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Conserved domains on  [gi|1410802039|emb|SPX83323|]
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DNA-binding transcriptional activator GutM [Listeria innocua]

Protein Classification

transcriptional regulator GutM( domain architecture ID 10536509)

transcriptional regulator GutM functions as a positive regulator for glucitol operon expression

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GutM pfam06923
Glucitol operon activator protein (GutM); This family consists of several glucitol operon ...
2-112 2.12e-25

Glucitol operon activator protein (GutM); This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP, cAMP receptor protein). Synthesis of the mRNA, which initiates at the promoter specific to the gutR gene, occurs within the gutM gene. Expressional control of the gut operon appears to occur as a consequence of the antagonistic action of the products of the autogenously regulated gutM and gutR genes.


:

Pssm-ID: 429193  Cd Length: 105  Bit Score: 91.83  E-value: 2.12e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1410802039   2 KIVLIASVIFIAQTFLAFFQVRYYQHHMNKVASKyaGKIGYhlysEMERLKFRTSAVAILVVNEEHIVHECQILTGKTIF 81
Cdd:pfam06923   1 ILILIAVLAWLLQILLGFFQIKHFNKAYKELRRK--GRVGI----GRSKGRFRPGVIVLLAIDEDGIIVEARKMKGVTVF 74
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1410802039  82 AKFKTFTDYHQKELSEILQELHEKKKHSIQE 112
Cdd:pfam06923  75 ARFKELEELEGKNLGEIDPEVLKQKDKLTQK 105
 
Name Accession Description Interval E-value
GutM pfam06923
Glucitol operon activator protein (GutM); This family consists of several glucitol operon ...
2-112 2.12e-25

Glucitol operon activator protein (GutM); This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP, cAMP receptor protein). Synthesis of the mRNA, which initiates at the promoter specific to the gutR gene, occurs within the gutM gene. Expressional control of the gut operon appears to occur as a consequence of the antagonistic action of the products of the autogenously regulated gutM and gutR genes.


Pssm-ID: 429193  Cd Length: 105  Bit Score: 91.83  E-value: 2.12e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1410802039   2 KIVLIASVIFIAQTFLAFFQVRYYQHHMNKVASKyaGKIGYhlysEMERLKFRTSAVAILVVNEEHIVHECQILTGKTIF 81
Cdd:pfam06923   1 ILILIAVLAWLLQILLGFFQIKHFNKAYKELRRK--GRVGI----GRSKGRFRPGVIVLLAIDEDGIIVEARKMKGVTVF 74
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1410802039  82 AKFKTFTDYHQKELSEILQELHEKKKHSIQE 112
Cdd:pfam06923  75 ARFKELEELEGKNLGEIDPEVLKQKDKLTQK 105
GutM COG4578
DNA-binding transcriptional regulator of glucitol operon [Transcription];
1-126 1.38e-23

DNA-binding transcriptional regulator of glucitol operon [Transcription];


Pssm-ID: 443635  Cd Length: 127  Bit Score: 88.11  E-value: 1.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1410802039   1 MKIVLIASVIFIAQTFLAFFQVRYYQHHMNKVASKyagkiGYHLYSeMERLKFRTSAVAILVVNEEHIVHECQILTGKTI 80
Cdd:COG4578     5 IALILLAALAWLLQLALGWWQIRRFNRAFGELRNK-----GRVGIG-RSKGRFKPGVIVLLAVDRNGRVVDALIMKGVTV 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1410802039  81 FAKFKTFTDYHQKELSEILQELHEKKKHSIQeKAIIKTANSCMKAL 126
Cdd:COG4578    79 FARFKPLEELEGLDLDEIEPDLIFPKDKLLA-KALLAALEQIDRVR 123
 
Name Accession Description Interval E-value
GutM pfam06923
Glucitol operon activator protein (GutM); This family consists of several glucitol operon ...
2-112 2.12e-25

Glucitol operon activator protein (GutM); This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP, cAMP receptor protein). Synthesis of the mRNA, which initiates at the promoter specific to the gutR gene, occurs within the gutM gene. Expressional control of the gut operon appears to occur as a consequence of the antagonistic action of the products of the autogenously regulated gutM and gutR genes.


Pssm-ID: 429193  Cd Length: 105  Bit Score: 91.83  E-value: 2.12e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1410802039   2 KIVLIASVIFIAQTFLAFFQVRYYQHHMNKVASKyaGKIGYhlysEMERLKFRTSAVAILVVNEEHIVHECQILTGKTIF 81
Cdd:pfam06923   1 ILILIAVLAWLLQILLGFFQIKHFNKAYKELRRK--GRVGI----GRSKGRFRPGVIVLLAIDEDGIIVEARKMKGVTVF 74
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1410802039  82 AKFKTFTDYHQKELSEILQELHEKKKHSIQE 112
Cdd:pfam06923  75 ARFKELEELEGKNLGEIDPEVLKQKDKLTQK 105
GutM COG4578
DNA-binding transcriptional regulator of glucitol operon [Transcription];
1-126 1.38e-23

DNA-binding transcriptional regulator of glucitol operon [Transcription];


Pssm-ID: 443635  Cd Length: 127  Bit Score: 88.11  E-value: 1.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1410802039   1 MKIVLIASVIFIAQTFLAFFQVRYYQHHMNKVASKyagkiGYHLYSeMERLKFRTSAVAILVVNEEHIVHECQILTGKTI 80
Cdd:COG4578     5 IALILLAALAWLLQLALGWWQIRRFNRAFGELRNK-----GRVGIG-RSKGRFKPGVIVLLAVDRNGRVVDALIMKGVTV 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1410802039  81 FAKFKTFTDYHQKELSEILQELHEKKKHSIQeKAIIKTANSCMKAL 126
Cdd:COG4578    79 FARFKPLEELEGLDLDEIEPDLIFPKDKLLA-KALLAALEQIDRVR 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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