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Conserved domains on  [gi|1456037117|emb|SYQ59276|]
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PTS system mannose-specific transporter subunit IIA [Klebsiella pneumoniae]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10006772)

PTS mannose/fructose/sorbose family sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

CATH:  3.40.50.510
Gene Ontology:  GO:0009401|GO:0016310|GO:0016301|GO:0008643|GO:1902495
PubMed:  11532441|10393270
SCOP:  4000512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 4-94 2.33e-24

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


:

Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 90.58  E-value: 2.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   4 IYVASHGHFARGLVNSLSLLIGDEHGVIPVCAYDEDivTTEQLEQTLEHLIVQAN-GDEVVIFTDLLGGSINNSAVSVLM 82
Cdd:COG2893     1 IVIATHGPLAEGLLSSAEMILGEQENVEAVDLYPGD--DPEDLREKLEEAIAELDsGDGVLILTDLFGGTPSNVAARLLA 78

                          90
                  ....*....|..
gi 1456037117  83 RHRNVFVVAGIN 94
Cdd:COG2893    79 KHENVEVIAGVN 90
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 4-94 2.33e-24

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 90.58  E-value: 2.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   4 IYVASHGHFARGLVNSLSLLIGDEHGVIPVCAYDEDivTTEQLEQTLEHLIVQAN-GDEVVIFTDLLGGSINNSAVSVLM 82
Cdd:COG2893     1 IVIATHGPLAEGLLSSAEMILGEQENVEAVDLYPGD--DPEDLREKLEEAIAELDsGDGVLILTDLFGGTPSNVAARLLA 78

                          90
                  ....*....|..
gi 1456037117  83 RHRNVFVVAGIN 94
Cdd:COG2893    79 KHENVEVIAGVN 90
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 2-94 2.83e-24

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 90.36  E-value: 2.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   2 KHIYVASHGHFARGLVNSLSLLIGDEHGVIPVCAYDEdiVTTEQLEQTLEHLIVQA-NGDEVVIFTDLLGGSINNSAVSV 80
Cdd:cd00006     1 VGIIIATHGGFASGLLNSAEMILGEQENVEAIDFPPG--ESPDDLLEKIKAALAELdSGEGVLILTDLFGGSPNNAAARL 78

                          90
                  ....*....|....
gi 1456037117  81 LMRHRNVFVVAGIN 94
Cdd:cd00006    79 SMEHPPVEVIAGVN 92
AgaF NF040761
PTS galactosamine/N-acetylgalactosamine transporter subunit IIA;
1-94 4.70e-14

PTS galactosamine/N-acetylgalactosamine transporter subunit IIA;


Pssm-ID: 468721  Cd Length: 144  Bit Score: 64.42  E-value: 4.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   1 MKHIYVASHGHFARGLVNSLSLLIGDEHGVIPVcAYDEDIvTTEQLEQTLEHLIVQ-ANGDEVVIFTDLLGGSINNSAVS 79
Cdd:NF040761    1 MIGIILTGHGGFASGLESAVEQIIGEQPQFIAI-DFPESM-STAQLEAQLEQALAElDSGEGVVFLTDLLGGSPFRVAST 78

                          90
                  ....*....|....*
gi 1456037117  80 VLMRHRNVFVVAGIN 94
Cdd:NF040761   79 LALQRPNIEVITGTN 93
EIIA-man pfam03610
PTS system fructose IIA component;
4-94 5.19e-12

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 58.41  E-value: 5.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   4 IYVASHGHFARGLVNSLSLLIGDEHGVIPVCaydediVTTEQLEQTLEHLIVQA-----NGDEVVIFTDLLGGSINNSAV 78
Cdd:pfam03610   2 IVIVSHGELAEGLLELAEMMAGEQENVIAVG------GTPGESIGTSFEKIVEAienldSGDGVLVLVDLGGATPNNEAA 75

                          90
                  ....*....|....*.
gi 1456037117  79 SVLMRHRNVFVVAGIN 94
Cdd:pfam03610  76 LELLEKERMEVITGVN 91
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 4-95 2.55e-03

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 36.51  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   4 IYVASHGHFARGLVNSLSLLIGDEHGVipvcAYdEDIVTTEQLEqTL-----EHLIVQANGDEVVIFTDLLGGSINNSAV 78
Cdd:PRK15088    5 IIIGTHGWAAEQLLKTAEMLLGEQENV----AW-IDFVPGENAE-TLiekynAQLAKLDTSKGVLFLVDTWGGSPFNAAS 78

                          90
                  ....*....|....*..
gi 1456037117  79 SVLMRHRNVFVVAGINL 95
Cdd:PRK15088   79 RIVVDKENYEVITGVNI 95
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 4-94 2.33e-24

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 90.58  E-value: 2.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   4 IYVASHGHFARGLVNSLSLLIGDEHGVIPVCAYDEDivTTEQLEQTLEHLIVQAN-GDEVVIFTDLLGGSINNSAVSVLM 82
Cdd:COG2893     1 IVIATHGPLAEGLLSSAEMILGEQENVEAVDLYPGD--DPEDLREKLEEAIAELDsGDGVLILTDLFGGTPSNVAARLLA 78

                          90
                  ....*....|..
gi 1456037117  83 RHRNVFVVAGIN 94
Cdd:COG2893    79 KHENVEVIAGVN 90
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 2-94 2.83e-24

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 90.36  E-value: 2.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   2 KHIYVASHGHFARGLVNSLSLLIGDEHGVIPVCAYDEdiVTTEQLEQTLEHLIVQA-NGDEVVIFTDLLGGSINNSAVSV 80
Cdd:cd00006     1 VGIIIATHGGFASGLLNSAEMILGEQENVEAIDFPPG--ESPDDLLEKIKAALAELdSGEGVLILTDLFGGSPNNAAARL 78

                          90
                  ....*....|....
gi 1456037117  81 LMRHRNVFVVAGIN 94
Cdd:cd00006    79 SMEHPPVEVIAGVN 92
AgaF NF040761
PTS galactosamine/N-acetylgalactosamine transporter subunit IIA;
1-94 4.70e-14

PTS galactosamine/N-acetylgalactosamine transporter subunit IIA;


Pssm-ID: 468721  Cd Length: 144  Bit Score: 64.42  E-value: 4.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   1 MKHIYVASHGHFARGLVNSLSLLIGDEHGVIPVcAYDEDIvTTEQLEQTLEHLIVQ-ANGDEVVIFTDLLGGSINNSAVS 79
Cdd:NF040761    1 MIGIILTGHGGFASGLESAVEQIIGEQPQFIAI-DFPESM-STAQLEAQLEQALAElDSGEGVVFLTDLLGGSPFRVAST 78

                          90
                  ....*....|....*
gi 1456037117  80 VLMRHRNVFVVAGIN 94
Cdd:NF040761   79 LALQRPNIEVITGTN 93
EIIA-man pfam03610
PTS system fructose IIA component;
4-94 5.19e-12

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 58.41  E-value: 5.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   4 IYVASHGHFARGLVNSLSLLIGDEHGVIPVCaydediVTTEQLEQTLEHLIVQA-----NGDEVVIFTDLLGGSINNSAV 78
Cdd:pfam03610   2 IVIVSHGELAEGLLELAEMMAGEQENVIAVG------GTPGESIGTSFEKIVEAienldSGDGVLVLVDLGGATPNNEAA 75

                          90
                  ....*....|....*.
gi 1456037117  79 SVLMRHRNVFVVAGIN 94
Cdd:pfam03610  76 LELLEKERMEVITGVN 91
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 4-95 2.55e-03

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 36.51  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1456037117   4 IYVASHGHFARGLVNSLSLLIGDEHGVipvcAYdEDIVTTEQLEqTL-----EHLIVQANGDEVVIFTDLLGGSINNSAV 78
Cdd:PRK15088    5 IIIGTHGWAAEQLLKTAEMLLGEQENV----AW-IDFVPGENAE-TLiekynAQLAKLDTSKGVLFLVDTWGGSPFNAAS 78

                          90
                  ....*....|....*..
gi 1456037117  79 SVLMRHRNVFVVAGINL 95
Cdd:PRK15088   79 RIVVDKENYEVITGVNI 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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