSFAVGIAL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 115 AVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVLLITLGGLILLCTVPVVVLARDEssdggPRLGHRPTE 194
Cdd:COG2223 118 VSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDP-----PAGAAAAAK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 195 GLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDA-GLTLHQIALVSGALSSAGALaGSALGGWLAFRYGRR 273
Cdd:COG2223 193 ASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGAL-GRPLGGWLSDRIGGR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 274 SALLFGGVSQTLAVGLYVAAALGIGGGAMVISATVLEHVFGGAALVALCTLMMDaceRDDAGADYTLLASAVVATQGLAG 353
Cdd:COG2223 272 RVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP---TKNAGAVYGLVGAAGGLGGFLGP 348
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1089117791 354 FAGAAVGDVLG-YSAAFTIGMVLSGLGCAVLVRGLDRGRGPAA 395
Cdd:COG2223 349 LLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
10-384 |
5.41e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.52 E-value: 5.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 10 FAQGLPFGFFTQAIPVLLRD-AGLSLTAISLTSFLYLPWGL--KFLWAPAVD----RIGTRRQWLLATQLGSAGVAFALA 82
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDvLGLSAALVGLILLVARLWDAitDPLIGALSDrtrtRWGRRRPWILIGAIPLALSFVLLF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 83 AT---DLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLG-PRERGLGNGIQTGAYRLGMIAGGGGLLWIYA------E 152
Cdd:COG2211 100 TApdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdaA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 153 GGWRVLLITLGGLILLCTVPVVVLARDessdggPRLGHRPTEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGP 232
Cdd:COG2211 180 LGYRLTALIFAVLGLLAFLLTFFGTKE------RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLY 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 233 FLHDA-GLTLHQIALVsGALSSAGALAGSALGGWLAFRYGRRSALLFGGVsqTLAVGLYVAAALGIGGGAMVISATVLEH 311
Cdd:COG2211 254 YFKYVlGLSAALVGLL-LALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL--LAALGLLLLFFLGPGNLWLLLVLAALAG 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 312 VFGGAALVALCTLMMDACERDD-------AGADYTLLASAVVATQGLAGFAGAAVGDVLGY--------SAAFTIGMVLS 376
Cdd:COG2211 331 IGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFGYvagaaqspSALTGIRLLFF 410
|
....*...
gi 1089117791 377 GLGCAVLV 384
Cdd:COG2211 411 LLPAVLLL 418
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-385 |
6.45e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.11 E-value: 6.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 1 MLLLLTGLYFAQGLPFGFFTQAIPVLLRDAGLSLTAISL--TSFLYLPWGLKFLWAPAVDRIGTRRqwLLATQLGSAGVA 78
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLlaSAFFLGYALGQIPAGLLADRFGRRR--VLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 79 FALAAtdLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVL 158
Cdd:COG2271 89 TLLFG--FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 159 LITLgglillcTVPVVVLArdessdggprlghrpteglgtawwhrlrrpgVIPLIGLLAAYKFGNAMASSIS---GPFLH 235
Cdd:COG2271 167 FLIL-------GLPGLLLA-------------------------------LLRFWLLALAYFLVYFALYGFLtwlPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 236 DA-GLTLHQIALVSgALSSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLYVAAALGIGGGAMVISATVLehVFG 314
Cdd:COG2271 209 EVrGLSLAQAGLLL-SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG--FGL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1089117791 315 GAALVALCTLMMDACERDDAGADYTLLASAVVATQGLAGFAGAAVGDVLGYSAAFTIGMVLSGLGCAVLVR 385
Cdd:COG2271 286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
10-385 |
7.31e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 50.73 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 10 FAQGLPFGFFTQAIPvLLRDAGLSLTAISL-TSFLYLPWGL-KFLWAPAVDRIGTRRQWLLATQLGSAGvafaLAATDLT 87
Cdd:cd17355 14 LSWGIRYYFGVFIIP-IIAEFGWSRAVISLaFTVGLLAFGLaQPFVGRLLDRFGPRRVMLLGLLLLAAG----LVLLALA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 88 GSLRWLFVAIAAINLLSA--TQDVATDGLAVRLLGPReRGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVLLITLGGL 165
Cdd:cd17355 89 TSLWQLYLLWGLLGGGGAgtLAAVAFATVAAWWFERR-RGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 166 ILLCTVPVVVLARDESSDGGPRLGHRP-TEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDAGLTLHQI 244
Cdd:cd17355 168 ALLVLVPVLLLLRRRPADLALRAYDDAsPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 245 ALVsGALSSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLYVAAALGIGGGAMVISATVLEHVFGGAALVALCTL 324
Cdd:cd17355 248 AVA-LALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAAR 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1089117791 325 MMDaceRDDAGADYTLLASAVVATQGLAGFAGAAVGDVLG-YSAAFTIGMVLSGLGCAVLVR 385
Cdd:cd17355 327 YFG---ARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-379 |
1.05e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.16 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 30 AGLSLTAISLTSFLYLPwglkfLWAPAVDRIGTRRQWLLATQLGSAGVAFALAATDLTGSLRWLFVAIAAINLLSATqdv 109
Cdd:cd17324 36 AGLLVSAYALGYALGAL-----LLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAI--- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 110 aTDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVLLITLGGLILLCTVPVVVLARDESSdggprlG 189
Cdd:cd17324 108 -AAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP------K 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 190 HRPTEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDAGLTLHQIALVSGALSSAGALAGSALGGWLAFR 269
Cdd:cd17324 181 KPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 270 YGRRSALLFGGvsqtLAVGLYVAAALGIGGGAMVISATVLEHVFGGAALVALCTLMMDACERDDAGADyTLLASAVVATQ 349
Cdd:cd17324 261 GGRRALLIALL----LLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLAS-SLYLAAYNLGG 335
|
330 340 350
....*....|....*....|....*....|
gi 1089117791 350 GLAGFAGAAVGDVLGYSAAFTIGMVLSGLG 379
Cdd:cd17324 336 ALGAALGGLVLDHGGWAGVGWVGAALLLLA 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-289 |
5.65e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.84 E-value: 5.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 1 MLLLLTGLYFAQGLPFGFFTQAIPVLLRDAGLSLTAISL-TSFLYLPWGLKFLWAPA-VDRIGTRRqwllATQLGSAGVA 78
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLlLFAFFLGYLLASLPAGRlIDRFGYKR----GLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 79 FALAATDLTGSLRWLFVAIAAINLLSATQDVATDGLAVrLLGPRERGLGNGIQTGAYRLGMIAG---GGGLLWIYAEGGW 155
Cdd:COG0738 85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGpllGGLLILLGLSLSW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 156 RVlliTLGGLILLCTVPVVVLARDESSDGGPRlgHRPTEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLH 235
Cdd:COG0738 164 HL---PYLILAVLLLLLALLFLRSKLPEIEEE--EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1089117791 236 DAGLTLHQIALVSGALSSAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGL 289
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-179 |
1.42e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.71 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 1 MLLLLTGLYFAQGLPFGFFTQAIPVLLRDA-GLSLTAISLTSFLYLPWGL--KFLWAPAVDRIGTRRQWLLAtqLGSAGV 77
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIvgSLLGGWLSDRLGRRRKLVLA--IGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 78 AFALAATDLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRV 157
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|..
gi 1089117791 158 LLITLGGLILLCTVPVVVLARD 179
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRE 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
202-395 |
5.86e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 202 HRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDAGLTLHQIALVSGAlSSAGALAGSALGGWLAFRYGRRSALLFGGV 281
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTA-YLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 282 SQTLAVGLYvaaaLGIGGGAMVISATVLEHVFGGAALVALCTLMMDACERDDAGADYTLLASAVVATQGLAGFAGAAVGD 361
Cdd:COG2814 84 LFALGSLLC----ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190
....*....|....*....|....*....|....
gi 1089117791 362 VLGYSAAFTIGMVLSGLGCAVLVRGLDRGRGPAA 395
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAAR 193
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
23-385 |
7.06e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.40 E-value: 7.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 23 IPVLLRDAGLSLTAIS-LTSFLYLPWGLKFLWAPA-VDRIGTRRqwllATQLGSAGVAFALAATDLTGSLRWLFVAIAAI 100
Cdd:COG2807 41 LPEIRADLGLSATQAGlLTTLPLLAFGLFAPLAPRlARRFGLER----TLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 101 NLLSATQDVATDGLaVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEGGWRVLLITLGGLILLCTVPVVVLARDE 180
Cdd:COG2807 117 GAGIAVGNVLLPGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 181 SSdggprlgHRPTEGLGTAWWHRLRRPGVIPLIGLLAAYKFGNAMASSISGPFLHDAGLTLHQIALVSgALSSAGALAGS 260
Cdd:COG2807 196 PA-------AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLL-SLFQLAGIPGS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 261 ALGGWLAFRYGRRSALLFGGVSQTLA--VGLYVAAALGIGGGAMVISatvlehvFGGAALVALCTLMMDACERDDAGady 338
Cdd:COG2807 268 LLVPLLADRLGDRRPLLLLLGLLGLAglLGLLLAPGSLPWLWAVLLG-------LGQGGLFPLALTLIGLRARTPAE--- 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1089117791 339 tllASAVVATQGLAGFAGAAVGDVL---------GYSAAFTIGMVLSGLGCAVLVR 385
Cdd:COG2807 338 ---AAALSGMAQSVGYLLAALGPLLvgalhdatgSWTAALLLLAALAVLMLVAGLL 390
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-156 |
7.64e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 38.33 E-value: 7.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 2 LLLLTGLYFAQGLPFGFFTQAIPVLLRD--------AGLSLTAISLTSFLYLPWGLKFlwapaVDRIGtRRQWLLAtqlG 73
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAElgglspaqIGLLFGAQGLASALSQPPAGKL-----SDRIG-RKPLILI---G 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 74 SAGVAFALAATDLTGSLRWLFVAIAAINLLSATQDVATDGLAVRLLGPRERGLGNGIQTGAYRLGMIAGGGGLLWIYAEG 153
Cdd:cd17325 272 LLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
...
gi 1089117791 154 GWR 156
Cdd:cd17325 352 GFA 354
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
221-383 |
9.70e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 37.96 E-value: 9.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 221 FGNAMASSISGPFLHDAGLTLHQIALVSGALSsAGALAGSALGGWLAFRYGRRSALLFGGVSQTLAVGLYvaaaLGIGGG 300
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFT-LAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY----LLATSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089117791 301 AMVISATVLEHVFGGAALVALCTLMMDACERDDAGADYTLLASAVVATQGLAGFAGAAVGDVLGYSAAFTIGMVLSGLGC 380
Cdd:cd17489 85 ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLAL 164
|
...
gi 1089117791 381 AVL 383
Cdd:cd17489 165 LLV 167
|
|
| |
