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Conserved domains on  [gi|1439265178|emb|STJ32156|]
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putative DNA methyltransferase [Escherichia coli]

Protein Classification

Dcm superfamily protein( domain architecture ID 1903316)

Dcm superfamily protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dcm super family cl43082
DNA-cytosine methylase [Replication, recombination and repair];
1-127 1.72e-23

DNA-cytosine methylase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0270:

Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 96.03  E-value: 1.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439265178   1 MKELCYGSVCSGIEAASIAWEPLGMRPAWFAEIEPFPSAVLAHRWPHVANL-GDMTKLAKKVLAGEIespDVLVGGTPCQ 79
Cdd:COG0270     1 SKKLTVIDLFAGAGGLSLGFEKAGFEVVFAVEIDPDACETYRANFPEAKVIeGDIRDIDPEELIPDV---DLLIGGPPCQ 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1439265178  80 AFSIAGLRGGLDDERGALTLKYVELANAiddkrsesfLKPTVIVWENV 127
Cdd:COG0270    78 PFSVAGKRKGLEDPRGTLFFEFIRIVEE---------LRPKAFVLENV 116
 
Name Accession Description Interval E-value
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
1-127 1.72e-23

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 96.03  E-value: 1.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439265178   1 MKELCYGSVCSGIEAASIAWEPLGMRPAWFAEIEPFPSAVLAHRWPHVANL-GDMTKLAKKVLAGEIespDVLVGGTPCQ 79
Cdd:COG0270     1 SKKLTVIDLFAGAGGLSLGFEKAGFEVVFAVEIDPDACETYRANFPEAKVIeGDIRDIDPEELIPDV---DLLIGGPPCQ 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1439265178  80 AFSIAGLRGGLDDERGALTLKYVELANAiddkrsesfLKPTVIVWENV 127
Cdd:COG0270    78 PFSVAGKRKGLEDPRGTLFFEFIRIVEE---------LRPKAFVLENV 116
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 8-128 1.25e-21

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 91.14  E-value: 1.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439265178   8 SVCSGIEAASIAWEPLGMRPAWFAEIEPFPSAVLAHRWPHVANLGDMTKLAKKVLageIESPDVLVGGTPCQAFSIAGLR 87
Cdd:cd00315     5 DLFAGIGGFRLGLEKAGFEIVAANEIDKSAAETYEANFPNKLIEGDITKIDEKDF---IPDIDLLTGGFPCQPFSIAGKR 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1439265178  88 GGLDDERGALTLKYVELANAIddkrsesflKPTVIVWENVQ 128
Cdd:cd00315    82 KGFEDTRGTLFFEIIRILKEK---------KPKYFLLENVK 113
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
8-127 2.74e-18

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 82.75  E-value: 2.74e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439265178   8 SVCSGIEAASIAWEPLGMRPAWFAEIEPFPSAVLAHRWPHVaNLGDMTKLAKKvlagEIESPDVLVGGTPCQAFSIAGLR 87
Cdd:pfam00145   5 DLFAGIGGFRLGLEQAGFECVAANEIDKSAAKTYEANFPKV-PIGDITLIDIK----DIPDIDILTGGFPCQDFSIAGKQ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1439265178  88 GGLDDERGALTLKYVELANAIddkrsesflKPTVIVWENV 127
Cdd:pfam00145  80 KGFEDTRGTLFFEIIRIIKEK---------KPKAFLLENV 110
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
 8-127 2.05e-16

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 77.37  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439265178   8 SVCSGIEAASIAWEPLGMRPAWFAEIEPFPSAVLAHRWPHVANLGDMTKLAKKvlagEIESPDVLVGGTPCQAFSIAGLR 87
Cdd:TIGR00675   3 DLFAGIGGIRLGFEQAGFKCVFASEIDKYAQKTYEANFGNKVPFGDITKISPS----DIPDFDILLGGFPCQPFSIAGKR 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1439265178  88 GGLDDERGALtlkYVELANAIDDKrsesflKPTVIVWENV 127
Cdd:TIGR00675  79 KGFEDTRGTL---FFEIVRILKEK------KPKFFLLENV 109
 
Name Accession Description Interval E-value
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
1-127 1.72e-23

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 96.03  E-value: 1.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439265178   1 MKELCYGSVCSGIEAASIAWEPLGMRPAWFAEIEPFPSAVLAHRWPHVANL-GDMTKLAKKVLAGEIespDVLVGGTPCQ 79
Cdd:COG0270     1 SKKLTVIDLFAGAGGLSLGFEKAGFEVVFAVEIDPDACETYRANFPEAKVIeGDIRDIDPEELIPDV---DLLIGGPPCQ 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1439265178  80 AFSIAGLRGGLDDERGALTLKYVELANAiddkrsesfLKPTVIVWENV 127
Cdd:COG0270    78 PFSVAGKRKGLEDPRGTLFFEFIRIVEE---------LRPKAFVLENV 116
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 8-128 1.25e-21

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 91.14  E-value: 1.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439265178   8 SVCSGIEAASIAWEPLGMRPAWFAEIEPFPSAVLAHRWPHVANLGDMTKLAKKVLageIESPDVLVGGTPCQAFSIAGLR 87
Cdd:cd00315     5 DLFAGIGGFRLGLEKAGFEIVAANEIDKSAAETYEANFPNKLIEGDITKIDEKDF---IPDIDLLTGGFPCQPFSIAGKR 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1439265178  88 GGLDDERGALTLKYVELANAIddkrsesflKPTVIVWENVQ 128
Cdd:cd00315    82 KGFEDTRGTLFFEIIRILKEK---------KPKYFLLENVK 113
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
8-127 2.74e-18

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 82.75  E-value: 2.74e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439265178   8 SVCSGIEAASIAWEPLGMRPAWFAEIEPFPSAVLAHRWPHVaNLGDMTKLAKKvlagEIESPDVLVGGTPCQAFSIAGLR 87
Cdd:pfam00145   5 DLFAGIGGFRLGLEQAGFECVAANEIDKSAAKTYEANFPKV-PIGDITLIDIK----DIPDIDILTGGFPCQDFSIAGKQ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1439265178  88 GGLDDERGALTLKYVELANAIddkrsesflKPTVIVWENV 127
Cdd:pfam00145  80 KGFEDTRGTLFFEIIRIIKEK---------KPKAFLLENV 110
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
 8-127 2.05e-16

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 77.37  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439265178   8 SVCSGIEAASIAWEPLGMRPAWFAEIEPFPSAVLAHRWPHVANLGDMTKLAKKvlagEIESPDVLVGGTPCQAFSIAGLR 87
Cdd:TIGR00675   3 DLFAGIGGIRLGFEQAGFKCVFASEIDKYAQKTYEANFGNKVPFGDITKISPS----DIPDFDILLGGFPCQPFSIAGKR 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1439265178  88 GGLDDERGALtlkYVELANAIDDKrsesflKPTVIVWENV 127
Cdd:TIGR00675  79 KGFEDTRGTL---FFEIVRILKEK------KPKFFLLENV 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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