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Conserved domains on  [gi|1195629572|emb|SME17973|]
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hypothetical protein BACERE00176_03029 [Bacillus paranthracis]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 47-168 4.76e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 4.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  47 IRFAQGEFYYQNKDFEAAIFKWEKV--NNELALWATKNIADAYFELGFLPKAEEMYQSIQTEDTTlTMEVSLQLLSLYIE 124
Cdd:COG2956    44 AHLALGNLYRRRGEYDRAIRIHQKLleRDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPD-DAEALRLLAEIYEQ 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195629572 125 QDRLGLAFKTISEAVAFQPDYPNITSIARSFYEKQEDWNNAIEL 168
Cdd:COG2956   123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEA 166
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 47-168 4.76e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 4.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  47 IRFAQGEFYYQNKDFEAAIFKWEKV--NNELALWATKNIADAYFELGFLPKAEEMYQSIQTEDTTlTMEVSLQLLSLYIE 124
Cdd:COG2956    44 AHLALGNLYRRRGEYDRAIRIHQKLleRDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPD-DAEALRLLAEIYEQ 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195629572 125 QDRLGLAFKTISEAVAFQPDYPNITSIARSFYEKQEDWNNAIEL 168
Cdd:COG2956   123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEA 166
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 79-175 6.13e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 39.99  E-value: 6.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  79 ATKNIADAYFELGFLPKAEEMYQSIQT-----EDTTLTMEVSLQLLSLYIEQDRLGLAFKTISEAVAFQPDYPN------ 147
Cdd:pfam17874  42 ATFVLGEAYLCLGDLDAALQAMREAEAlarraDSPHVTLWALLQQGEILRAQGRLHQALETYQQALQLARDHGLqhlplh 121

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1195629572 148 ---ITSIARSFYEkqedWNN--AIELAVQEGIR 175
Cdd:pfam17874 122 gflLVGLADLLYE----WNDleEAEQHAQQGIQ 150
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 47-168 4.76e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 4.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  47 IRFAQGEFYYQNKDFEAAIFKWEKV--NNELALWATKNIADAYFELGFLPKAEEMYQSIQTEDTTlTMEVSLQLLSLYIE 124
Cdd:COG2956    44 AHLALGNLYRRRGEYDRAIRIHQKLleRDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPD-DAEALRLLAEIYEQ 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195629572 125 QDRLGLAFKTISEAVAFQPDYPNITSIARSFYEKQEDWNNAIEL 168
Cdd:COG2956   123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEA 166
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 48-169 1.54e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.88  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  48 RFAQGEFYYQNKDFEAAIFKWEKV--NNELALWATKNIADAYFELGFLPKAEEMYQS-IQTEDTTLtmEVSLQLLSLYIE 124
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEAleLDPETVEAHLALGNLYRRRGEYDRAIRIHQKlLERDPDRA--EALLELAQDYLK 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195629572 125 QDRLGLAFKTISEAVAFQPDYPNITSIARSFYEKQEDWNNAIELA 169
Cdd:COG2956    89 AGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVL 133
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 45-172 1.64e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  45 SNIRFAQGEFYYQNKDFEAAIFKWEKV--NNELALWATKNIADAYFELGFLPKAEEMYQSIQTEDTTlTMEVSLQLLSLY 122
Cdd:COG2956   144 AHAYCELAELYLEQGDYDEAIEALEKAlkLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPD-YLPALPRLAELY 222

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195629572 123 IEQDRLGLAFKTISEAVAFQPDYPNITSIARsFYEKQEDWNNAIELAVQE 172
Cdd:COG2956   223 EKLGDPEEALELLRKALELDPSDDLLLALAD-LLERKEGLEAALALLERQ 271
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 48-171 7.69e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 7.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  48 RFAQGEFYYQNKDFEAAIFKWEKV--NNELALWATKNIADAYFELGFLPKAEEMYQ---SIQTEDTtltmEVSLQLLSLY 122
Cdd:COG4783     7 LYALAQALLLAGDYDEAEALLEKAleLDPDNPEAFALLGEILLQLGDLDEAIVLLHealELDPDEP----EARLNLGLAL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195629572 123 IEQDRLGLAFKTISEAVAFQPDYPNITSIARSFYEKQEDWNNAIELAVQ 171
Cdd:COG4783    83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEK 131
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-168 2.27e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  31 EAYINESTNEFSNISNIRFAQGEFYYQNKDFEAAIF---KWEKVNNELAlWATKNIADAYFELGFLPKAEEMYQSIQTED 107
Cdd:COG2956    96 EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEvleRLLKLGPENA-HAYCELAELYLEQGDYDEAIEALEKALKLD 174

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195629572 108 TTLtMEVSLQLLSLYIEQDRLGLAFKTISEAVAFQPDYPNITSIARSFYEKQEDWNNAIEL 168
Cdd:COG2956   175 PDC-ARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALEL 234
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
31-224 3.59e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 3.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  31 EAYINESTNEFSNISNIRFAQGEFYYQNKDFEAAIFKWEKV---NNELAlWATKNIADAYFELGFLPKAEEMYQ---SIQ 104
Cdd:COG0457    28 IEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQAlelDPDDA-EALNNLGLALQALGRYEEALEDYDkalELD 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572 105 TEDTtltmEVSLQLLSLYIEQDRLGLAFKTISEAVAFQPDYPNITSIARSFYEKQEDWNNAIELAVQEGIRTKSLHWFDT 184
Cdd:COG0457   107 PDDA----EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAA 182

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1195629572 185 LINYVNQGFTKQIKPEYFYESLKALYAIDQVQFKELVIAL 224
Cdd:COG0457   183 LGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAEL 222
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 46-171 1.69e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  46 NIRFAQGEFYYQNKDFEAAIFKWEKVN--NELALWATKNIADAYFELGFLPKAEEMYQ---SIQTEDTtltmEVSLQLLS 120
Cdd:COG3914    79 ALLELAALLLQALGRYEEALALYRRALalNPDNAEALFNLGNLLLALGRLEEALAALRralALNPDFA----EAYLNLGE 154

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195629572 121 LYIEQDRLGLAFKTISEAVAFQPDYPNI-TSIARsFYEKQEDWNNAIELAVQ 171
Cdd:COG3914   155 ALRRLGRLEEAIAALRRALELDPDNAEAlNNLGN-ALQDLGRLEEAIAAYRR 205
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 46-103 1.91e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.90  E-value: 1.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195629572  46 NIRFAQGEFYYQNKDFEAAIFKWEKV-----NNELALWATKNIADAYFELGFLPKAEEMYQSI 103
Cdd:COG1729    31 DALYWLGEAYYALGDYDEAAEAFEKLlkrypDSPKAPDALLKLGLSYLELGDYDKARATLEEL 93
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
43-168 1.23e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  43 NISNIRFAQGEFYYQNKDFEAAIFKWEKVnneLAL-----WATKNIADAYFELGFLPKAEEMYQ---SIQTEDTtltmEV 114
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA---LELdpddaEALYNLGLAYLRLGRYEEALADYEqalELDPDDA----EA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195629572 115 SLQLLSLYIEQDRLGLAFKTISEAVAFQPDYPNITSIARSFYEKQEDWNNAIEL 168
Cdd:COG0457    79 LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEA 132
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 55-147 3.08e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.43  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  55 YYQNKDFEAAIFKWEKV-----NNELALWATKNIADAYFELGFLPKAEEMYQSIQTE--DTTLTMEVSLQLLSLYIEQDR 127
Cdd:COG1729     3 LLKAGDYDEAIAAFKAFlkrypNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRypDSPKAPDALLKLGLSYLELGD 82

                          90       100
                  ....*....|....*....|
gi 1195629572 128 LGLAFKTISEAVAfqpDYPN 147
Cdd:COG1729    83 YDKARATLEELIK---KYPD 99
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 79-175 6.13e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 39.99  E-value: 6.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195629572  79 ATKNIADAYFELGFLPKAEEMYQSIQT-----EDTTLTMEVSLQLLSLYIEQDRLGLAFKTISEAVAFQPDYPN------ 147
Cdd:pfam17874  42 ATFVLGEAYLCLGDLDAALQAMREAEAlarraDSPHVTLWALLQQGEILRAQGRLHQALETYQQALQLARDHGLqhlplh 121

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1195629572 148 ---ITSIARSFYEkqedWNN--AIELAVQEGIR 175
Cdd:pfam17874 122 gflLVGLADLLYE----WNDleEAEQHAQQGIQ 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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