|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
94-344 |
3.44e-61 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 200.93 E-value: 3.44e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 94 EIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRL 173
Cdd:COG5002 136 LRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERL 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 174 STLFDDMTHIITLNTGK-TYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALK 252
Cdd:COG5002 216 SRLVNDLLDLSRLESGElKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIK 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 253 FSNVGSRIDINISENKDQdtIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSS 332
Cdd:COG5002 296 YTPEGGTITVSLREEDDQ--VRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVES 373
|
250
....*....|..
gi 1106261775 333 DIDVGTTMTVTL 344
Cdd:COG5002 374 EPGKGTTFTITL 385
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
108-344 |
1.01e-59 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 192.04 E-value: 1.01e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 108 EITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDMTHIITLN 187
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 188 TGK-TYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISE 266
Cdd:COG2205 81 SGKlSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1106261775 267 NKDQdtIDIAISDEGIGIIPELQERIFERTFRVENSRNtkTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:COG2205 161 EGDG--VRISVSDNGPGIPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
120-344 |
4.91e-55 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 183.19 E-value: 4.91e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 120 QQEKTELIQNLAHDLKTPLASIISYSEGLRDgiiTKDHEIKESYDILIKQANRLSTLFDDMTHIITLNTGK-TYPPELIQ 198
Cdd:COG0642 107 NEAKSRFLANVSHELRTPLTAIRGYLELLLE---ELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKlELEPEPVD 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 199 LDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISEnkDQDTIDIAIS 278
Cdd:COG0642 184 LAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR--EGDRVRISVE 261
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1106261775 279 DEGIGIIPELQERIFERTFRVENSRntKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:COG0642 262 DTGPGIPPEDLERIFEPFFRTDPSR--RGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
239-344 |
8.98e-32 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 115.01 E-value: 8.98e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSRIDINISENKDQDTIDiaISDEGIGIIPELQERIFERTFRVENSRntKTGGSGLGLYIAN 318
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLE--VEDNGPGIPEEDLERIFERFYRGDKSR--EGGGTGLGLAIVR 76
|
90 100
....*....|....*....|....*.
gi 1106261775 319 ELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd00075 77 RIVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
125-344 |
2.41e-31 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 122.38 E-value: 2.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 125 ELIQNLAHDLKTPLASIISYSE----GLRDGIITKDHEIKESYDILIKQANRLSTLFDDMthiitLNTGKTYPPEL--IQ 198
Cdd:COG5000 203 ELARRIAHEIKNPLTPIQLSAErlrrKLADKLEEDREDLERALDTIIRQVDRLKRIVDEF-----LDFARLPEPQLepVD 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 199 LDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISENKDQdtIDIAIS 278
Cdd:COG5000 278 LNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGR--VRIEVS 355
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1106261775 279 DEGIGIIPELQERIFERTFrvensrNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:COG5000 356 DNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
108-344 |
3.81e-30 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 120.28 E-value: 3.81e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 108 EITQQMNQIKSEQQEKTELIQNL--------------AHDLKTPLASIISYSEGLRDGIITK-DHEIKESYDILIKQANR 172
Cdd:COG4251 253 ELLELRLELEELEEELEERTAELersneeleqfayvaSHDLREPLRKISGFSQLLEEDYGDKlDEEGREYLERIRDAAER 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 173 LSTLFDDMTHIITLNTgKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAfyqYRTPLERILTNLLDNALK 252
Cdd:COG4251 333 MQALIDDLLAYSRVGR-QELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRG---DPTLLRQVFQNLISNAIK 408
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 253 FSNVGSRIDINISENKDQDTIDIAISDEGIGIIPELQERIFErTFRVENSRNtKTGGSGLGLYIANELAQQNNAKISVSS 332
Cdd:COG4251 409 YSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFE-IFQRLHSRD-EYEGTGIGLAIVKKIVERHGGRIWVES 486
|
250
....*....|..
gi 1106261775 333 DIDVGTTMTVTL 344
Cdd:COG4251 487 EPGEGATFYFTL 498
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
236-346 |
4.41e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 110.82 E-value: 4.41e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 236 RTPLERILTNLLDNALKFSNVGSRIDINISenKDQDTIDIAISDEGIGIIPELQERIFERTFRVENsRNTKTGGSGLGLY 315
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLE--RDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 1106261775 316 IANELAQQNNAKISVSSDIDVGTTMTVTLHK 346
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
94-344 |
3.31e-29 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 115.28 E-value: 3.31e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 94 EIYELNQSFNKMASEITQQMNQIksEQQEKT----ELIQNLAHDLKTPLASIISYSEGLRDGI--ITKDHEIKESYDILI 167
Cdd:COG4191 111 ELERDITELERAEEELRELQEQL--VQSEKLaalgELAAGIAHEINNPLAAILGNAELLRRRLedEPDPEELREALERIL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 168 KQANRLSTLFDDMTHIITLNTGKtypPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLERILTNLL 247
Cdd:COG4191 189 EGAERAAEIVRSLRAFSRRDEEE---REPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLL 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 248 DNALK-FSNVGSRIdINISENKDQDTIDIAISDEGIGIIPELQERIFERTFrvensrNTK--TGGSGLGLYIANELAQQN 324
Cdd:COG4191 266 INAIDaMEEGEGGR-ITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF------TTKpvGKGTGLGLSISYGIVEKH 338
|
250 260
....*....|....*....|
gi 1106261775 325 NAKISVSSDIDVGTTMTVTL 344
Cdd:COG4191 339 GGRIEVESEPGGGTTFTITL 358
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
108-344 |
2.05e-26 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 107.62 E-value: 2.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 108 EITQQMNQikSEQQEKT-ELIQNLAHDLKTPLASIISYSEGLRDGIitKDHEIKESYDILIKQANRLSTLFDDMthiitL 186
Cdd:COG3852 121 RLERELRR--AEKLAAVgELAAGLAHEIRNPLTGIRGAAQLLEREL--PDDELREYTQLIIEEADRLNNLVDRL-----L 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 187 NTGKTYPPEL--IQLDQLLVSILQPYEQRIKHeNRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDI-- 262
Cdd:COG3852 192 SFSRPRPPERepVNLHEVLERVLELLRAEAPK-NIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIrt 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 263 ------NISENKDQDTIDIAISDEGIGIIPELQERIFERTFRvensrnTKTGGSGLGLYIANELAQQNNAKISVSSDIDV 336
Cdd:COG3852 271 rverqvTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFT------TKEKGTGLGLAIVQKIVEQHGGTIEVESEPGK 344
|
....*...
gi 1106261775 337 GTTMTVTL 344
Cdd:COG3852 345 GTTFRIYL 352
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
107-344 |
2.77e-26 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 109.67 E-value: 2.77e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 107 SEITQQMN-QIKSEQQEKT----ELIQNLAHDLKTPLASIISYSEGLRDGiiTKDHEIKESYDILIKQANRLSTLFDDMt 181
Cdd:PRK11360 369 SDLTERKRlQRRVARQERLaalgELVAGVAHEIRNPLTAIRGYVQIWRQQ--TSDPPSQEYLSVVLREVDRLNKVIDQL- 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 182 hiitLNTGKTYPPELIQ--LDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALKFSNVGSR 259
Cdd:PRK11360 446 ----LEFSRPRESQWQPvsLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGK 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 260 IDINISENKDqDTIDIAISDEGIGIIPELQERIFERTFrvensrNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTT 339
Cdd:PRK11360 522 IRIRTWQYSD-GQVAVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTT 594
|
....*
gi 1106261775 340 MTVTL 344
Cdd:PRK11360 595 FTLYL 599
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
236-344 |
5.42e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 100.14 E-value: 5.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 236 RTPLERILTNLLDNALKFSNVGSRIDINISENkdqDTIDIAISDEGIGIIPELQERIFERTFRvenSRNTKTGGSGLGLY 315
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSEG---GELTLTVEDNGIGIPPEDLPRIFEPFST---ADKRGGGGTGLGLS 76
|
90 100
....*....|....*....|....*....
gi 1106261775 316 IANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTL 105
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
74-344 |
1.91e-25 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 106.26 E-value: 1.91e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 74 TKQFANGNYASNdKTFNSPKEIYELNQSFNKMAS--EITQQMNQikseqqektELIQNLAHDLKTPLASIISYSEGLRDG 151
Cdd:PRK10549 199 THKLAAGDFTTR-VTPTSRDELGRLAQDFNQLAStlEKNEQMRR---------DFMADISHELRTPLAVLRGELEAIQDG 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 152 IITKDheiKESYDILIKQANRLSTLFDDMtHIITL-NTGK-TYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEI 229
Cdd:PRK10549 269 VRKFT---PESVASLQAEVGTLTKLVDDL-HQLSLsDEGAlAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSA 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 230 DAFYQyRTPLERILTNLLDNALKFSNVGSRIDIniSENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGG 309
Cdd:PRK10549 345 TVFGD-PDRLMQLFNNLLENSLRYTDSGGSLHI--SAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGG 421
|
250 260 270
....*....|....*....|....*....|....*
gi 1106261775 310 SGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:PRK10549 422 SGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
239-345 |
1.93e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 98.72 E-value: 1.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSrIDINIS---ENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLY 315
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGE-VTLRVSleeEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 1106261775 316 IANELAQQNNAKISVSSDIDVGTTMTVTLH 345
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
90-344 |
4.95e-24 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 102.47 E-value: 4.95e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 90 NSPKEIYELNQSFNKMASEIT---QQMNQIKSeqqekteliqNLAHDLKTPLASIISYSEGLrdgiITKDHEIKESYDIL 166
Cdd:TIGR01386 215 RAPAELRELAQSFNAMLGRLEdafQRLSQFSA----------DLAHELRTPLTNLLGQTQVA----LSQPRTGEEYREVL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 167 ---IKQANRLSTLFDDMTHIITLNTGKTYPP-ELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYrtpLERI 242
Cdd:TIGR01386 281 esnLEELERLSRMVSDMLFLARADNGQLALErVRLDLAAELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQM---FRRA 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 243 LTNLLDNALKFSNVGSRIDINISEnkDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANELAQ 322
Cdd:TIGR01386 358 ISNLLSNALRHTPDGGTITVRIER--RSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIME 435
|
250 260
....*....|....*....|..
gi 1106261775 323 QNNAKISVSSDiDVGTTMTVTL 344
Cdd:TIGR01386 436 AHGGRASAESP-DGKTRFILRF 456
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
127-346 |
5.58e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 99.53 E-value: 5.58e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 127 IQNLAHDLKTPLASIISYSEGLRDGIITKDHE-----IKEsydilikQANRLSTLFDDMTHIITLNTGKT-YPPELIQLD 200
Cdd:PRK11100 260 VQTLTHELKSPLAAIRGAAELLQEDPPPEDRArftgnILT-------QSARLQQLIDRLLELARLEQRQElEVLEPVALA 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 201 QLLVSILQPYEQRIkhENRTLEVNF-CSEI----DAFYqyrtpLERILTNLLDNALKFSNVGSRIDINISenKDQDTIDI 275
Cdd:PRK11100 333 ALLEELVEAREAQA--AAKGITLRLrPDDArvlgDPFL-----LRQALGNLLDNAIDFSPEGGTITLSAE--VDGEQVAL 403
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1106261775 276 AISDEGIGiIPE-LQERIFERTF---RVENSRNtktgGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHK 346
Cdd:PRK11100 404 SVEDQGPG-IPDyALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
58-332 |
2.50e-20 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 91.20 E-value: 2.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 58 IFINPLIQKIKQFNIKTKQFANGNYASNdKTFNSPKEIYELNQSFNKMASEItQQMnqIKSEQQekteLIQNLAHDLKTP 137
Cdd:PRK10604 155 LWMRPHWQDMLKLEAAAQRLGDGHLAER-IHFDEGSSLERLGVAFNQMADNI-NAL--IASKKQ----LIDGIAHELRTP 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 138 LASI---ISYSEGLrdgiiTKDHEIKESYDIlikqaNRLSTLFDDMthiitLNTGKTYPPEL------IQLDQLLVSILQ 208
Cdd:PRK10604 227 LVRLryrLEMSDNL-----SAAESQALNRDI-----GQLEALIEEL-----LTYARLDRPQNelhlsePDLPAWLSTHLA 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 209 pyEQRIKHENRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALKFSnvGSRIDINISENKDQDTIDIAisDEGIGIIPEL 288
Cdd:PRK10604 292 --DIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVE--DDGPGIPPEE 365
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1106261775 289 QERIFERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSS 332
Cdd:PRK10604 366 RERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDE 409
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-344 |
5.74e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 84.49 E-value: 5.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSRIDINISEnkDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIAN 318
Cdd:cd16947 21 LQRILKNLISNAIKYGSDGKFLGMTLRE--DEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITK 98
|
90 100
....*....|....*....|....*.
gi 1106261775 319 ELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16947 99 RLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-344 |
8.27e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 80.45 E-value: 8.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNvgSRIDINISENKDQDTIDIaiSDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIAN 318
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITI--TDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAE 76
|
90 100
....*....|....*....|....*.
gi 1106261775 319 ELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16949 77 RAIEQHGGKIKASNRKPGGLRVRIWL 102
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-344 |
2.02e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 79.81 E-value: 2.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSRIDINISENKDQDTIDIAisDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIAN 318
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVE--DSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICH 82
|
90 100
....*....|....*....|....*.
gi 1106261775 319 ELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16946 83 NIALAHGGTISAEHSPLGGLRLVLTL 108
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
242-344 |
2.85e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 79.25 E-value: 2.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 242 ILTNLLDNALKFSNVGSRIDINISENKDQdtIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTgGSGLGLYIANELA 321
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQG--VVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE-STGMGLYLVKKLC 85
|
90 100
....*....|....*....|...
gi 1106261775 322 QQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITF 108
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
236-344 |
8.01e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 78.22 E-value: 8.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 236 RTPLERILTNLLDNALKFSNVGSRIDINISEnkdQDTIDIAISDEGIGIIPELQERIFERTFRvenSRNTKTGGSGLGLY 315
Cdd:cd16940 11 ALLLFLLLRNLVDNAVRYSPQGSRVEIKLSA---DDGAVIRVEDNGPGIDEEELEALFERFYR---SDGQNYGGSGLGLS 84
|
90 100
....*....|....*....|....*....
gi 1106261775 316 IANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16940 85 IVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-344 |
1.06e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 77.43 E-value: 1.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSRIDINISEnkDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNtkTGGSGLGLYIAN 318
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFL--TDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAK 76
|
90 100
....*....|....*....|....*.
gi 1106261775 319 ELAQQNNAKISVSSDiDVGTTMTVTL 344
Cdd:cd16923 77 AIIELHGGSASAEYD-DNHDLFKVRL 101
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
107-346 |
1.33e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 82.97 E-value: 1.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 107 SEITQQMNQIKSeQQEKTELIQNLAHDLKTPLASIISYSEglrdgiitkdheiKESYDILIKQANRLSTLFDDMTHIITL 186
Cdd:COG3290 174 TELERLEEELEG-VKELAEALRAQRHDFRNHLHTISGLLQ-------------LGEYDEALEYIDEISEELQELIDSLLS 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 187 NTGktyppeliqlDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLERILTNLLDNAL----KFSNVGSRIDI 262
Cdd:COG3290 240 RIG----------NPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVEL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 263 NISEnkDQDTIDIAISDEGIGIIPELQERIFERTFRvensrnTKTG-GSGLGLYIANELAQQNNAKISVSSDIDVGTTMT 341
Cdd:COG3290 310 SIRD--DGDELVIEVEDSGPGIPEELLEKIFERGFS------TKLGeGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFT 381
|
....*
gi 1106261775 342 VTLHK 346
Cdd:COG3290 382 VRLPK 386
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
107-344 |
1.93e-17 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 82.31 E-value: 1.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 107 SEITQQMNQIKSE----QQEKTELIQNL----------AHDLKTPL--ASIIsySEGLRDGIITKDHEIKESY-DILIKQ 169
Cdd:PRK09303 121 GRYSQELLQLSDElfvlRQENETLLEQLkfkdrvlamlAHDLRTPLtaASLA--LETLELGQIDEDTELKPALiEQLQDQ 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 170 ANRlstLFDDMTHIIT--LNTGKTYPPEL------IQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLER 241
Cdd:PRK09303 199 ARR---QLEEIERLITdlLEVGRTRWEALrfnpqkLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQ 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 242 ILTNLLDNALKFSNVGSRIDINISENKDQdTIDIAISDEGIGIIPELQERIFERTFRVenSRNTKTGGSGLGLYIANELA 321
Cdd:PRK09303 276 VLLNLLDNAIKYTPEGGTITLSMLHRTTQ-KVQVSICDTGPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSVCRRIV 352
|
250 260
....*....|....*....|...
gi 1106261775 322 QQNNAKISVSSDIDVGTTMTVTL 344
Cdd:PRK09303 353 RVHYGQIWVDSEPGQGSCFHFTL 375
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
239-344 |
6.40e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 75.61 E-value: 6.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSRIDINISENkDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIAN 318
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILEKF-RLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVK 83
|
90 100
....*....|....*....|....*.
gi 1106261775 319 ELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16925 84 EFVELHGGTVTVSDAPGGGALFQVEL 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
92-347 |
1.32e-16 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 80.59 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 92 PKEIYELNQSFNKMASEI----TQQMNqikseqqekteLIQNLAHDLKTPLASIISYSEGlrdgIITKDHEIKESYDIL- 166
Cdd:PRK09835 238 PIELEQLVLSFNHMIERIedvfTRQSN-----------FSADIAHEIRTPITNLITQTEI----ALSQSRSQKELEDVLy 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 167 --IKQANRLSTLFDDMTHIITLNTGKTYPPEL-IQLDQLLVSILQPYEQRIkhENRTLEVNFCSEIDAFYQYRTPLERIL 243
Cdd:PRK09835 303 snLEELTRMAKMVSDMLFLAQADNNQLIPEKKmLDLADEVGKVFDFFEAWA--EERGVELRFVGDPCQVAGDPLMLRRAI 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 244 TNLLDNALKFSNVGSRIDINISENkdQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANELAQQ 323
Cdd:PRK09835 381 SNLLSNALRYTPAGEAITVRCQEV--DHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVA 458
|
250 260
....*....|....*....|....
gi 1106261775 324 NNAKISVSSDIDvGTTMTVTLHKL 347
Cdd:PRK09835 459 HKGTVAVTSDAR-GTRFVISLPRL 481
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
119-344 |
1.51e-16 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 80.40 E-value: 1.51e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 119 EQQEKT----ELIQNLAHDLKTPLASIISYSEGLRDgiiTKDHEIKESYDILIKQANRlstlfddMTHIIT----LNTGK 190
Cdd:COG5809 262 RKSEKLsvvgELAAGIAHEIRNPLTSLKGFIQLLKD---TIDEEQKTYLDIMLSELDR-------IESIISeflvLAKPQ 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 191 TYPPELIQLDQLL---VSILQPyeQRIkHENRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISEn 267
Cdd:COG5809 332 AIKYEPKDLNTLIeevIPLLQP--QAL-LKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKA- 407
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1106261775 268 KDQDTIDIAISDEGIGIIPELQERIFERTFrvensrNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:COG5809 408 EDDDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
78-344 |
5.15e-16 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 78.82 E-value: 5.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 78 ANGNYASNDKTFNSPKEIYELNQSFNKMaseiTQQMNQIKSEQQEkteLIQNLAHDLKTPLASIisyseGLRDGIITKDH 157
Cdd:PRK09470 205 AQGNLRQHPELETGPQEFRQAGASFNQM----VTALERMMTSQQR---LLSDISHELRTPLTRL-----QLATALLRRRQ 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 158 -EIKESYDILIkQANRLSTLFDD------MTHIITLNTgktyppELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEID 230
Cdd:PRK09470 273 gESKELERIET-EAQRLDSMINDllvlsrNQQKNHLER------ETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPW 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 231 AFYQYRTPLERILTNLLDNALKFSNvgSRIDINISEnkDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGS 310
Cdd:PRK09470 346 PINGNPNALASALENIVRNALRYSH--TKIEVAFSV--DKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGT 421
|
250 260 270
....*....|....*....|....*....|....
gi 1106261775 311 GLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:PRK09470 422 GLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWL 455
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
94-331 |
6.05e-16 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 78.41 E-value: 6.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 94 EIYELNQSFNKMASeitqqmnQIKSEQQEKTELIQNLAHDLKTPLASIISYSEG-------LRDGIITkdheikesyDIl 166
Cdd:PRK09467 207 EVRSVTRAFNQMAA-------GIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMmseedgyLAESINK---------DI- 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 167 ikqanrlstlfDDMTHIIT-----LNTGKTYPPELIQLDQLLVSILQ---PYEQRIkhenrtlEVNFCSEIDAFYQYRTP 238
Cdd:PRK09467 270 -----------EECNAIIEqfidyLRTGQEMPMEMADLNALLGEVIAaesGYEREI-------ETALQPGPIEVPMNPIA 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNvGsriDINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKtgGSGLGLYIAN 318
Cdd:PRK09467 332 IKRALANLVVNAARYGN-G---WIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVK 405
|
250
....*....|...
gi 1106261775 319 ELAQQNNAKISVS 331
Cdd:PRK09467 406 RIVDQHNGKVELG 418
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
90-343 |
3.55e-15 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 76.21 E-value: 3.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 90 NSPKEIYELNQSFNKMaseitqqmnqIKSEQQEKTEL---IQNLAHDLKTPLASIISYSEGLRDGiitKDHEIKESYDIL 166
Cdd:PRK10815 240 NPPRELTSLVRNLNRL----------LKNERERYTKYrttLTDLTHSLKTPLAVLQSTLRSLRSG---KQMSVEQAEPIM 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 167 IKQANRLSTLFDDMTHIITLNTGKT-YPPEL----IQLDQLLVSILQPYeQRiKHENRTL----EVNFCSEIDAFYQyrt 237
Cdd:PRK10815 307 LEQISRISQQIGYYLHRASMRSEHNlLSRELhsvaPLLDNLTSALNKVY-QR-KGVNITLdispEITFVGEKNDFME--- 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 238 plerILTNLLDNA----LKFsnvgsridINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNtktgGSGLG 313
Cdd:PRK10815 382 ----VMGNVLDNAckycLEF--------VEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLG 445
|
250 260 270
....*....|....*....|....*....|
gi 1106261775 314 LYIANELAQQNNAKISVSSDIDVGTTMTVT 343
Cdd:PRK10815 446 LSVAREITEQYEGKISAGDSPLGGARMEVI 475
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
121-345 |
4.57e-15 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 76.52 E-value: 4.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 121 QEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDheiKESYDILIK-QANRLSTLFDDmthIITLN------------ 187
Cdd:PRK11091 281 RDKTTFISTISHELRTPLNGIVGLSRILLDTELTAE---QRKYLKTIHvSAITLGNIFND---IIDMDkmerrklqldnq 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 188 ----TGktYPPELIQLDQLLVsilQPYEQRIKHEnRTLEVNFCSEIDAfyqyrTPLERILTNLLDNALKFSNVGSRIDIN 263
Cdd:PRK11091 355 pidfTD--FLADLENLSGLQA---EQKGLRFDLE-PLLPLPHKVITDG-----TRLRQILWNLISNAVKFTQQGGVTVRV 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 264 ISENKDQDTIDIaiSDEGIGIIPELQERIFERTFRVENSRNTKTG-GSGLGLYIANELAQQNNAKISVSSDIDVGTTMTV 342
Cdd:PRK11091 424 RYEEGDMLTFEV--EDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTL 501
|
...
gi 1106261775 343 TLH 345
Cdd:PRK11091 502 TIH 504
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
98-344 |
4.83e-14 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 73.15 E-value: 4.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 98 LNQSFNKMASEITQQMNQIKSEQQEK----TELIQN-----LAHDLKTPLASIISYSEglrdgIITKDHEIKESYDIliK 168
Cdd:PRK10490 630 LLETFTLLIANALERLTLTASEEQARlaseREQLRNallaaLSHDLRTPLTVLFGQAE-----ILTLDLASEGSPHA--R 702
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 169 QAN----------RLSTLFDDMTHI----ITLNTgktyppELIQLDQLLVSILQPYEQRIKheNRTLEVNFCSEIDAFYQ 234
Cdd:PRK10490 703 QASeirqqvlnttRLVNNLLDMARIqsggFNLRK------EWLTLEEVVGSALQMLEPGLS--GHPINLSLPEPLTLIHV 774
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 235 YRTPLERILTNLLDNALKFSnvGSRIDINISENKDQDTIDIAISDEGIGIIPELQERIFERtFrvenSRNTKTG---GSG 311
Cdd:PRK10490 775 DGPLFERVLINLLENAVKYA--GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDK-F----ARGNKESaipGVG 847
|
250 260 270
....*....|....*....|....*....|...
gi 1106261775 312 LGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:PRK10490 848 LGLAICRAIVEVHGGTIWAENRPEGGACFRVTL 880
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-341 |
4.99e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 67.61 E-value: 4.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSRIDINISenKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIAN 318
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWS--QEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVK 78
|
90 100
....*....|....*....|...
gi 1106261775 319 ELAQQNNAKISVSSDIDVGTTMT 341
Cdd:cd16952 79 HVMSRHDARLLIASELGKGSRFT 101
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
125-344 |
9.28e-14 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 72.07 E-value: 9.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 125 ELIQNLAHDLKTPLASIISYSEGLRDGIITKDHeikeSYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLV 204
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEE----YFDIMLSELDRIESIISEFLALAKPQAVNKEKENINELIQDVV 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 205 SILQPyeQRIKHeNRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISENkdQDTIDIAISDEGIGI 284
Cdd:COG5805 365 TLLET--EAILH-NIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEE--DNSVIIRVIDEGIGI 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 285 IPELQERIFERTFrvensrNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:COG5805 440 PEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-322 |
9.40e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 66.68 E-value: 9.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNvgSRIDINISENKDQDTIDIaiSDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIAN 318
Cdd:cd16939 1 MARALDNLLRNALRYAH--RTVRIALLVSGGRLTLIV--EDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVH 76
|
....
gi 1106261775 319 ELAQ 322
Cdd:cd16939 77 RVAL 80
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-344 |
1.14e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 66.20 E-value: 1.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFS--NVGSRIDINISENKDQDTidIAISDEGIGIIPELQERIFeRTFRVENSRNtKTGGSGLGLYI 316
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWT--FYVRDNGIGIDPEYAEKVF-GIFQRLHSRE-EYEGTGVGLAI 76
|
90 100
....*....|....*....|....*...
gi 1106261775 317 ANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16921 77 VRKIIERHGGRIWLESEPGEGTTFYFTL 104
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
103-344 |
1.36e-13 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 71.98 E-value: 1.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 103 NKMAsEITQQMNQIKSEQQE----KTELIQNLAHDLKTPLASIISYSEGLRDGIIT-KDHEIKE-----SYDILIKQANR 172
Cdd:PRK15347 375 NKVA-ERTQALAEAKQRAEQankrKSEHLTTISHEIRTPLNGVLGALELLQNTPLTaEQMDLADtarqcTLSLLAIINNL 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 173 LstlfdDMTHI----ITLNTGKTYPPELiqLDQLLVSI-LQPYEQRIkhenrTLEVNFCSEIDA-FYQYRTPLERILTNL 246
Cdd:PRK15347 454 L-----DFSRIesgqMTLSLEETALLPL--LDQAMLTIqGPAQSKSL-----TLRTFVGAHVPLyLHLDSLRLRQILVNL 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 247 LDNALKFSNVGSridINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVEnsrnTKTGGSGLGLYIANELAQQNNA 326
Cdd:PRK15347 522 LGNAVKFTETGG---IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD----THSQGTGLGLTIASSLAKMMGG 594
|
250
....*....|....*...
gi 1106261775 327 KISVSSDIDVGTTMTVTL 344
Cdd:PRK15347 595 ELTLFSTPGVGSCFSLVL 612
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
106-344 |
2.32e-13 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 70.42 E-value: 2.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 106 ASEITQqMNQIKSEQQEkteLIQNLAHDLKTPLASIISYSEglrdgiITKDHEI-----KESYDILIKQANRLSTLfddM 180
Cdd:PRK11006 191 ARDVTQ-MHQLEGARRN---FFANVSHELRTPLTVLQGYLE------MMQDQPLegalrEKALHTMREQTQRMEGL---V 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 181 THIITLNTGKTYPpeLIQLDQ-----LLVSILQPYEQRIKHENRTLEVNFCSEIDAF---YQYRTPLerilTNLLDNALK 252
Cdd:PRK11006 258 KQLLTLSKIEAAP--TIDLNEkvdvpMMLRVLEREAQTLSQGKHTITFEVDNSLKVFgneDQLRSAI----SNLVYNAVN 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 253 FSNVGSRIDIniSENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSS 332
Cdd:PRK11006 332 HTPEGTHITV--RWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIES 409
|
250
....*....|..
gi 1106261775 333 DIDVGTTMTVTL 344
Cdd:PRK11006 410 EVGKGTRFSFVL 421
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
123-344 |
2.79e-13 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 70.92 E-value: 2.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 123 KTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIkESYDILIKQANRLSTLFDDMTHIITLNTGK-TYPPELIQLDQ 201
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRV-EAISLAYATGQSLLGLIGEILDVDKIESGNyQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 202 LLVSILQPYEQRIKHENRTLEvnfCSEI--DAFYQYRTP--LERILTNLLDNALKFSNVGS-RIDINISENKDQDT-IDI 275
Cdd:PRK09959 791 LVQNTCHSFGAIAASKSIALS---CSSTfpDHYLVKIDPqaFKQVLSNLLSNALKFTTEGAvKITTSLGHIDDNHAvIKM 867
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1106261775 276 AISDEGIGIIPELQERIFERTFRVENSRntKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:PRK09959 868 TIMDSGSGLSQEEQQQLFKRYSQTSAGR--QQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
109-332 |
3.86e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 69.34 E-value: 3.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 109 ITQQMNQiKSEQQEKTELIQNLAHDLKTPLAsiisyseGLRDG--IITK---DHEIKESYDILIKQANRLSTLFDDMThi 183
Cdd:PRK11073 117 LSQEQLQ-HAQQVAARDLVRGLAHEIKNPLG-------GLRGAaqLLSKalpDPALTEYTKVIIEQADRLRNLVDRLL-- 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 184 itlntGKTYPPELIQldQLLVSILQPYEQRIKHE---NRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALK-FSNVGSR 259
Cdd:PRK11073 187 -----GPQRPGTHVT--ESIHKVAERVVQLVSLElpdNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQaLGPEGGT 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 260 I--------DINISENKDQDTIDIAISDEGIGIIPELQERIFERTFrvensrNTKTGGSGLGLYIANELAQQNNAKISVS 331
Cdd:PRK11073 260 ItlrtrtafQLTLHGERYRLAARIDIEDNGPGIPPHLQDTLFYPMV------SGREGGTGLGLSIARNLIDQHSGKIEFT 333
|
.
gi 1106261775 332 S 332
Cdd:PRK11073 334 S 334
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
236-344 |
4.00e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 64.75 E-value: 4.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 236 RTPLERILTNLLDNALKFSNVGSRIDINISENKDQdtIDIAISDEGIGIIPELQERIFERTFrvensrNTKTGGS--GLG 313
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQ--VLIEVEDTGSGIDPEILGRIFDPFF------TTKPVGEgtGLG 72
|
90 100 110
....*....|....*....|....*....|.
gi 1106261775 314 LYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16943 73 LSLSYRIIQKHGGTIRVASVPGGGTRFTIIL 103
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
121-344 |
4.24e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 70.32 E-value: 4.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 121 QEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHE-----IKESYDILikqanrLSTLFD--DMTHIITLNTGKTYP 193
Cdd:PRK11466 442 QAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRddlraITDSGESL------LTILNDilDYSAIEAGGKNVSVS 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 194 PELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQyRTP--LERILTNLLDNALKFSNVGSridINISENKDQD 271
Cdd:PRK11466 516 DEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPTALM-GDPrrIRQVITNLLSNALRFTDEGS---IVLRSRTDGE 591
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1106261775 272 TIDIAISDEGIGIIPELQERIFERTFRVENSRntktGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:PRK11466 592 QWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRL 660
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
2-344 |
5.30e-13 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 69.66 E-value: 5.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 2 VLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQK-IKQFNIKTKQFANG 80
Cdd:COG2972 119 LLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRpIKRLKKAMKKVEKG 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 81 NYASNDktFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTEL-IQNLA-----HDLKTPLASIISYseglrdgiit 154
Cdd:COG2972 199 DLVRLE--VSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAeLKALQaqinpHFLFNTLNSIRWL---------- 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 155 kdheikesydILIKQANRLSTLFDDMTHI--ITLNTGKTYPPELIQLDQL--LVSIlqpyeQRIKHENRtLEVNFcsEID 230
Cdd:COG2972 267 ----------AELEDPEEAEEMLEALSKLlrYSLSKGDELVTLEEELELIksYLEI-----QKLRFGDR-LEVEI--EID 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 231 -AFYQYRTPLeRILTNLLDNALK--FSNVGSRIDINISENKDQDTIDIAISDEGIGIIPELQERIFERTfrvensrNTKT 307
Cdd:COG2972 329 eELLDLLIPK-LILQPLVENAIEhgIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKG 400
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1106261775 308 GGSGLGLYIANE---LAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:COG2972 401 EGRGIGLRNVRErlkLYYGEEYGLEIESEPGEGTTVTIRI 440
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
236-344 |
2.21e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 63.42 E-value: 2.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 236 RTPLER-----ILTNLLDNALKFSNvgSRIDINISenKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNtktgGS 310
Cdd:cd16954 30 RFPGERndlmeLLGNLLDNACKWCL--EFVEVTAR--QTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQ 101
|
90 100 110
....*....|....*....|....*....|....
gi 1106261775 311 GLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16954 102 GLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-331 |
3.12e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 62.08 E-value: 3.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNvgsrIDINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNtkTGGSGLGLYIAN 318
Cdd:cd16950 1 LKRVLSNLVDNALRYGG----GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQ 74
|
90
....*....|...
gi 1106261775 319 ELAQQNNAKISVS 331
Cdd:cd16950 75 RISDAHGGSLTLA 87
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
120-344 |
3.13e-12 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 67.12 E-value: 3.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 120 QQEKTELIQNLA----HDLKTPLASIISYSE--GLRDGIITKDHEIKEsydILIKQANRLSTLFDDMTHIitlntgkTYP 193
Cdd:PRK10364 230 RKEKLVALGHLAagvaHEIRNPLSSIKGLAKyfAERAPAGGEAHQLAQ---VMAKEADRLNRVVSELLEL-------VKP 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 194 PEL----IQLDQLLVSILQPYEQriKHENRTLEVNF-----CSEIDAfyqyrTP--LERILTNLLDNALKFSNVGSRIDI 262
Cdd:PRK10364 300 THLalqaVDLNDLINHSLQLVSQ--DANSREIQLRFtandtLPEIQA-----DPdrLTQVLLNLYLNAIQAIGQHGVISV 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 263 NISENKDQdtIDIAISDEGIGIIPELQERIFERTFrvensrNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTV 342
Cdd:PRK10364 373 TASESGAG--VKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
|
..
gi 1106261775 343 TL 344
Cdd:PRK10364 445 WL 446
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
239-350 |
3.69e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 67.57 E-value: 3.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSrIDINI---SENKDQDTIDIAISDEGIGIIPELQERIFErTFR-VENSRNTKTGGSGLGL 314
Cdd:PRK11107 409 LQQIITNLVGNAIKFTESGN-IDILVelrALSNTKVQLEVQIRDTGIGISERQQSQLFQ-AFRqADASISRRHGGTGLGL 486
|
90 100 110
....*....|....*....|....*....|....*.
gi 1106261775 315 YIANELAQQNNAKISVSSDIDVGTTMTVTLhKLDIT 350
Cdd:PRK11107 487 VITQKLVNEMGGDISFHSQPNRGSTFWFHL-PLDLN 521
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
242-344 |
7.42e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 61.15 E-value: 7.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 242 ILTNLLDNALKFS----NVGSRIDINISEnkDQDTIDIAISDEGIGIIPELQERIFERTFrvensrNTK-TGGSGLGLYI 316
Cdd:cd16915 4 IVGNLIDNALDALaatgAPNKQVEVFLRD--EGDDLVIEVRDTGPGIAPELRDKVFERGV------STKgQGERGIGLAL 75
|
90 100
....*....|....*....|....*...
gi 1106261775 317 ANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16915 76 VRQSVERLGGSITVESEPGGGTTFSIRI 103
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-330 |
1.47e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 60.55 E-value: 1.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSriDINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTgGSGLGLYIAN 318
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGG--LIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQ 81
|
90
....*....|..
gi 1106261775 319 ELAQQNNAKISV 330
Cdd:cd16945 82 EVAQLHGGRITL 93
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
120-180 |
5.89e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 57.61 E-value: 5.89e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1106261775 120 QQEKTELIQNLAHDLKTPLASIISYSEGLRDGiITKDHEIKESYDILIKQANRLSTLFDDM 180
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEE-LLDDEEQREYLERIREEAERLLRLINDL 60
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
242-344 |
1.41e-10 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 62.24 E-value: 1.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 242 ILTNLLDNALK-FSNVGSRiDINISENKDQDTIDIAISDEGIGIIPELQERIFERTFrvensrNTKTGGSGLGLYIANEL 320
Cdd:PRK11086 437 ILGNLIENALEaVGGEEGG-EISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQS 509
|
90 100
....*....|....*....|....
gi 1106261775 321 AQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:PRK11086 510 VENLGGSIAVESEPGVGTQFFVQI 533
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
245-322 |
3.01e-10 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 61.20 E-value: 3.01e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1106261775 245 NLLDNALKFSNVGSRIDINISENKdqdtidIAISDEGIGIIPELQERIFERTFRVENSRNTktgGSGLGLYIANELAQ 322
Cdd:PRK10337 359 NLLDNAIRYSPQGSVVDVTLNARN------FTVRDNGPGVTPEALARIGERFYRPPGQEAT---GSGLGLSIVRRIAK 427
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
122-180 |
4.96e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 54.91 E-value: 4.96e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1106261775 122 EKTELIQNLAHDLKTPLASIISYSEGLRDGiiTKDHEIKESYDILIKQANRLSTLFDDM 180
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDE--KLDEEQREYLETILRSAERLLRLINDL 57
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
122-180 |
1.85e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 53.34 E-value: 1.85e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1106261775 122 EKTELIQNLAHDLKTPLASIISYSEGLRDGiiTKDHEIKESYDILIKQANRLSTLFDDM 180
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDT--ELSEEQREYLETILREAERLLRLINDL 57
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
239-344 |
2.79e-09 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 58.54 E-value: 2.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSRIDINIS--ENKDQDTID-----------IAISDEGIGIIPELQERIFERTFrvensrNT 305
Cdd:PRK13837 561 LQQVLMNLCSNAAQAMDGAGRVDISLSraKLRAPKVLShgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFF------TT 634
|
90 100 110
....*....|....*....|....*....|....*....
gi 1106261775 306 KTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:PRK13837 635 RAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYL 673
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-320 |
6.94e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 52.96 E-value: 6.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSrIDINISENKDQDTIDIAISDEGIGIIPELQERIFERtFRVENSRNTKTG-GSGLGLYIA 317
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDT-GRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDR-FYTERPANEAFGqHSGLGLSIS 78
|
...
gi 1106261775 318 NEL 320
Cdd:cd16953 79 RQI 81
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
120-345 |
4.06e-08 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 54.94 E-value: 4.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 120 QQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEikESYDILIKQANRLSTLFDDMTHIITLNTGK-TYPPELIQ 198
Cdd:PRK10618 447 QQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQ--PELDQLAEQSDVLVRLVDNIQLLNMLETQDwKPEQELFS 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 199 LDQLLVSILQPYEQRIKHENRTLEVNFcsEIDAFYQY---RTPLERILTNLLDNALKFSNVGsRIDINI-SENKDQDTID 274
Cdd:PRK10618 525 LQDLIDEVLPEVLPAIKRKGLQLLIHN--HLKAEQLRigdRDALRKILLLLLNYAITTTAYG-KITLEVdQDESSPDRLT 601
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1106261775 275 IAISDEGIGIIPELQERIfERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLH 345
Cdd:PRK10618 602 IRILDTGAGVSIKELDNL-HFPFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
237-346 |
1.08e-07 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 53.30 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 237 TPLERILTNLLDNA----LKFSNVGSRIDINISENKDQDTIDIAisDEGIGIIPELQERIFERTFrveNSRNTKTGGSGL 312
Cdd:PRK15053 431 TEFAAIVGNLLDNAfeasLRSDEGNKIVELFLSDEGDDVVIEVA--DQGCGVPESLRDKIFEQGV---STRADEPGEHGI 505
|
90 100 110
....*....|....*....|....*....|....
gi 1106261775 313 GLYIANELAQQNNAKISVSSDIDVGTTMTVTLHK 346
Cdd:PRK15053 506 GLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
239-344 |
1.60e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 49.30 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSRIDINIS-ENKDQDT------------IDIAISDEGIGIIPELQERIFERTFrvensrNT 305
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSnQRVDADYalnyrdlipgnyVCLEVSDTGSGMPAEVLRRAFEPFF------TT 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1106261775 306 KT--GGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16919 75 KEvgKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
239-342 |
1.86e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 53.05 E-value: 1.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSridINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIAN 318
Cdd:PRK10841 563 LQQVISNLLSNAIKFTDTGC---IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICE 639
|
90 100
....*....|....*....|....
gi 1106261775 319 ELAQQNNAKISVSSDIDVGTTMTV 342
Cdd:PRK10841 640 KLINMMDGDISVDSEPGMGSQFTI 663
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-344 |
2.31e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 48.55 E-value: 2.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALK-FSNVGS-RIDINIS-ENKDQDTIDIAISDEGIGIIPELQERIFERTFrvensrNTKTGGSGLGLY 315
Cdd:cd16920 1 IQQVLINLVRNGIEaMSEGGCeRRELTIRtSPADDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLS 74
|
90 100
....*....|....*....|....*....
gi 1106261775 316 IANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTL 103
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-342 |
2.76e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 48.23 E-value: 2.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALKFSNVGSRIDINISEnkDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKtGGSGLGLYIAN 318
Cdd:cd16975 5 LSRALINIISNACQYAPEGGTVSISIYD--EEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYIAK 81
|
90 100
....*....|....*....|....
gi 1106261775 319 ELAQQNNAKISVSSDIDVGTTMTV 342
Cdd:cd16975 82 NLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-332 |
5.24e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 47.78 E-value: 5.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALK-FSNVGSRIDI--------NISENKDQDTIDIAISDEGIGIIPELQERIFERTFrvensrNTKTGG 309
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILrtrtqrqvTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100
....*....|....*....|...
gi 1106261775 310 SGLGLYIANELAQQNNAKISVSS 332
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDS 97
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
89-344 |
1.09e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 50.29 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 89 FNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISyseglrdgII------TKDHEIKES 162
Cdd:COG3920 261 LLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLLRELHHRVKNNLQVVSS--------LLrlqarrADDPEAREA 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 163 YDILIkqaNRLSTLfdDMTHIITLNTGKTyppELIQLDQLLVSILQPYEQRIKHENRTLEVnfcsEIDAFY---QYRTPL 239
Cdd:COG3920 333 LEESQ---NRIQAL--ALVHELLYQSEDW---EGVDLRDYLRELLEPLRDSYGGRGIRIEL----DGPDVElpaDAAVPL 400
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 240 ERILTNLLDNALKF---SNVGSRIDINISenKDQDTIDIAISDEGIGIIPELQERifertfrvensrntktGGSGLGLYI 316
Cdd:COG3920 401 GLILNELVTNALKHaflSGEGGRIRVSWR--REDGRLRLTVSDNGVGLPEDVDPP----------------ARKGLGLRL 462
|
250 260
....*....|....*....|....*...
gi 1106261775 317 ANELAQQNNAKISVSSdiDVGTTMTVTL 344
Cdd:COG3920 463 IRALVRQLGGTLELDR--PEGTRVRITF 488
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
111-344 |
2.28e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 48.08 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 111 QQMNQIKSEQQEKTELIQ-------------NLAHDLktplASIISYSEGLRDGIITKDHEIKESYDILIKQANRLStlf 177
Cdd:COG4585 33 ERAAELERELAARAEEAReeerrriarelhdGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREAL--- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 178 DDMTHIIT-LNtgktyPPELIQLDqlLVSILQPYEQRIKHENR-TLEVNFCSEIDAF-YQYRTPLERILTNLLDNALKFS 254
Cdd:COG4585 106 AELRRLVRgLR-----PPALDDLG--LAAALEELAERLLRAAGiRVELDVDGDPDRLpPEVELALYRIVQEALTNALKHA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 255 NvGSRIDINISEnkDQDTIDIAISDEGIGIIPElqerifertfrvensrntKTGGSGLGLYIANELAQQNNAKISVSSDI 334
Cdd:COG4585 179 G-ATRVTVTLEV--DDGELTLTVRDDGVGFDPE------------------AAPGGGLGLRGMRERAEALGGTLTIGSAP 237
|
250
....*....|
gi 1106261775 335 DVGTTMTVTL 344
Cdd:COG4585 238 GGGTRVRATL 247
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
50-322 |
4.24e-06 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 48.04 E-value: 4.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 50 CLTLLICSIFINPLIQKIKQFNIKTKQFANGNYASNDkTFNSPKEIYELNQSFNKMASEITqqmNQIKSEQQekteLIQN 129
Cdd:PRK10755 72 SLTLLICFQAVRWITRPLAELQKELEARTADNLTPIA-IHSSTLEIEAVTSALNQLVSRLT---STLDQERL----FTAD 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 130 LAHDLKTPLASIISYSEglrdgIITKDHEIKESydILIKqanRLstlfDDMTHII-----------TLNTGKTYPPELIQ 198
Cdd:PRK10755 144 VAHELRTPLAGIRLHLE-----LLEKQHHIDVA--PLIA---RL----DQMMHTVeqllqlaragqSFSSGHYQTVKLLE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 199 -----LDQLLVSILQPYEQRIK--HENRTLEVnfcsEIDAfyqyrTPLERILTNLLDNALKFSNVGSRIDINISEnkDQD 271
Cdd:PRK10755 210 dvilpSQDELSEMLEQRQQTLLlpESAADITV----QGDA-----TLLRLLLRNLVENAHRYSPEGSTITIKLSQ--EDG 278
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1106261775 272 TIDIAISDEGIGiIPELQERIFERTFRVENSRntkTGGSGLGLYIANELAQ 322
Cdd:PRK10755 279 GAVLAVEDEGPG-IDESKCGELSKAFVRMDSR---YGGIGLGLSIVSRITQ 325
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
108-337 |
1.13e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 46.99 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 108 EITQQMNQIKSEQQEKTELIQ------------NLAHDLKTPLASIISYSEGLRDGIItkdheiKESYDILIKQANRLST 175
Cdd:COG4192 406 EIEERKRIEKNLRQTQDELIQaakmavvgqtmtSLAHELNQPLNAMSMYLFSAKKALE------QENYAQLPTSLDKIEG 479
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 176 LFDDMTHIIT--------LNTgktyPPELIQLDQLLVSILQPYEQRIKHENRTLEVNfcSEIDAFYQyRTPLERILTNLL 247
Cdd:COG4192 480 LIERMDKIIKslrqfsrkSDT----PLQPVDLRQVIEQAWELVESRAKPQQITLHIP--DDLMVQGD-QVLLEQVLVNLL 552
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 248 DNALKFSNVGSRIDINISENkdQDTIDIAISDEGIGIipELQERIFERTFrvensrNTKTGGSGLGLYIANELAQQNNAK 327
Cdd:COG4192 553 VNALDAVATQPQISVDLLSN--AENLRVAISDNGNGW--PLVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGD 622
|
250
....*....|
gi 1106261775 328 ISVSSDIDVG 337
Cdd:COG4192 623 LYLASTLERG 632
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
120-341 |
2.22e-05 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 46.20 E-value: 2.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 120 QQEKTELIQNL----AHDLKTPLASIISYSE----GLRDGIITKDhEIKESYDILIKQANRLSTLfddmTH--------- 182
Cdd:PRK13557 156 QAQKMEALGQLtggiAHDFNNLLQVMSGYLDviqaALSHPDADRG-RMARSVENIRAAAERAATL----TQqllafarkq 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 183 -----IITLNTgktyppeliqldqlLVSILQPYEQRIKHENRTLEVNFC-----SEIDafyqyRTPLERILTNLLDNALK 252
Cdd:PRK13557 231 rlegrVLNLNG--------------LVSGMGELAERTLGDAVTIETDLApdlwnCRID-----PTQAEVALLNVLINARD 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 253 FSNVGSRIDINiSENKDQDTID--------------IAISDEGIGIIPELQERIFERTFrvensrNTKT--GGSGLGLYI 316
Cdd:PRK13557 292 AMPEGGRVTIR-TRNVEIEDEDlamyhglppgryvsIAVTDTGSGMPPEILARVMDPFF------TTKEegKGTGLGLSM 364
|
250 260
....*....|....*....|....*
gi 1106261775 317 ANELAQQNNAKISVSSDIDVGTTMT 341
Cdd:PRK13557 365 VYGFAKQSGGAVRIYSEVGEGTTVR 389
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-344 |
5.56e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 41.67 E-value: 5.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 239 LERILTNLLDNALkfSNVGSRID--INISENKDQDTIDIAISDEGIGIIPELQERIFERTFrvensrNTKT--GGSGLGL 314
Cdd:cd16976 1 IQQVLMNLLQNAL--DAMGKVENprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF------TTKPvgKGTGLGL 72
|
90 100 110
....*....|....*....|....*....|
gi 1106261775 315 YIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16976 73 SISYGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
241-344 |
8.96e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 40.61 E-value: 8.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 241 RILTNLLDNALKFSNvGSRIDINISENKDQDTIDIaiSDEGIGIIPElqerifertfrvensrnTKTGGSGLGLYIANEL 320
Cdd:cd16917 3 RIVQEALTNALKHAG-ASRVRVTLSYTADELTLTV--VDDGVGFDGP-----------------APPGGGGFGLLGMRER 62
|
90 100
....*....|....*....|....
gi 1106261775 321 AQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16917 63 AELLGGTLTIGSRPGGGTRVTARL 86
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
249-345 |
9.57e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 44.07 E-value: 9.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 249 NALKFSNvGSRIDINISENKDQDtIDIAISDEGIGiIPELQERIfertfrvensrntktGGSGLGlyIANELAQQNNAKI 328
Cdd:PRK10935 482 NAIKHAN-ASEIAVSCVTNPDGE-HTVSIRDDGIG-IGELKEPE---------------GHYGLN--IMQERAERLGGTL 541
|
90
....*....|....*..
gi 1106261775 329 SVSSDIDVGTTMTVTLH 345
Cdd:PRK10935 542 TISQPPGGGTTVSLTFP 558
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
232-344 |
1.30e-04 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 41.94 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 232 FYQYRTPLERILTNLLDNAL----KFSNVGSRI--DINISENKDQDTIDIAISDEGIGIIPELQERIF------------ 293
Cdd:cd16929 37 FPYVPSHLYYILFELLKNAMratvESHGDDSDDlpPIKVTVAKGDEDLTIKISDRGGGIPREDLARLFsymystapqpsl 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1106261775 294 -ERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16929 117 dDFSDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYL 168
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
236-331 |
5.67e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 39.06 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 236 RTPLERILTNLLDNALK----FSNVGSRIDINISENKDQDtIDIAISDEGIGIIPELQERIFERTFrvensrNTKTGGSG 311
Cdd:cd16944 2 TTQISQVLTNILKNAAEaiegRPSDVGEVRIRVEADQDGR-IVLIVCDNGKGFPREMRHRATEPYV------TTRPKGTG 74
|
90 100
....*....|....*....|
gi 1106261775 312 LGLYIANELAQQNNAKISVS 331
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLS 94
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
237-344 |
7.15e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 36.24 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 237 TPLERILTNLLDNALK--FSNvGSRIDINISENKDQDTIDIAISDEGIGiIPElqerifertfrVENSRNTktggSGLGL 314
Cdd:cd16951 38 TAIGLVVNELLQNALKhaFSD-REGGTITIRSVVDGDYLRITVIDDGVG-LPQ-----------DEDWPNK----GSLGL 100
|
90 100 110
....*....|....*....|....*....|
gi 1106261775 315 YIANELAQQNNAKISVSSDIDVGTTMTVTL 344
Cdd:cd16951 101 QIVRSLVEGELKAFLEVQSAENGTRVNIDI 130
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
50-342 |
7.61e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 38.17 E-value: 7.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 50 CLTLLICSIFINPLIQKIKQFNIKTKQFANGNYaSNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQN 129
Cdd:COG2770 223 LLALLLALLLARRITRPLRRLAEAARRIAAGDL-DVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELAR 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 130 LAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQP 209
Cdd:COG2770 302 LLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEA 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1106261775 210 YEQRIKHENRTLEVNFCSEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISENKDQDTIDIAISDEGIGIIPELQ 289
Cdd:COG2770 382 LALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELE 461
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1106261775 290 ERIFERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTV 342
Cdd:COG2770 462 AEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEG 514
|
|
| |
