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Conserved domains on  [gi|1582538263|gb|TBD18998|]
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ActS/PrrB/RegB family redox-sensitive histidine kinase [Rhizobium ruizarguesonis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 12-431 0e+00

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


:

Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 693.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263  12 DRHNSRRLRLQTLVRLRWLAVGGQALTVFIVAFWLKFPLPLIASSSLIAALAWVNFYLTIRYPPTHRLEPPAAFALLGFD 91
Cdd:NF033792    1 LGRRSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFPPNRRLSDREAALLLAFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263  92 LLQLCALLFITGGLANPFAALVCVPVIISFASQPIRYSTALIGFAMVCITVLAFSPFPLPWFDGVEINVHNVMQFGVWCS 171
Cdd:NF033792   81 ILQLAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWYDGEPLVLPPLYLFGVWLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 172 IASTMAFAAFYAYRVSMEASQLADALAATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRFRED 251
Cdd:NF033792  161 LVIGIAFTAVYAWRVAEEARRLSDALAATELVLAREQHLSALDGLAAAAAHELGTPLATIALVAKELERELPDDPPLRED 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 252 VMLLRSQSERCRDILRRLTTLSSEGEAHMRRLPLSSMIEEIVAPHREFGIALELIEKSPRKGEPVTDRNAGIMYGLGNLI 331
Cdd:NF033792  241 AELLRSQAERCRDILRRLTSLGEEGDAHLDRLPLSALIEEAAAPHRGFGKEIEVVVAGDPGEEPVIRRNPEILYGLGNLI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 332 ENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKED---TAGGLGLGLFIAKTLLERSGASLV 408
Cdd:NF033792  321 ENAVDFARSTVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRGEErrpGGGGLGLGLFIAKTLLERSGATVT 400

                         410       420
                  ....*....|....*....|...
gi 1582538263 409 FENRDPESAGARIRIEWPRMLID 431
Cdd:NF033792  401 FANRPPPEGGAVVTVRWPRAALE 423
 
Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 12-431 0e+00

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 693.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263  12 DRHNSRRLRLQTLVRLRWLAVGGQALTVFIVAFWLKFPLPLIASSSLIAALAWVNFYLTIRYPPTHRLEPPAAFALLGFD 91
Cdd:NF033792    1 LGRRSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFPPNRRLSDREAALLLAFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263  92 LLQLCALLFITGGLANPFAALVCVPVIISFASQPIRYSTALIGFAMVCITVLAFSPFPLPWFDGVEINVHNVMQFGVWCS 171
Cdd:NF033792   81 ILQLAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWYDGEPLVLPPLYLFGVWLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 172 IASTMAFAAFYAYRVSMEASQLADALAATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRFRED 251
Cdd:NF033792  161 LVIGIAFTAVYAWRVAEEARRLSDALAATELVLAREQHLSALDGLAAAAAHELGTPLATIALVAKELERELPDDPPLRED 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 252 VMLLRSQSERCRDILRRLTTLSSEGEAHMRRLPLSSMIEEIVAPHREFGIALELIEKSPRKGEPVTDRNAGIMYGLGNLI 331
Cdd:NF033792  241 AELLRSQAERCRDILRRLTSLGEEGDAHLDRLPLSALIEEAAAPHRGFGKEIEVVVAGDPGEEPVIRRNPEILYGLGNLI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 332 ENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKED---TAGGLGLGLFIAKTLLERSGASLV 408
Cdd:NF033792  321 ENAVDFARSTVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRGEErrpGGGGLGLGLFIAKTLLERSGATVT 400

                         410       420
                  ....*....|....*....|...
gi 1582538263 409 FENRDPESAGARIRIEWPRMLID 431
Cdd:NF033792  401 FANRPPPEGGAVVTVRWPRAALE 423
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
189-427 1.04e-35

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 134.27  E-value: 1.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 189 EASQLADALAATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELknDDRFREDVMLLRSQSERCRDILRR 268
Cdd:COG0642    86 LLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQREYLETILRSADRLLRLIND 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 269 LTTLS----SEGEAHMRRLPLSSMIEEIVAPHREF----GIALELiEKSPRKGEPVTDRNAgIMYGLGNLIENAVDYARE 340
Cdd:COG0642   164 LLDLSrleaGKLELEPEPVDLAELLEEVVELFRPLaeekGIELEL-DLPDDLPTVRGDPDR-LRQVLLNLLSNAIKYTPE 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 341 --KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTaGGLGLGLFIAKTLLERSGASLVFENRDPEsaG 418
Cdd:COG0642   242 ggTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESEPGK--G 318


                  ....*....
gi 1582538263 419 ARIRIEWPR 427
Cdd:COG0642   319 TTFTVTLPL 327
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 327-426 4.56e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 96.18  E-value: 4.56e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263  327 LGNLIENAVDYARE--KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTAGGLGLGLFIAKTLLERSG 404
Cdd:smart00387  10 LSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVELHG 89

                           90       100
                   ....*....|....*....|..
gi 1582538263  405 ASLVFENRDPEsaGARIRIEWP 426
Cdd:smart00387  90 GEISVESEPGG--GTTFTITLP 109
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-426 5.24e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 78.91  E-value: 5.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYV---TKRQKEdtAGGLGLGLFIAKTLLERSGA 405
Cdd:cd16949     7 NVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdSARDRE--SGGTGLGLAIAERAIEQHGG 84

                          90       100
                  ....*....|....*....|.
gi 1582538263 406 SLVFENRDPEsaGARIRIEWP 426
Cdd:cd16949    85 KIKASNRKPG--GLRVRIWLP 103
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 327-426 6.18e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.95  E-value: 6.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTVTVE-HDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQkeDTAGGLGLGLFIAKTLLERSGA 405
Cdd:pfam02518  10 LSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK--RGGGGTGLGLSIVRKLVELLGG 87

                          90       100
                  ....*....|....*....|.
gi 1582538263 406 SLVFENRDPEsaGARIRIEWP 426
Cdd:pfam02518  88 TITVESEPGG--GTTVTLTLP 106
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 121-427 2.45e-16

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 80.66  E-value: 2.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 121 FASQPIRYSTALIGFAMVCITVLAFSPFplpwfdgVEINVHNVMQFGVWcSIASTMAFAAFYAYRVSMEASQL---ADAL 197
Cdd:PRK11100  149 YVAAPIRDGGRIIGVLSVGKPNSSMAPF-------IKRSERRILWAGAL-LLGIALLIGAGVVWWLNRSIRRLtryADAV 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 198 AATELVLQREKHLSQLDGLAAAA--------------------AHELGTPLATISVVAKEMERELKNDDRFREdVMLLRS 257
Cdd:PRK11100  221 TEGKPVPLPKLGSSELRELAQALesmrvklegkayveqyvqtlTHELKSPLAAIRGAAELLQEDPPPEDRARF-TGNILT 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 258 QSERCRDILRRLTTLSS----EGEAHMRRLPLSSMIEEIVAPH----REFGIALEL-IEKSPRKGEPVTDRNAgimygLG 328
Cdd:PRK11100  300 QSARLQQLIDRLLELARleqrQELEVLEPVALAALLEELVEAReaqaAAKGITLRLrPDDARVLGDPFLLRQA-----LG 374

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDYAREK--VTVTVEHDHDKVLIVIEDDGNG---YApdiLTRIGEPYVTKRQKEDTAGGLGLGLFIAKTLLERS 403
Cdd:PRK11100  375 NLLDNAIDFSPEGgtITLSAEVDGEQVALSVEDQGPGipdYA---LPRIFERFYSLPRPANGRKSTGLGLAFVREVARLH 451

                         330       340
                  ....*....|....*....|....
gi 1582538263 404 GASLVFENRDPesAGARIRIEWPR 427
Cdd:PRK11100  452 GGEVTLRNRPE--GGVLATLTLPR 473
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 185-422 1.54e-06

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 50.08  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 185 RVSMEASQLADALAAtelVLQR-EKHLSQLDGLAAAAAHELGTPLATISV---VAKEMER--------------ELKNDD 246
Cdd:TIGR01386 215 RAPAELRELAQSFNA---MLGRlEDAFQRLSQFSADLAHELRTPLTNLLGqtqVALSQPRtgeeyrevlesnleELERLS 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 247 RFREDvMLLRSQSERCRDILRRlTTLSSEGEahmrrlpLSSMIE--EIVAPHREFGIALEliekspRKGEPVTDRnagIM 324
Cdd:TIGR01386 292 RMVSD-MLFLARADNGQLALER-VRLDLAAE-------LAKVAEyfEPLAEERGVRIRVE------GEGLVRGDP---QM 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 325 Y--GLGNLIENAVDYARE--KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEP-YVTKRQKEDTAGGLGLGLFIAKTL 399
Cdd:TIGR01386 354 FrrAISNLLSNALRHTPDggTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRfYRVDPARSNSGEGTGLGLAIVRSI 433

                         250       260
                  ....*....|....*....|...
gi 1582538263 400 LERSGASLvfenrDPESAGARIR 422
Cdd:TIGR01386 434 MEAHGGRA-----SAESPDGKTR 451
 
Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 12-431 0e+00

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 693.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263  12 DRHNSRRLRLQTLVRLRWLAVGGQALTVFIVAFWLKFPLPLIASSSLIAALAWVNFYLTIRYPPTHRLEPPAAFALLGFD 91
Cdd:NF033792    1 LGRRSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFPPNRRLSDREAALLLAFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263  92 LLQLCALLFITGGLANPFAALVCVPVIISFASQPIRYSTALIGFAMVCITVLAFSPFPLPWFDGVEINVHNVMQFGVWCS 171
Cdd:NF033792   81 ILQLAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWYDGEPLVLPPLYLFGVWLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 172 IASTMAFAAFYAYRVSMEASQLADALAATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRFRED 251
Cdd:NF033792  161 LVIGIAFTAVYAWRVAEEARRLSDALAATELVLAREQHLSALDGLAAAAAHELGTPLATIALVAKELERELPDDPPLRED 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 252 VMLLRSQSERCRDILRRLTTLSSEGEAHMRRLPLSSMIEEIVAPHREFGIALELIEKSPRKGEPVTDRNAGIMYGLGNLI 331
Cdd:NF033792  241 AELLRSQAERCRDILRRLTSLGEEGDAHLDRLPLSALIEEAAAPHRGFGKEIEVVVAGDPGEEPVIRRNPEILYGLGNLI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 332 ENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKED---TAGGLGLGLFIAKTLLERSGASLV 408
Cdd:NF033792  321 ENAVDFARSTVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRGEErrpGGGGLGLGLFIAKTLLERSGATVT 400

                         410       420
                  ....*....|....*....|...
gi 1582538263 409 FENRDPESAGARIRIEWPRMLID 431
Cdd:NF033792  401 FANRPPPEGGAVVTVRWPRAALE 423
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
189-427 1.04e-35

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 134.27  E-value: 1.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 189 EASQLADALAATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELknDDRFREDVMLLRSQSERCRDILRR 268
Cdd:COG0642    86 LLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQREYLETILRSADRLLRLIND 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 269 LTTLS----SEGEAHMRRLPLSSMIEEIVAPHREF----GIALELiEKSPRKGEPVTDRNAgIMYGLGNLIENAVDYARE 340
Cdd:COG0642   164 LLDLSrleaGKLELEPEPVDLAELLEEVVELFRPLaeekGIELEL-DLPDDLPTVRGDPDR-LRQVLLNLLSNAIKYTPE 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 341 --KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTaGGLGLGLFIAKTLLERSGASLVFENRDPEsaG 418
Cdd:COG0642   242 ggTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESEPGK--G 318


                  ....*....
gi 1582538263 419 ARIRIEWPR 427
Cdd:COG0642   319 TTFTVTLPL 327
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
204-427 1.02e-33

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 126.56  E-value: 1.02e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 204 LQREKHLSQL-DGLAAAAAHELGTPLATISVVAKEMERELK-NDDRFREDVMLLRSQSERCRDILRRLTTLS----SEGE 277
Cdd:COG2205     6 LEELEELERLkSEFLANVSHELRTPLTSILGAAELLLDEEDlSPEERRELLEIIRESAERLLRLIEDLLDLSrlesGKLS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 278 AHMRRLPLSSMIEEIVAPHR----EFGIALElIEKSPRKGEPVTDRNAgIMYGLGNLIENAVDYARE--KVTVTVEHDHD 351
Cdd:COG2205    86 LELEPVDLAELLEEAVEELRplaeEKGIRLE-LDLPPELPLVYADPEL-LEQVLANLLDNAIKYSPPggTITISARREGD 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1582538263 352 KVLIVIEDDGNGYAPDILTRIGEPYVTKRqKEDTAGGLGLGLFIAKTLLERSGASLVFENRDPEsaGARIRIEWPR 427
Cdd:COG2205   164 GVRISVSDNGPGIPEEELERIFERFYRGD-NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGG--GTTFTVTLPL 236
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 193-427 6.21e-31

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 121.83  E-value: 6.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 193 LADALAATELVLQREKhLSQLDGLAAAAAHELGTPLATISVVAKEMERELK---NDDRFREDVMLLRSQSERCRDILRRL 269
Cdd:COG4191   123 EEELRELQEQLVQSEK-LAALGELAAGIAHEINNPLAAILGNAELLRRRLEdepDPEELREALERILEGAERAAEIVRSL 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 270 TTLSSEGEAHMRRLPLSSMIEE---IVAPH-REFGIAlelIEKSPRKGEPVTDRNAG-----IMyglgNLIENAVD---- 336
Cdd:COG4191   202 RAFSRRDEEEREPVDLNELIDEaleLLRPRlKARGIE---VELDLPPDLPPVLGDPGqleqvLL----NLLINAIDamee 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 337 YAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYV-TKRQKEdtagGLGLGLFIAKTLLERSGASLVFENRDPE 415
Cdd:COG4191   275 GEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFtTKPVGK----GTGLGLSISYGIVEKHGGRIEVESEPGG 350

                         250
                  ....*....|..
gi 1582538263 416 saGARIRIEWPR 427
Cdd:COG4191   351 --GTTFTITLPL 360
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 216-427 6.39e-26

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 108.90  E-value: 6.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 216 LAAAAAHELGTPLATIS----VVAKEMERELKND-DRFREDVMLLRSQSERCRDILRRLTTLSSEGEAHMRRLPLSSMIE 290
Cdd:COG5000   204 LARRIAHEIKNPLTPIQlsaeRLRRKLADKLEEDrEDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLR 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 291 EIVA----PHREFGIALELIeksprkgepvTDRNAGIMYG--------LGNLIENAVDYARE--KVTVTVEHDHDKVLIV 356
Cdd:COG5000   284 EVLAlyepALKEKDIRLELD----------LDPDLPEVLAdrdqleqvLINLLKNAIEAIEEggEIEVSTRREDGRVRIE 353

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1582538263 357 IEDDGNGYAPDILTRIGEPYVTKRQKedtagGLGLGLFIAKTLLERSGASLVFENRDPEsaGARIRIEWPR 427
Cdd:COG5000   354 VSDNGPGIPEEVLERIFEPFFTTKPK-----GTGLGLAIVKKIVEEHGGTIELESRPGG--GTTFTIRLPL 417
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 327-426 4.56e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 96.18  E-value: 4.56e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263  327 LGNLIENAVDYARE--KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTAGGLGLGLFIAKTLLERSG 404
Cdd:smart00387  10 LSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVELHG 89

                           90       100
                   ....*....|....*....|..
gi 1582538263  405 ASLVFENRDPEsaGARIRIEWP 426
Cdd:smart00387  90 GEISVESEPGG--GTTFTITLP 109
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
216-427 8.55e-24

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 102.32  E-value: 8.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 216 LAAAAAHELGTPLATISVVAKEMERELKNDDRFREDVM-LLRSQSERCRDILRRLTTLS----SEGEAHMRRLPLSSMIE 290
Cdd:COG5002   168 FVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLeIILEEAERLSRLVNDLLDLSrlesGELKLEKEPVDLAELLE 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 291 EIVAPHR----EFGIALELieKSPRKGEPVT-DRNAgIMYGLGNLIENAVDYARE--KVTVTVEHDHDKVLIVIEDDGNG 363
Cdd:COG5002   248 EVVEELRplaeEKGIELEL--DLPEDPLLVLgDPDR-LEQVLTNLLDNAIKYTPEggTITVSLREEDDQVRISVRDTGIG 324

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1582538263 364 YAPDILTRIGEP-YVTKRQKEDTAGGLGLGLFIAKTLLERSGASLVFENRdpESAGARIRIEWPR 427
Cdd:COG5002   325 IPEEDLPRIFERfYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESE--PGKGTTFTITLPL 387
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
185-434 1.60e-20

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 92.22  E-value: 1.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 185 RVSMEASQLADALAATELVLQREKHLSqLDGLAAAAAHELGTPLATISVVAKEMERELKnDDRFREDVMLLRSQSERCRD 264
Cdd:COG3852   108 GVLLVLRDITERKRLERELRRAEKLAA-VGELAAGLAHEIRNPLTGIRGAAQLLERELP-DDELREYTQLIIEEADRLNN 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 265 ILRRLTTLSSEGEAHMRRLPLSSMIEEIvaphrefgiaLELIEKSPRKG-EPVTDRNAGI--MYG--------LGNLIEN 333
Cdd:COG3852   186 LVDRLLSFSRPRPPEREPVNLHEVLERV----------LELLRAEAPKNiRIVRDYDPSLpeVLGdpdqliqvLLNLVRN 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 334 AVD------------YAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRqkedtAGGLGLGLFIAKTLLE 401
Cdd:COG3852   256 AAEampeggtitirtRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTK-----EKGTGLGLAIVQKIVE 330

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1582538263 402 RSGASLVFENRDPEsaGARIRIEWPRMLIDANS 434
Cdd:COG3852   331 QHGGTIEVESEPGK--GTTFRIYLPLEQAEEEP 361
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-426 5.24e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 78.91  E-value: 5.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYV---TKRQKEdtAGGLGLGLFIAKTLLERSGA 405
Cdd:cd16949     7 NVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdSARDRE--SGGTGLGLAIAERAIEQHGG 84

                          90       100
                  ....*....|....*....|.
gi 1582538263 406 SLVFENRDPEsaGARIRIEWP 426
Cdd:cd16949    85 KIKASNRKPG--GLRVRIWLP 103
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 327-426 6.18e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.95  E-value: 6.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTVTVE-HDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQkeDTAGGLGLGLFIAKTLLERSGA 405
Cdd:pfam02518  10 LSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK--RGGGGTGLGLSIVRKLVELLGG 87

                          90       100
                  ....*....|....*....|.
gi 1582538263 406 SLVFENRDPEsaGARIRIEWP 426
Cdd:pfam02518  88 TITVESEPGG--GTTVTLTLP 106
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 199-410 9.80e-17

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 82.09  E-value: 9.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 199 ATELVLQREKhLSQLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRFReDVMLlrSQSERCRDILRRLTTLSSEGEA 278
Cdd:COG5805   274 AEELMARSEK-LSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYF-DIML--SELDRIESIISEFLALAKPQAV 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 279 HMRRLPLSSMIEEIV------APHREFGIALELIEKSPrkgEPVTDRNAgIMYGLGNLIENAVDyAREK---VTVTVEHD 349
Cdd:COG5805   350 NKEKENINELIQDVVtlleteAILHNIQIRLELLDEDP---FIYCDENQ-IKQVFINLIKNAIE-AMPNggtITIHTEEE 424

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1582538263 350 HDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKedtagGLGLGLFIAKTLLERSGASLVFE 410
Cdd:COG5805   425 DNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK-----GTGLGLMVSYKIIENHNGTIDID 480
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 297-423 1.15e-16

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 81.43  E-value: 1.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 297 REFGIALELIEKSPRKGEPVTDRNAGIMygLGNLIENAVDYARE------KVTVTVEHDHDKVLIVIEDDGNGYAPDILT 370
Cdd:COG3290   258 RERGIDLTIDIDSDLPDLPLSDTDLVTI--LGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVEDSGPGIPEELLE 335

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1582538263 371 RIGEPYV-TKrqkedTAGGLGLGLFIAKTLLERSGASLVFENRDPESAGARIRI 423
Cdd:COG3290   336 KIFERGFsTK-----LGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 121-427 2.45e-16

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 80.66  E-value: 2.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 121 FASQPIRYSTALIGFAMVCITVLAFSPFplpwfdgVEINVHNVMQFGVWcSIASTMAFAAFYAYRVSMEASQL---ADAL 197
Cdd:PRK11100  149 YVAAPIRDGGRIIGVLSVGKPNSSMAPF-------IKRSERRILWAGAL-LLGIALLIGAGVVWWLNRSIRRLtryADAV 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 198 AATELVLQREKHLSQLDGLAAAA--------------------AHELGTPLATISVVAKEMERELKNDDRFREdVMLLRS 257
Cdd:PRK11100  221 TEGKPVPLPKLGSSELRELAQALesmrvklegkayveqyvqtlTHELKSPLAAIRGAAELLQEDPPPEDRARF-TGNILT 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 258 QSERCRDILRRLTTLSS----EGEAHMRRLPLSSMIEEIVAPH----REFGIALEL-IEKSPRKGEPVTDRNAgimygLG 328
Cdd:PRK11100  300 QSARLQQLIDRLLELARleqrQELEVLEPVALAALLEELVEAReaqaAAKGITLRLrPDDARVLGDPFLLRQA-----LG 374

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDYAREK--VTVTVEHDHDKVLIVIEDDGNG---YApdiLTRIGEPYVTKRQKEDTAGGLGLGLFIAKTLLERS 403
Cdd:PRK11100  375 NLLDNAIDFSPEGgtITLSAEVDGEQVALSVEDQGPGipdYA---LPRIFERFYSLPRPANGRKSTGLGLAFVREVARLH 451

                         330       340
                  ....*....|....*....|....
gi 1582538263 404 GASLVFENRDPesAGARIRIEWPR 427
Cdd:PRK11100  452 GGEVTLRNRPE--GGVLATLTLPR 473
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-426 7.07e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 70.26  E-value: 7.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREK------VTVTVEHDHD-KVLIVIEDDGNGYAPDILTRIGEPYVTKRQKedtagGLGLGLFIAKTL 399
Cdd:cd16944     9 LTNILKNAAEAIEGRpsdvgeVRIRVEADQDgRIVLIVCDNGKGFPREMRHRATEPYVTTRPK-----GTGLGLAIVKKI 83

                          90       100
                  ....*....|....*....|....*..
gi 1582538263 400 LERSGASLVFENRDPEsaGARIRIEWP 426
Cdd:cd16944    84 MEEHGGRISLSNREAG--GACIRIILP 108
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-424 7.55e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 70.18  E-value: 7.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDYAREK--VTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTAGGLGLGLFIAKTLLERSGAS 406
Cdd:cd16975    11 NIISNACQYAPEGgtVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKNLVEKHGGS 90

                          90
                  ....*....|....*...
gi 1582538263 407 LVFENrdPESAGARIRIE 424
Cdd:cd16975    91 LIIEN--SQKGGAEVTVK 106
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 199-427 2.73e-14

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 74.44  E-value: 2.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 199 ATELVLQREKHLSQ----LDGLAAAAAHELGTPLATISVVAKEMERELKN--DDRFREDVMLLRSQSERCRDILRRLTTL 272
Cdd:COG4251   264 LEEELEERTAELERsneeLEQFAYVASHDLREPLRKISGFSQLLEEDYGDklDEEGREYLERIRDAAERMQALIDDLLAY 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 273 S--SEGEAHMRRLPLSSMIEEIVA----PHREFGIALElIEKSPrkgEPVTDRNAgIMYGLGNLIENAVDYARE----KV 342
Cdd:COG4251   344 SrvGRQELEFEPVDLNELLEEVLEdlepRIEERGAEIE-VGPLP---TVRGDPTL-LRQVFQNLISNAIKYSRPgeppRI 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 343 TVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYvtKR-QKEDTAGGLGLGLFIAKTLLERSGASLVFENRDPEsaGARI 421
Cdd:COG4251   419 EIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIF--QRlHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGE--GATF 494


                  ....*.
gi 1582538263 422 RIEWPR 427
Cdd:COG4251   495 YFTLPK 500
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 200-426 7.85e-14

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 73.09  E-value: 7.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 200 TELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRFREDVMLlrSQSERCRDILRRLTTLSSEGEAH 279
Cdd:COG5809   257 LEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIML--SELDRIESIISEFLVLAKPQAIK 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 280 MRRLPLSSMIEEIV------APHREFGIALELIEKSPR-KGEPVTDRNAGImyglgNLIENAVDYAREKVTVTVE---HD 349
Cdd:COG5809   335 YEPKDLNTLIEEVIpllqpqALLKNVQIELELEDDIPDiLGDENQLKQVFI-----NLLKNAIEAMPEGGNITIEtkaED 409

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1582538263 350 HDKVLIVIEDDGNGYAPDILTRIGEP-YVTKRQkedtagGLGLGLFIAKTLLERSGASLVFENRdpESAGARIRIEWP 426
Cdd:COG5809   410 DDKVVISVTDEGCGIPEERLKKLGEPfYTTKEK------GTGLGLMVSYKIIEEHGGKITVESE--VGKGTTFSITLP 479
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 284-424 7.21e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 65.35  E-value: 7.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 284 PLSSMIEEIvapHREFGIALELiEKSPRKGEPVtDRNAGiMYGLGNLIENAVDYAREKVTVTVEHDHDKVLIVIEDDGNG 363
Cdd:cd16954     5 SLCSALNKV---YQRKGVSISL-DISPELRFPG-ERNDL-MELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPG 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1582538263 364 YAPDILTRIGEpyvtKRQKEDTA-GGLGLGLFIAKTLLERSGASLVFEnrDPESAGARIRIE 424
Cdd:cd16954    79 VPESQRSKIFQ----RGQRLDEQrPGQGLGLAIAKEIVEQYGGELSLS--DSPLGGARFEVV 134
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-426 8.68e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 64.01  E-value: 8.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYvTKRQKEDTAGGLGLGLFIAKTLLERSGAS 406
Cdd:cd16950     5 LSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPF-YRGDNARGTSGTGLGLAIVQRISDAHGGS 83

                          90       100
                  ....*....|....*....|
gi 1582538263 407 LVFENRDpeSAGARIRIEWP 426
Cdd:cd16950    84 LTLANRA--GGGLCARIELP 101
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-427 1.21e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 63.99  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTA-GGLGLGLFIAKTLLERSGA 405
Cdd:cd16939     5 LDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRAtGGFGLGLAIVHRVALWHGG 84

                          90       100
                  ....*....|....*....|..
gi 1582538263 406 SLVFEnrDPESAGARIRIEWPR 427
Cdd:cd16939    85 HVECD--DSELGGACFRLTWPR 104
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
172-426 2.37e-12

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 68.27  E-value: 2.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 172 IASTMAFaaFYAYRVSMEASQLADALAatelvlqREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRFRED 251
Cdd:PRK10364  205 LASLLAF--FWYRRYLRSRQLLQDEMK-------RKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQL 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 252 VMLLRSQSERCRDILRRLTTLSSEGEAHMRRLPLSSMIEE----IVAPHREFGIALELiekSPRKGEPVT----DRNAGI 323
Cdd:PRK10364  276 AQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHslqlVSQDANSREIQLRF---TANDTLPEIqadpDRLTQV 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 324 mygLGNLIENAVDYARE--KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRqkedtAGGLGLGLFIAKTLLE 401
Cdd:PRK10364  353 ---LLNLYLNAIQAIGQhgVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK-----AEGTGLGLAVVHNIVE 424

                         250       260
                  ....*....|....*....|....*
gi 1582538263 402 RSGASLVFENRdpESAGARIRIEWP 426
Cdd:PRK10364  425 QHGGTIQVASQ--EGKGATFTLWLP 447
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-425 6.35e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 62.04  E-value: 6.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYARE--KVTVTVEHDhDKVLIVIEDDGNGYAPDILTRIGEPYVtkRQKEDTAGGLGLGLFIAKTLLERSG 404
Cdd:cd16940    18 LRNLVDNAVRYSPQgsRVEIKLSAD-DGAVIRVEDNGPGIDEEELEALFERFY--RSDGQNYGGSGLGLSIVKRIVELHG 94

                          90       100
                  ....*....|....*....|.
gi 1582538263 405 ASLVFENRdpESAGARIRIEW 425
Cdd:cd16940    95 GQIFLGNA--QGGGLEAWVRL 113
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-427 7.89e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 61.67  E-value: 7.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDY--AREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEP-YVTKRQKEdtagGLGLGLFIAKTLLERSGA 405
Cdd:cd16943    10 NLLVNAAQAmeGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPfFTTKPVGE----GTGLGLSLSYRIIQKHGG 85

                          90       100
                  ....*....|....*....|..
gi 1582538263 406 SLVFENRDPEsaGARIRIEWPR 427
Cdd:cd16943    86 TIRVASVPGG--GTRFTIILPI 105
PRK10604 PRK10604
sensor protein RstB; Provisional
 327-429 1.37e-11

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 65.78  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTA-GGLGLGLFIAKTLLERSGA 405
Cdd:PRK10604  324 LDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRAtGGCGLGLAIVHSIALAMGG 403

                          90       100
                  ....*....|....*....|....
gi 1582538263 406 SLVFEnrDPESAGARIRIEWPRML 429
Cdd:PRK10604  404 SVNCD--ESELGGARFSFSWPVWH 425
envZ PRK09467
osmolarity sensor protein; Provisional
 216-426 4.58e-11

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 64.16  E-value: 4.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 216 LAAAAAHELGTPLATISVvAKEMERElkNDDRFREDVMllrSQSERCRDILRR-LTTLSSEGEAHMRRLPLSSMIEEIVA 294
Cdd:PRK09467  232 LMAGVSHDLRTPLTRIRL-ATEMMSE--EDGYLAESIN---KDIEECNAIIEQfIDYLRTGQEMPMEMADLNALLGEVIA 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 295 --PHREFGIALELIEKSPR-KGEPVTDRNAgimygLGNLIENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDILTR 371
Cdd:PRK09467  306 aeSGYEREIETALQPGPIEvPMNPIAIKRA-----LANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKH 380

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1582538263 372 IGEPYVtkrqKEDTA---GGLGLGLFIAKTLLERSGASLVFENRdpESAGARIRIEWP 426
Cdd:PRK09467  381 LFQPFT----RGDSArgsSGTGLGLAIVKRIVDQHNGKVELGNS--EEGGLSARAWLP 432
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
176-393 7.24e-11

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 64.31  E-value: 7.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 176 MAFAAFYAYRVSMEASQLADALAATelvLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRFREDVMLL 255
Cdd:PRK13837  416 LALDCLAHAIERRRLETERDALERR---LEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEI 492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 256 RSQSERCRDILRRLTTLSSEGEAHMRRLPLSSMIEEIVAPHR---EFGIALELieKSPRKGEPVTDRNAGIMYGLGNLIE 332
Cdd:PRK13837  493 ISAGARARLIIDQILAFGRKGERNTKPFDLSELVTEIAPLLRvslPPGVELDF--DQDQEPAVVEGNPAELQQVLMNLCS 570

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1582538263 333 NAVDYAREKVTVTVEHDH-----------------DKVLIVIEDDGNGYAPDILTRIGEPYVTKRqkedtAGGLGLGL 393
Cdd:PRK13837  571 NAAQAMDGAGRVDISLSRaklrapkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFTTR-----AGGTGLGL 643
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-426 1.30e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 58.35  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYARE---KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTAG-GLGLGLFIAKTLLER 402
Cdd:cd16953     5 LRNLIGNAISFSPPdtgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGqHSGLGLSISRQIIEA 84

                          90       100
                  ....*....|....*....|....*.
gi 1582538263 403 SGASLVFENRDP--ESAGARIRIEWP 426
Cdd:cd16953    85 HGGISVAENHNQpgQVIGARFTVQLP 110
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-423 1.33e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 58.07  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYARE------KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEP-YVTKRQKEDtagglGLGLFIAKTL 399
Cdd:cd16915     5 VGNLIDNALDALAAtgapnkQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERgVSTKGQGER-----GIGLALVRQS 79

                          90       100
                  ....*....|....*....|....
gi 1582538263 400 LERSGASLVFENRDPESAGARIRI 423
Cdd:cd16915    80 VERLGGSITVESEPGGGTTFSIRI 103
PRK10337 PRK10337
sensor protein QseC; Provisional
 185-413 1.85e-10

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 62.36  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 185 RVSMEASQLADAL----AATELVLQREKHLSqldglaAAAAHELGTPLATISV---VAkemerELKNDD-RFREDVML-L 255
Cdd:PRK10337  211 GVPSEVRPLVEALnqlfARTHAMMVRERRFT------SDAAHELRSPLAALKVqteVA-----QLSDDDpQARKKALLqL 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 256 RSQSERCRDILRRLTTLS---SEG------EAHMRRLpLSSMIEEIVAPHREFGIALEL-IEKSP--RKGEPvtdrnagI 323
Cdd:PRK10337  280 HAGIDRATRLVDQLLTLSrldSLDnlqdvaEIPLEDL-LQSAVMDIYHTAQQAGIDVRLtLNAHPviRTGQP-------L 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 324 MYGL--GNLIENAVDYAREKVTVTVEHDHDkvLIVIEDDGNGYAPDILTRIGEPYVtkRQKEDTAGGLGLGLFIAKTLLE 401
Cdd:PRK10337  352 LLSLlvRNLLDNAIRYSPQGSVVDVTLNAR--NFTVRDNGPGVTPEALARIGERFY--RPPGQEATGSGLGLSIVRRIAK 427

                         250
                  ....*....|..
gi 1582538263 402 RSGASLVFENRD 413
Cdd:PRK10337  428 LHGMNVSFGNAP 439
PRK09303 PRK09303
histidine kinase;
185-393 1.98e-09

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 59.19  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 185 RVSMEASQLADALaateLVLQREKH--LSQL---DGLAAAAAHELGTPL--ATISVVAKEMERELKNDDRFREDVMLLRS 257
Cdd:PRK09303  122 RYSQELLQLSDEL----FVLRQENEtlLEQLkfkDRVLAMLAHDLRTPLtaASLALETLELGQIDEDTELKPALIEQLQD 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 258 QSER--------CRDILRRLTTLSSEGEAHMRRLPLSSMIEEIVAPHREFGIA--LELIEKSPRKGEPV---TDRnagIM 324
Cdd:PRK09303  198 QARRqleeierlITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAksLEIQTDIPSDLPSVyadQER---IR 274

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1582538263 325 YGLGNLIENAVDYARE--KVTVTVEHDHD-KVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTAG-GLGLGL 393
Cdd:PRK09303  275 QVLLNLLDNAIKYTPEggTITLSMLHRTTqKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGyGIGLSV 347
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 297-425 2.63e-09

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 59.16  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 297 REFGIALELIEKS--PRKGEP--VTDrnagIMYGLGNLIENAVDYAREK----VTVTVEHDHDKVLIVIEDDGNGYAPDI 368
Cdd:PRK11086  408 RELGITLIISEDSqlPDSGDEdqVHE----LITILGNLIENALEAVGGEeggeISVSLHYRNGWLHCEVSDDGPGIAPDE 483

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1582538263 369 LTRIGEP-YVTKRQkedtagGLGLGLFIAKTLLERSGASLVFENRDPESAGARIRIEW 425
Cdd:PRK11086  484 IDAIFDKgYSTKGS------NRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPW 535
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-424 2.72e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 54.39  E-value: 2.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDYA--REKVTVTVEHD--HDKVLIVIEDDGNGYAPDILTRIGEPYVTKRqkeDTAGGLGLGLFIAKTLLERSG 404
Cdd:cd16976     7 NLLQNALDAMgkVENPRIRIAARrlGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTK---PVGKGTGLGLSISYGIVEEHG 83

                          90       100
                  ....*....|....*....|
gi 1582538263 405 ASLVFENRdpESAGARIRIE 424
Cdd:cd16976    84 GRLSVANE--EGAGARFTFD 101
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 210-273 9.86e-09

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 51.44  E-value: 9.86e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1582538263 210 LSQLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRFREDVMLLRSQSERCRDILRRLTTLS 273
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
204-427 1.62e-08

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 56.51  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 204 LQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRfREDVMLLRSQSERCRDILRRLTTLSSEGEAHMRRL 283
Cdd:PRK11360  381 VARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPS-QEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPV 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 284 PLSSMIEE------------IVAPHREFGIALELIEKSPRKGEPVtdrnagimygLGNLIENAVDY--AREKVTVTVEHD 349
Cdd:PRK11360  460 SLNALVEEvlqlfqtagvqaRVDFETELDNELPPIWADPELLKQV----------LLNILINAVQAisARGKIRIRTWQY 529

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1582538263 350 HDKVLIV-IEDDGNGYAPDILTRIGEPYVTKRQKedtagGLGLGLFIAKTLLERSGASLVFENRdpESAGARIRIEWPR 427
Cdd:PRK11360  530 SDGQVAVsIEDNGCGIDPELLKKIFDPFFTTKAK-----GTGLGLALSQRIINAHGGDIEVESE--PGVGTTFTLYLPI 601
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 221-407 3.12e-08

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 55.85  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 221 AHELGTPLATIS--VVAKEMERELKNDDRFREDVMLLRSQSERCRDILRRLTTLSSEGEAHMRRLPLSSMIE---EIVAP 295
Cdd:COG4192   441 AHELNQPLNAMSmyLFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEqawELVES 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 296 -HREFGIALELIEKSPRKGEPVtdrnaGIMYGLGNLIENAVDYAREKVTVTVE--HDHDKVLIVIEDDGNGYApdILTRI 372
Cdd:COG4192   521 rAKPQQITLHIPDDLMVQGDQV-----LLEQVLVNLLVNALDAVATQPQISVDllSNAENLRVAISDNGNGWP--LVDKL 593

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1582538263 373 GEPYVTKRQKedtagGLGLGLFIAKTLLERSGASL 407
Cdd:COG4192   594 FTPFTTTKEV-----GLGLGLSICRSIMQQFGGDL 623
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
327-421 1.61e-07

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 53.48  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPDiltrigepyvtKR-------QKEDT-AGGLGLGLFIAKT 398
Cdd:PRK10815  383 MGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPES-----------KRelifdrgQRADTlRPGQGLGLSVARE 451

                          90       100
                  ....*....|....*....|...
gi 1582538263 399 LLERSGASLVFEnrDPESAGARI 421
Cdd:PRK10815  452 ITEQYEGKISAG--DSPLGGARM 472
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 212-274 1.91e-07

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 47.98  E-value: 1.91e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1582538263 212 QLDGLAAAAAHELGTPLATISVVAkEMERELKNDDRFREDVMLLRSQSERCRDILRRLTTLSS 274
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYL-ELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
204-427 3.40e-07

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 51.89  E-value: 3.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 204 LQREKHLSQLDGL-AAAAAHELGTPLATISVVAKEMERElknddrFREDVMLLRSQSERCRDILRRLTTLSSEGEA---- 278
Cdd:PRK10755  127 VSRLTSTLDQERLfTADVAHELRTPLAGIRLHLELLEKQ------HHIDVAPLIARLDQMMHTVEQLLQLARAGQSfssg 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 279 HMRRLplsSMIEEIVAPHR-EFGIALELIEKSPRKGEPVTDrnaGIMYG--------LGNLIENAVDYAREKVTVTV--- 346
Cdd:PRK10755  201 HYQTV---KLLEDVILPSQdELSEMLEQRQQTLLLPESAAD---ITVQGdatllrllLRNLVENAHRYSPEGSTITIkls 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 347 EHDHDKVLIViEDDGNGYAPDILTRIGEPYVTKRQKedtAGGLGLGLFIAKTLLERSGASLVFENRdPESAGARIRIEWP 426
Cdd:PRK10755  275 QEDGGAVLAV-EDEGPGIDESKCGELSKAFVRMDSR---YGGIGLGLSIVSRITQLHHGQFFLQNR-QERSGTRAWVWLP 349


                  .
gi 1582538263 427 R 427
Cdd:PRK10755  350 K 350
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
330-399 4.32e-07

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 48.76  E-value: 4.32e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1582538263 330 LIENAVDYARE-----KVTVTVEHDHDKVLIVIEDDGNGYAPDiltRIGEPYvtkrqkeDTAGGLGLGLFIAKTL 399
Cdd:COG2172    42 AVTNAVRHAYGgdpdgPVEVELELDPDGLEIEVRDEGPGFDPE---DLPDPY-------STLAEGGRGLFLIRRL 106
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-411 8.31e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 47.20  E-value: 8.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDYAREKVTVTV--EHDHDKVLIVIEDDGNGYAPDILTRIGEP-YVTKRQKEDTAGGLGLGLFIAKTLLERSGA 405
Cdd:cd16952     7 NLVSNAVKYTPPSDTITVrwSQEESGARLSVEDTGPGIPPEHIPRLTERfYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86


                  ....*.
gi 1582538263 406 SLVFEN 411
Cdd:cd16952    87 RLLIAS 92
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-426 1.00e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 47.01  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDYARE------KVTVTVE-HDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRqkedtAGGLGLGLFIAKTLLE 401
Cdd:cd16920     7 NLVRNGIEAMSEggcerrELTIRTSpADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTK-----SEGLGMGLSICRSIIE 81

                          90       100
                  ....*....|....*....|....*
gi 1582538263 402 RSGASLVFENrdPESAGARIRIEWP 426
Cdd:cd16920    82 AHGGRLSVES--PAGGGATFQFTLP 104
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-426 1.14e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 47.07  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYARE--KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEP-YVTKRQKEDTAGGLGLGLFIAKTLLERS 403
Cdd:cd16946     9 FVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERfYRVESSRNRASGGSGLGLAICHNIALAH 88

                          90       100
                  ....*....|....*....|...
gi 1582538263 404 GASLVFENRdpESAGARIRIEWP 426
Cdd:cd16946    89 GGTISAEHS--PLGGLRLVLTLP 109
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
192-426 1.44e-06

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 50.40  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 192 QLADALaatelvlqrEKHLSQLDGLAAAAAHELGTPLAtisVVAKEME------RELKNddrfrEDVMLLrsQSE----- 260
Cdd:PRK10549  228 QLASTL---------EKNEQMRRDFMADISHELRTPLA---VLRGELEaiqdgvRKFTP-----ESVASL--QAEvgtlt 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 261 RCRDILRRLTtLSSEGEAHMRRLP--LSSMIEEIVAPHRE------FGIALELIEKSPRKGEPvtDRnagIMYGLGNLIE 332
Cdd:PRK10549  289 KLVDDLHQLS-LSDEGALAYRKTPvdLVPLLEVAGGAFRErfasrgLTLQLSLPDSATVFGDP--DR---LMQLFNNLLE 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 333 NAVDYARE--KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEP-YVTKRQKEDTAGGLGLGLFIAKTLLERSGASLVF 409
Cdd:PRK10549  363 NSLRYTDSggSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERfYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIA 442

                         250
                  ....*....|....*..
gi 1582538263 410 ENRDpeSAGARIRIEWP 426
Cdd:PRK10549  443 AHSP--FGGVSITVELP 457
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 185-422 1.54e-06

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 50.08  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 185 RVSMEASQLADALAAtelVLQR-EKHLSQLDGLAAAAAHELGTPLATISV---VAKEMER--------------ELKNDD 246
Cdd:TIGR01386 215 RAPAELRELAQSFNA---MLGRlEDAFQRLSQFSADLAHELRTPLTNLLGqtqVALSQPRtgeeyrevlesnleELERLS 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 247 RFREDvMLLRSQSERCRDILRRlTTLSSEGEahmrrlpLSSMIE--EIVAPHREFGIALEliekspRKGEPVTDRnagIM 324
Cdd:TIGR01386 292 RMVSD-MLFLARADNGQLALER-VRLDLAAE-------LAKVAEyfEPLAEERGVRIRVE------GEGLVRGDP---QM 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 325 Y--GLGNLIENAVDYARE--KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEP-YVTKRQKEDTAGGLGLGLFIAKTL 399
Cdd:TIGR01386 354 FrrAISNLLSNALRHTPDggTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRfYRVDPARSNSGEGTGLGLAIVRSI 433

                         250       260
                  ....*....|....*....|...
gi 1582538263 400 LERSGASLvfenrDPESAGARIR 422
Cdd:TIGR01386 434 MEAHGGRA-----SAESPDGKTR 451
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
327-427 2.18e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 49.63  E-value: 2.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYARE------KVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQkedtagGLGLGLFIAK--- 397
Cdd:COG2972   341 LQPLVENAIEHGIEpkegggTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGE------GRGIGLRNVRerl 414

                          90       100       110
                  ....*....|....*....|....*....|
gi 1582538263 398 TLLERSGASLVFENRDPEsaGARIRIEWPR 427
Cdd:COG2972   415 KLYYGEEYGLEIESEPGE--GTTVTIRIPL 442
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 212-277 2.54e-06

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 44.86  E-value: 2.54e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1582538263  212 QLDGLAAAAAHELGTPLATISVVAKEMERELKNDDRfREDVMLLRSQSERCRDILRRLTTLSSEGE 277
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ-REYLETILREAERLLRLINDLLDLSRIEA 65
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
222-398 3.99e-06

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 48.78  E-value: 3.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 222 HELGTPLATISVVAKEMERelknddRFREDVMLLR--SQSERCRDILRRLTTLS-SEGEAHMRR--LPLSSMIEEIV--- 293
Cdd:PRK09470  252 HELRTPLTRLQLATALLRR------RQGESKELERieTEAQRLDSMINDLLVLSrNQQKNHLERetFKANSLWSEVLeda 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 294 ---APHRefGIALELI---EKSPRKGEPVTdrnagIMYGLGNLIENAVDYAREKVTVTVEHDHDKVLIVIEDDGNGYAPD 367
Cdd:PRK09470  326 kfeAEQM--GKSLTVSappGPWPINGNPNA-----LASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEE 398

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1582538263 368 ILTRIGEP-YVTKRQKEDTAGGLGLGLFIAKT 398
Cdd:PRK09470  399 EREQIFRPfYRVDEARDRESGGTGLGLAIVEN 430
PRK10490 PRK10490
sensor protein KdpD; Provisional
 327-426 4.41e-06

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 49.26  E-value: 4.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTVTV--EHDHDKVLIVIEDDGNGYAPDILTRIGEPYvTKRQKEDTAGGLGLGLFIAKTLLERSG 404
Cdd:PRK10490  783 LINLLENAVKYAGAQAEIGIdaHVEGERLQLDVWDNGPGIPPGQEQLIFDKF-ARGNKESAIPGVGLGLAICRAIVEVHG 861

                          90       100
                  ....*....|....*....|..
gi 1582538263 405 ASLVFENRDpeSAGARIRIEWP 426
Cdd:PRK10490  862 GTIWAENRP--EGGACFRVTLP 881
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-415 5.49e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 45.65  E-value: 5.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYARE------KVTVTVEHDHDKVLIVIEddgNGYAPDILTRIGEPYVTKRQKEDtagglGLGLFIAKTLL 400
Cdd:cd16935    41 FGNLLDNAIEACAKidkenrFIHLKIRQKKGFLIISIE---NSYEGELKKKNGLFLSTKKDKNH-----GIGLKSIREIV 112

                          90
                  ....*....|....*
gi 1582538263 401 ERSGASLVFENRDPE 415
Cdd:cd16935   113 KKYNGNLSIEYENGI 127
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-412 1.17e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 43.93  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 329 NLIENAVDYAREK-------------VTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRqkedtAGGLGLGLFI 395
Cdd:cd16918     7 NLVRNAAQALAGSggeiilrtrtqrqVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGR-----ENGTGLGLAI 81

                          90
                  ....*....|....*..
gi 1582538263 396 AKTLLERSGASLVFENR 412
Cdd:cd16918    82 AQNIVSQHGGVIECDSQ 98
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 327-415 3.15e-05

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 42.59  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYARE-----KVTVTVEHDHDKVLIVIEddgNGYAPDIlTRIGEPYVTKRQKEdtagGLGLGLFIAKTLLE 401
Cdd:pfam14501  10 FGNLLDNAIEACSKiddnrFIRLKIREKQNFLIIRIE---NTYEGEL-KFEGKLPSTKTKGD----GHGIGLKSIRRIVK 81

                          90
                  ....*....|....
gi 1582538263 402 RSGASLVFENRDPE 415
Cdd:pfam14501  82 KYGGNLSTEIENGI 95
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-410 4.17e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 42.37  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTV--TVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTaGGLGLGLFIAKTLLERSG 404
Cdd:cd16923     5 FSNLLSNAIKYSPENTRIyiTSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT-EGAGLGLSIAKAIIELHG 83


                  ....*.
gi 1582538263 405 ASLVFE 410
Cdd:cd16923    84 GSASAE 89
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
168-427 6.63e-05

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 44.22  E-value: 6.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 168 VWCSIASTMAFAAFYAYRVSMEASQLADALAATELVLQRE-KHLSQL--DGLAAAaahelgtpLATISVVAKEMERELKN 244
Cdd:COG4585    14 VGALLGLLLALVLLRARRAERAAELERELAARAEEAREEErRRIARElhDGVGQS--------LSAIKLQLEAARRLLDA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 245 D-DRFREDVMLLRSQSERCRDILRRLttLSSEGEAHMRRLPLSSMIEEIVAPH-REFGIALEL-IEKSPRKGEPVTDRNA 321
Cdd:COG4585    86 DpEAAREELEEIRELAREALAELRRL--VRGLRPPALDDLGLAAALEELAERLlRAAGIRVELdVDGDPDRLPPEVELAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 322 gimYG-LGNLIENAVDYAR-EKVTVTVEHDHDKVLIVIEDDGNGYAPdiltrigepyvtkrqkeDTAGGLGLGLFIAKTL 399
Cdd:COG4585   164 ---YRiVQEALTNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDP-----------------EAAPGGGLGLRGMRER 223

                         250       260
                  ....*....|....*....|....*...
gi 1582538263 400 LERSGASLVFENRDPEsaGARIRIEWPR 427
Cdd:COG4585   224 AEALGGTLTIGSAPGG--GTRVRATLPL 249
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 330-426 6.67e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 41.65  E-value: 6.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 330 LIENAVDYA------REKVTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPyvtkrqkedTAGGLGLGLfIAKTLLERS 403
Cdd:cd16956     9 IVENAVKHGlsglldGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARILIR---------SSNGLGLNL-VDKRLRQAF 78

                          90       100
                  ....*....|....*....|....*
gi 1582538263 404 GAS--LVFENRDPEsaGARIRIEWP 426
Cdd:cd16956    79 GNDygLDIECAPGE--GTRITIRLP 101
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 330-426 7.37e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 42.41  E-value: 7.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 330 LIENAVDYA---REKVTVTV--EHDHDKVLIVIEDDGngyapdiltrIGEPyvtkrQKEDTAGGLGLGLFIAKTLLERSG 404
Cdd:cd16951    47 LLQNALKHAfsdREGGTITIrsVVDGDYLRITVIDDG----------VGLP-----QDEDWPNKGSLGLQIVRSLVEGEL 111

                          90       100
                  ....*....|....*....|..
gi 1582538263 405 ASlvFENRDPESAGARIRIEWP 426
Cdd:cd16951   112 KA--FLEVQSAENGTRVNIDIP 131
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-412 7.78e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 42.12  E-value: 7.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREK--VTVTVEHDHDKVLIVIEDDGNG----YAPDILTRIgepYVTKRQKEDTAGGLGLGLFIAKTLL 400
Cdd:cd16947    25 LKNLISNAIKYGSDGkfLGMTLREDEKHVYIDIWDKGKGisetEKDHVFERL---YTLEDSRNSAKQGNGLGLTITKRLA 101

                          90
                  ....*....|..
gi 1582538263 401 ERSGASLVFENR 412
Cdd:cd16947   102 ESMGGSIYVNSK 113
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 254-426 8.54e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 44.90  E-value: 8.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 254 LLRSQSERC---------RDILRRLTTLSSegeAH--------MRRLPLSSMIEEIVAPHREF----GIALELieksprK 312
Cdd:COG3920   316 LLRLQARRAddpearealEESQNRIQALAL---VHellyqsedWEGVDLRDYLRELLEPLRDSyggrGIRIEL------D 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 313 GEPVT-DRNAGIMYGL--GNLIENAVDYARE-----KVTVTVEHDHDKVLIVIEDDGNGYAPDIltrigepyvtkrqkeD 384
Cdd:COG3920   387 GPDVElPADAAVPLGLilNELVTNALKHAFLsgeggRIRVSWRREDGRLRLTVSDNGVGLPEDV---------------D 451

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1582538263 385 TAGGLGLGLFIAKTLLERSGASLVFENRDpesaGARIRIEWP 426
Cdd:COG3920   452 PPARKGLGLRLIRALVRQLGGTLELDRPE----GTRVRITFP 489
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 330-426 1.13e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 41.28  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 330 LIENAVDYAREK------VTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGepyvtkrQKEDTAGGLGLgLFIAKTLLERS 403
Cdd:cd16924     9 LVENAIQHGLSPltdkgvVTISALKEDNHVMIEVEDNGRGIDPKVLNILG-------KKPKEGNGIGL-YNVHQRLILLF 80

                          90       100
                  ....*....|....*....|...
gi 1582538263 404 GASLVFENRDPESAGARIRIEWP 426
Cdd:cd16924    81 GEDYGIHIASEPDKGTRITFTIP 103
PRK13557 PRK13557
histidine kinase; Provisional
 327-426 3.20e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 43.12  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTVTVE------HDHDK-----------VLIVIEDDGNGYAPDILTRIGEPYVTKRqkeDTAGGL 389
Cdd:PRK13557  282 LLNVLINARDAMPEGGRVTIRtrnveiEDEDLamyhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTK---EEGKGT 358

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1582538263 390 GLGLFIAKTLLERSGASLVFENRdpESAGARIRIEWP 426
Cdd:PRK13557  359 GLGLSMVYGFAKQSGGAVRIYSE--VGEGTTVRLYFP 393
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-426 4.34e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 39.62  E-value: 4.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREK----VTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEpyVTKR-QKEDTAGGLGLGLFIAKTLLE 401
Cdd:cd16921     5 LTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFG--IFQRlHSREEYEGTGVGLAIVRKIIE 82

                          90       100
                  ....*....|....*....|....*
gi 1582538263 402 RSGASLVFENRDPEsaGARIRIEWP 426
Cdd:cd16921    83 RHGGRIWLESEPGE--GTTFYFTLP 105
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 330-396 8.80e-04

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 39.24  E-value: 8.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1582538263 330 LIENAVDYAREKVTVTVEHDHDKVL-IVIEDDGNGYAPDILT---RIGEPYVTKRQKEDTAGGLGLGLFIA 396
Cdd:pfam13589   8 LIDNSIDADATNIKIEVNKNRGGGTeIVIEDDGHGMSPEELInalRLATSAKEAKRGSTDLGRYGIGLKLA 78
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 218-426 8.98e-04

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 41.81  E-value: 8.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 218 AAAAHELGTPLATISVVAKEM-ERELKNddRFREDVMLLRSQSERCRDILRRLTTLSSEgEAHMRRLPLSsmiEEIVAPH 296
Cdd:PRK11466  449 AAMSHEIRTPLYGILGTAQLLaDNPALN--AQRDDLRAITDSGESLLTILNDILDYSAI-EAGGKNVSVS---DEPFEPR 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 297 REFGIALELIEKSPR------------------KGEPVTDRNAGImyglgNLIENAVDYA-REKVTVTVEHDHDKVLIVI 357
Cdd:PRK11466  523 PLLESTLQLMSGRVKgrpirlatdiaddlptalMGDPRRIRQVIT-----NLLSNALRFTdEGSIVLRSRTDGEQWLVEV 597

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1582538263 358 EDDGNGYAPDILTRIGEPYVtkrQKEDTAGGLGLGLFIAKTLLERSGASLvfENRDPESAGARIRIEWP 426
Cdd:PRK11466  598 EDSGCGIDPAKLAEIFQPFV---QVSGKRGGTGLGLTISSRLAQAMGGEL--SATSTPEVGSCFCLRLP 661
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 297-414 9.52e-04

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 41.36  E-value: 9.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 297 REFGIALELIEKSPRKGEPVTDRNAGIMYGLGNLIENAVDYA------REKVTVTVEHDHDKVLIVIEDDGNGYAPDILT 370
Cdd:PRK15053  407 RELGLKMVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASlrsdegNKIVELFLSDEGDDVVIEVADQGCGVPESLRD 486

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1582538263 371 RIGEPYVTKRQKEdtAGGLGLGLFIAKTLLERSGASLVFENRDP 414
Cdd:PRK15053  487 KIFEQGVSTRADE--PGEHGIGLYLIASYVTRCGGVITLEDNDP 528
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 330-425 1.71e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 37.63  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 330 LIENAVDYAREK-----VTVTVEHDHDKVLIVIEDDGNGYAPdilTRIGEPyvtkrqkEDTAGGLGLGLFIAKTLLERSG 404
Cdd:cd16936     8 AVTNAVRHAYRHdgpgpVRLELDLDPDRLRVEVTDSGPGFDP---LRPADP-------DAGLREGGRGLALIRALMDEVG 77

                          90       100
                  ....*....|....*....|.
gi 1582538263 405 ASlvfenrdPESAGARIRIEW 425
Cdd:cd16936    78 YR-------RTPGGKTVWLEL 91
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-386 2.47e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 37.40  E-value: 2.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1582538263 325 YGLGNLIENAVDYAREK------VTVTVEHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTA 386
Cdd:cd16957     4 FALQVLVENAIRHAFPKrkenneVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEKGTGTA 71
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 327-399 2.72e-03

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 40.31  E-value: 2.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1582538263 327 LGNLIENAVDYARE-KVTVTVEHD-HDKVLIVIEDDGNGYAPDILTRIGEPY--VTKRQKEDTAGGLGLGLFIAKTL 399
Cdd:PRK11091  403 LWNLISNAVKFTQQgGVTVRVRYEeGDMLTFEVEDSGIGIPEDELDKIFAMYyqVKDSHGGKPATGTGIGLAVSKRL 479
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-423 3.08e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 37.05  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 327 LGNLIENAVDYAREKVTVTV--EHDHDKVLIVIEDDGNGYAPDILTRIGEPYVTKRQKEDTAGGLGLGLFIAKTLLERSG 404
Cdd:cd16945     9 INNLLDNAIDFSPEGGLIALqlEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFVQEVAQLHG 88

                          90
                  ....*....|....*....
gi 1582538263 405 ASLVFENRdPESAGARIRI 423
Cdd:cd16945    89 GRITLRNR-PDGVLAFLTL 106
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 351-426 3.64e-03

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 36.97  E-value: 3.64e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1582538263 351 DKVLIVIEDDGNGYAPDILTRIGEPYVTKRQkedTAGGLGLGLFIAKTLLERSGASLVFENRdpESAGARIRIEWP 426
Cdd:cd16919    46 NYVCLEVSDTGSGMPAEVLRRAFEPFFTTKE---VGKGTGLGLSMVYGFVKQSGGHLRIYSE--PGVGTTVRIYLP 116
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-426 7.42e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 35.61  E-value: 7.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1582538263 333 NAVDYAR-EKVTVTVEHDHDKVLIVIEDDGNGyapdiltrigepyvtkRQKEDTAGGLGLGLFIAKTLLERSGASLVFEN 411
Cdd:cd16917    11 NALKHAGaSRVRVTLSYTADELTLTVVDDGVG----------------FDGPAPPGGGGFGLLGMRERAELLGGTLTIGS 74

                          90
                  ....*....|....*
gi 1582538263 412 RDPEsaGARIRIEWP 426
Cdd:cd16917    75 RPGG--GTRVTARLP 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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