NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1247787713|emb|SOC90299.1|]
View 

DNA-binding transcriptional regulator, MarR family [Rhizobium sp. AN5]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
23-165 5.64e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 96.19  E-value: 5.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247787713  23 PDIDPFPMELLGRLGEIALLIMRdRLTPFFMEHGLQSGEFDVLATLRRSGapyELTPTRLYESAMLSSGGMTARIDRLER 102
Cdd:COG1846     3 DEPDPAEERLGLLLRRLARALRR-ALDRALAELGLTPAQFRVLAALAEAG---GLTQSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1247787713 103 EGLVERRRHPTDRRGVLVALTPIGVSLIDKMLAQHVENERIALAGLTVAEQQQFNALSIKLLE 165
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
23-165 5.64e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 96.19  E-value: 5.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247787713  23 PDIDPFPMELLGRLGEIALLIMRdRLTPFFMEHGLQSGEFDVLATLRRSGapyELTPTRLYESAMLSSGGMTARIDRLER 102
Cdd:COG1846     3 DEPDPAEERLGLLLRRLARALRR-ALDRALAELGLTPAQFRVLAALAEAG---GLTQSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1247787713 103 EGLVERRRHPTDRRGVLVALTPIGVSLIDKMLAQHVENERIALAGLTVAEQQQFNALSIKLLE 165
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
51-153 5.16e-20

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 79.95  E-value: 5.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247787713   51 FFMEHGLQSGEFDVLATLRRSGApyeLTPTRLYESAMLSSGGMTARIDRLEREGLVERRRHPTDRRGVLVALTPIGVSLI 130
Cdd:smart00347   2 ELKPLGLTPTQFLVLRILYEEGP---LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELI 78

                           90       100
                   ....*....|....*....|...
gi 1247787713  131 DKMLAQHVENERIALAGLTVAEQ 153
Cdd:smart00347  79 EQLLEARSETLAELLAGLTAEEQ 101
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
43-132 2.23e-09

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 52.98  E-value: 2.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247787713  43 IMRDRLTPFfmehGLQSGEFDVLATLRRSGApyeLTPTRLYESAMLSSGGMTARIDRLEREGLVERRRHPTDRRGVLVAL 122
Cdd:PRK11512   28 LLNEYLSPL----DITAAQFKVLCSIRCAAC---ITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKL 100

                          90
                  ....*....|
gi 1247787713 123 TPIGVSLIDK 132
Cdd:PRK11512  101 TTSGAAICEQ 110
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 55-117 2.49e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 50.67  E-value: 2.49e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1247787713  55 HGLQSGEFDVLATLRRSGapyELTPTRLYESAMLSSGGMTARIDRLEREGLVERRRHPTDRRG 117
Cdd:pfam12802   1 LGLTPAQFRVLLALARNP---GLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
23-165 5.64e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 96.19  E-value: 5.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247787713  23 PDIDPFPMELLGRLGEIALLIMRdRLTPFFMEHGLQSGEFDVLATLRRSGapyELTPTRLYESAMLSSGGMTARIDRLER 102
Cdd:COG1846     3 DEPDPAEERLGLLLRRLARALRR-ALDRALAELGLTPAQFRVLAALAEAG---GLTQSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1247787713 103 EGLVERRRHPTDRRGVLVALTPIGVSLIDKMLAQHVENERIALAGLTVAEQQQFNALSIKLLE 165
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
51-153 5.16e-20

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 79.95  E-value: 5.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247787713   51 FFMEHGLQSGEFDVLATLRRSGApyeLTPTRLYESAMLSSGGMTARIDRLEREGLVERRRHPTDRRGVLVALTPIGVSLI 130
Cdd:smart00347   2 ELKPLGLTPTQFLVLRILYEEGP---LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELI 78

                           90       100
                   ....*....|....*....|...
gi 1247787713  131 DKMLAQHVENERIALAGLTVAEQ 153
Cdd:smart00347  79 EQLLEARSETLAELLAGLTAEEQ 101
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
43-132 2.23e-09

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 52.98  E-value: 2.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247787713  43 IMRDRLTPFfmehGLQSGEFDVLATLRRSGApyeLTPTRLYESAMLSSGGMTARIDRLEREGLVERRRHPTDRRGVLVAL 122
Cdd:PRK11512   28 LLNEYLSPL----DITAAQFKVLCSIRCAAC---ITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKL 100

                          90
                  ....*....|
gi 1247787713 123 TPIGVSLIDK 132
Cdd:PRK11512  101 TTSGAAICEQ 110
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 55-117 2.49e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 50.67  E-value: 2.49e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1247787713  55 HGLQSGEFDVLATLRRSGapyELTPTRLYESAMLSSGGMTARIDRLEREGLVERRRHPTDRRG 117
Cdd:pfam12802   1 LGLTPAQFRVLLALARNP---GLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 61-118 2.64e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 50.62  E-value: 2.64e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1247787713  61 EFDVLATLRRSGApyeLTPTRLYESAMLSSGGMTARIDRLEREGLVERRRHPTDRRGV 118
Cdd:pfam01047   5 QFHILRILYEHGP---LTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 54-167 8.17e-05

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 40.89  E-value: 8.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247787713  54 EHGLQSGEFDVLATLRrSGAPYELTPTRLyESAMLSSGGMTARI-DRLEREGLVERRRHPTDRRGVLVALTPIGVSLIDK 132
Cdd:PRK10870   50 AQGINETLFMALITLE-SQENHSIQPSEL-SCALGSSRTNATRIaDELEKRGWIERRESDNDRRCLHLQLTEKGHEFLRE 127

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1247787713 133 MLAQHVENERIALAGLTVAEQQQFNALSIKLLEGL 167
Cdd:PRK10870  128 VLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRL 162
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
94-135 2.05e-04

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 38.69  E-value: 2.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1247787713  94 TARIDRLEREGLVERRRHPTDRRGVLVALTPIGVSLIDKMLA 135
Cdd:COG1733    54 TQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSLLPVLDA 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH