|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10864 |
PRK10864 |
putative methyltransferase; Provisional |
1-361 |
0e+00 |
|
putative methyltransferase; Provisional
Pssm-ID: 236779 [Multi-domain] Cd Length: 346 Bit Score: 684.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 1 MSDELKNKSGKVKVMYVRSDDDSDKRTHNPRTGKGGGRP-GKSRVDGRSRPARDERNSRGDDRKRDdrkrddrkrddfhr 79
Cdd:PRK10864 1 MNDELKGKSGKVKVMYVRSDDDSDKRTHNPRTGKGGGRPsGKSRADGGRRPARDDRNSQSRDRKWE-------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 80 ddASPWRTVSRAPGDETPVKEDHGGISGKSFIDPEVLRRQRAEETRVYGENACQALFQSRPEAIVRAWFIQSVTPRFKEA 159
Cdd:PRK10864 67 --DSPWRTVSRAPGDETPEKADHGGISGKSFIDPEVLRRQRAEETRVYGENACQALFQSRPEAIVRAWFIQSVTPRFKEA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 160 LRWMAANRKAYHVVDEAELAKASGTEHHGGVCFLIKKRHGTSVAQWVAKAGEEDCVLALEDVGNPHNLGAIMRSCAHFGV 239
Cdd:PRK10864 145 LRWMAANRKAYHVVDEAELTKASGTEHHGGVCFLIKKRNGTDVQQWLAQAGAQDCVLALEDVGNPHNLGGIMRSCAHFGV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 240 KGVVVQDAGVLESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTSSHNGTPLFKAELPKKMVLALGQERDGL 319
Cdd:PRK10864 225 KGVVVQDAALLESGAAIRTAEGGAEHVQPITGDSFVDVLDDFRQAGYTIVTTSSHKGTPLFKASLPAKMVLVLGQEYDGL 304
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1457296494 320 SDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEWWRQNKA 361
Cdd:PRK10864 305 SDAARQQGDLSVSIDGTGNVESLNVSVATGVLLAEWWRQNKA 346
|
|
| SpoU |
COG0566 |
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ... |
117-361 |
9.99e-75 |
|
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440332 [Multi-domain] Cd Length: 265 Bit Score: 232.01 E-value: 9.99e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 117 RRQRAEETR--VYGENACQALFQSRpEAIVRAWFIQSVTPRFKEALRWMAANRKAYHVVDEAELAKASGTEHHGGVCFLI 194
Cdd:COG0566 18 KKYREEEGLflAEGRHAVEEALKAG-REIEELLVTEGALDRLAELLALAKAAGIPVYEVSREVLDKLSGTETHQGVLAVV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 195 KKRHGTSVAQWVAKAGEEDCVLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGV-LESGAAIRTAEGGAEHVEPITGDS 273
Cdd:COG0566 97 RPPEYADLEDLLAEAGEPPLLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRAdPYNPKVVRASAGALFHVPVARVTN 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 274 FIDTLDQFRKAGYAIVSTSSHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLA 353
Cdd:COG0566 177 LADALEELKEAGFWVVGTDLDGEASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLY 256
|
....*...
gi 1457296494 354 EWWRQNKA 361
Cdd:COG0566 257 EAARQRRA 264
|
|
| SpoU-like_rRNA-MTase |
cd18095 |
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ... |
214-355 |
1.95e-51 |
|
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349968 Cd Length: 143 Bit Score: 167.99 E-value: 1.95e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 214 CVLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGV-LESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTS 292
Cdd:cd18095 1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVdPYNPKVVRASMGALFRLPIIRVDDLEELLEELKEAGYKVVAAD 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1457296494 293 SHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEW 355
Cdd:cd18095 81 LDGGSSLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTIPMSGGVESLNVAVAAAILLYEL 143
|
|
| SpoU_methylase |
pfam00588 |
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet. |
215-352 |
3.02e-42 |
|
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
Pssm-ID: 425768 Cd Length: 142 Bit Score: 144.21 E-value: 3.02e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGV--LESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTS 292
Cdd:pfam00588 3 VVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSadPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVATS 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 293 sHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLL 352
Cdd:pfam00588 83 -LGGKSLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIAL 141
|
|
| rRNA_methyl_3 |
TIGR00186 |
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ... |
125-358 |
2.13e-26 |
|
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 129290 [Multi-domain] Cd Length: 237 Bit Score: 105.12 E-value: 2.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 125 RVYGENACQALFQSRPEAivrawFIQSVT--PRFKEALRWMAANRKAYHVVDEAELAKASGTEHHGGVCFLIKKRHGTSV 202
Cdd:TIGR00186 3 YLYGKNAVLEALLNQQRV-----FILKGLesKRLKKLIQLAKKQGINIQLVDRQKLDQLTKGGNHQGIAAKVKPILYKDL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 203 AQWVAKAGEEDC--VLALEDVGNPHNLGAIMRSCAHFGVKGVVV--QDAGVLESGAaIRTAEGGAEHVEPITGDSFIDTL 278
Cdd:TIGR00186 78 NDLYKTAKSKKQpfLLILDEITDPHNLGAILRTAEAFGVDGVILpkRRSAPLNSTV-VKTSSGAVEYVPLARVTNLSRTI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 279 DQFRKAGYAIVSTSSHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEWWRQ 358
Cdd:TIGR00186 157 TKLKESGFWTVGTDLDAQDTLYQVKLTKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQ 236
|
|
| SpoU_sub_bind |
smart00967 |
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ... |
126-196 |
5.50e-09 |
|
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.
Pssm-ID: 214943 [Multi-domain] Cd Length: 70 Bit Score: 52.15 E-value: 5.50e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1457296494 126 VYGENACQALFQSrPEAIVRAWFIQSVTPRFKEALRWMAANRKAYHVVDEAELAKASGTEHHGGVCFLIKK 196
Cdd:smart00967 1 IEGRHAVEEALKS-GRRIKELYLTEGRAERLKELLKLAKERGIKVIEVSKKELDKLSGTANHQGVVAVVKP 70
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10864 |
PRK10864 |
putative methyltransferase; Provisional |
1-361 |
0e+00 |
|
putative methyltransferase; Provisional
Pssm-ID: 236779 [Multi-domain] Cd Length: 346 Bit Score: 684.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 1 MSDELKNKSGKVKVMYVRSDDDSDKRTHNPRTGKGGGRP-GKSRVDGRSRPARDERNSRGDDRKRDdrkrddrkrddfhr 79
Cdd:PRK10864 1 MNDELKGKSGKVKVMYVRSDDDSDKRTHNPRTGKGGGRPsGKSRADGGRRPARDDRNSQSRDRKWE-------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 80 ddASPWRTVSRAPGDETPVKEDHGGISGKSFIDPEVLRRQRAEETRVYGENACQALFQSRPEAIVRAWFIQSVTPRFKEA 159
Cdd:PRK10864 67 --DSPWRTVSRAPGDETPEKADHGGISGKSFIDPEVLRRQRAEETRVYGENACQALFQSRPEAIVRAWFIQSVTPRFKEA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 160 LRWMAANRKAYHVVDEAELAKASGTEHHGGVCFLIKKRHGTSVAQWVAKAGEEDCVLALEDVGNPHNLGAIMRSCAHFGV 239
Cdd:PRK10864 145 LRWMAANRKAYHVVDEAELTKASGTEHHGGVCFLIKKRNGTDVQQWLAQAGAQDCVLALEDVGNPHNLGGIMRSCAHFGV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 240 KGVVVQDAGVLESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTSSHNGTPLFKAELPKKMVLALGQERDGL 319
Cdd:PRK10864 225 KGVVVQDAALLESGAAIRTAEGGAEHVQPITGDSFVDVLDDFRQAGYTIVTTSSHKGTPLFKASLPAKMVLVLGQEYDGL 304
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1457296494 320 SDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEWWRQNKA 361
Cdd:PRK10864 305 SDAARQQGDLSVSIDGTGNVESLNVSVATGVLLAEWWRQNKA 346
|
|
| SpoU |
COG0566 |
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ... |
117-361 |
9.99e-75 |
|
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440332 [Multi-domain] Cd Length: 265 Bit Score: 232.01 E-value: 9.99e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 117 RRQRAEETR--VYGENACQALFQSRpEAIVRAWFIQSVTPRFKEALRWMAANRKAYHVVDEAELAKASGTEHHGGVCFLI 194
Cdd:COG0566 18 KKYREEEGLflAEGRHAVEEALKAG-REIEELLVTEGALDRLAELLALAKAAGIPVYEVSREVLDKLSGTETHQGVLAVV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 195 KKRHGTSVAQWVAKAGEEDCVLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGV-LESGAAIRTAEGGAEHVEPITGDS 273
Cdd:COG0566 97 RPPEYADLEDLLAEAGEPPLLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRAdPYNPKVVRASAGALFHVPVARVTN 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 274 FIDTLDQFRKAGYAIVSTSSHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLA 353
Cdd:COG0566 177 LADALEELKEAGFWVVGTDLDGEASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLY 256
|
....*...
gi 1457296494 354 EWWRQNKA 361
Cdd:COG0566 257 EAARQRRA 264
|
|
| SpoU-like_rRNA-MTase |
cd18095 |
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ... |
214-355 |
1.95e-51 |
|
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349968 Cd Length: 143 Bit Score: 167.99 E-value: 1.95e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 214 CVLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGV-LESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTS 292
Cdd:cd18095 1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVdPYNPKVVRASMGALFRLPIIRVDDLEELLEELKEAGYKVVAAD 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1457296494 293 SHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEW 355
Cdd:cd18095 81 LDGGSSLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTIPMSGGVESLNVAVAAAILLYEL 143
|
|
| SpoU_methylase |
pfam00588 |
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet. |
215-352 |
3.02e-42 |
|
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
Pssm-ID: 425768 Cd Length: 142 Bit Score: 144.21 E-value: 3.02e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGV--LESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTS 292
Cdd:pfam00588 3 VVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSadPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVATS 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 293 sHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLL 352
Cdd:pfam00588 83 -LGGKSLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIAL 141
|
|
| SpoU-like_RlmB |
cd18103 |
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ... |
215-355 |
2.27e-38 |
|
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349976 Cd Length: 143 Bit Score: 134.05 E-value: 2.27e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVKGVVVQ-DAGVLESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTSS 293
Cdd:cd18103 2 LLILDGITDPHNLGAIIRSAEAFGVDGVIIPkRRSAPLTPTVAKASAGALEHLPIARVTNLARALEELKEAGFWIYGADG 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1457296494 294 HNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEW 355
Cdd:cd18103 82 EAEKSLYDVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKIPMAGKVDSLNVSVAAGIILYEI 143
|
|
| SpoU-like_TrmH |
cd18092 |
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ... |
215-354 |
1.01e-29 |
|
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349965 Cd Length: 162 Bit Score: 111.79 E-value: 1.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVkgvvvQDAGVLESGAAI----RTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVS 290
Cdd:cd18092 18 TVVLENVHDPHNASAVLRTCDAFGV-----QDVHVIEPKNKFkknrGVAMGADKWLDVHRHDSTEECLAALKEQGYRIVA 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1457296494 291 TSSHNGT-PLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAE 354
Cdd:cd18092 93 TSLSPDAvPLDELDYTRPTALVFGNEKDGVSEEALAAADERVYIPMYGFVESLNVSVAAAIILYE 157
|
|
| SpoU-like_family |
cd18082 |
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ... |
215-355 |
5.07e-29 |
|
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349955 Cd Length: 145 Bit Score: 109.62 E-value: 5.07e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVKGV-VVQDAGVLESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTSS 293
Cdd:cd18082 1 HLVLDNIRSPGNIGSIFRTADAFGVEKIyLVGPTADIFDPKAKRTSRGTHFSVPYERVDNFEEYLKSLKEEGYPLIGLEL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1457296494 294 H-NGTPL--FKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEW 355
Cdd:cd18082 81 TdGSIPLseFKFKKPKKIALIFGNERSGLSPELLALCDYTVHIPMSGKNSSLNVSVATGIALYEF 145
|
|
| rRNA_methyl_3 |
TIGR00186 |
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ... |
125-358 |
2.13e-26 |
|
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 129290 [Multi-domain] Cd Length: 237 Bit Score: 105.12 E-value: 2.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 125 RVYGENACQALFQSRPEAivrawFIQSVT--PRFKEALRWMAANRKAYHVVDEAELAKASGTEHHGGVCFLIKKRHGTSV 202
Cdd:TIGR00186 3 YLYGKNAVLEALLNQQRV-----FILKGLesKRLKKLIQLAKKQGINIQLVDRQKLDQLTKGGNHQGIAAKVKPILYKDL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 203 AQWVAKAGEEDC--VLALEDVGNPHNLGAIMRSCAHFGVKGVVV--QDAGVLESGAaIRTAEGGAEHVEPITGDSFIDTL 278
Cdd:TIGR00186 78 NDLYKTAKSKKQpfLLILDEITDPHNLGAILRTAEAFGVDGVILpkRRSAPLNSTV-VKTSSGAVEYVPLARVTNLSRTI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 279 DQFRKAGYAIVSTSSHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEWWRQ 358
Cdd:TIGR00186 157 TKLKESGFWTVGTDLDAQDTLYQVKLTKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQ 236
|
|
| SpoU-like_RNA-MTase |
cd18104 |
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ... |
215-359 |
3.35e-26 |
|
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349977 Cd Length: 146 Bit Score: 101.89 E-value: 3.35e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGV-LESGAAIRtAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTSS 293
Cdd:cd18104 2 ILVLEGLEKPGNLGAILRSADAAGADAVILCDPKTdLFNPNVIR-ASLGAVFTLPVAEASSEETLAWLKENKIRILATTP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1457296494 294 HNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEWWRQN 359
Cdd:cd18104 81 KAEKLYYEADLRGPIAIVVGSESEGLSEFWLKAADERVRIPMAGQADSLNVSVAAAILLYEALRQR 146
|
|
| SpoU-like_RNA-MTase |
cd18109 |
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ... |
215-355 |
3.71e-25 |
|
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349982 Cd Length: 141 Bit Score: 99.15 E-value: 3.71e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGV-LESGAAIRTAEGGAEHVEPITGDsFIDTLDQFRKAgyAIVSTSS 293
Cdd:cd18109 2 TLALDGIQDPGNLGTIIRTADWFGIRQIICSPDTVdPYNPKVVQASMGSIFRVQIHYTD-LPALLAELKKA--FPVYGAD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1457296494 294 HNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGN-VESLNVSVATGVLLAEW 355
Cdd:cd18109 79 LDGENLYEFTLPEKGILVMGNEGHGISPEVLKLLTHRLTIPRYGKgAESLNVAVATAILLSEF 141
|
|
| SpoU-like_MRM1 |
cd18105 |
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ... |
215-352 |
2.21e-24 |
|
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349978 Cd Length: 158 Bit Score: 97.59 E-value: 2.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVKGVVVQD---AGVleSGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVST 291
Cdd:cd18105 2 WLLLDEITDPQNLGAILRSAYFLGVDGVVVSSknsAPL--SPVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGT 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1457296494 292 SSHNGTPLFKAELP----------KKMVLALGQERDGLSDAAISSADLSVAIDG-----TGNVESLNVSVATGVLL 352
Cdd:cd18105 80 SAPPSASSDKKTIPanelsellleKPTILVLGNEGRGLRTNIKNLCDYLVSIPGgrsaeNPGVDSLNVSVAAGILL 155
|
|
| PRK11181 |
PRK11181 |
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB; |
126-358 |
5.11e-22 |
|
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
Pssm-ID: 183021 [Multi-domain] Cd Length: 244 Bit Score: 93.49 E-value: 5.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 126 VYGENACQALFQSRPEAIVRAWFIQS-----VTPRFKEALRW----MAANRKAyhvVDEaelaKASGTEHHGgvcfLIKK 196
Cdd:PRK11181 5 IYGIHAVQALLERAPERFIEVFVLKGredkrLLPLINELEAQgiviQLANRQT---LDE----KAEGAVHQG----IIAR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 197 rhgtsvaqwvAKAG----EEDC-----------VLALEDVGNPHNLGAIMRSCAHFGVKGVVV-QDAGVLESGAAIRTAE 260
Cdd:PRK11181 74 ----------VKPGrqlqENDLpdllasleqpfLLILDGVTDPHNLGACLRSADAAGVHAVIVpKDRSAQLNATAKKVAC 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 261 GGAEHVEPITGDSFIDTLDQFRKAGYAIVSTSSHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVE 340
Cdd:PRK11181 144 GAAETVPLIRVTNLARTMRMLQEKNIWIVGTAGEADHTLYQSKLTGPLALVMGAEGEGMRRLTREHCDELISIPMAGSVS 223
|
250
....*....|....*...
gi 1457296494 341 SLNVSVATGVLLAEWWRQ 358
Cdd:PRK11181 224 SLNVSVATGICLFEAVRQ 241
|
|
| SpoU-like_TRM3-like |
cd18091 |
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ... |
223-355 |
2.75e-20 |
|
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.
Pssm-ID: 349964 Cd Length: 145 Bit Score: 86.05 E-value: 2.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 223 NPHNLGAIMRSCAHFGVKGVVVQDAGVLESGAAIRTAEGGAEHVePITG---DSFIDTLDQFRKAGYAIVS-TSSHNGTP 298
Cdd:cd18091 10 KPPNLGGLCRTCEIFGVSKLVLPNLAVVEDKQFKALSVSAEKWL-PIEEvkpEDLLPYLKEKKQEGYTIVGlEQTANSVS 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1457296494 299 LFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEW 355
Cdd:cd18091 89 LHDFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIAIYEY 145
|
|
| SpoU-like |
cd18097 |
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ... |
214-355 |
5.08e-19 |
|
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349970 Cd Length: 144 Bit Score: 82.61 E-value: 5.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 214 CVLALEDVGNPHNLGAIMRSCAHFGVKGVVV-QDAGVLESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVST- 291
Cdd:cd18097 1 LVVVLDNLRSAHNVGSIFRTADAAGVEKIYLcGYTPTPPHPKVAKTALGAEESVPWEHFEDTLEAVRALKARGYTIIALe 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1457296494 292 SSHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEW 355
Cdd:cd18097 81 TTENSVPLHEARLPRPLALVLGNEVRGVSPEVLALCDAVVEIPMFGRKNSLNVAVAAAVALYEL 144
|
|
| SpoU-like |
cd18096 |
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ... |
214-355 |
3.10e-16 |
|
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349969 Cd Length: 140 Bit Score: 74.56 E-value: 3.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 214 CVLALEDVGNPHNLGAIMRSCAHFGVKGVVVqdagVLESGAAIRTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTSS 293
Cdd:cd18096 1 LYLVLHNVAKRHNIGTIVRSANAFGVKEVHL----VGRRKFNPFGAMGTDRHVKFRHFDTLAEAKEYLKERGIRLVGVEI 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1457296494 294 HNGT-PLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGN-VESLNVSVATGVLLAEW 355
Cdd:cd18096 77 VPGAePIETHPFPGDTAFVLGNEGTGLSDEQLAICDGFVYIPQYGSgTASLNVSVAASIVLHHF 140
|
|
| SpoU-like_AviRb |
cd18107 |
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ... |
215-354 |
2.40e-15 |
|
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349980 Cd Length: 148 Bit Score: 72.42 E-value: 2.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGV-LESGAAIRTAEGGAEHVEPITGDSFIDTLD--QFRKA---GYAI 288
Cdd:cd18107 2 VVLFDRPTSPGNLGTIIRSADALGAHGLVVTGHAAdVYDPKTIRASTGSLFSLPIVRVPSNRELEDwvEARKArgtPLQL 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1457296494 289 VSTSSHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAE 354
Cdd:cd18107 82 VGTDEHGDHQIADHDFTRPTLLLIGNETAGLSAAWRELCDETVSIPMAGSASSLNAACAASIFLYE 147
|
|
| PRK11081 |
PRK11081 |
tRNA guanosine-2'-O-methyltransferase; Provisional |
213-358 |
7.87e-15 |
|
tRNA guanosine-2'-O-methyltransferase; Provisional
Pssm-ID: 236837 [Multi-domain] Cd Length: 229 Bit Score: 72.72 E-value: 7.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 213 DCVLALEDVGNPHNLGAIMRSCAHFGVKGV--VVQDAGVLESGAairTAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVS 290
Cdd:PRK11081 19 DLTVCMEQVHKPHNVSAIIRTADAVGVHEVhaVWPGSRMRTMGS---TAAGSNSWVQVKTHRTIGDAVAHLKGQGMQILA 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1457296494 291 TS-SHNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEWWRQ 358
Cdd:PRK11081 96 THlSDTAVDFREIDYTRPTCILMGQEKTGISQEALALADQDIIIPMIGMVQSLNVSVASALILYEAQRQ 164
|
|
| SpoU_sub_bind |
pfam08032 |
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ... |
126-196 |
8.18e-13 |
|
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.
Pssm-ID: 429793 [Multi-domain] Cd Length: 74 Bit Score: 63.03 E-value: 8.18e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1457296494 126 VYGENACQALFQSRPEaIVRAWFIQSV-TPRFKEALRWMAANRKAYHVVDEAELAKASGTEHHGGVCFLIKK 196
Cdd:pfam08032 2 IYGRHAVLEALKSGPE-IKKLYLTEGRrDPRLKELLKLAKERGIKVEEVDRKKLDKLSGTANHQGVVAEVKP 72
|
|
| SpoU-like_NHR |
cd18108 |
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ... |
215-354 |
5.81e-10 |
|
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349981 Cd Length: 144 Bit Score: 57.10 E-value: 5.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 215 VLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGvLESGAAIR--TAEGGAEHVEPITGDSFIDTLDQFRKAGYAIVSTS 292
Cdd:cd18108 2 VVVLDGVRIVGNIGAIVRTSLALGAAGIVLVDSD-LATVADRRllRASRGYVFSLPVVLADREEAVAFLRDNDIPLMTLD 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1457296494 293 SHNGTPLFK-AELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAE 354
Cdd:cd18108 81 ADGDVPVKElGDRPDRLALVFGSEKGGPSGLFEEAAAGTVSIPMSSSTESLNVSVSAGIALHE 143
|
|
| SpoU-like_TrmL |
cd18094 |
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ... |
224-359 |
6.07e-10 |
|
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349967 Cd Length: 145 Bit Score: 57.08 E-value: 6.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 224 PHNLGAIMRSCAHFGVKGVVVQDAGVLESGAAIRTAegGA---EHVEPITGDSFidtlDQFRKA--GYAIVSTSSHNGTP 298
Cdd:cd18094 10 PQNTGNIARTCAATGARLHLIEPLGFSLDDKRLKRA--GLdywDHVDLTVHDSW----EAFLEAlpPGRLFLFTTKGTKP 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1457296494 299 LFKAELPKKMVLALGQERDGLSDAAISSA-DLSVAIDGTGNVESLNVSVATGVLLAEWWRQN 359
Cdd:cd18094 84 YTDFDFKPGDYLVFGRESTGLPEEILDAFpDRRLRIPMRPKVRSLNLSNSVAIVLYEALRQL 145
|
|
| SpoU_sub_bind |
smart00967 |
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ... |
126-196 |
5.50e-09 |
|
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.
Pssm-ID: 214943 [Multi-domain] Cd Length: 70 Bit Score: 52.15 E-value: 5.50e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1457296494 126 VYGENACQALFQSrPEAIVRAWFIQSVTPRFKEALRWMAANRKAYHVVDEAELAKASGTEHHGGVCFLIKK 196
Cdd:smart00967 1 IEGRHAVEEALKS-GRRIKELYLTEGRAERLKELLKLAKERGIKVIEVSKKELDKLSGTANHQGVVAVVKP 70
|
|
| SpoU-like_RNMTL1 |
cd18106 |
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ... |
224-354 |
1.98e-08 |
|
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349979 Cd Length: 148 Bit Score: 52.64 E-value: 1.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 224 PHNLGAIMRSCAHFGVKGVVVQ-------DAGVLESGAairtaegGAEHVEPITGDSFIDTLDQFRKAGYAIVSTSSHNG 296
Cdd:cd18106 11 PGNLGSILRSAAAAGCSKVLLTkgcvdpwEPKVLRAGA-------GAHFRLPIYGNLSWDDIPNYLPDDSKVFLADNNLP 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1457296494 297 T-PLFKAELPKK-MVLALGQERDGLSDAAISSADLS----VAIDGTGNVESLNVSVATGVLLAE 354
Cdd:cd18106 84 VqPYDSIDYCSGpIVLVIGGETHGVSPEAYKLAHSTggsrVHIPLANGVDSLNSAVAASILLFE 147
|
|
| SpoU-like_TrmJ |
cd18093 |
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ... |
224-355 |
3.20e-08 |
|
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349966 Cd Length: 153 Bit Score: 52.11 E-value: 3.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 224 PHNLGAIMRSCAHFGVKG-VVVQDAGVLESGAAIRTAeGGAEHVepITGDSFIDTLDQFRKAGYAIVSTSSHNGTPLFKA 302
Cdd:cd18093 11 PGNIGAVARAMKNFGLSDlRLVNPRCDDPEEAARALA-SGAEDV--LENAKVYDTLEEALADCDLVVATTARPRGLRRPL 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1457296494 303 ELP-------------KKMVLALGQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEW 355
Cdd:cd18093 88 LTPrelaellkehaagGKVALVFGREDSGLTNEELALCDLLVTIPTNPEYPSLNLAQAVAIVLYEL 153
|
|
| SpoU-like |
cd18098 |
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ... |
214-352 |
1.62e-07 |
|
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349971 Cd Length: 138 Bit Score: 49.95 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 214 CVLALEDVGNPHNLGAIMRSCAHFGVKGVVVQDAGVLESGAAIRTAEgGAEHVEPITGDSFIDTLDQFRKAGYAIVSTSS 293
Cdd:cd18098 1 FAIGIENPKTPKNVGTLWRAAGCLGASFVFTIGARYKRRKQSTDTSK-AWRHIPLFHYDDLEDLAEPLPFGAVLVAVELT 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1457296494 294 HNGTPLFKAELPKKMVLALGQERDGLSDAAISSADLSVAIDGTGnveSLNVSVATGVLL 352
Cdd:cd18098 80 EGATPLPDFKHPDRAVYLLGPEDGGLPQEVLARCHHVVYLPTRG---SLNVAVAGSIVL 135
|
|
| TrmL |
COG0219 |
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ... |
224-359 |
1.17e-05 |
|
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 439989 Cd Length: 153 Bit Score: 44.64 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 224 PHNLGAIMRSCAHFGVK-------GVVVQDAgvlesgaAIRTAegG---AEHVEpITgdsFIDTLDQFRKA--GYAIVST 291
Cdd:COG0219 12 PQNTGNIIRLCAATGARlhlieplGFSLDDK-------KLKRA--GldyWELVD-LT---VHDSWEAFLEAlpGGRLFLF 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1457296494 292 SSHNGTPLFKAELPKKMVLALGQERDGLSDAAISS-ADLSVAIDGTGNVESLNVSVATGVLLAEWWRQN 359
Cdd:COG0219 79 TTKGTKPYTDVDYQPGDVLLFGRETAGLPEEVLAApADQRLRIPMRPGVRSLNLSNAVAIVLYEALRQL 147
|
|
| TrmJ |
COG0565 |
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ... |
226-358 |
2.15e-03 |
|
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440331 [Multi-domain] Cd Length: 237 Bit Score: 39.33 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1457296494 226 NLGAIMRSCAHFGVKGVVVQDAGVLESGAAIRTAeGGAEHVepITGDSFIDTLDQFRKAGYAIVSTSS---HNGTPLFKA 302
Cdd:COG0565 16 NIGAAARAMKNFGLSDLRLVNPRGWPDEEARAMA-SGADDV--LENARVVDTLEEALADCDLVVGTTArprELRKPVLTP 92
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1457296494 303 -ELPKKMV-------LAL--GQERDGLSDAAISSADLSVAIDGTGNVESLNVSVATGVLLAEWWRQ 358
Cdd:COG0565 93 rEAAEELLaraaggkVALvfGRERSGLTNEELALCDALVTIPTNPEYPSLNLAQAVQVVAYELRKA 158
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