|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
2-321 |
0e+00 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 584.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 2 VKKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPE 81
Cdd:PRK03202 1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 82 VRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEeHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTS 161
Cdd:PRK03202 81 GRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTE-HGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 162 HQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITELMTDVHQLAREIEERFG 241
Cdd:PRK03202 160 HERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGKKHAIIVVAEGVMPAEELAKEIEERTG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 242 HETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNEKLVHHDIIDAITNMRRPFKEEIFNTSRKLF 321
Cdd:PRK03202 240 LETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKLS 319
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-320 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 514.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 3 KKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPEV 82
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 83 RAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEeHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTSH 162
Cdd:cd00763 81 QAKAIEQLKKHGIDALVVIGGDGSYMGAMRLTE-HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSSH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 163 QRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITELMTDVHQLAREIEERFGH 242
Cdd:cd00763 160 QRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKHAIVVVAEGVYDVDELAKEIEEATGF 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1436932782 243 ETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNEKLVHHDIIDAITNMrRPFKEEIFNTSRKL 320
Cdd:cd00763 240 ETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGLAVGIQNEQLVHHDIIDAIENM-KPFKKDWLALAKKL 316
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
2-320 |
6.10e-166 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 464.93 E-value: 6.10e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 2 VKKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPE 81
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 82 VRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTS 161
Cdd:COG0205 81 GREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 162 HQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITE----------------- 224
Cdd:COG0205 161 HERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGYSIIVVAEgagdedgeavleadtda 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 225 -----LMTDVHQLAREIEERFGHETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNEKLVHHDII 299
Cdd:COG0205 241 fghvrLGGIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTGVMVGIRRGEIVLVPLE 320
|
330 340
....*....|....*....|..
gi 1436932782 300 DAITNMRR-PFKEEIFNTSRKL 320
Cdd:COG0205 321 EVANKEKPvDPDSPLIQLAREL 342
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
4-275 |
3.48e-159 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 445.25 E-value: 3.48e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPEVR 83
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 84 AKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTSHQ 163
Cdd:pfam00365 81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEERGIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSHN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 164 RISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFnKGKRHAIIAITELMTDVHQLAREIEERFGHE 243
Cdd:pfam00365 161 RVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFSIIVVAEGASDGEFLAKLIEEGTGIE 239
|
250 260 270
....*....|....*....|....*....|..
gi 1436932782 244 TRAAVLGHTQRGGAPCAFDRILASRMGVYAVE 275
Cdd:pfam00365 240 TRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
4-302 |
1.06e-150 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 424.84 E-value: 1.06e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPEVR 83
Cdd:TIGR02482 1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 84 AKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTSHQ 163
Cdd:TIGR02482 81 EKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEEGGIPVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 164 RISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITE--LMTDVHQLAREIEERFG 241
Cdd:TIGR02482 161 RAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDIDELIQRLKEQHEAGKKHSIIIVAEgnIVGSAKEVAKKIEEKTG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1436932782 242 HETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNEKLVHHDIIDAI 302
Cdd:TIGR02482 241 IETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGVMIGIQNNKIVTHPIEEAL 301
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
2-321 |
0e+00 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 584.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 2 VKKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPE 81
Cdd:PRK03202 1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 82 VRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEeHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTS 161
Cdd:PRK03202 81 GRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTE-HGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 162 HQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITELMTDVHQLAREIEERFG 241
Cdd:PRK03202 160 HERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGKKHAIIVVAEGVMPAEELAKEIEERTG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 242 HETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNEKLVHHDIIDAITNMRRPFKEEIFNTSRKLF 321
Cdd:PRK03202 240 LETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKLS 319
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-320 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 514.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 3 KKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPEV 82
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 83 RAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEeHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTSH 162
Cdd:cd00763 81 QAKAIEQLKKHGIDALVVIGGDGSYMGAMRLTE-HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSSH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 163 QRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITELMTDVHQLAREIEERFGH 242
Cdd:cd00763 160 QRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKHAIVVVAEGVYDVDELAKEIEEATGF 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1436932782 243 ETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNEKLVHHDIIDAITNMrRPFKEEIFNTSRKL 320
Cdd:cd00763 240 ETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGLAVGIQNEQLVHHDIIDAIENM-KPFKKDWLALAKKL 316
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
2-320 |
6.10e-166 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 464.93 E-value: 6.10e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 2 VKKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPE 81
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 82 VRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTS 161
Cdd:COG0205 81 GREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 162 HQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITE----------------- 224
Cdd:COG0205 161 HERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGYSIIVVAEgagdedgeavleadtda 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 225 -----LMTDVHQLAREIEERFGHETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNEKLVHHDII 299
Cdd:COG0205 241 fghvrLGGIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTGVMVGIRRGEIVLVPLE 320
|
330 340
....*....|....*....|..
gi 1436932782 300 DAITNMRR-PFKEEIFNTSRKL 320
Cdd:COG0205 321 EVANKEKPvDPDSPLIQLAREL 342
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
4-275 |
3.48e-159 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 445.25 E-value: 3.48e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPEVR 83
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 84 AKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTSHQ 163
Cdd:pfam00365 81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEERGIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSHN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 164 RISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFnKGKRHAIIAITELMTDVHQLAREIEERFGHE 243
Cdd:pfam00365 161 RVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFSIIVVAEGASDGEFLAKLIEEGTGIE 239
|
250 260 270
....*....|....*....|....*....|..
gi 1436932782 244 TRAAVLGHTQRGGAPCAFDRILASRMGVYAVE 275
Cdd:pfam00365 240 TRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-307 |
2.22e-156 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 440.58 E-value: 2.22e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 3 KKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPEV 82
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 83 RAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEH-----GIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRD 157
Cdd:cd00363 81 RAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWpskyqGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 158 TSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDK---ESLIRNIEDGFNKGKRHAIIAITELMTD------ 228
Cdd:cd00363 161 TASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADeweEEMVDVIKKRRERGKRHGIVIVAEGAIDfipkpi 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 229 -VHQLAREIEERFGHETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNE---KLVHHDIIDAITN 304
Cdd:cd00363 241 tEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGIQNLnenQVVRHPLTEAVNM 320
|
...
gi 1436932782 305 MRR 307
Cdd:cd00363 321 TKR 323
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
4-302 |
1.06e-150 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 424.84 E-value: 1.06e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPEVR 83
Cdd:TIGR02482 1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 84 AKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTSHQ 163
Cdd:TIGR02482 81 EKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEEGGIPVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 164 RISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITE--LMTDVHQLAREIEERFG 241
Cdd:TIGR02482 161 RAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDIDELIQRLKEQHEAGKKHSIIIVAEgnIVGSAKEVAKKIEEKTG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1436932782 242 HETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNEKLVHHDIIDAI 302
Cdd:TIGR02482 241 IETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGVMIGIQNNKIVTHPIEEAL 301
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
3-280 |
1.35e-91 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 288.08 E-value: 1.35e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 3 KKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYH--DRVIKLERRSVSEVINRGGTFLGSARFPEFKNP 80
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDggDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 81 EVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEE----------------------HGIACIGLPGTIDNDVAGTDYT 138
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEwpslleelvdtgkitaeqaeehRHLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 139 IGFQTALETALEAIDRLRDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFD---KESLIRNIEDGFNKGK 215
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEegwEDQLCHKLKRNRKAGK 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1436932782 216 RHAIIAITELMTDVH-------QLAREIEERFGHETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQG 280
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDlnpitseDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLES 312
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
2-307 |
8.45e-79 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 244.21 E-value: 8.45e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 2 VKKIAVLTSGGDAPGMNAAIRGVV-RAGLSEGLEVYGIQDGYYGLYHD--RVIKLERRSVSEVINRGGTFLGSAR----- 73
Cdd:PRK14071 4 KKRIGILTSGGDCAGLNAVIRAVVhRARGTYGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgdpf 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 74 -FPeFKNPEVRAKCVETLKKY---EIDALVVIGGDGSYMGAKLLTEEHGIACIGLPGTIDNDVAGTDYTIGFQTALETAL 149
Cdd:PRK14071 84 aFP-MPDGSLRDRSQEIIDGYhslGLDALIGIGGDGSLAILRRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVNIAT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 150 EAIDRLRDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITE-LMTD 228
Cdd:PRK14071 163 EALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTLENVCKKIRERQEEGKNFCLVVVSEaVRTE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 229 V-------------------HQLAREIEERFGHETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQ 289
Cdd:PRK14071 243 EgeqvtktqalgedryggigQYLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQGKFDRMVAWQ 322
|
330
....*....|....*...
gi 1436932782 290 NEKLVHHDIIDAITNMRR 307
Cdd:PRK14071 323 NRQVVSVPIAEAIATYRA 340
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-280 |
1.27e-77 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 251.67 E-value: 1.27e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 3 KKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYH--DRVIKLERRSVSEVINRGGTFLGSARFPEFKNP 80
Cdd:cd00764 4 KAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKggDYIKQAEWESVSNWLQEGGTIIGSARCKEFRER 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 81 EVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHG----------------------IACIGLPGTIDNDVAGTDYT 138
Cdd:cd00764 84 EGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPslleelvkdgkiteeevakyqhLNIVGMVGSIDNDFCGTDMT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 139 IGFQTALETALEAIDRLRDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFD---KESLIRNIEDGFNKGK 215
Cdd:cd00764 164 IGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEdgwEDQMCRRLSEHRSRGK 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1436932782 216 RHAIIAITE----------LMTDVHQLareIEERFGHETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQG 280
Cdd:cd00764 244 RLNIIIVAEgaiddqlkpiTSEDVKDL---VVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEA 315
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
3-277 |
3.24e-51 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 180.23 E-value: 3.24e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 3 KKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSAR-FPEFKNPE 81
Cdd:TIGR02478 390 LRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRsLPGDDLGT 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 82 VRAKcvetLKKYEIDALVVIGGDGSYMGAKLLT---EEHGIACI---GLPGTIDNDVAGTDYTIGFQTALETALEAIDRL 155
Cdd:TIGR02478 470 IAYY----FQQHKIDGLIIIGGFEAFEALYQLDaarEKYPAFRIpmvVIPATISNNVPGTEYSLGSDTALNEITEYCDNI 545
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 156 RDT-STSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIE---DGFNKGKRHAII-----AITELM 226
Cdd:TIGR02478 546 KQSaSASKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEhlkETFAEGRAGKLIlrnekASKVYT 625
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1436932782 227 TDVhqLAREIEE----RFghETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELL 277
Cdd:TIGR02478 626 TDF--IARIISEegkgRF--DARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFI 676
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-279 |
9.71e-50 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 176.55 E-value: 9.71e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPEVR 83
Cdd:cd00764 391 NIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETI 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 84 AkcvETLKKYEIDALVVIGGDGSYMGAKLLT---EEHGIACIGL---PGTIDNDVAGTDYTIGFQTALETALEAIDRLRD 157
Cdd:cd00764 471 A---YNFQKYGIDGLIIVGGFEAYKGLLQLRearEQYEEFCIPMvliPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQ 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 158 T-STSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDgFNKGKRHAI-------------IAIT 223
Cdd:cd00764 548 SaSGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEH-LTEKMKTTIgrglvlrnekcneNYTT 626
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1436932782 224 ELMTDVhqLAREIEERFGheTRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQ 279
Cdd:cd00764 627 VFTYEL--YSEEGKGVFD--CRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQ 678
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
4-294 |
4.29e-46 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 162.13 E-value: 4.29e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVRAGLSE-GLE-VYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARfpefkNPE 81
Cdd:PTZ00286 89 KAGIVTCGGLCPGLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSR-----GGF 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 82 VRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEE-----HGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLR 156
Cdd:PTZ00286 164 DPKVMVDTLIRHGINILFTLGGDGTHRGALAIYKElrrrkLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAY 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 157 DTSTSHQR-ISIVEIMGRHCGDLTLSAALAGGCEYI-IIPEKGFDKESLIRNIEDGFNKgKRHAIIAITE---------- 224
Cdd:PTZ00286 244 VEAKSAKNgVGIVKLMGRDSGFIALHASVASADVNVcLIPEFDIPLEGVLEYIEQRLQK-KGHCVIVVAEgagqslkdad 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 225 --LMTDV-----HQ-----LAREIEERFGHETRAAVLGHTQ-----RGGAPCAFDRILASRMGVYAVELLMQGYGGRCVG 287
Cdd:PTZ00286 323 ldLGTDAsgnkkLWdigvyLKDEITKYLKKKKPEHTVKYIDpsymiRAVPANAADAKFCTQLAQNAVHGAMAGFTGFIIG 402
|
....*..
gi 1436932782 288 IQNEKLV 294
Cdd:PTZ00286 403 HVHNNYV 409
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
4-307 |
1.65e-36 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 135.77 E-value: 1.65e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVRA-----GLSEgleVYGIQDGYYGL---YHDRVIKLERRSVSEVINRGGTFLGSARFP 75
Cdd:PRK06830 82 KAAIVTCGGLCPGLNDVIRAIVLElhhhyGVRR---ILGIRYGYQGLiprYGHDPVELTPEVVADIHEFGGTILGSSRGP 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 76 EfkNPEVrakCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHG-----IACIGLPGTIDNDVAGTDYTIGFQTALETALE 150
Cdd:PRK06830 159 Q--DPEE---IVDTLERMNINILFVIGGDGTLRGASAIAEEIErrglkISVIGIPKTIDNDINFIQKSFGFETAVEKATE 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 151 AIDRLRDTSTSHQR-ISIVEIMGRHCGDLTLSAALAGG-CEYIIIPEKGFDKESlirniEDGFNK-------GKRHAIIA 221
Cdd:PRK06830 234 AIRCAHVEANGAPNgIGLVKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEG-----PNGLLAalekrlaERGHAVIV 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 222 ITE-----LMTDVHQ---------------LAREIEERFGHETRAAVL-----GHTQRGGAPCAFDRILASRMGVYAVEL 276
Cdd:PRK06830 309 VAEgagqeLFDDTGEtdasgnpklgdiglfLKDRIKEYFKARGIPINLkyidpSYIIRSVPANANDSVYCGFLGQNAVHA 388
|
330 340 350
....*....|....*....|....*....|.
gi 1436932782 277 LMQGYGGRCVGIQNEKLVHHDiIDAITNMRR 307
Cdd:PRK06830 389 AMAGKTGMVVGRWNNRFVHLP-IDLAVSKRK 418
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
1-289 |
9.69e-36 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 133.45 E-value: 9.69e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 1 MVKKIAVLTSGGDAPGMNAAIRGVVRA--GLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGT---FLGSARFP 75
Cdd:PRK14072 2 MKGNALYAQSGGPTAVINASAAGVIEEarKHKKIGKVYGARNGIIGILDEDLIDLSKESDEALAALAHTpsgALGSCRYK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 76 EFKNPEVRAKC---VETLKKYEIDALVVIGGDGSyMG--AKL--LTEEHG--IACIGLPGTIDNDVAGTDYTIGF----- 141
Cdd:PRK14072 82 LKSLEEDRAEYerlLEVFKAHDIGYFFYNGGNDS-MDtaLKVsqLAKKMGypIRCIGIPKTIDNDLPGTDHCPGFgsaak 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 142 ---QTALETALeaidrlrDTS--TSHQRISIVEIMGRHCGDLTLSAALA-----GGCEYIIIPEKGFDKESLIRNIEDGF 211
Cdd:PRK14072 161 yiaTSVLEAAL-------DVAamANTSKVFILEVMGRHAGWLAAAAALAkqnpdDAPHLIYLPERPFDEEKFLADVRAIV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 212 NKGKRHAI-------------IAITELMTDVH---QL-------AREIEERFGHETRAAVLGHTQRGGAPCA--FDRILA 266
Cdd:PRK14072 234 KRYGYCVVvvsegirdadgkfIAEAGLAEDAFghaQLggvapvlANLIKEKLGKKVHWAVLDYLQRAARHIAskTDVEEA 313
|
330 340
....*....|....*....|...
gi 1436932782 267 SRMGVYAVELLMQGYGGRCVGIQ 289
Cdd:PRK14072 314 YAVGKAAVEYALAGKNGVMPAIR 336
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
4-224 |
1.64e-31 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 122.93 E-value: 1.64e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVrAGLSE--GL-EVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARfpefkNP 80
Cdd:PLN02564 89 RACIVTCGGLCPGLNTVIREIV-CGLSYmyGVtRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSR-----GG 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 81 EVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEE---HG--IACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRL 155
Cdd:PLN02564 163 HDTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEEirrRGlkVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAA 242
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1436932782 156 RDTSTS-HQRISIVEIMGRHCGDLTLSAALAG-GCEYIIIPEKGF---DKESLIRNIEDGFnKGKRHAIIAITE 224
Cdd:PLN02564 243 HVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPFyleGKGGLFEFIEKRL-KENGHMVIVVAE 315
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
4-307 |
7.08e-30 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 117.22 E-value: 7.08e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVRAglsegLEVYG------IQDGYYGLYHDRV--IKLERRSVSEVINRGGTFLGSARfp 75
Cdd:PLN02884 55 KAAIVTCGGLCPGLNDVIRQIVFT-----LEIYGvknivgIPFGYRGFFEKGLseMPLSRKVVQNIHLSGGSLLGVSR-- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 76 efKNPEVrAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEE-----HGIACIGLPGTIDNDVAGTDYTIGFQTALETALE 150
Cdd:PLN02884 128 --GGAKT-SDIVDSIEARGINMLFVLGGNGTHAGANAIHNEcrkrkMKVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQR 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 151 AIDRLRDTSTS-HQRISIVEIMGRHCGDLTLSAALAGG-CEYIIIPEKGFD---KESLIRNIEDGFNKgKRHAIIAITE- 224
Cdd:PLN02884 205 AINSAYIEAHSaYHGIGLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTldgPNGVLRHLEHLIET-KGSAVVCVAEg 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 225 ----LM-----TD-----------VHqLAREIEERFGHETRAAVLGHTQ-----RGGAPCAFDRILASRMGVYAVELLMQ 279
Cdd:PLN02884 284 agqdLLqktnaTDasgnpvlgdigVH-LQQEIKKHFKDIGVPADVKYIDptymiRACRANASDAILCTVLGQNAVHGAFA 362
|
330 340
....*....|....*....|....*...
gi 1436932782 280 GYGGRCVGIQNEKLVHHDIIDAITNMRR 307
Cdd:PLN02884 363 GFSGITVGICNTHYVYLPIPEVIAYPRR 390
|
|
| PRK07085 |
PRK07085 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
3-244 |
2.54e-22 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 235930 Cd Length: 555 Bit Score: 97.30 E-value: 2.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 3 KKIAVLTSGGDAPGMNAAIrgvvrAGLSEGLEV-------YGIQDGYYGLYHDRVIKLERRSVSEVINRGG-TFLGSARf 74
Cdd:PRK07085 71 LKVGVILSGGQAPGGHNVI-----AGLFDGLKKlnpdsklFGFIGGPLGLLNGKYIEITEEVIDEYRNTGGfDMIGSGR- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 75 PEFKNPEVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTE-----EHGIACIGLPGTIDNDVAGT--DYTIGFQTALET 147
Cdd:PRK07085 145 TKIETEEQKEACLETVKKLKLDGLVIIGGDDSNTNAAILAEyfakhGCKTQVIGVPKTIDGDLKNEfiETSFGFDTATKT 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 148 ALEAIDRL-RDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPE----KGFDKESLIRNIEDG----FNKGKRHA 218
Cdd:PRK07085 225 YSEMIGNIsRDALSAKKYWHFIKLMGRSASHIALECALQTHPNICLISEevaeKKMSLQDIVHYIASViadrAAKGKNYG 304
|
250 260 270
....*....|....*....|....*....|
gi 1436932782 219 IIAI----TELMTDVHQLAREIEERFGHET 244
Cdd:PRK07085 305 VILIpeglIEFIPEMKSLIKELNSLLAENE 334
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
1-201 |
1.35e-19 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 88.53 E-value: 1.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 1 MVKKIAVLTSGGDAPGMNAAIRGVVRA--GLSEGLEVYGIQDGYYGLYHDRVIKL--ERRSVSEVINR-GGTFLGSAR-- 73
Cdd:PRK06555 2 AVKKVALLTAGGLAPCLSSAVGGLIERytEIAPEVEIIAYRSGYQGLLLGDSIEItpAVRANAGLLHRyGGSPIGNSRvk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 74 ------------FPEFKNP-EVRAkcvETLKKYEIDALVVIGGD-----GSYMGAKLLTEEHGIACIGLPGTIDNDVAGT 135
Cdd:PRK06555 82 ltnvadcvkrglVKEGENPlKVAA---ERLAADGVDILHTIGGDdtnttAADLAAYLAENGYDLTVVGLPKTIDNDVVPI 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1436932782 136 DYTIGFQTALETALEAIDRLRDTSTSHQRISIV-EIMGRHCGDLTLSAALA-----GGCEYiiIPEKGFDKE 201
Cdd:PRK06555 159 RQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATARAyrewlDRQEY--VPGFGLSAE 228
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
2-224 |
5.87e-19 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 87.79 E-value: 5.87e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 2 VKKIAVLTSGGDAPGMNAAIRGVVRAG--LSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGG-TFLGSARfPEFK 78
Cdd:PTZ00287 177 VLKIGIILSGGPAPGGHNVISGIYDYAkrYNEQSQVIGFLGGIDGLYSKNYVTITDSLMNRFRNLGGfNMLWSGR-GKVR 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 79 NPEVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHG-----IACIGLPGTIDNDVA--GTDYTIGFQTALETALEA 151
Cdd:PTZ00287 256 NKDDLIAIENIVAKLKLNGLVIIGGDGSNSNAALISEYFAerqipISIIGIPKTIDGDLKseAIEISFGFDTATKTYSEV 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 152 IDRL-RDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKgFDKESL-----IRNIEDGFNK----GKRHAIIA 221
Cdd:PTZ00287 336 IGNLcTDVKTGHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEE-VEKENLslkdiVSNIVNTILKrrslNKNYGVIL 414
|
...
gi 1436932782 222 ITE 224
Cdd:PTZ00287 415 IPE 417
|
|
| PLN02251 |
PLN02251 |
pyrophosphate-dependent phosphofructokinase |
4-244 |
1.28e-18 |
|
pyrophosphate-dependent phosphofructokinase
Pssm-ID: 215140 Cd Length: 568 Bit Score: 86.38 E-value: 1.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVV-----RAglsEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGG-TFLGSARfPEF 77
Cdd:PLN02251 98 KIGVVLSGGQAPGGHNVISGIFdylqeHA---KGSVLYGFKGGPAGIMKCKYVELTAEFIYPYRNQGGfDMICSGR-DKI 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 78 KNPEVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTE---EHGIAC--IGLPGTIDNDVAGTDYTI--GFQTALETALE 150
Cdd:PLN02251 174 ETPEQFKQAEETATKLDLDGLVVIGGDDSNTNACLLAEyfrAKNLKTrvIGCPKTIDGDLKSKEVPTsfGFDTACKIYSE 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 151 AI-DRLRDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGF--------NKGKRHAIIA 221
Cdd:PLN02251 254 MIgNVMIDARSTGKYYHFVRLMGRAASHITLECALQTHPNITIIGEEVAAKKLTLKNVTDYIvdvickraELGYNYGVIL 333
|
250 260
....*....|....*....|....*..
gi 1436932782 222 ITELMTD----VHQLAREIEERFGHET 244
Cdd:PLN02251 334 IPEGLIDfipeVQHLIAELNEILAHDV 360
|
|
| Pyrophosphate_PFK |
cd00765 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-209 |
9.11e-18 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.
Pssm-ID: 238390 Cd Length: 550 Bit Score: 83.77 E-value: 9.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPGMNAAIRGVVRA--GLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGG-TFLGSARfPEFKNP 80
Cdd:cd00765 74 KIGIVLSGGQAPGGHNVISGLFDYlkERAKGSTLYGFKGGPAGILKCDYIELNAEYIQPYRNTGGfDMICSGR-TKIETE 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 81 EVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEH-----GIACIGLPGTIDNDVAG--TDYTIGFQTALETALEAID 153
Cdd:cd00765 153 DQFKQAEETAKKLDLDALVVIGGDDSNTNAALLAENFrskglKTRVIGVPKTIDGDLKNkeIETSFGFDTATKIYSELIG 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1436932782 154 RL-RDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIED 209
Cdd:cd00765 233 NVmRDARSTGKYWHFVKLMGRSASHIALECALKTHPNICIISEEVSAQKQTLKNITD 289
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
3-224 |
1.97e-17 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 83.10 E-value: 1.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 3 KKIAVLTSGGDAPGMNAAIRGVVR--AGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGG-TFLGSARFPEFKN 79
Cdd:PTZ00468 103 RRIGVVLSGGQASGGHNVIAGLMSyiKLCNQSSQLFGFLGGPEGVYSERYRELTEDDINGILNQGGfNIICSGRHKIETE 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 80 PEVRAKcVETLKKYEIDALVVIGGDGSYMGAKLLTE-----EHGIACIGLPGTIDNDVAG--TDYTIGFQTALETALEAI 152
Cdd:PTZ00468 183 EQMRAS-LEICEKLKLHGLVVIGGDDSNTNAAVLAEyfkrnSSSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQI 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 153 DRLRDT-STSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGF--------NKGKRHAIIAIT 223
Cdd:PTZ00468 262 GSIMDAiKTEGYGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEENRSLMSIVDEIvemilkrdSLGKKHGIVLLP 341
|
.
gi 1436932782 224 E 224
Cdd:PTZ00468 342 E 342
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
4-209 |
8.60e-08 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 53.89 E-value: 8.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 4 KIAVLTSGGDAPG-MNaairgvVRAGLSEGLEVY-GIQDGYYGLY---HDRVIKLERRSVSEVINRGGTFLgSARFPEFK 78
Cdd:PTZ00287 838 KIGIVFLSRQAPGaMN------VLCGLYRRLKLLkGVCIAFYGLYgllNNKYIIIDDDNIAKHVNQGGLEL-TGNSPEHS 910
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 79 --NPEVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTE---EHGI--ACIGLPGTIDNDVAG--TDYTIGFQTALETAL 149
Cdd:PTZ00287 911 lfDKENRNKVCETVTNLQLNGLVMPGSNVTITEAALLAEyflEKKIptSVVGIPLTGSNNLIHelIETCVGFDSSTKVYA 990
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1436932782 150 EAI-DRLRDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEK-GFDKESLIRNIED 209
Cdd:PTZ00287 991 SLIgNVLTDAVSMPKYWHFIRLMGRSPSHEVLECALQTHPNMVIISEEyGAADKTLWRVVQD 1052
|
|
| PLN03028 |
PLN03028 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
2-236 |
1.38e-05 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 215543 Cd Length: 610 Bit Score: 46.69 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 2 VKKIAVLTSGGDAPGMNAAIrgvvrAGLSEGLEVY-------GIQDGYYGLYHDRVIKLERRSVSEVINRGG-TFLGSAR 73
Cdd:PLN03028 79 AVRVGVVFCGRQSPGGHNVI-----WGLHDALKAHnpnsvllGFLGGTEGLFAQKTLEITDDVLSTYKNQGGyDLLGRTK 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 74 fPEFKNPEVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTE---EHGIA--CIGLPGTIDNDVAG--TDYTIGFQTALE 146
Cdd:PLN03028 154 -DQIRTTEQVNAALAACEALKLDGLVIIGGVTSNTDAAQLAEtfaEAKCKtkVVGVPVTLNGDLKNqfVETNVGFDTICK 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436932782 147 TALEAIDRL-RDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEK-GFDKESL---IRNIEDGFN----KGKRH 217
Cdd:PLN03028 233 VNSQLISNVcTDALSAEKYYYFIRLMGRKASHVALECALQSHPNMVILGEEvAASKLTLfdiTKQICDAVQaraeQDKNH 312
|
250 260
....*....|....*....|...
gi 1436932782 218 AIIAI----TELMTDVHQLAREI 236
Cdd:PLN03028 313 GVILIpeglIESIPEVYALLQEI 335
|
|
| |
