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Conserved domains on  [gi|1457638236|emb|SVN02985|]
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phospho-2-dehydro-3-deoxyheptonate aldolase [Klebsiella pneumoniae]

Protein Classification

3-deoxy-7-phosphoheptulonate synthase( domain architecture ID 10014072)

3-deoxy-7-phosphoheptulonate synthase catalyzes stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP)

EC:  2.5.1.54
Gene Ontology:  GO:0009073|GO:0003849|GO:0008652
SCOP:  4003245

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK12755 PRK12755
phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional
1-353 0e+00

phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional


:

Pssm-ID: 237190  Cd Length: 353  Bit Score: 715.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236   1 MQKDALNNVHITDEHVLMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKAL 80
Cdd:PRK12755    1 MQKDAINNVRITAEQPLITPEELKAELPLSEAAQAQVAASRQAIADILHGRDDRLLVVVGPCSIHDPEAALEYARRLKAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  81 AAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSW 160
Cdd:PRK12755   81 ADELSDRLLIVMRVYFEKPRTTVGWKGLINDPHLDGSFDIEEGLRIARKLLLDLVELGLPLATEALDPISPQYLGDLISW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 161 SAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGG-KA 239
Cdd:PRK12755  161 GAIGARTTESQTHREMASGLSMPVGFKNGTDGSLKVAINAIRAAAQPHRFLGINQEGQVALLETRGNPDGHVILRGGkKG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 240 PNYGPEDVAKCEKEMAQAGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEqPREA 319
Cdd:PRK12755  241 PNYDAASVAACEAQLEKAGLRPRLMIDCSHANSGKDYRRQPAVAEDVVAQIAAGNRSIIGVMIESHLEEGNQSSP-PLSE 319
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1457638236 320 MKYGVSVTDACISWETTEALLRELDKDLRGHLAA 353
Cdd:PRK12755  320 LKYGVSITDACIGWETTEALLRELAQALRARRAA 353
 
Name Accession Description Interval E-value
PRK12755 PRK12755
phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional
1-353 0e+00

phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional


Pssm-ID: 237190  Cd Length: 353  Bit Score: 715.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236   1 MQKDALNNVHITDEHVLMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKAL 80
Cdd:PRK12755    1 MQKDAINNVRITAEQPLITPEELKAELPLSEAAQAQVAASRQAIADILHGRDDRLLVVVGPCSIHDPEAALEYARRLKAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  81 AAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSW 160
Cdd:PRK12755   81 ADELSDRLLIVMRVYFEKPRTTVGWKGLINDPHLDGSFDIEEGLRIARKLLLDLVELGLPLATEALDPISPQYLGDLISW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 161 SAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGG-KA 239
Cdd:PRK12755  161 GAIGARTTESQTHREMASGLSMPVGFKNGTDGSLKVAINAIRAAAQPHRFLGINQEGQVALLETRGNPDGHVILRGGkKG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 240 PNYGPEDVAKCEKEMAQAGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEqPREA 319
Cdd:PRK12755  241 PNYDAASVAACEAQLEKAGLRPRLMIDCSHANSGKDYRRQPAVAEDVVAQIAAGNRSIIGVMIESHLEEGNQSSP-PLSE 319
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1457638236 320 MKYGVSVTDACISWETTEALLRELDKDLRGHLAA 353
Cdd:PRK12755  320 LKYGVSITDACIGWETTEALLRELAQALRARRAA 353
AroG1 COG0722
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ...
2-352 0e+00

3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440486  Cd Length: 351  Bit Score: 702.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236   2 QKDALNNVHITDEHVLMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKALA 81
Cdd:COG0722     1 MMDQTDDLRIREIKPLITPAELKEELPLSEAAAETVAESRQAIRDILHGKDDRLLVVVGPCSIHDPDAALEYARRLKALA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  82 AEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSWS 161
Cdd:COG0722    81 EELSDDLLIVMRVYFEKPRTTVGWKGLINDPHLDGSFDINKGLRLARKLLLDINELGLPAATEFLDPITPQYIADLISWG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 162 AIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGGKA-P 240
Cdd:COG0722   161 AIGARTTESQTHRELASGLSCPVGFKNGTDGNLQIAIDAIRAASAPHHFLGIDKDGQSAIVQTTGNPDCHVILRGGKGgP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 241 NYGPEDVAKCEKEMAQAGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEqPREAM 320
Cdd:COG0722   241 NYDAESVAAAEEALAKAGLPPRLMVDCSHANSGKDHRRQPEVAEDVAAQIAAGNRSIIGVMLESHLVEGNQDLP-PGSPL 319
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1457638236 321 KYGVSVTDACISWETTEALLRELDKDLRGHLA 352
Cdd:COG0722   320 VYGQSITDACIGWETTEELLRELAEAVRARRA 351
aroFGH TIGR00034
phospho-2-dehydro-3-deoxyheptonate aldolase; [Amino acid biosynthesis, Aromatic amino acid ...
4-349 0e+00

phospho-2-dehydro-3-deoxyheptonate aldolase; [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 129145  Cd Length: 344  Bit Score: 618.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236   4 DALNNVHItdeHVLMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKALAAE 83
Cdd:TIGR00034   1 DDLRIVRI---DELLTPAELAAKFPLTPKQAANVAQSRQEIADIIAGKDDRLLVVIGPCSIHDPEAAIEYATRLKALREE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  84 VSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSWSAI 163
Cdd:TIGR00034  78 LKDDLEIVMRVYFEKPRTTVGWKGLINDPDLNGSFRINHGLRIARKLLLDLVNLGLPIAGEFLDMISPQYLADLFSWGAI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 164 GARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGGKAPNYG 243
Cdd:TIGR00034 158 GARTTESQVHRELASGLSCPVGFKNGTDGNLQVAIDAIRAAAAPHYFLSVTKDGQMAIVQTSGNPDGHIILRGGKKPNYS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 244 PEDVAKCEKEMAQAGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEQpREAMKYG 323
Cdd:TIGR00034 238 AADVAAAKKQLEKAGLPPHLMIDFSHGNSNKDHRRQPDVAEDVCEQIANGSKAIIGVMIESNLVEGNQSIPG-GQPLKYG 316
                         330       340
                  ....*....|....*....|....*.
gi 1457638236 324 VSVTDACISWETTEALLRELDKDLRG 349
Cdd:TIGR00034 317 QSITDACIGWEDTEALLRQLADAVRT 342
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
45-341 6.45e-124

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 357.40  E-value: 6.45e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  45 SDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKALAAEVSdsLYLVMRVYFEKPRTT-VGWKGLINDPHMDGSFDVEGG 123
Cdd:pfam00793   8 QDIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLK--LIIIMRAYFEKPRTSpVGFKGLGNDPDLNILFRIKDG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 124 LkiarrllvelvnmGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVGFKNGTDgslaTAINAMRA 203
Cdd:pfam00793  86 L-------------GLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTD----AAIDEMLA 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 204 AAMPHRFVGInqagqvcllqTQGNPNGHVILRGGKAPNYGPEDVAKCEKEMAQAGLKPsLMVDCSHGNSNKDFRRQPAVA 283
Cdd:pfam00793 149 AAEYHLFLGV----------TKGNILCERGIRGGEGPNRNTLDVSAVAILKEETGHLP-VMVDVSHANGRKDGGRQPLVL 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1457638236 284 ESVVAQIKDGnrsIIGLMIESNIHEGNQSSEqPREAMKYGVSVTDACISWETTEALLR 341
Cdd:pfam00793 218 PLAKAAIAVG---IDGLMIEVHPNPGNALSD-GPQQLKYGKSETDACILWELTELLLE 271
 
Name Accession Description Interval E-value
PRK12755 PRK12755
phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional
1-353 0e+00

phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional


Pssm-ID: 237190  Cd Length: 353  Bit Score: 715.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236   1 MQKDALNNVHITDEHVLMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKAL 80
Cdd:PRK12755    1 MQKDAINNVRITAEQPLITPEELKAELPLSEAAQAQVAASRQAIADILHGRDDRLLVVVGPCSIHDPEAALEYARRLKAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  81 AAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSW 160
Cdd:PRK12755   81 ADELSDRLLIVMRVYFEKPRTTVGWKGLINDPHLDGSFDIEEGLRIARKLLLDLVELGLPLATEALDPISPQYLGDLISW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 161 SAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGG-KA 239
Cdd:PRK12755  161 GAIGARTTESQTHREMASGLSMPVGFKNGTDGSLKVAINAIRAAAQPHRFLGINQEGQVALLETRGNPDGHVILRGGkKG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 240 PNYGPEDVAKCEKEMAQAGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEqPREA 319
Cdd:PRK12755  241 PNYDAASVAACEAQLEKAGLRPRLMIDCSHANSGKDYRRQPAVAEDVVAQIAAGNRSIIGVMIESHLEEGNQSSP-PLSE 319
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1457638236 320 MKYGVSVTDACISWETTEALLRELDKDLRGHLAA 353
Cdd:PRK12755  320 LKYGVSITDACIGWETTEALLRELAQALRARRAA 353
AroG1 COG0722
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ...
2-352 0e+00

3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440486  Cd Length: 351  Bit Score: 702.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236   2 QKDALNNVHITDEHVLMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKALA 81
Cdd:COG0722     1 MMDQTDDLRIREIKPLITPAELKEELPLSEAAAETVAESRQAIRDILHGKDDRLLVVVGPCSIHDPDAALEYARRLKALA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  82 AEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSWS 161
Cdd:COG0722    81 EELSDDLLIVMRVYFEKPRTTVGWKGLINDPHLDGSFDINKGLRLARKLLLDINELGLPAATEFLDPITPQYIADLISWG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 162 AIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGGKA-P 240
Cdd:COG0722   161 AIGARTTESQTHRELASGLSCPVGFKNGTDGNLQIAIDAIRAASAPHHFLGIDKDGQSAIVQTTGNPDCHVILRGGKGgP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 241 NYGPEDVAKCEKEMAQAGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEqPREAM 320
Cdd:COG0722   241 NYDAESVAAAEEALAKAGLPPRLMVDCSHANSGKDHRRQPEVAEDVAAQIAAGNRSIIGVMLESHLVEGNQDLP-PGSPL 319
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1457638236 321 KYGVSVTDACISWETTEALLRELDKDLRGHLA 352
Cdd:COG0722   320 VYGQSITDACIGWETTEELLRELAEAVRARRA 351
PRK09261 PRK09261
phospho-2-dehydro-3-deoxyheptonate aldolase; Validated
2-343 0e+00

phospho-2-dehydro-3-deoxyheptonate aldolase; Validated


Pssm-ID: 236435  Cd Length: 349  Bit Score: 652.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236   2 QKDALNNVHITDEHVLMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKALA 81
Cdd:PRK09261    1 MMYQTDDLRIKEIKPLIPPAELKEELPLTEEAAETVARSRKEIHNILHGKDDRLLVVVGPCSIHDPKAALEYARRLAKLR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  82 AEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSWS 161
Cdd:PRK09261   81 EELKDKLEIVMRVYFEKPRTTVGWKGLINDPDLDGSFDINDGLRIARKLLLDINELGLPAATEFLDPITPQYIADLISWG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 162 AIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGG-KAP 240
Cdd:PRK09261  161 AIGARTTESQVHRELASGLSCPVGFKNGTDGNIKVAIDAIIAASAPHHFLGITKDGRSAIVSTTGNPDCHVILRGGnKGP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 241 NYGPEDVAKCEKEMAQAGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEqprEAM 320
Cdd:PRK09261  241 NYDAESVAEAKERLEKAGLPPRIMIDCSHANSGKDHKRQPEVARDVAAQIAAGNKAIIGVMIESHLVEGNQDLP---PKL 317
                         330       340
                  ....*....|....*....|...
gi 1457638236 321 KYGVSVTDACISWETTEALLREL 343
Cdd:PRK09261  318 VYGQSITDACIGWEDTEALLREL 340
aroFGH TIGR00034
phospho-2-dehydro-3-deoxyheptonate aldolase; [Amino acid biosynthesis, Aromatic amino acid ...
4-349 0e+00

phospho-2-dehydro-3-deoxyheptonate aldolase; [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 129145  Cd Length: 344  Bit Score: 618.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236   4 DALNNVHItdeHVLMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKALAAE 83
Cdd:TIGR00034   1 DDLRIVRI---DELLTPAELAAKFPLTPKQAANVAQSRQEIADIIAGKDDRLLVVIGPCSIHDPEAAIEYATRLKALREE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  84 VSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSWSAI 163
Cdd:TIGR00034  78 LKDDLEIVMRVYFEKPRTTVGWKGLINDPDLNGSFRINHGLRIARKLLLDLVNLGLPIAGEFLDMISPQYLADLFSWGAI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 164 GARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGGKAPNYG 243
Cdd:TIGR00034 158 GARTTESQVHRELASGLSCPVGFKNGTDGNLQVAIDAIRAAAAPHYFLSVTKDGQMAIVQTSGNPDGHIILRGGKKPNYS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 244 PEDVAKCEKEMAQAGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEQpREAMKYG 323
Cdd:TIGR00034 238 AADVAAAKKQLEKAGLPPHLMIDFSHGNSNKDHRRQPDVAEDVCEQIANGSKAIIGVMIESNLVEGNQSIPG-GQPLKYG 316
                         330       340
                  ....*....|....*....|....*.
gi 1457638236 324 VSVTDACISWETTEALLRELDKDLRG 349
Cdd:TIGR00034 317 QSITDACIGWEDTEALLRQLADAVRT 342
PRK12756 PRK12756
Trp-sensitive 3-deoxy-7-phosphoheptulonate synthase AroH;
17-343 3.33e-171

Trp-sensitive 3-deoxy-7-phosphoheptulonate synthase AroH;


Pssm-ID: 183726  Cd Length: 348  Bit Score: 480.20  E-value: 3.33e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  17 LMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKALAAEVSDSLYLVMRVYF 96
Cdd:PRK12756   15 LITPAELASEYPITPDVADHVTDSRRRIEKILNGEDPRLLVIIGPCSIHDTDAALDYATRLAALREQYQDRLEIVMRTYF 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  97 EKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREM 176
Cdd:PRK12756   95 EKPRTVVGWKGLISDPDLDGSYRVNHGLELARKLLLQINELGLPTATEFLDMVTGQYIADLISWGAIGARTTESQIHREM 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 177 ASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGGKAPNYGPEDVAKCEKEMAQ 256
Cdd:PRK12756  175 ASALSCPVGFKNGTDGNTRIAIDAIRAARASHMFLSPDKDGQMTIYQTSGNPYGHIIMRGGKKPNYHAEDIAAACDTLRE 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 257 AGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEQPrEAMKYGVSVTDACISWETT 336
Cdd:PRK12756  255 FDLPEHLVVDFSHGNCQKQHRRQLDVAEDICQQIRNGSTAIAGIMAESFLREGTQKIVAG-QPLTYGQSITDPCLGWEDT 333

                  ....*..
gi 1457638236 337 EALLREL 343
Cdd:PRK12756  334 ERLLELL 340
PRK12822 PRK12822
phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional
17-343 2.60e-147

phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional


Pssm-ID: 237217  Cd Length: 356  Bit Score: 420.00  E-value: 2.60e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  17 LMTPEQLKAEFPLSVEQEAQIAHARQTISDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKALAAEVSDSLYLVMRVYF 96
Cdd:PRK12822   16 LPSVAEILKEIPCSEETETWISQQRQDIRNILLGKDPRLLVIIGPCSIHDPQAALEYAKRLAVLQHQYLDQLYIVMRTYF 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  97 EKPRTTVGWKGLINDPHMDGSFDVEGGLKIARRLLVELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREM 176
Cdd:PRK12822   96 EKPRTRKGWKGLIFDPDLDGSNDIEKGLRLARQLLLSINTLGLATATEFLDTTSFPYIADLICWGAIGARTTESQVHRQL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 177 ASGLSMPVGFKNGTDGSLATAINAMRAAAMPHRFVGINQAGQVCLLQTQGNPNGHVILRGGKAPNYGPEDVAKCEKEMAQ 256
Cdd:PRK12822  176 ASALPCPVGFKNGTDGNIRIAIDAILAARSPHLVTVPGLTGCISTLLSDGNPHGHIILRGGREPNYGLSDVTKASKLLHD 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 257 AGLKPSLMVDCSHGNSNKDFRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSeqPREAMKYGVSVTDACISWETT 336
Cdd:PRK12822  256 EGLNHRLIIDCSHGNSQKVAKNQISVARELCDQLKEGEGAIAGVMVESFLQGGSQKA--DSAPLEYGQSVTDECLSWQDT 333

                  ....*..
gi 1457638236 337 EALLREL 343
Cdd:PRK12822  334 EQLLNTL 340
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
45-341 6.45e-124

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 357.40  E-value: 6.45e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  45 SDIIAGRDPRLLVVCGPCSIHDPEAAIEYARRFKALAAEVSdsLYLVMRVYFEKPRTT-VGWKGLINDPHMDGSFDVEGG 123
Cdd:pfam00793   8 QDIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLK--LIIIMRAYFEKPRTSpVGFKGLGNDPDLNILFRIKDG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 124 LkiarrllvelvnmGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVGFKNGTDgslaTAINAMRA 203
Cdd:pfam00793  86 L-------------GLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTD----AAIDEMLA 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236 204 AAMPHRFVGInqagqvcllqTQGNPNGHVILRGGKAPNYGPEDVAKCEKEMAQAGLKPsLMVDCSHGNSNKDFRRQPAVA 283
Cdd:pfam00793 149 AAEYHLFLGV----------TKGNILCERGIRGGEGPNRNTLDVSAVAILKEETGHLP-VMVDVSHANGRKDGGRQPLVL 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1457638236 284 ESVVAQIKDGnrsIIGLMIESNIHEGNQSSEqPREAMKYGVSVTDACISWETTEALLR 341
Cdd:pfam00793 218 PLAKAAIAVG---IDGLMIEVHPNPGNALSD-GPQQLKYGKSETDACILWELTELLLE 271
PRK08673 PRK08673
3-deoxy-7-phosphoheptulonate synthase; Reviewed
44-166 4.31e-04

3-deoxy-7-phosphoheptulonate synthase; Reviewed


Pssm-ID: 181535 [Multi-domain]  Cd Length: 335  Bit Score: 41.80  E-value: 4.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457638236  44 ISDIIAGrDPRLLVVCGPCSIHDPEAAIEYARRFKALAAEVsdslylvMR--VYfeKPRTTvgwkglindPHmdgSFD-- 119
Cdd:PRK08673   84 VGDVEIG-GGKPVVIAGPCSVESEEQILEIARAVKEAGAQI-------LRggAF--KPRTS---------PY---SFQgl 141
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1457638236 120 VEGGLKI---ARRLLvelvnmGLPLATEALDPNSPqylgDLFSWSA----IGAR 166
Cdd:PRK08673  142 GEEGLKLlaeAREET------GLPIVTEVMDPRDV----ELVAEYVdilqIGAR 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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