|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
5-375 |
1.06e-103 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 311.47 E-value: 1.06e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 5 ALVGLYAAQSITGSMVQSALPVVLRDAGVALDRIGLLSLLFLPWVLKVFWSPLVDRFSTP-----RRWILMCQGLLALSY 79
Cdd:cd17485 1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPrlgrrRSWLLPTQLGLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 80 VIGAAFAPTTQLAALLPVVFVMALLAATQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYARAGWELS 159
Cdd:cd17485 81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 160 MVFLAVAMLLLTLPVRALRIERPEGTT--------KRPSLRHSLKNRTLIRGVGFLLLWQSAVRLGAAMTGPMLVDAGFS 231
Cdd:cd17485 161 LLSLAALYLLLLLPVLFLRELELPQQPpasergaaLKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 232 LDAIGWLRGAGGMITGLIAAVAGTLMCRRFGTRSVLLSAGLGVGACCVGLAIWAVAPGALW--GLATLQLSLSALTAISF 309
Cdd:cd17485 241 LSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNwvLLLASLALLHLVGGMIT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1110199404 310 VALYAEMMNWCAPDQVATDFALLQSLDAGLAVIIGILAGQIAQHLGYAPVFGGAVALLFCALPLVR 375
Cdd:cd17485 321 TALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
9-372 |
7.02e-42 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 151.21 E-value: 7.02e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 9 LYAAQSITGSMVQSALPVVLRDAGVALDRIGLLSLLFLPWVLKVFWSPLVDRFSTP-----RRWILMCQGLLALSYVIGA 83
Cdd:cd17486 4 LGFASGLPYLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDRYSTPflgrrRGWILLTQILLMAALIALA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 84 AFAPTTQLAALLPVVFVMALLAATQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYARAGWelSMVFL 163
Cdd:cd17486 84 FLDPFTNLVLSALLFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSW--SAVYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 164 AVAMLLLTLPVRALRIERPEGT--------TKRPSLRHSLKNRTLIRGVGFLLLWQSAVRLG----AAMTGPMLVDAGFS 231
Cdd:cd17486 162 IMAALMGPGILATLFAPEPPRTdppanslsETVVAFFAPFKDFFGQPGALLILAFILLYKLGdamlGAMATPFLLDLGFT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 232 LDAIGWLRGAGGMITGLIAAVAGTLMCRRFGTRSVLLsaglgvgaccVGLAIWAVAPGALWGLATLQLSLSALTAISFV- 310
Cdd:cd17486 242 KTEIGAVYKTVGLIATIVGGLLGGFLMSRLGLKRSLW----------LFGILQALSNLGFIYLAHAGPNLTLLVAAVAVe 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1110199404 311 ---------ALYAEMMNWCAPDQVATDFALLQSLDAGLAVIIGILAGQIAQHLGYAPVFggaVALLFCALP 372
Cdd:cd17486 312 nfggglgttAFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEALGWTGFF---LLTTLAAIP 379
|
|
| sider_RhtX_FptX |
TIGR02718 |
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ... |
6-376 |
3.43e-27 |
|
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 131765 Cd Length: 390 Bit Score: 111.14 E-value: 3.43e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 6 LVGLYAAQSITGSMVQSALPVVLRDAGVALDRIGLLSLLFLPWVLKVFWSPLVDRFST-----PRRWILMCQGLLALSYV 80
Cdd:TIGR02718 6 LGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNWWSwrlgrRRSWVLPMQCLVSACLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 81 IGAAFAPTTQLAAL-LPVVFVMALLAATQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYARAGWELS 159
Cdd:TIGR02718 86 SLALVGPDVAGAGWaVGLLACASLASATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKFGQRPA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 160 mvFLAVAMLLLTLPVRALRIERPEGTTKRPSLRHS------LKNRTLIRGVGFLLLWQSAVRLGAAMTGPMLVDAGFSLD 233
Cdd:TIGR02718 166 --FLLVACVPLASLVCVLWLKDRAVASPEAPLARRaslfrfFRRPLAWSLLALALLSAMTAVSGFGLSKLYLVDAGWPLE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 234 AIGWLRGAGGMITGLIAAVAGTLMCRRFGTRSVLlsAGLGVGACCVGLAIWAVAPGALWGLATLQLSLSAL----TAISF 309
Cdd:TIGR02718 244 WIGRLGMAGGAVTVLLGCGGGAWLVRRAGLWRTF--ILGVGLAGSLALLWFAQAAFWLAPGIAVAWSCSAFgsliTGITS 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1110199404 310 VALYAEMMNWCA-PDQVATDFALLQSLDAGLAVIIGILAGQIAQHLGYAPVFGGAVALLFCALPLVRR 376
Cdd:TIGR02718 322 VAIYTAFMRFAGdGDQAGTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAILLAVR 389
|
|
| ampG |
PRK11902 |
muropeptide transporter; Reviewed |
32-375 |
3.73e-21 |
|
muropeptide transporter; Reviewed
Pssm-ID: 183369 [Multi-domain] Cd Length: 402 Bit Score: 94.15 E-value: 3.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 32 GVALDRIGLLSLLFLPWVLKVFWSPLVDRFSTP-----RRWILMCQGLLALSYVIGAAFAPTTQLAALLPVVFVMALLAA 106
Cdd:PRK11902 30 GLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPllgrrRGWLLLTQVGLAASIAAMAFCPPHAALWPLAGLAVLVAFLSA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 107 TQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYARA-GWELSMVFLAVAMLLLTL-------PVRALR 178
Cdd:PRK11902 110 SQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLADRVlGWGNTYLLMAGLMLAGALttlwapePEVPAR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 179 IERPEGTTKRPSLRHSLKNRTLIRGVGFLLLWQSAVRLGAAMTGPMLV-DAGFSLDAIGWLRGAGGMITGLIAAVAGTLM 257
Cdd:PRK11902 190 PPRSLGEAVVGPLRDFFSRRGAWALLLLIVLYKLGDAFAGSLSTTFLIrGAGFSAGEVGIVNKTLGLAATIVGALAGGTL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 258 CRRFGTRSVLLSAGLGVGACCVGLAIWAVAPGALWGLAT---LQLSLSALTAISFVALyaeMMNWCAPDQVATDFALLQS 334
Cdd:PRK11902 270 MVRLGLYRSLMLFGVLQAVSNLGYWVLAVTPKHLWTMALaigIENLCGGMGTAAFVAL---LMALCNRSFSATQYALLSA 346
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1110199404 335 LDAGLAVIIGILAGQIAQHLGYAPVFGGAVALLFCALPLVR 375
Cdd:PRK11902 347 LASVGRVYVGPTSGYLVEAYGWPGFYLMTVVIALPGLALLW 387
|
|
| ampG |
PRK11010 |
muropeptide MFS transporter AmpG; |
32-357 |
3.86e-14 |
|
muropeptide MFS transporter AmpG;
Pssm-ID: 182898 [Multi-domain] Cd Length: 491 Bit Score: 73.52 E-value: 3.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 32 GVALDRIGLLSLLFLPWVLKVFWSPLVDRFSTP-----RRWILMCQGLLALSYVIGAAFAPTTQLAALLPVVFVMALLAA 106
Cdd:PRK11010 43 NIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPflgrrRGWLLATQLLLLVAIAAMGFLEPGTQLRWLAALAVVIAFCSA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 107 TQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYAR-AGWElSMVFLAVAMLLLTLpVRALRIERPEGT 185
Cdd:PRK11010 123 SQDIVFDAWKTDVLPAEERGAGAAISVLGYRLAMLVSGGLALWLADRyLGWQ-GMYWLMAALLIPCI-IATLLAPEPTDT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 186 TKRP-SLRHSL----------KNRTLIrgVGFLLLWQSAVRLGAAMTGPMLV-DAGFSLDAIGWLRGAGGMITGLIAAVA 253
Cdd:PRK11010 201 IPVPkTLEQAVvaplrdffgrNNAWLI--LLLIVLYKLGDAFAMSLTTTFLIrGVGFDAGEVGLVNKTLGLLATIVGALY 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 254 GTLMCRRFGTRSVLLSAGLGVGACCVGLAIWAVAPGALWGLAT---LQLSLSALTAISFVALyaeMMNWCAPDQVATDFA 330
Cdd:PRK11010 279 GGILMQRLSLFRALMIFGILQGVSNAGYWLLSITDKNLYSMGAavfFENLCGGMGTAAFVAL---LMTLCNKSFSATQFA 355
|
330 340
....*....|....*....|....*..
gi 1110199404 331 LLQSLDAGLAVIIGILAGQIAQHLGYA 357
Cdd:PRK11010 356 LLSALSAVGRVYVGPVAGWFVEAHGWP 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-358 |
2.01e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 65.31 E-value: 2.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 11 AAQSITGSMVQSALPVVLRD-AGVALDRIGLLslLFLPWVLKVFWSPLV----DRFSTP----RRWILMCQGLLALSYVI 81
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDvLGLSAALVGLI--LLVARLWDAITDPLIgalsDRTRTRwgrrRPWILIGAIPLALSFVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 82 gAAFAPTTQLAALLPVVFVMALLAAT----QDIATDA-AGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYA---- 152
Cdd:COG2211 98 -LFTAPDLSPTGKLIYALVTYLLLGLaytlVNIPYSAlGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAafgg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 153 --RAGWELSMVFLAVAMLLLTLPVRALRIERPEGTTKRPSLRHSL----KNRTLIRGVGFLLLWQSAVRLGAAMTGPMLV 226
Cdd:COG2211 177 daALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLkallKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 227 DA-GFSLDAIGWLrGAGGMITGLIAAVAGTLMCRRFGTRSVLLSAGLGVGACCVGLaiWAVAPGALWGLATLQLSLSALT 305
Cdd:COG2211 257 YVlGLSAALVGLL-LALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL--FFLGPGNLWLLLVLAALAGIGL 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 306 AISFVALYAEMMNWCAPDQVATD------FALLQSLDAGLAVIIG-ILAGQIAQHLGYAP 358
Cdd:COG2211 334 GAILVLPWAMLADVVDYDEWKTGrrreglYFGIFTFAIKLGQALAgALAGLLLALFGYVA 393
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-376 |
2.34e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.52 E-value: 2.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 14 SITGSMVQSALPVVLRDAGVALDRIGLLSLLFL--PWVLKVFWSPLVDRFStprRWILMCQGLLALSyVIGAAFAPTTQL 91
Cdd:cd17325 9 MLGYGIIIPILPLYAESLGASVAQIGLIVAAYAlaQLLFSPPAGRLSDRFG---RKRLLLLGLLLLA-VSTLLFAFATSY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 92 AALLPVVFVMALLAATQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYARAGWElsMVFLAVAML-LL 170
Cdd:cd17325 85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYR--APFLVCAALaLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 171 TLPVRALRIERPEGTTKRPSLRHSLKNRTLIRGVGFLLLWQSAVRLGAAMTGPMLVDAGFSLDA----------IGWLRG 240
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAaelgglspaqIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 241 AGGMITGLIAAVAGTLMcRRFGTRSVLLSAGLGVGACCVGLAIwavaPGALWGLATLQLSLSALTAISFVALYAEMMNWC 320
Cdd:cd17325 243 AQGLASALSQPPAGKLS-DRIGRKPLILIGLLLSAVALLLLPL----ATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1110199404 321 APDQVATDFALLQSLDAGLAVIIGILAGQIAQHLGYAPVFGGAVALLFCALPLVRR 376
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
49-381 |
4.25e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 60.66 E-value: 4.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 49 VLKVFWSPLVDRFStPRRWILMCQGLLALSyVIGAAFAPTtqlaalLPVVFVMALLAATQDIATDAAGVHATTR----QT 124
Cdd:COG2223 55 LLRIPLGFLVDRFG-PRRVLLIGLLLLGIG-LLLLALAVS------YWLLLLLGLLLGIGGGGSFAVGIALVSKwfppDR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 125 RSLASGASTVGGYAGFLIGGGLWLWVYARAGWELSMVFLAVAMLLLTLPVRALRIERPEGTTKRP-----SLRHSLKNRT 199
Cdd:COG2223 127 RGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAkaslrDQLEALRDPR 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 200 LIRGVGFLLLWQSAVRLGAAMTGPMLVDA-GFSLDAIGWLRGAGGMITGLIAAVAGTLmCRRFGTRSVLLSAGLGVGACC 278
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWL-SDRIGGRRVLLIVFALMALGL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 279 VGLAIwavAPGALWGLATLQLSLSALTAISFVALYAEMMNWCAPDQVATDFALLQSLDAGLAVIIGILAGQIAQHLG-YA 357
Cdd:COG2223 286 LLLAL---ALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYT 362
|
330 340
....*....|....*....|....
gi 1110199404 358 PVFGGAVALLFCALPLVRRCMGKP 381
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLYRRP 386
|
|
| Acatn |
pfam13000 |
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ... |
4-137 |
5.32e-10 |
|
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pssm-ID: 372424 [Multi-domain] Cd Length: 543 Bit Score: 60.84 E-value: 5.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 4 FALVGLYAAQSITGSMVQSALPVVLRdaGVALD----RIGLLSLLFLPWVLKVFWSPLVDRFSTP-----RRWILMCQG- 73
Cdd:pfam13000 2 YLLVALYFLQGIPVGLAFGTIPFLLK--SMAKEtsftSLGIFSMATYPYSLKILWSPIVDSIYSKkigrrRSWIIPVQLv 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 74 ----LLALSYVIG---------AAFAP-------TTQLAALLPVVFVMALLAATQDIATDAAGVHATTRQTRSLASGAST 133
Cdd:pfam13000 80 sgimLIILGYCISkglifpgvdDAFHGrlskgvlNVNITTLTWYFGILVFLCATQDIAVDGWALTILSKQSLSYASTAQT 159
|
....*..
gi 1110199404 134 VG---GY 137
Cdd:pfam13000 160 VGlntGY 166
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
6-373 |
5.59e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 60.52 E-value: 5.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 6 LVGLYAAQSITGSMVQSALPVVLRDAGVALDRIGLLSLLFL--PWVLKVFWSPLVDRFStPRRWILMCQGLLALSYVIGA 83
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSlgYALLQPLAGLLADRFG-RRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 84 AFaptTQLAALLPVVFVMALLAATQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGG--GLWLWVYARAGWELSMV 161
Cdd:cd06174 80 FA---PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPllGGILASSLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 162 FLAVAMLLLTLPVRALRIERPEGTTKRP----------SLRHSLKNRTLIRGVGFLLLWQSAVRLGAAMTGPMLVD-AGF 230
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNeeassksvlkLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 231 SLDAIGWLRGAGGMITGLIAAVAGTLMCRRFGTRSVLLSAGLGVGACCVGLAIWAVAPGALWGLATLQLSLSALTAISFV 310
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1110199404 311 ALYAEMmnwcAPDQVATDFALLQSLDAGLAVIIGILAGQI-AQHLGYAPVFGGAVALLFCALPL 373
Cdd:cd06174 317 LIAELF----PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-312 |
1.55e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.83 E-value: 1.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 1 MPAFALVGLYAAQSITGSMVQSALPVVLRDAGVALDRIGLLSLLFL--PWVLKVFWSPLVDRFStPRRWILMCQGLLALS 78
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLlgAALGAPLAGRLADRFG-RRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 79 YVIgAAFAPTtqLAALLPVVFVMALLAATQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYARAGWEL 158
Cdd:COG2814 89 SLL-CALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 159 SMVFLAVAMLLLTLPVRAL--RIERPEGTTKRPSLRHSLKNRTLIRGVGFLLLWQSAVRLGAAMTGPMLVD-AGFSLDAI 235
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLlpESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAA 245
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1110199404 236 GWLRGAGGMITGLIAAVAGTLMcRRFGTRSVLLSAGLGVGACCVGLAIWAVAPGALWGLATLQLSLSALTAISFVAL 312
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLA-DRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
40-370 |
3.67e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.01 E-value: 3.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 40 LLSLLFLPWVLKVFWS-PLVDRFStPRRWILMCQGLLALSYVIGA--AFAPTTQLAALLPVVFVMALLAATQDIATDAAG 116
Cdd:cd06173 39 VLAAFFLPFLLFSPFAgVLADRFD-RRRLLILADLLRALLAAVLAllALLGSLSLWLLLVLAFLLGIASAFFGPARQALL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 117 VHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYARAGWELSMV-----FLAVAMLLLTLPVRALRIERPEGTTKRPSL 191
Cdd:cd06173 118 PELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAinalsFLLSALLLLFIRRPPPAAPGESSSLLLRDL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 192 RHSLKNRTLIRGVGFLLLWQSAVRLGAAMTGPMLV-----DAGFSLDAIGWLRGAGGmITGLIAAVAGTLMCRRFGTRSV 266
Cdd:cd06173 198 REGLRYLRRSPLLRLLLLALALFALLGGALTVLLPllakeVLGGGAAGYGLLLAAFG-VGALLGALLLGRLSKRRRRGRL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 267 LLSAGLGVGACCVGLAiwavAPGALWGLATLQLSLSALTAISFVALYAEMMNWCAPDQVATDFALLQSLDAGLAVIIGIL 346
Cdd:cd06173 277 LLIGALLLGLALLVLG----LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
330 340
....*....|....*....|....
gi 1110199404 347 AGQIAQHLGYAPVFGGAVALLFCA 370
Cdd:cd06173 353 AGLLADALGLSAVFLLAGALLLLA 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
6-335 |
4.50e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.43 E-value: 4.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 6 LVGLYAAQSITGSMVQSALPVVLRDA-GVALDRIGLLSLLFL--PWVLKVFWSPLVDRFStPRRWILMCQGLLALSYVIG 82
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSlgYALAQPLAGRLSDRFG-RRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 83 AAFAPTTQLAALLpvvFVMALLAATQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYARAGWELSMVF 162
Cdd:pfam07690 80 LFASSLWLLLVLR---VLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 163 LAVAMLLLTL--------PVRALRIERPEGTTKRPSLRHSLKNRTLIRGVGFLLLWQSAVRLGAAMTGPMLVDAGFSLDA 234
Cdd:pfam07690 157 LAILSLLAAVllllprppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 235 IGWLRGAGGMITGLIAAVAGTLMcRRFGTRSVLLSAGLGVGACCVGLAIWAVAPGALWGLATLqLSLSALTAISFVALYA 314
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLS-DRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL-LLLGFGFGLVFPALNA 314
|
330 340
....*....|....*....|.
gi 1110199404 315 EMMNWCAPDQVATDFALLQSL 335
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTA 335
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
125-376 |
6.35e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 6.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 125 RSLASGASTVGGYAGFLIGGGLWLWVYARAGWELSMVFLAVAMLLLTLPVRALRIERP---EGTTKRPSLRHSLKNRTLI 201
Cdd:COG2807 139 VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPaaaAAAPAAASLRSLWRSPLAW 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 202 RGVGFLLLwQSAvrLGAAMTG---PMLVDAGFSLDAIGWLrGAGGMITGLIAAVAGTLMCRRFGTRSVLLSAGLGVGAcc 278
Cdd:COG2807 219 LLTLFFGL-QSL--LYYAVVAwlpPILRDAGLSAATAGLL-LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGL-- 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 279 VGLAIWAVAPGALWGLATLQLSLSA----LTAISFVALYAEmmnwcAPDQVATDFALLQSLDAGLAVIIGILAGQIAQHL 354
Cdd:COG2807 293 AGLLGLLLAPGSLPWLWAVLLGLGQgglfPLALTLIGLRAR-----TPAEAAALSGMAQSVGYLLAALGPLLVGALHDAT 367
|
250 260
....*....|....*....|...
gi 1110199404 355 G-YAPVFGGAVALLFCALPLVRR 376
Cdd:COG2807 368 GsWTAALLLLAALAVLMLVAGLL 390
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
39-261 |
3.31e-06 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 48.76 E-value: 3.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 39 GLLSLLFLPWVLKVFWSPLVDRFST----PRRWILMCQGLLALSYVIGAAFAPTTQLAALLpVVFVMALLAATQDIATDA 114
Cdd:cd17484 37 ALTSIASLPWAIKPLYGLLSDSVPIfgyrRKPYLILAGALGALSWLALALVSNSSLALALL-LLLLASLGVAFSDVVIDA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 115 AGVHATTRQTRSLAS-------GASTVGGYAGFLIGGglwlwvYARAGWELSMVFLAVAMLLLTLPVRALRIERPEGTTK 187
Cdd:cd17484 116 LVVEASRGAPQSLAGdlqslcwGSSAIGGIVGSYFSG------YLLELLGPRTVFAVTSFFPLLLLIVAFFVKEERVPPH 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 188 RPSLRHSLKNRTLIRGVG---------FLLLWQSAVRLGAAMTGPMLVDAGFSLDAIGWLRgaggmITGLIAAVAGTLMC 258
Cdd:cd17484 190 RTKENFDEQLKALWETVKqpsiwlpalFIFLYQATPSSGSAMFYFMTNELGFSPEFLGRLR-----VIGSIASLLGVLLY 264
|
...
gi 1110199404 259 RRF 261
Cdd:cd17484 265 NRF 267
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-374 |
1.60e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 4 FALVGLYAAQSITGSMVQSALPVVLRDAGVALDRIGLLSLLFL--PWVLKVFWSPLVDRFStPRRWILMCQGLLALSYvI 81
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFlgYALGQIPAGLLADRFG-RRRVLAIGLLLWGLAT-L 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 82 GAAFAPTtqLAALLPVVFVMALLAATQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIGGGLWLWVYARAGWELSMV 161
Cdd:COG2271 91 LFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 162 FLAVAMLLLTLPvralrierpegttkrpslrhslknrTLIRGVGFLLLWQSAVRLGAAMTGPMLVDA-GFSLDAIGWLrG 240
Cdd:COG2271 169 ILGLPGLLLALL-------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLL-L 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 241 AGGMITGLIAAVAGTLMCRRFGTRSVLLSAGLGVGACCVGLAIWAVapGALWGLATLQLSLSALTAISFVALYAEMMNWC 320
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1110199404 321 APDQVATDFALLQSLDAGLAVIIGILAGQIAQHLGYAPVFGGAVALLFCALPLV 374
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
19-374 |
2.69e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.06 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 19 MVQSALPVVLRDAGVALDRIGLLSLLFLpwVLKVFWSPLVDRFST---PRRWILMCQGLLALSYVI-GAAFAPTTQLAAL 94
Cdd:cd17331 18 LQQPVLPYLTKKLGVDSVVFGYLQTTFS--VLQLVGGPLFGRFGDlfgPRAALVLSFLSSALSYLLlAFASSVPMLFLSR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 95 LPVVFVMALLAAtQDIATDAagvhaTTRQTRSLASG----ASTVGGYAGFLIGGglWLWVY------ARAGWELSMVFLA 164
Cdd:cd17331 96 LPSVFMHAMQAA-QMVVTDL-----TDPGERAAALGrlglSYGIGMVVGSFLGG--LLTKKfgeqaaALVAAVGSLLSIV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 165 VAMLLLTLPVRALRIERPEGTTKRPSLRHSLKNRTLIR--GVGFLLLWQSAVRLGAAMTGPM----LVDA-GFSLDAIGW 237
Cdd:cd17331 168 LVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRlpGVAFLLLVKLLSGLPIGMFQSMfslvAMDFfGLTPEENGY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 238 LRGAGGMITGLIAAVAGTLMCRRFGTRSVLLsagLGVGACCVGLAIWAVAPGALWGLATLqLSLSALTAISFVALYAEMM 317
Cdd:cd17331 248 LMSYAGVLGMVVQGLLVGPLTKRFGERSLLK---LSVALLAIGYLLLAFVTTVWQLLVLL-LPLVIGGSVLYTVITSLLT 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1110199404 318 NWCAPDQVATDFALLQSLDAGLAVIIGILAGQIAQHLGYAPV--FGGAVALLFCALPLV 374
Cdd:cd17331 324 KAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFglLGAAINGLLTVYLLL 382
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
24-373 |
3.86e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.27 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 24 LPVVLRDAGVALDRIGLLSLL--FLPWVLKVFWSPLVDRFSTPRRWILMCQGLLALSYVigAAFAPTTQLAALLPVVFVM 101
Cdd:cd17335 20 LSVYLKQLGLSPTQIGILIGIrpFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFL--SLFFVAQIFWLLLLLVILG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 102 ALLAATQDIATDAAGVHATTRQtrSLASGASTVGGYAGFLIGGGL--WLWVYARAGWELSMVF-LAVAMLLLTLPVRALR 178
Cdd:cd17335 98 AFFSAPVVPLVDSITLQYLGEE--RERYGKQRLWGSIGFGIAALLvgILIDRSSTYKNYTIAFyVFAVLMLLALLLALKF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 179 IERPEGTTKRPSLRHSLKnrtLIRGVGFLLLWQSAVRLGAAMtGPM-------LVDAGFSLDAIGWLRGAGGMITGLIAA 251
Cdd:cd17335 176 PFRPKHPEPNENTGGLLA---LLRNPRVLAFLLVAFLMGFGH-GLIysflfwhLQDLGGSKTLIGLLWTVGVVSEIPFFF 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 252 VAGTLMcRRFGTRSVLLSAGLGVGACCVGLAiWAVAPGALWGLATLQ---LSLSALTAISFVALYAEmmnwcaPDQVATD 328
Cdd:cd17335 252 FSSRLI-QRFGHVGLLYLGLLAYVVRWLLYS-FLENPWLVLPIELLHgltFALVWAAAVSYASAAAP------PGLRATA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1110199404 329 FALLQSLDAGLAVIIG-ILAGQIAQHLGYAPVFGGAVALLFCALPL 373
Cdd:cd17335 324 QGLLQGLYFGLGGGLGsLIGGYLYEAFGARTTFRFFAIAALAGLLA 369
|
|
| BT1 |
pfam03092 |
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ... |
46-184 |
3.00e-04 |
|
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).
Pssm-ID: 308617 Cd Length: 432 Bit Score: 42.72 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 46 LPWVLKVFWSPLVDRF---STPRRWILMCQGLLALSYVIGAAFAPTT--QLAALLPVVFVMALLAATQDIATDAAgVHAT 120
Cdd:pfam03092 36 LPWSIKPLYGMLSDGFalfGYRRRWYLALSGLLGGAFWLLYGLLPASeaSAPVAAAFIFLSSLGVAIVDVLVDAL-VSER 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1110199404 121 TRQTR-------SLASGASTVGGYAGFLIGGGLWLWVYARAGwelsmVFLAVAMLLLTLPVRALRIERPEG 184
Cdd:pfam03092 115 ARQSPtpgpslqSWIWGCSAVGGIIGSVLSGPLLDTFKPQIS-----FFVTAALQLLTCVVALLIKESSLG 180
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
53-317 |
3.92e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.26 E-value: 3.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 53 FWSPLVDRFStPRRWILMCQGLLALSYVIGAAFAPTTQLAALLPVVFVMALLAATQDIATDAAGVHATTRqtRSLASGAS 132
Cdd:cd17355 57 FVGRLLDRFG-PRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERR--RGLALGIL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 133 TVGGYAGFLIGGGLWLWVYARAGWELSMVFLAVAMLLLTLPVRALRIERPEGTTKRPSLRHSLKN-----RTLIRGVGFL 207
Cdd:cd17355 134 TAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASpgstlKEALRSASFW 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 208 LLWQSAVRLGAAMTG------PMLVDAGFSLDAIGWLRGAGGmITGLIAAVAGTLMCRRFGTRSVLLSAGLGVGACCVGL 281
Cdd:cd17355 214 LLALAFFLCGFAVVGlivhlvPYLADRGISPAAAAVALALIG-LFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALL 292
|
250 260 270
....*....|....*....|....*....|....*.
gi 1110199404 282 AIWAVAPGALWGLATLQLSLSALTAISFVALYAEMM 317
Cdd:cd17355 293 LLLPFPPLALLLFAALFGLGWGATVPLTAALAARYF 328
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
57-374 |
4.35e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 57 LVDRFSTPRRWILMCQGLLALSYVIGAAFapTTQLAALLPVVFVMALLAAT--------QDIATDAAGVHATTRQT--RS 126
Cdd:cd17471 55 LSDRGGDRKPLILLALLAGALGYLLFAFL--RNYWVLLLVGVVLLSLGAAAfpqlfalaREYADRSSGRDATLFNSvlRA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 127 LASGASTVGGYAGFLIGGGL-WLWVYaragweLSMVFLAVAMLLLTLPVRALRIERPEGTTKRPSLRHSLKNRTLIR-GV 204
Cdd:cd17471 133 AFSLAWVIGPPLAFLLLDVLgFTGLF------LLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLlFA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 205 GFLLLWQSAVRLGAAMTGPMLVDAGFSLDAIGWLRGAGGMITGLIAAVAGtLMCRRFGTRSVLLSAGLgvgACCVGLAIW 284
Cdd:cd17471 207 AFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAG-LLAKRFGKRRLLLAGFL---AGVLFYLGL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 285 AVAPgALWGLATLQLSLSALTAIsFVALYAEMMNWCAPDQVATDFALLQSLDAGLAVIIGILAGQIAQHLGYAPVFGGAV 364
Cdd:cd17471 283 ALAT-SLWQLIALQLLNAIFIGI-TAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCA 360
|
330
....*....|
gi 1110199404 365 ALLFCALPLV 374
Cdd:cd17471 361 VLALLALVLL 370
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
126-376 |
1.25e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 126 SLASGASTVGGYAGFLIGGGLwlwvYARAGWELSMVF---LAVAMLLLTLPVRALRIERPEGTTKRPSLRHSLKNRTLIr 202
Cdd:cd17490 123 GLINLVNNLGQLIAFLIGGLI----AEHFGMRAPFLLaalAGVLGFILSLFIKEERREKKPVLTELKELLSVLKDKKLL- 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 203 GVGFLLLWQSAVRLGAAM--TGPMLVDAGFSLDAIGWLRGAGGMITGLIAAVAGTLMCRRFGTRSVLLSAGLGVGACCVG 280
Cdd:cd17490 198 FFSLLAILQQMITFSTTFgfTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFL 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 281 LAIwavaPGALWGLATLQLSLSALTAISFVALYAEMMNWCAPDQVATDFALLQSLDAgLAVIIG-ILAGQIAQHLGYAPV 359
Cdd:cd17490 278 IPF----APNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYA-LGMFLGpVLVGIISEAFGLQTG 352
|
250
....*....|....*..
gi 1110199404 360 FGGAVALLFCALPLVRR 376
Cdd:cd17490 353 FFVIGVIALLAAILSLA 369
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
11-297 |
1.96e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 11 AAQSITGSMVQSALPVVLRDAGVALDRIGLLSLLFlpWVLKVFWSPLVDRFSTPRRWILMCQGLLALSYVIGAAFAPTTQ 90
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAY--YLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 91 LAALLPVVFVMALLAATQDIATDAAGVHATTRQTRSLASGASTVGGYAGFLIgGGLWLWVYARAGWELsMVFLAVAMLLL 170
Cdd:cd17477 84 PWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGALP-FLIAAVLLLLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 171 TLPVRALRIERPEgttkrPSLRHSLKNRTLIRGVGFLLLwqsAVRLGAAMTGPM-------LVDAGFSLDAIGWLRGAgG 243
Cdd:cd17477 162 LVPLLLTRRAAPE-----IEEAESISLRRLLRIAPLALL---GAFVAGFLEGAFysllplyGLRLGLSVAQAALLLAA-F 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1110199404 244 MITGLIAAVAGTLMCRRFGTRSVLLSAGLGVGACCVGLAIWAVAPGALWGLATL 297
Cdd:cd17477 233 VLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFL 286
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-376 |
4.83e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.68 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 2 PAFALVGLYAAQSITGSMVQSALPVVLRDAGVALDRIGLL-SLLFLPWVLKVFWSP-LVDRFSTpRRWILMCQGLLALSY 79
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLlFAFFLGYLLASLPAGrLIDRFGY-KRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 80 VIgaaFAPTTQLAALLPVVFVMALLAATQDIATDAAGVHATTRQTRSLAS--------GASTVGGYAGFLIGGGL---WL 148
Cdd:COG0738 88 LL---FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNllhaffslGALLGPLLGGLLILLGLslsWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 149 WVYaragWELSMVFLAVAMLLLTLPVRALRIERPEGTTKRPSLRHSLKNRTLIRGVGFLLLwQSAVRLGAAMTGPMLVDA 228
Cdd:COG0738 165 LPY----LILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFL-YVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110199404 229 GFSLD-AIGWLRGAGGMITGLIAAVAGTLMCRRFGTRSVLLSAGLGVGACCVGLAIWAVAPGALWGLATLQLSLSALtai 307
Cdd:COG0738 240 VLGLSeATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM--- 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1110199404 308 sFVALYAEMMNWCAPDQVATDFALLQSLDAGLAV---IIGILAGQIAQHLGYAPVFGGAVALLFCALPLVRR 376
Cdd:COG0738 317 -FPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIgppLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| |
