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Conserved domains on  [gi|1133996286|emb|SIT77728|]
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MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG [Yoonia rosea]

Protein Classification

MFS transporter( domain architecture ID 13024765)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides; similar to mammalian predicted acetyl-CoA transporter MFSD3

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 12-391 4.77e-110

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 328.03  E-value: 4.77e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  12 AIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRLCHMPRFGHRGVVGMFMFVTLTGV 91
Cdd:cd17485     1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  92 LILSSLDPVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLVGWSSA 171
Cdd:cd17485    81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 172 LWIMAVVTLVAVTPFFRLPAQEGLRQLPP----MAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVDQGFT 247
Cdd:cd17485   161 LLSLAALYLLLLLPVLFLRELELPQQPPAsergAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 248 LSEIGALSGISAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWP--LVALSAGDTFLRYIEM 325
Cdd:cd17485   241 LSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWvlLLASLALLHLVGGMIT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1133996286 326 VALFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYGPVFLIATILSAASGMIAL 391
Cdd:cd17485   321 TALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
 
Name Accession Description Interval E-value
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 12-391 4.77e-110

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 328.03  E-value: 4.77e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  12 AIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRLCHMPRFGHRGVVGMFMFVTLTGV 91
Cdd:cd17485     1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  92 LILSSLDPVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLVGWSSA 171
Cdd:cd17485    81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 172 LWIMAVVTLVAVTPFFRLPAQEGLRQLPP----MAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVDQGFT 247
Cdd:cd17485   161 LLSLAALYLLLLLPVLFLRELELPQQPPAsergAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 248 LSEIGALSGISAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWP--LVALSAGDTFLRYIEM 325
Cdd:cd17485   241 LSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWvlLLASLALLHLVGGMIT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1133996286 326 VALFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYGPVFLIATILSAASGMIAL 391
Cdd:cd17485   321 TALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
sider_RhtX_FptX TIGR02718
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ...
 8-391 3.60e-64

siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131765  Cd Length: 390  Bit Score: 210.52  E-value: 3.60e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286   8 RISLAIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRLCHMPRFGHRGVVGMFMFVT 87
Cdd:TIGR02718   1 RLVITLGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNWWSWRLGRRRSWVLPMQCLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  88 LTGVLILSSLDPVTDAATF-FPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLV 166
Cdd:TIGR02718  81 SACLASLALVGPDVAGAGWaVGLLACASLASATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 167 GWSSALWIMAVVTLVAVTPFFRLPAQEGLRQLPPMAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVDQGF 246
Cdd:TIGR02718 161 GQRPAFLLVACVPLASLVCVLWLKDRAVASPEAPLARRASLFRFFRRPLAWSLLALALLSAMTAVSGFGLSKLYLVDAGW 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 247 TLSEIGALSGISAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWPLVALSAG--DTFLRYIE 324
Cdd:TIGR02718 241 PLEWIGRLGMAGGAVTVLLGCGGGAWLVRRAGLWRTFILGVGLAGSLALLWFAQAAFWLAPGIAVAWSCSafGSLITGIT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133996286 325 MVALFTVYMRFNS-LQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYGPVFLIATILSAASGMIAL 391
Cdd:TIGR02718 321 SVAIYTAFMRFAGdGDQAGTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAILLAV 388
ampG PRK11902
muropeptide transporter; Reviewed
 12-391 7.32e-20

muropeptide transporter; Reviewed


Pssm-ID: 183369 [Multi-domain]  Cd Length: 402  Bit Score: 90.68  E-value: 7.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  12 AIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRLCHMPRFGHRGVVGMFMFVTLTGV 91
Cdd:PRK11902    3 AMLLLGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRGWLLLTQVGLAASI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  92 LILSSLDPVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLV-GWSS 170
Cdd:PRK11902   83 AAMAFCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLADRVlGWGN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 171 ALWIMAVVTLVAVTPFFRLPAQEGLRQLPPMAGRA---RFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLV-DQGF 246
Cdd:PRK11902  163 TYLLMAGLMLAGALTTLWAPEPEVPARPPRSLGEAvvgPLRDFFSRRGAWALLLLIVLYKLGDAFAGSLSTTFLIrGAGF 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 247 TLSEIGALSGISAAVVGIFGAFAGAYVISRIGLLR---FFLLLIAARTLAFWLFYVAATAgigTWPLVALSAGDTFLRYI 323
Cdd:PRK11902  243 SAGEVGIVNKTLGLAATIVGALAGGTLMVRLGLYRslmLFGVLQAVSNLGYWVLAVTPKH---LWTMALAIGIENLCGGM 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133996286 324 EMVALFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYgPVFLIATILSAASGMIAL 391
Cdd:PRK11902  320 GTAAFVALLMALCNRSFSATQYALLSALASVGRVYVGPTSGYLVEAYGW-PGFYLMTVVIALPGLALL 386
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
11-400 4.62e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 51.41  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  11 LAIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIG-GMGLLLAPWVLKVFWAPLIDRlchmpRFGHRGVVGMFMFVTLT 89
Cdd:COG2807    21 LAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGlLTTLPLLAFGLFAPLAPRLAR-----RFGLERTLLLALLLLAA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  90 GVLILSSldpVTDAATFFPILMVMSISSATQDIASDGWtIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLVGWS 169
Cdd:COG2807    96 GLLLRSL---APSVALLLAGTALIGAGIAVGNVLLPGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 170 SALWIMAVVTLVAVTPFFRLPAQEGlRQLPPMAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVDQGFTLS 249
Cdd:COG2807   172 GALAVWALLALLALLLWLPLLRRRP-AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAA 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 250 EIGALSGIsAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLA-FWLFYVAATAGIGTWPLVA-LSAGDTFLryiemVA 327
Cdd:COG2807   251 TAGLLLSL-FQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAgLLGLLLAPGSLPWLWAVLLgLGQGGLFP-----LA 324

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1133996286 328 LFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAEL-HGYGPVFLIATILSAASGMIALLFLSPKVRA 400
Cdd:COG2807   325 LTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAtGSWTAALLLLAALAVLMLVAGLLAGRPYVED 398
MFS_1 pfam07690
Major Facilitator Superfamily;
13-313 6.06e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  13 IFGLYLAQAIPLYLVAAALPPILRAN-GIGLDVIG--GMGLLLAPWVLKVFWAPLIDRlchmprFGHRGVVGMFMFVTLT 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGllLTLFSLGYALAQPLAGRLSDR------FGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  90 GVLILSSLDPVTdaaTFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLVGWS 169
Cdd:pfam07690  75 GLLLLLFASSLW---LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 170 SALWIMAVVTLVAVTPFFRL-----PAQEGLRQLPPMAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEqAFLVDQ 244
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPrpppeSKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1133996286 245 GFTLSEIGALSGIsAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWPLVAL 313
Cdd:pfam07690 231 GLSALLAGLLLGL-GGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298
 
Name Accession Description Interval E-value
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 12-391 4.77e-110

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 328.03  E-value: 4.77e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  12 AIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRLCHMPRFGHRGVVGMFMFVTLTGV 91
Cdd:cd17485     1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  92 LILSSLDPVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLVGWSSA 171
Cdd:cd17485    81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 172 LWIMAVVTLVAVTPFFRLPAQEGLRQLPP----MAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVDQGFT 247
Cdd:cd17485   161 LLSLAALYLLLLLPVLFLRELELPQQPPAsergAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 248 LSEIGALSGISAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWP--LVALSAGDTFLRYIEM 325
Cdd:cd17485   241 LSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWvlLLASLALLHLVGGMIT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1133996286 326 VALFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYGPVFLIATILSAASGMIAL 391
Cdd:cd17485   321 TALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
sider_RhtX_FptX TIGR02718
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ...
 8-391 3.60e-64

siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131765  Cd Length: 390  Bit Score: 210.52  E-value: 3.60e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286   8 RISLAIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRLCHMPRFGHRGVVGMFMFVT 87
Cdd:TIGR02718   1 RLVITLGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNWWSWRLGRRRSWVLPMQCLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  88 LTGVLILSSLDPVTDAATF-FPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLV 166
Cdd:TIGR02718  81 SACLASLALVGPDVAGAGWaVGLLACASLASATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 167 GWSSALWIMAVVTLVAVTPFFRLPAQEGLRQLPPMAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVDQGF 246
Cdd:TIGR02718 161 GQRPAFLLVACVPLASLVCVLWLKDRAVASPEAPLARRASLFRFFRRPLAWSLLALALLSAMTAVSGFGLSKLYLVDAGW 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 247 TLSEIGALSGISAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWPLVALSAG--DTFLRYIE 324
Cdd:TIGR02718 241 PLEWIGRLGMAGGAVTVLLGCGGGAWLVRRAGLWRTFILGVGLAGSLALLWFAQAAFWLAPGIAVAWSCSafGSLITGIT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133996286 325 MVALFTVYMRFNS-LQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYGPVFLIATILSAASGMIAL 391
Cdd:TIGR02718 321 SVAIYTAFMRFAGdGDQAGTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAILLAV 388
MFS_AmpG_like cd17486
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ...
 13-394 4.91e-54

AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341039 [Multi-domain]  Cd Length: 387  Bit Score: 183.57  E-value: 4.91e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  13 IFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRLcHMPRFGH-RGVVGMFMFVTLTGV 91
Cdd:cd17486     1 ILLLGFASGLPYLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDRY-STPFLGRrRGWILLTQILLMAAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  92 LILSSLDPVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLVGWSSA 171
Cdd:cd17486    80 IALAFLDPFTNLVLSALLFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 172 LWIMAVVTLVA------VTPFFRLPAQEGLRQLPPMAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVDQG 245
Cdd:cd17486   160 YLIMAALMGPGilatlfAPEPPRTDPPANSLSETVVAFFAPFKDFFGQPGALLILAFILLYKLGDAMLGAMATPFLLDLG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 246 FTLSEIGALSGISAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWPLVALSAGDTFLRYIEM 325
Cdd:cd17486   240 FTKTEIGAVYKTVGLIATIVGGLLGGFLMSRLGLKRSLWLFGILQALSNLGFIYLAHAGPNLTLLVAAVAVENFGGGLGT 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1133996286 326 VALFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYgPVFLIATILSAASGMIALLFL 394
Cdd:cd17486   320 TAFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEALGW-TGFFLLTTLAAIPGLLLLLKV 387
2A0125 TIGR00901
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]
 22-349 4.26e-24

AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273329 [Multi-domain]  Cd Length: 356  Bit Score: 102.08  E-value: 4.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  22 IPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRLcHMPRFGHR-GVVGMFMFVTLTGVLILSSLDPV 100
Cdd:TIGR00901   2 LPLGLVGNTLPYWLRSKNVSLKTIGFFSLVGLPYSLKFLWSPLVDTV-YLPFFGRRrSWLVLTQVLLLSLLLILSFLVPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 101 TDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIIND--------LVGWSSAL 172
Cdd:TIGR00901  81 TDLPLLAGLAFLIAFFSATQDIALDAWRLEILSDEELGYGSTIYIVGYRAGMLLSGSLALVLASpefantglITLWGYIF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 173 WIMAVVTLVAVTPFFRL---PAQEGLRQLPPMAG-RARFRQFFAIPGAFAILGFALLI---RIPEGLVKALEQAFLVDQG 245
Cdd:TIGR00901 161 FWTALLILPGLLVTLFLakePQEDASVPKPLTQAvLKPIREFFQRKNMIQALLLLLLIvlyKLGDSAATVLTTLFLLDMG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 246 FTLSEIGALSGISAAVVGIFGAFAGAYVISRIGLLR----FFLLLIAARTLAFWLFYVAATAGIGT---WPLVALSAGDT 318
Cdd:TIGR00901 241 FSKEEIALVAKINGLLGAILGGLIGGIIMQPLNILYalllFGIVQALTNAGFVWLASNGHHDGITFphlLMLFLTITLEA 320

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1133996286 319 FLRYIEMVALFTVYMRFNSLQQAGTDFTILT 349
Cdd:TIGR00901 321 VTGGLGTVAFVAFLSKLSNPKFGATQMALLS 351
ampG PRK11902
muropeptide transporter; Reviewed
 12-391 7.32e-20

muropeptide transporter; Reviewed


Pssm-ID: 183369 [Multi-domain]  Cd Length: 402  Bit Score: 90.68  E-value: 7.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  12 AIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRLCHMPRFGHRGVVGMFMFVTLTGV 91
Cdd:PRK11902    3 AMLLLGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRGWLLLTQVGLAASI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  92 LILSSLDPVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLV-GWSS 170
Cdd:PRK11902   83 AAMAFCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLADRVlGWGN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 171 ALWIMAVVTLVAVTPFFRLPAQEGLRQLPPMAGRA---RFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLV-DQGF 246
Cdd:PRK11902  163 TYLLMAGLMLAGALTTLWAPEPEVPARPPRSLGEAvvgPLRDFFSRRGAWALLLLIVLYKLGDAFAGSLSTTFLIrGAGF 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 247 TLSEIGALSGISAAVVGIFGAFAGAYVISRIGLLR---FFLLLIAARTLAFWLFYVAATAgigTWPLVALSAGDTFLRYI 323
Cdd:PRK11902  243 SAGEVGIVNKTLGLAATIVGALAGGTLMVRLGLYRslmLFGVLQAVSNLGYWVLAVTPKH---LWTMALAIGIENLCGGM 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133996286 324 EMVALFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYgPVFLIATILSAASGMIAL 391
Cdd:PRK11902  320 GTAAFVALLMALCNRSFSATQYALLSALASVGRVYVGPTSGYLVEAYGW-PGFYLMTVVIALPGLALL 386
ampG PRK11010
muropeptide MFS transporter AmpG;
5-393 2.50e-18

muropeptide MFS transporter AmpG;


Pssm-ID: 182898 [Multi-domain]  Cd Length: 491  Bit Score: 86.62  E-value: 2.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286   5 PNNRIsLAIFGLylAQAIPLYLVAAALPPILRANGIGLDVIGGMGLLLAPWVLKVFWAPLIDRlcHMPRF--GHRGVVGM 82
Cdd:PRK11010   12 PNSAI-LLILGF--ASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDR--YTPPFlgRRRGWLLA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  83 FMFVTLTGVLILSSLDPVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLII 162
Cdd:PRK11010   87 TQLLLLVAIAAMGFLEPGTQLRWLAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLAMLVSGGLALWL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 163 ND-LVGWSSALWIMA-------VVTLVAVTPFFRLPAQEGLRQlppmAGRARFRQFFAIPGAFAILGFALLIRIPEGLVK 234
Cdd:PRK11010  167 ADrYLGWQGMYWLMAallipciIATLLAPEPTDTIPVPKTLEQ----AVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 235 ALEQAFLVDQ-GFTLSEIGALSGISAAVVGIFGAFAGAYVISRIGLLR---FFLLLIAARTLAFWLF-------YVAATA 303
Cdd:PRK11010  243 SLTTTFLIRGvGFDAGEVGLVNKTLGLLATIVGALYGGILMQRLSLFRalmIFGILQGVSNAGYWLLsitdknlYSMGAA 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 304 --------GIGTWPLVALsagdtflryiemvaLFTVYMRFNSlqqaGTDFTILTCATLFTYMVGGMVAGTIAELHGYgPV 375
Cdd:PRK11010  323 vffenlcgGMGTAAFVAL--------------LMTLCNKSFS----ATQFALLSALSAVGRVYVGPVAGWFVEAHGW-PT 383

                         410
                  ....*....|....*...
gi 1133996286 376 FLIATILSAASGMIALLF 393
Cdd:PRK11010  384 FYLFSVAAAVPGLLLLLV 401
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
11-400 4.62e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 51.41  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  11 LAIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIG-GMGLLLAPWVLKVFWAPLIDRlchmpRFGHRGVVGMFMFVTLT 89
Cdd:COG2807    21 LAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGlLTTLPLLAFGLFAPLAPRLAR-----RFGLERTLLLALLLLAA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  90 GVLILSSldpVTDAATFFPILMVMSISSATQDIASDGWtIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLVGWS 169
Cdd:COG2807    96 GLLLRSL---APSVALLLAGTALIGAGIAVGNVLLPGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 170 SALWIMAVVTLVAVTPFFRLPAQEGlRQLPPMAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVDQGFTLS 249
Cdd:COG2807   172 GALAVWALLALLALLLWLPLLRRRP-AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAA 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 250 EIGALSGIsAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLA-FWLFYVAATAGIGTWPLVA-LSAGDTFLryiemVA 327
Cdd:COG2807   251 TAGLLLSL-FQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAgLLGLLLAPGSLPWLWAVLLgLGQGGLFP-----LA 324

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1133996286 328 LFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAEL-HGYGPVFLIATILSAASGMIALLFLSPKVRA 400
Cdd:COG2807   325 LTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAtGSWTAALLLLAALAVLMLVAGLLAGRPYVED 398
MFS_1 pfam07690
Major Facilitator Superfamily;
13-313 6.06e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  13 IFGLYLAQAIPLYLVAAALPPILRAN-GIGLDVIG--GMGLLLAPWVLKVFWAPLIDRlchmprFGHRGVVGMFMFVTLT 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGllLTLFSLGYALAQPLAGRLSDR------FGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  90 GVLILSSLDPVTdaaTFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLVGWS 169
Cdd:pfam07690  75 GLLLLLFASSLW---LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 170 SALWIMAVVTLVAVTPFFRL-----PAQEGLRQLPPMAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEqAFLVDQ 244
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPrpppeSKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1133996286 245 GFTLSEIGALSGIsAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWPLVAL 313
Cdd:pfam07690 231 GLSALLAGLLLGL-GGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
8-399 1.05e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286   8 RISLAIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGMG--LLLAPWVLKVFWAPLIDRlchmprFGHRGVVGMFMF 85
Cdd:COG2271    10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLAsaFFLGYALGQIPAGLLADR------FGRRRVLAIGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  86 VTLTGVLILSSldpVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDL 165
Cdd:COG2271    84 LWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 166 VGWSSALWIMAVVTLVAVTPFFRLPAqeglrqlppmagrarFRQFFAIPGAFAILGFalliripegLVKALEQAFlvdqG 245
Cdd:COG2271   161 FGWRAAFLILGLPGLLLALLRFWLLA---------------LAYFLVYFALYGFLTW---------LPTYLVEVR----G 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 246 FTLSEIGALSGIsAAVVGIFGAFAGAYVISRIGLLRFFLLLIAArtLAFWLFYVAATAGIGTWPLVALSAGDTFLRYIEM 325
Cdd:COG2271   213 LSLAQAGLLLSL-PFLAGIVGSLLGGWLSDRLGRRRKLVLAIGL--LLAALALLLLALLPSPALAIALLFLAGFGLGGAF 289

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1133996286 326 VALFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYGPVFLIATILSAASGMIALLFLSPKVR 399
Cdd:COG2271   290 GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 13-391 1.17e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  13 IFGLYLAQAIPLYLVAAALPPILRANGIGLDVIG--GMGLLLAPWVLKVFWAPLIDRlchmprFGHRGVVGMFMFVTLTG 90
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGllFALFSLGYALLQPLAGLLADR------FGRRPVLLLGLLLFALG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  91 VLILSSLDPVtdaATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGG--SGTLIINDLVGW 168
Cdd:cd06174    75 ALLFAFAPSF---WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPllGGILASSLGFGW 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 169 SSALWIMAVVTLVAVTPFFRLPAQEGLRQLPPMAGR------ARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLV 242
Cdd:cd06174   152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEAssksvlKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 243 DQGFTLSEIGALSGISAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWPLVALSAGDTFLRY 322
Cdd:cd06174   232 DLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 323 IEMVALFTVYMrfnSLQQAGTDFTILTCATLFTYMVGGMVAGTI-AELHGYGPVFLIATILSAASGMIAL 391
Cdd:cd06174   312 PLSFALIAELF---PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
71-403 2.74e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.03  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  71 MPRFGHRGVVGMFMFVTLTGVLILSSLDPVTDAATFFpilMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAF 150
Cdd:COG2223    64 VDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLG---LLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 151 GVLVGGSGTLIINDLVGWSSALWIMAVVTLVAVTPFFRL----------PAQEGLRQLPPMAGRARFRQFFAIPGAFAIL 220
Cdd:COG2223   141 GAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFlrdppagaaaAAKASLRDQLEALRDPRFWLLSLLYFGTFGS 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 221 GFALLIRIPeglvkaleqAFLVDQ-GFTLSEIGALSGIsAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFyv 299
Cdd:COG2223   221 FIGFSSWLP---------PYLVDQfGLSAATAGLLAAL-FALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL-- 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 300 aATAGIGTWPLVALSAGDTFLRYIEMVALFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHG-YGPVFLI 378
Cdd:COG2223   289 -ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLV 367

                         330       340
                  ....*....|....*....|....*
gi 1133996286 379 ATILSAASGMIALLFLSPKVRAIAA 403
Cdd:COG2223   368 FAVLALVALVLTLLLYRRPRRAAAA 392
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 79-393 3.82e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.22  E-value: 3.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  79 VVGMFMFVTLTGVLILSSLDPVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSG 158
Cdd:cd06173    68 ILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPAL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 159 TLIINDLVGWSSALWIMAVVTLVAVTPFFRLPAQEGLRQLPP-----MAGRARFRQFFAIPGAFAILGFALLIRIPEGLV 233
Cdd:cd06173   148 GGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESsslllRDLREGLRYLRRSPLLRLLLLALALFALLGGAL 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 234 KALEQAFLVDQ-GFTLSEIGALSGISAAvvgifGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWPLVA 312
Cdd:cd06173   228 TVLLPLLAKEVlGGGAAGYGLLLAAFGV-----GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLA 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 313 LSAGDTFLRYIEMVALFTVYMRFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYGPVFLIATILSAASGMIALL 392
Cdd:cd06173   303 ALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382


                  .
gi 1133996286 393 F 393
Cdd:cd06173   383 L 383
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
8-316 9.71e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.11  E-value: 9.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286   8 RISLAIFGLYLAQAIPLYLVAAALPPILRANGIGLDVIGGM--GLLLAPWVLKVFWAPLIDRlchmprFGHRGVVgMFMF 85
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVvtAYLLGAALGAPLAGRLADR------FGRRRVL-LLGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  86 VTLTGVLILSSLdpVTDAATFFPILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDL 165
Cdd:COG2814    83 LLFALGSLLCAL--APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 166 VGWSSALWIMAVVTLVAVTPFFRLPAQEGLRQLPPMagRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVDQ- 244
Cdd:COG2814   161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARL--RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVl 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1133996286 245 GFTLSEIGALSGIsAAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIGTWPLVALSAG 316
Cdd:COG2814   239 GLSASAAGLLLAL-FGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFG 309
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 109-387 1.09e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.99  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 109 ILMVMSISSATQDIASDGWTIEHLPPDEQPTGNAVQGSAVAFGVLVGGSGTLIINDLVGWSSALWIMAVVTLVAVTPFFR 188
Cdd:cd17471    95 VLLSLGAAAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLF 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 189 LPAQEGLRQLPPMAGRARFRQFFAIPGAFAILGFALL--------IRIPEGLVKALeqaflvdqGFTLSEIGALSGIsAA 260
Cdd:cd17471   175 LLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLfaansmyiIAMPLYVTNEL--------GGSESWVGLLFGL-AA 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 261 VVGIFGAFAGAYVISRIGLLRffllLIAARTLAFWLFYVAATAGIGTWPLVALSAGDTFLRYIeMVALFTVYMRFNSLQQ 340
Cdd:cd17471   246 ALEIPIMLLAGLLAKRFGKRR----LLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGI-TAGLGISYFQDLMPGQ 320

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1133996286 341 AGTDFTILTCATLFTYMVGGMVAGTIAELHGYGPVFLIATILSAASG 387
Cdd:cd17471   321 PGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLAL 367
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
18-396 4.19e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.12  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  18 LAQAIPLYLVAAALPPILRAN-GIGLDVIGGMGLLLAPW--VLKVFWAPLIDRLCHmpRFGHRGVVGMFMFVTLTGVLIL 94
Cdd:COG2211    20 LGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWdaITDPLIGALSDRTRT--RWGRRRPWILIGAIPLALSFVL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286  95 ----SSLDPVTDAATFFPILMVMSISSATQDIASDGWTIEHLP-PDEQPTGNAVQGSAVAFGVLVGGSGTLII------N 163
Cdd:COG2211    98 lftaPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLvaafggD 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 164 DLVGWSSALWIMAVVTLVAVTPFFRLPAQEGLRQLPPMAGRARFRQFFAIPGAFAILGFALLIRIPEGLVKALEQAFLVD 243
Cdd:COG2211   178 AALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 244 Q-GFTLSEIGALSGISaAVVGIFGAFAGAYVISRIGLLRFFLLLIAARTLAFWLFYVAATAGIgtWPLVALSAGDTFLRY 322
Cdd:COG2211   258 VlGLSAALVGLLLALY-FLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNL--WLLLVLAALAGIGLG 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133996286 323 IEMVALFTVYM-------RFNSLQQAGTDFTILTCATLFTYMVGGMVAGTIAELHGYGPVflIATILSAASGMIALLFLS 395
Cdd:COG2211   335 AILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAG--AAQSPSALTGIRLLFFLL 412


                  .
gi 1133996286 396 P 396
Cdd:COG2211   413 P 413
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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