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Conserved domains on  [gi|1581432337|gb|TAT47068|]
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MarR family transcriptional regulator [Lactiplantibacillus plantarum]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
22-162 2.97e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 86.95  E-value: 2.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1581432337  22 ASSSADAEQVLAFLdFQWTFRTMQATYEQLLDQYQLSESKFIILMLLENETDHTllPSELATKLGSARATVSKLLVGLQK 101
Cdd:COG1846     2 SDEPDPAEERLGLL-LRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLT--QSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1581432337 102 RGWVEKQHPQDDKRTVAIHLTAAGSSVLTQFLPANFKAVTTIFASFTVQEQQQFKGLLDKI 162
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRL 139
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
22-162 2.97e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 86.95  E-value: 2.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1581432337  22 ASSSADAEQVLAFLdFQWTFRTMQATYEQLLDQYQLSESKFIILMLLENETDHTllPSELATKLGSARATVSKLLVGLQK 101
Cdd:COG1846     2 SDEPDPAEERLGLL-LRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLT--QSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1581432337 102 RGWVEKQHPQDDKRTVAIHLTAAGSSVLTQFLPANFKAVTTIFASFTVQEQQQFKGLLDKI 162
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRL 139
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 50-162 1.52e-18

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 78.25  E-value: 1.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1581432337  50 QLLDQYQLSESKFIILMLLENETDHTLLPSELATKLGSARATVSKLLVGLQKRGWVEKQHPQDDKRTVAIHLTAAGSSVL 129
Cdd:PRK10870   46 KMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFL 125

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1581432337 130 TQFLPANFKAVTTIFASFTVQEQQQFKGLLDKI 162
Cdd:PRK10870  126 REVLPPQHNCLHQLWSALSTTEKDQLEQITRKL 158
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
52-152 1.09e-15

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 68.77  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1581432337   52 LDQYQLSESKFIILMLLENETdhTLLPSELATKLGSARATVSKLLVGLQKRGWVEKQHPQDDKRTVAIHLTAAGSSVLTQ 131
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEG--PLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 1581432337  132 FLPANFKAVTTIFASFTVQEQ 152
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 57-117 2.57e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 51.01  E-value: 2.57e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1581432337  57 LSESKFIILMLLENETDHTLlpSELATKLGSARATVSKLLVGLQKRGWVEKQHPQDDKRTV 117
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTV--SELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 48-109 4.55e-03

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 34.35  E-value: 4.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1581432337  48 YEQLLDQyqlseskfIILMLLENE-TDHTLLPSE--LATKLGSARATVSKLLVGLQKRGWVEKQH 109
Cdd:cd07377     3 YEQIADQ--------LREAILSGElKPGDRLPSEreLAEELGVSRTTVREALRELEAEGLVERRP 59
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
22-162 2.97e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 86.95  E-value: 2.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1581432337  22 ASSSADAEQVLAFLdFQWTFRTMQATYEQLLDQYQLSESKFIILMLLENETDHTllPSELATKLGSARATVSKLLVGLQK 101
Cdd:COG1846     2 SDEPDPAEERLGLL-LRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLT--QSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1581432337 102 RGWVEKQHPQDDKRTVAIHLTAAGSSVLTQFLPANFKAVTTIFASFTVQEQQQFKGLLDKI 162
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRL 139
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 50-162 1.52e-18

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 78.25  E-value: 1.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1581432337  50 QLLDQYQLSESKFIILMLLENETDHTLLPSELATKLGSARATVSKLLVGLQKRGWVEKQHPQDDKRTVAIHLTAAGSSVL 129
Cdd:PRK10870   46 KMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFL 125

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1581432337 130 TQFLPANFKAVTTIFASFTVQEQQQFKGLLDKI 162
Cdd:PRK10870  126 REVLPPQHNCLHQLWSALSTTEKDQLEQITRKL 158
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
52-152 1.09e-15

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 68.77  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1581432337   52 LDQYQLSESKFIILMLLENETdhTLLPSELATKLGSARATVSKLLVGLQKRGWVEKQHPQDDKRTVAIHLTAAGSSVLTQ 131
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEG--PLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 1581432337  132 FLPANFKAVTTIFASFTVQEQ 152
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 57-117 2.57e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 51.01  E-value: 2.57e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1581432337  57 LSESKFIILMLLENETDHTLlpSELATKLGSARATVSKLLVGLQKRGWVEKQHPQDDKRTV 117
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTV--SELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 55-115 1.00e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 44.12  E-value: 1.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1581432337  55 YQLSESKFIILMLLENETDHTllPSELATKLGSARATVSKLLVGLQKRGWVEKQHPQDDKR 115
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLT--VAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
HTH_IclR pfam09339
IclR helix-turn-helix domain;
65-108 5.44e-05

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 38.93  E-value: 5.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1581432337  65 LMLLE--NETDHTLLPSELATKLGSARATVSKLLVGLQKRGWVEKQ 108
Cdd:pfam09339   6 LAILDalAEAPGPLTLTEIARRTGLPKSTAHRLLQTLVELGYVEQD 51
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
79-129 2.54e-04

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 38.33  E-value: 2.54e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1581432337   79 SELATKLGSARATVSKLLVGLQKRGWVEkQHPQDDKRTVAIHLTAAGSSVL 129
Cdd:smart00346  24 AELAERLGLSKSTAHRLLNTLQELGYVE-QDGQNGRYRLGPKVLELGQSYL 73
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
65-132 3.26e-04

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 39.80  E-value: 3.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1581432337  65 LMLLE--NETDHTLLPSELATKLGSARATVSKLLVGLQKRGWVEkQHPQDDKRTVAIHLTAAGSSVLTQF 132
Cdd:COG1414    12 LAILEalAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVE-RDPEGGRYRLGPRLLELGSAALRRL 80
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
63-122 4.10e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.09  E-value: 4.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1581432337  63 IILMLLENETDHtllPSELATKLGSARATVSKLLVGLQKRGWVEKqhpQDDKRTVAIHLT 122
Cdd:COG3398   102 ILLYLLENPGAT---NKELAEELGISRSTVSWHLKRLEEDGLVER---ERDGRNVRYYLN 155
HTH_27 pfam13463
Winged helix DNA-binding domain;
66-125 1.03e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 36.11  E-value: 1.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1581432337  66 MLLENeTDHTLLPSELAT---KLGSARATVSKLLVGLQKRGWVEKQHPQDDKRTVAIHLTAAG 125
Cdd:pfam13463   7 LILHN-IGHRGDPKTLADicfRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
63-134 1.80e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 37.57  E-value: 1.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1581432337  63 IILMLLENETDhtllPSELATKLGSARATVSKLLVGLQKRGWVEKqhpqDDKRtvaIHLTAAGSSVLTQFLP 134
Cdd:COG4742    21 ILLLLAEGPKT----RSELAESLDVSRSTILRQLKELEERGLIER----DDGE---YELTTLGRLVVEEMEP 81
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
64-125 2.05e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 36.72  E-value: 2.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1581432337  64 ILMLleNETDHTLLPSELATKLGSARATVSKLLVGLQKRGWVEKQHPQddkrtvAIHLTAAG 125
Cdd:COG1321    15 IYEL--SEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYG------GITLTEEG 68
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 48-109 4.55e-03

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 34.35  E-value: 4.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1581432337  48 YEQLLDQyqlseskfIILMLLENE-TDHTLLPSE--LATKLGSARATVSKLLVGLQKRGWVEKQH 109
Cdd:cd07377     3 YEQIADQ--------LREAILSGElKPGDRLPSEreLAEELGVSRTTVREALRELEAEGLVERRP 59
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 57-107 7.71e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 34.12  E-value: 7.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1581432337  57 LSESKFIILMLLEnETDHTLLPSELATKLGSARATVSKLLVGLQKRGWVEK 107
Cdd:COG2512    13 LLEDERRVLELLR-ENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEK 62
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 64-109 9.25e-03

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 33.58  E-value: 9.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1581432337  64 ILMLLENETDHTL-LP---SELATKLGSARATVSKLLVGLQKRGWVEKQH 109
Cdd:pfam13545   7 LLELAARDGGGRIdLPltqEDLADLLGTTRETVSRVLSELRREGLIERGR 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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