|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
22-425 |
1.47e-85 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 269.37 E-value: 1.47e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 22 AAKILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGEL 101
Cdd:cd13131 2 LRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 102 FGQGIWMSLLITVIGAIGLLNPDFLINLAGeLSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVAS 181
Cdd:cd13131 82 VRQGLWLALLLSLPLMLLLWLAPPILPLMG-QEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 182 LPLKFFINWLLIFGHLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRL--RLSRPKPHIIAEILRLGIPMGA 259
Cdd:cd13131 161 LVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLfaRFWRPDWARLKELLRLGLPIGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 260 SYLVEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFI 339
Cdd:cd13131 241 TIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 340 LTIALVLLMKNEIIGLYTQDPQVALIAGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQTVCLLGIGIGIGFYFG 419
Cdd:cd13131 321 LTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLLA 400
|
....*.
gi 1436876125 420 FGAGKG 425
Cdd:cd13131 401 FTTGLG 406
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
30-425 |
2.35e-74 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 240.87 E-value: 2.35e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 30 WPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFGQGIWMS 109
Cdd:PRK01766 19 LPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAHQVRQGLWLA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 110 LLITVIGAIGLLNPDFLINLAGELSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPLKFFIN 189
Cdd:PRK01766 99 LFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGFLGLLINIPLN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 190 WLLIFGHLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRL--RLSRPKPHIIAEILRLGIPMGASYLVEICA 267
Cdd:PRK01766 179 YIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLfkGLYKPDWAVIKRLLKLGLPIGLAIFFEVSL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 268 FTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTIALVLL 347
Cdd:PRK01766 259 FAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVGLGMALLTAIFLVL 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1436876125 348 MKNEIIGLYTQDPQVALIAGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQTVCLLGIGIGIGFYFGFGAGKG 425
Cdd:PRK01766 339 FREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGLPLGYILALTDPMG 416
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
24-460 |
7.36e-67 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 220.40 E-value: 7.36e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 24 KILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFG 103
Cdd:COG0534 9 LLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 104 QGIWMSLLIT-VIGAIGLLNPDFLINLAGeLSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASL 182
Cdd:COG0534 89 QALLLALLLGlLLTLLGLLFAPPLLRLLG-ADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 183 PLKFFINWLLIFGhlgfSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASYL 262
Cdd:COG0534 168 VLNIVLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 263 VEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTI 342
Cdd:COG0534 244 AESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 343 ALVLLMKNEIIGLYTQDPQVALIAGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQTVCLLGIGIGIGFYFGFGA 422
Cdd:COG0534 324 LLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLG 403
|
410 420 430
....*....|....*....|....*....|....*...
gi 1436876125 423 GkgqlalitqvlmphsttGLASLWLMNALSLMVCSLVL 460
Cdd:COG0534 404 L-----------------GLTGVWLALPIGEVLRALLL 424
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
31-372 |
1.96e-44 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 158.95 E-value: 1.96e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 31 PILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFGQGIWMSL 110
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 111 LITVIGAIGLLNPDFLINLAGELSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPLKFFINW 190
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 191 LLIFGHLGFsqMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASYLVEICAFTF 270
Cdd:TIGR00797 161 ILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 271 ITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTIALVLLMKN 350
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330 340
....*....|....*....|..
gi 1436876125 351 EIIGLYTQDPQVALIAGGLLSF 372
Cdd:TIGR00797 319 FIARLFTNDPEVLELAAIYLIF 340
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
24-366 |
4.89e-41 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 151.91 E-value: 4.89e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 24 KILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFG 103
Cdd:cd13133 6 EILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 104 QGIWMSLLITVIGA-IGLLNPDFLINLAGElSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASL 182
Cdd:cd13133 86 QGLYFSLLLAPLLAlLSALAAPLLFLLLGH-SPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 183 PLKFFINWLLIFGHLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLS-RPKPHIIAEILRLGIPMGASY 261
Cdd:cd13133 165 VVNIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAwRFDRELLRRILRLGLPSGLQF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 262 LVEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILT 341
Cdd:cd13133 245 FLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLL 324
|
330 340
....*....|....*....|....*
gi 1436876125 342 IALVLLMKNEIIGLYTQDPQVALIA 366
Cdd:cd13133 325 GILFLLFPELLLSIFTPGADFALIA 349
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
24-472 |
1.48e-39 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 148.04 E-value: 1.48e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 24 KILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFG 103
Cdd:cd13137 2 RIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 104 QGIWMSLLIT-VIGAIGLLNPDFLINLAGeLSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASL 182
Cdd:cd13137 82 QSLLLALLLSlPLALLGLLFAEPLLRLLG-ADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 183 PLKFFINWLLIFGHLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASYL 262
Cdd:cd13137 161 VLNIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 263 VEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTI 342
Cdd:cd13137 241 LRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 343 ALVLLMKNEIIGLYTQDPQVALIAGGLLS-------FFPVIHCWDGlqclntyALRAHRIATVPFILQTVCLLGIGIGIG 415
Cdd:cd13137 321 LLLFIFAPPLASLFTPDPEVIELGVLYLRivalsqpFLAISFVLSG-------ALRGAGDTRPPLIINLISMWLVRLPLA 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1436876125 416 FYFGFGAGKgqlalitqvlmphsttGLASLWLMNALSLMVCSLvlhsWYWYVYRKNK 472
Cdd:cd13137 394 YLLGFVLGL----------------GLTGIWLAMFVDTIVRAI----LLLYRFRKGK 430
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
25-425 |
5.59e-39 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 146.81 E-value: 5.59e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 25 ILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFGQ 104
Cdd:PRK00187 12 ILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGAGDIEGATRLAQA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 105 GIWMSLLITVIGAIGLLNPDFLINLAGElSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPL 184
Cdd:PRK00187 92 GLWLAWLLALVAALLLWNLKPLLLLFGQ-APQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLAGAVA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 185 KFFINWLLIFGHLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLR--LSRPKPHIIAEILRLGIPMGASYL 262
Cdd:PRK00187 171 NLLLNYALIEGWFGLPKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAYPLRkgLSRPSRAALRELWRLGLPIGGTYA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 263 VEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTI 342
Cdd:PRK00187 251 VEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVMLLFA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 343 ALVLLMKNEIIGLYTQ--DPQVALI---AGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQTVCLLGIGIGIGFY 417
Cdd:PRK00187 331 GLFWLLPEAIIGLFLDrnDPAFAEIvqlAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWL 410
|
....*...
gi 1436876125 418 FGFGAGKG 425
Cdd:PRK00187 411 LAFTLGWG 418
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
25-425 |
9.00e-39 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 145.72 E-value: 9.00e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 25 ILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFGQ 104
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 105 GIWMSLLI-TVIGAIGLLNPDFLINLAGeLSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLP 183
Cdd:cd13134 85 ALLFNLLLgLVFSLLLLFFGAELLRLMG-LPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 184 LKFFINWLLIFGHLGFSQMGSDGAGISTaVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKP-HIIAEILRLGIPMGASYL 262
Cdd:cd13134 164 LNIVGNYLLIFGWFGLPKLGVAGVAIST-VISRAVGLVLLFILLFRKLKIRFRLKDLRPFPkKLLKKILKIGLPSAGEEL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 263 VEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTI 342
Cdd:cd13134 243 SYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 343 ALVLLMKNEIIGLYTQDPQVALIAGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQTVCLLGIGIGIGFYFGFGA 422
Cdd:cd13134 323 LLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLGIVL 402
|
...
gi 1436876125 423 GKG 425
Cdd:cd13134 403 GLG 405
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
30-465 |
2.48e-34 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 133.22 E-value: 2.48e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 30 WPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFGQGIWMS 109
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 110 LLITVIGAIGLLNPDFLINLAGELSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPLKFFIN 189
Cdd:cd12082 82 ILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 190 WLLIFGhLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASYLVEICAFT 269
Cdd:cd12082 162 PLLIFG-LGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 270 FITLFVAR-EGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTIALVLLM 348
Cdd:cd12082 241 IIVAIVAAfGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 349 KNEIIGLYTQDPQVALIAGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQTVCLLGIGIGIGFyfgfgagkgqla 428
Cdd:cd12082 321 PEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAY------------ 388
|
410 420 430
....*....|....*....|....*....|....*..
gi 1436876125 429 litqvLMPHSTTGLASLWLMNALSLMVCSLVLHSWYW 465
Cdd:cd12082 389 -----VLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
22-471 |
8.87e-32 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 126.15 E-value: 8.87e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 22 AAKILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIY-VTIVISLMGVIHALIPICAQTIGANKLHEVGE 100
Cdd:cd13132 2 AKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFAnVTGFSILLGLASALDTLCGQAFGAKNYKLVGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 101 LFGQGIWMSLLITVIGAIGLLNPDFLINLAGElSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVA 180
Cdd:cd13132 82 YLQRALVILLLCCVPISLLWLNTEPILLLLGQ-DPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 181 SLPLKFFINWLLIFGHlgfsQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGAS 260
Cdd:cd13132 161 ALLLNILLNYLLVFVL----GLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALM 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 261 YLVEICAFTFITLFVAREGAYVS-ASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFI 339
Cdd:cd13132 237 LCLEWWAFEILVLLAGLLPGTVAlAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 340 LTIALVLLMKNEIIGLYTQDPQVALIAGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQTVCLLGIGIGIGFYFG 419
Cdd:cd13132 317 VVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLA 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1436876125 420 FGAGKgqlalitqvlmphsttGLASLWLMNALSLMVCSLVLhswYWYVYRKN 471
Cdd:cd13132 397 FVLGL----------------GLKGLWIGLIAGLILQAVIL---LLIILRTD 429
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
30-425 |
5.57e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 124.23 E-value: 5.57e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 30 WPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIyVTIVISL-MGVIHALIPICAQTIGANKLHEVGELFGQGIWM 108
Cdd:cd13142 18 WPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPL-IFLFISLgGGLTVAGTALVAQYTGAGDYDKANKVAGQTFSF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 109 SLLI-TVIGAIGLLNPDFLINLAGELSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPLKFF 187
Cdd:cd13142 97 VIILsLILAVLGYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFGSVLLNVI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 188 INWLLIFGHLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASYLVEICA 267
Cdd:cd13142 177 LDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLRDLKPDWEWLKKIFRIGLPSSIEQSARALG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 268 FTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTIALVLL 347
Cdd:cd13142 257 FTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFL 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1436876125 348 MKNEIIGLYTQDPQVALIAGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQTVCLLGIGIGIGFYFGFGAGKG 425
Cdd:cd13142 337 FAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLG 414
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
21-470 |
2.25e-30 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 122.18 E-value: 2.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 21 LAAKILRQVWPILISQWVGVAFAIIDSVMLGNF-SVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVG 99
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFlGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 100 ELFGQGIWMSLLITVI-GAIGLLNPDFLINLAGeLSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLS 178
Cdd:cd13138 81 KAVGTLLVLFLILGIVlTILGLLFAPPILRLMN-TPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 179 VASLPLKFFINWLLIFGHlgfsQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMG 258
Cdd:cd13138 160 IIACVLNIILDLLFIAVF----HMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKEILKIGLPSA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 259 ASYLVEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGF 338
Cdd:cd13138 236 LQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 339 ILTIALVLLMKNEIIGLYTQDPQVALIAGGLLSFFpVIHCW--DGLQCLNTYaLRAHRIATVPFILQTVCLLGIGIGigf 416
Cdd:cd13138 316 LIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIY-SIDYIlfGILFVFNGL-FRGLGKTKFPMIISILRLWLVRIP--- 390
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1436876125 417 yfgfgagkgqLALITQVLMPHsttGLASLWLMNALSLMVCSLVLHSWYWYVYRK 470
Cdd:cd13138 391 ----------LAYLLSRLTGL---GLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
23-366 |
6.00e-19 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 88.77 E-value: 6.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 23 AKILRQVWPILISQWVGVAFAIIDSVMLGNF-SVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGEL 101
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLgSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 102 FGQGIWMSLLITVIGAIGLLNPDFLINLAGELSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVAS 181
Cdd:cd13136 83 LVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 182 LPLKFFINWLLIFGhlgfSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASY 261
Cdd:cd13136 163 NVVNIVLDPLFVFG----LGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 262 LVEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILT 341
Cdd:cd13136 239 LALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLL 318
|
330 340
....*....|....*....|....*
gi 1436876125 342 IALVLLMKNEIIGLYTQDPQVALIA 366
Cdd:cd13136 319 ALLFFLGGEPIIRLFTDDPAVLALA 343
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
24-370 |
8.44e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 85.27 E-value: 8.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 24 KILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAA-SIYVTIVISLMGVIHALIPIcAQTIGANKLHEVGELF 102
Cdd:cd13140 6 TLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAGfFVWLAYALALLSKIGAQVKV-SQSIGAKDEKEARKYA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 103 GQGIWMSLLITVI-GAIGLLNPDFLINLAGELSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVAS 181
Cdd:cd13140 85 RNALQLNLLLGILyGLLLLLFAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 182 LPLKFFINWLLIFGHLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGasy 261
Cdd:cd13140 165 LVLNIILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLPVA--- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 262 lVEICAFTFITLFVARE----GAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIA- 336
Cdd:cd13140 242 -LQSILFALISMILARIiasfGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAi 320
|
330 340 350
....*....|....*....|....*....|....
gi 1436876125 337 GFILTIALVLLmKNEIIGLYTQDPQVALIAGGLL 370
Cdd:cd13140 321 GLFATLLLFFF-GEPLFSLFIPDPETIAIGVDYL 353
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
31-366 |
5.94e-17 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 82.56 E-value: 5.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 31 PILISQWVGVAFAIIDSVMLGNF-SVQALQTISIAASIY-VTIVISLM-GVIHAliPICAQTIGANKLHEVGELFGQGIW 107
Cdd:cd13143 12 PAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIImLLMALGLMiGVGGA--SLISRRLGAGDREKANRIFSTALL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 108 MSLLIT-VIGAIGLLNPDFLINLAGElSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPLKF 186
Cdd:cd13143 90 LSLILGlLLTILGLLFLDPLLRLLGA-SGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 187 FINWLLIFGHlgfsQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASYLVEIC 266
Cdd:cd13143 169 ILDPLFIFVL----GLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLMQLSSSV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 267 AFTFITLFVAR-EGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTIALV 345
Cdd:cd13143 245 VTIVLNLTLLGyGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLIL 324
|
330 340
....*....|....*....|.
gi 1436876125 346 LLMKNEIIGLYTQDPQVALIA 366
Cdd:cd13143 325 LLFPEQIVSLFTDDPELIALA 345
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
31-191 |
1.24e-15 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 74.14 E-value: 1.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 31 PILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFGQGIWMSL 110
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 111 LITV-IGAIGLLNPDFLINLAGElSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPLKFFIN 189
Cdd:pfam01554 81 LLSLpIALLVLLFSEPILSLFGQ-DEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 1436876125 190 WL 191
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
24-421 |
4.75e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 76.95 E-value: 4.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 24 KILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFG 103
Cdd:cd13135 2 KINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 104 QGIWMSLLITVIGAIGLLNPDFLINLAGELSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLP 183
Cdd:cd13135 82 SSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 184 LKFFINWLLIFGHLGFSQMGSDGAGISTaVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAE---ILRLGIPMGAS 260
Cdd:cd13135 162 LNVILDYVLIFGNFGFPRLGIIGAAIAT-TIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRPykfTIKLGLPLGGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 261 YLVEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFIL 340
Cdd:cd13135 241 EFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 341 TIALVLLMKNEIIGLYTQDPQVALIAGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQ---TVCLLGIGIGIGFY 417
Cdd:cd13135 321 AAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQiigTIIVVSVALLLIFV 400
|
....
gi 1436876125 418 FGFG 421
Cdd:cd13135 401 FKLG 404
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
42-373 |
6.87e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 76.50 E-value: 6.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 42 FAIIDSVMLGNFSVQALQTISIAASIyVTIVISL-MGVIHALIPICAQTIGANKLHEVGELFGQGIWMSLLIT-VIGAIG 119
Cdd:cd13139 33 FAVVDLYFVSRLGALAIATVGLTESV-LTIVYSIaIGLSMAATALVARRIGEKDPEGAGFAAVQAILLGVALSlILSILG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 120 LLNPDFLINLAGeLSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPLKFFINWLLIFGHLGF 199
Cdd:cd13139 112 YFFAEDILSLMG-ASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNIILDPLFIFGLGPI 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 200 SQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASYLVEICAFTFITLFVAREG 279
Cdd:cd13139 191 PAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLKLDWAIIKKIIKIAVGGILQFLIASSSWIFLVRIIAEFG 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 280 AYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSV-LAGFALAIagFILTIALV-LLMKNEIIGLYT 357
Cdd:cd13139 271 STALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVwRAGKYNMV--FLGIVSLVfFLFAEPLVSFFT 348
|
330
....*....|....*.
gi 1436876125 358 QDPQVALIAGGLLSFF 373
Cdd:cd13139 349 TDPEVIAIAVEALRII 364
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
40-363 |
1.09e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 69.64 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 40 VAFAIIDSVMLGNFSVQALQTISIAASIyVTIVISL-MGVIHALIPICAQTIGANKLHEVGELFGQGIWMSLLITV-IGA 117
Cdd:cd13149 26 LIFNLTDTFFVGKLGTKELAAISFTFPV-VLFLNSLtIGLGIGASAVISRAIGAGDRNKAKRLATDSLILSLLLSViVSL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 118 IGLLNPDFLINLAGElSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPLKFFINWLLIFGHL 197
Cdd:cd13149 105 LGLFTIPPLFSLLGA-SGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAALVNVILDPILIFGFG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 198 GFSQMGSDGAGISTaVVSWFQLVVGLLLLLldpHYQRYRLRLSRPKPHIIA----EILRLGIPMGASYLVEICAFTFITL 273
Cdd:cd13149 184 PIPGMGIAGAAIAT-VISRALGLGAALYFL---HYHHRLIDFSEPSLKALFrswkDILSIGIPAALSNILTPLSAAFITA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 274 FVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIA-GFILTIALVLLMKNeI 352
Cdd:cd13149 260 LVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIyGAILGIVLALFAGW-L 338
|
330
....*....|.
gi 1436876125 353 IGLYTQDPQVA 363
Cdd:cd13149 339 ASLFSAEPEVI 349
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
42-370 |
9.63e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 66.85 E-value: 9.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 42 FAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGELFGQGIWMSLLIT-VIGAIGL 120
Cdd:cd13145 28 FNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAiLLTVIGL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 121 LNPDFLINLAGElSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLPLKFFINWLLIFGHLGFS 200
Cdd:cd13145 108 FAAPPLFRLLGA-EGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILDPLFIFGGGGIP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 201 QMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASYLVEICAFTFITLFVAREGA 280
Cdd:cd13145 187 AMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQGFPASLNMMTIGLGIFVITYFVGQFGD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 281 YVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQ----WEVAHRSVLAGFALAIAGfiltIALVLLMKNEIIGLY 356
Cdd:cd13145 267 EAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKydrvRETYKKALKYGFVIMVVA----TVFLLFFAEPLMSLF 342
|
330
....*....|....
gi 1436876125 357 TQDPQVALIAGGLL 370
Cdd:cd13145 343 TNDPAVIAIGAGYL 356
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
256-408 |
2.17e-10 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 59.12 E-value: 2.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 256 PMGASYLVEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAI 335
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1436876125 336 AGFILTIALVLLMKNEIIGLYTQDPQVALIAGGLLSFFPVIHCWDGLQCLNTYALRAHRIATVPFILQTVCLL 408
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLL 153
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
31-434 |
3.87e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 55.32 E-value: 3.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 31 PILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYvTIVISL---MGV-IHALIpicAQTIGANKLHEVGELFGQGI 106
Cdd:cd13144 16 PAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQ-NLMIAVavgTGVgVNALL---SRSLGEKDQKEANKAANNGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 107 WMSLLIT---VIGAIGLLNPDFLINLAgelSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVASLP 183
Cdd:cd13144 92 LLALLSYllfLLLGLFGVKPFFRLFTD---DPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 184 LKFFINWLLIFGHLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGASYLV 263
Cdd:cd13144 169 INIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIYAVGLPSIIMQAI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 264 EICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFILTIA 343
Cdd:cd13144 249 SSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIMLAGGL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 344 LVLLMKNEIIGLYTQDPQVALIAggllsffpvihcwdglqclnTYALrahRIATVPFILQTVCLLGIGIGIgfyfgfGAG 423
Cdd:cd13144 329 LFQLFPDQLLGLFNASEEMLAIG--------------------VPAL---RIISLSFLFAALSIILSGLFQ------ALG 379
|
410
....*....|.
gi 1436876125 424 KGQLALITQVL 434
Cdd:cd13144 380 RGVYSLIISVA 390
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
25-372 |
6.25e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 48.47 E-value: 6.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 25 ILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVtIVISLMGVIH-ALIPICAQTIGANKLHEVGELFG 103
Cdd:cd13141 13 IISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMF-FVMALTQVLNvGTAALVSHAVGRKDQGEANAVFN 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 104 QGIWMSLLITVIGAIG--LLNPDFLINLAGElspevRADVASYLRYTFYGLPAALMfRVVYSICTASQRAS----TVMYL 177
Cdd:cd13141 92 QSLLLAAVLGLVVLVLgyLFGRLYLETLAAD-----AATVEAATTYLYWFIPSLAL-QFILTVLGAALRGTgivkPFMVI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 178 SVASLPLKFFINWLLIFGHLGFSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPM 257
Cdd:cd13141 166 QILAVLLNIILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWRPDLPTWKRLLKIGLPS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 258 GASYLVEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAhRSVLAGFALAIAG 337
Cdd:cd13141 246 GGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRV-RETFRITAILTTA 324
|
330 340 350
....*....|....*....|....*....|....*.
gi 1436876125 338 FILTIALVLLMKNE-IIGLYTQDPQVALIAGGLLSF 372
Cdd:cd13141 325 LMLVLTLLCQLVPElLVTPFSDDAAVIAVAATFLRY 360
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
25-367 |
6.26e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 45.08 E-value: 6.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 25 ILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLM---GVIHALIPICAQTIGANKLHEVGEL 101
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVGGIGLVFPLGMIFLAlgnGIQVGVSSLLARAIGAQRAKELDQA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 102 FGQGIWMSLLI-TVIGAIGLLNPDFLIN-LAGELSPEVRAdvASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSV 179
Cdd:cd13146 90 ADSGLALALLAaTVIVVLGYIFAEPLLQlLGAKGLLLEYA--LEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAML 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 180 ASLPLKFFINWLLIFGhlgfSQMGSDGAGISTAVVSWFQLVVGLLLLLLDPHYQRYRLRLSRPKPHIIAEILRLGIPMGA 259
Cdd:cd13146 168 IGTVVNIVLDPILIFV----FDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSNISSSVIVEILRVGLPQML 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 260 SYLVEICAFTFITLFVAREGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVLAGFALAIAGFI 339
Cdd:cd13146 244 LQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVL 323
|
330 340
....*....|....*....|....*...
gi 1436876125 340 LTIALVLLMKNEIIGLYTQDPQVALIAG 367
Cdd:cd13146 324 VLVLGYVLVAPWLFSLFTTVPEVVAYAV 351
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
25-376 |
1.08e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 44.45 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 25 ILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYVTIVISLMGV---IHALIpicAQTIGANKLHEVGEL 101
Cdd:cd13147 11 IIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLgagASSAI---SRRIGAKDKEGADNA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 102 FGQGIWMSLLITVIGAIGL---LNPDFLINLAGElspeVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLS 178
Cdd:cd13147 88 AVHSILLGLIISIILTIVLlpfLEPILVLMGAGE----VLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 179 VASLPLKFFINWLLIFGhLGfsqMGSDGA----GISTAVVS-----WFqlvvglllLLLDPHYQRYRLRLSRPKPHIIAE 249
Cdd:cd13147 164 VAGSILNIILDPIFIYT-LG---LGIAGAawatVISMLISSlvllyWF--------FVKKDTYVSLSLKNFKFDKKIVKD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 250 ILRLGIPMGASYLVEICAFTFITLFVAR-EGAYVSASHQILFNLISFTYMIPMSIGIATAAQTAQALGARQWEVAHRSVL 328
Cdd:cd13147 232 ILKVGIPASLEQLIMSVLMIILNLILVIvAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYN 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1436876125 329 AGFALAIAGFILTIALVLLMKNEIIGLYTQDPQVALIAGGLLSFFPVI 376
Cdd:cd13147 312 YSIKLGLIIELIIAILIFIFAPQIAYLFTYSEESAHLAPEIVAFLRIM 359
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
24-218 |
1.76e-04 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 43.99 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 24 KILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYvTIVISLMGV--IHALIPICAQTIGANKLHEVGEL 101
Cdd:COG0728 223 RVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLY-QLPLGLFGVaiGTALLPRLSRAAAAGDLEEFRRT 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 102 FGQGIWMSLLITVIGAIGL-LNPDFLINLA---GELSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYL 177
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLiVLAEPIVRLLferGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRI 381
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1436876125 178 SVASLPLKFFINWLLIFghlgfsQMGSDGAGISTAVVSWFQ 218
Cdd:COG0728 382 AVIAVVVNIVLNLLLVP------PLGHAGLALATSLSALVN 416
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
23-217 |
2.49e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 43.36 E-value: 2.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 23 AKILRQVWPILISQW-VGVAFAIIdSVMLGNFSVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEVGEL 101
Cdd:cd13145 234 KEILKQGFPASLNMMtIGLGIFVI-TYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRET 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 102 FGQGIWMSLLITVIGAIGLL-NPDFLINLAGElSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYLSVA 180
Cdd:cd13145 313 YKKALKYGFVIMVVATVFLLfFAEPLMSLFTN-DPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLY 391
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1436876125 181 -SLPLKFFINWLLIFG-HLGFSQM--GSDGAGISTAVVSWF 217
Cdd:cd13145 392 rQLVGPALVFWLLVNVlGLGVTGIwwGIFTIVWSAAIIALL 432
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
20-218 |
1.19e-03 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 41.09 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 20 TLAAKILRQVWPILISQWVGVAFAIIDSVMLGNF-SVQALQTISIAASIYVTIVISLMGVIHALIPICAQTIGANKLHEV 98
Cdd:COG2244 170 GLWGLVLKYSLPLLLSGLLGLLLTNLDRLLLGALlGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREEL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 99 GELFGQGIWMSLLITVIGAIGL-LNPDFLINLageLSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYL 177
Cdd:COG2244 250 RRLYRKALRLLLLLGLPLALGLaLLAPPLLSL---LFGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLII 326
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1436876125 178 SVASLPLKFFINWLLIfghlgfSQMGSDGAGISTAVVSWFQ 218
Cdd:COG2244 327 SLIGAVLNLVLNLLLI------PRYGLVGAAIATLLSYLVL 361
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
24-218 |
1.35e-03 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 40.90 E-value: 1.35e-03
10 20 30 40 50 60 70 80
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gi 1436876125 24 KILRQVWPILISQWVGVAFAIIDSVMLGNFSVQALQTISIAASIYvTIVISLMGV--IHALIPICAQTIGANKLHEVGEL 101
Cdd:cd13123 216 RVLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRLY-QLPLGIFGVaiATALLPRLSRLAAAGDLDEFRRT 294
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436876125 102 FGQGIWMSLLITVIGAIGLLN-PDFLINLA---GELSPEVRADVASYLRYTFYGLPAALMFRVVYSICTASQRASTVMYL 177
Cdd:cd13123 295 LSRGLRLVLFLLLPAAVGLIVlAEPIVRLLferGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKI 374
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170 180 190 200
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gi 1436876125 178 SVASLPLKFFINWLLIFGhlgfsqMGSDGAGISTAVVSWFQ 218
Cdd:cd13123 375 AVIAVAVNILLNLLLIKP------LGHVGLALATSLSAWVN 409
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