|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-372 |
4.16e-66 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 215.60 E-value: 4.16e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 13 RWVLITLCVTEITSWGVLYYAFTVLsASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVV 92
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFI-IPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 93 AVLAVVVAPNYACFVAAWILAGVAMSGVFYAPAFAALT-RYFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQT 171
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAaWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 172 YLVLAALLAVITIPAHLFGLRRPWPPVQ-------HHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQR 244
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALrayddasPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 245 GFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGVFTT--LAALVAASIVAGMARGIMTLL 322
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFppLALLLFAALFGLGWGATVPLT 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1583667162 323 QATAVTdRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLLDGYDAMF 372
Cdd:cd17355 321 AALAAR-YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAW 369
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-372 |
1.22e-26 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 110.35 E-value: 1.22e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 3 PPSLSAGPGLRWVLITLCVTEITSWGVLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWI 82
Cdd:COG2807 6 SSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 83 MTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMsGVFYAPAFAALTRYFAPNAVRALTVLTLVAGLSSTVFAPLTAAL 162
Cdd:COG2807 86 LLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI-AVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 163 GSHLSWRQTYLVLAALLAVITIPAHLFGLRRPWPPVQHHHNVeAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMV 242
Cdd:COG2807 165 AAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA-SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 243 QRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLL 322
Cdd:COG2807 244 DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPL 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1583667162 323 QATAVTDRWGTT-HYGHLSGMLMAPIMITTALGPFVGAALASLLDGYDAMF 372
Cdd:COG2807 324 ALTLIGLRARTPaEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAAL 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-372 |
1.23e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 104.19 E-value: 1.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 13 RWVLITLCVTEITSWGVlYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVV 92
Cdd:COG2223 4 WRVLLLATLAFFLAFGV-WYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 93 AVLAVVVAPNYACFVAAWILAGVAMsGVFYAPAFAALTRYFAPNAV-RALTVLTLVAGLSSTVFAPLTAALGSHLSWRQT 171
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGG-GGSFAVGIALVSKWFPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 172 YLVLAALLAVITIPAHLFGLRRP-WPPVQHHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMV-QRGFSTS 249
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPaGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVdQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 250 AAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGVFT-TLAALVAASIVAGMARGIMTLLQATAVT 328
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVP 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1583667162 329 DRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLLDGYDAMF 372
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAF 365
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-372 |
1.06e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 95.71 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 13 RWVLITLCVTEITSWGVLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVV 92
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 93 AVLAVVVAPNYACFVAAWILAGVAMsGVFYAPAFAALTRYFAPNAV-RALTVLTLVAGLSSTVFAPLTAALGSHLSWRQT 171
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGE-AGFFPAALKLIAEWFPPKERgRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 172 YLVLAALLAVITIpahlfglrrpwppvqhhhnveaptrtarsAPFLALMVSFALAALASYAVIVNLVPLMVQ-RGFSTSA 250
Cdd:COG2271 167 FLILGLPGLLLAL-----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 251 AAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLI--MAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVT 328
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAigLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1583667162 329 DRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLLdGYDAMF 372
Cdd:COG2271 298 ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAF 340
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
29-372 |
1.46e-21 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 95.37 E-value: 1.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 29 VLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYA-CFV 107
Cdd:cd17353 17 GYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPlLFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 108 AAWILAGVAmSGVFYAPAFAALTRYFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAh 187
Cdd:cd17353 97 GYGVLGGIG-AGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIG- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 188 LFGLRRP---WPPVQHHHNVEA---------PTRTARSAPFLALMVSFALAALASYAVIVNLVPL-MVQRGFSTSAAAVA 254
Cdd:cd17353 175 AFLIRDPpkgWVPPGVDPLANNaensprdytPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIgQEFAGLDAGIAALA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 255 LGLGGAGQVLGRLGYQTMARRIG--VVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLqATAVTDRWG 332
Cdd:cd17353 255 VSILSIFNGGGRPFWGWLSDKIGrkNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALF-PALTADFFG 333
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1583667162 333 TTHYGHLSGMLMAPIMITTALGPFVGAALASLLdGYDAMF 372
Cdd:cd17353 334 TKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTG-GYNAAF 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-353 |
2.39e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 91.57 E-value: 2.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 7 SAGPGLRWVLITLCVTEITSWGVLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIG 86
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 87 SVLGVVAVLAVVVAPNYACFVAAWILAGVAmSGVFYAPAFAALTRYFAP-NAVRALTVLTLVAGLSSTVFAPLTAALGSH 165
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLG-AGALFPAALALIADLVPPeRRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 166 LSWRQTYLVLAALLAVITIPAHLFglRRPWPPVQHHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQR- 244
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRL--LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVl 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 245 GFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQA 324
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318
|
330 340
....*....|....*....|....*....
gi 1583667162 325 TAVTDRWGTTHYGHLSGMLMAPIMITTAL 353
Cdd:COG2814 319 ALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-355 |
2.53e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 88.24 E-value: 2.53e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 19 LCVTEITSWGVLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVV 98
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 99 VAPNYACFVAAWILAGVAMsGVFYAPAFAALTRYFAPNAV-RALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAA 177
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGA-GALFPAALALIADWFPPEERgRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 178 LLAVITIPAHLF----GLRRPWPPVQHHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAV 253
Cdd:pfam07690 160 LSLLAAVLLLLPrpppESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 254 ALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTT---ALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDR 330
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*
gi 1583667162 331 WGTTHYGHLSGMLMAPIMITTALGP 355
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
15-372 |
1.51e-18 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 86.45 E-value: 1.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 15 VLITLCVTEITSWGVLYyAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAV 94
Cdd:cd17352 4 VVFASFLVNFFTDGILN-SFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 95 LAVVVAPNYACFVAAW-ILAGVAMsGVFYAPAFAALTRYFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYL 173
Cdd:cd17352 83 LLSSFATSLWQLYLTYgVLGGLGL-GLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 174 VLAALLAVITIPAHLFGLRrpwppvqhhhnveaptrtaRSAPFLALMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAV 253
Cdd:cd17352 162 ILGGLCLNLCVCGLLLRLL-------------------KDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 254 ALGLGGAGQVLGR--LGYQTMARRIGVVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRW 331
Cdd:cd17352 223 LLSIIGISDIVGRilLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLV 302
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1583667162 332 GTTHYGHLSGMLMAPIMITTALGPFVGAALASLLDGYDAMF 372
Cdd:cd17352 303 GLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAF 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
55-365 |
2.07e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.15 E-value: 2.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 55 AFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSgvFYAPAFAALTRYFA 134
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA--AVWPAAMALIADIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 135 PNAVR--ALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAHLFgLRRPWPPVQHHHNVEAPTRT-- 210
Cdd:cd17325 114 PPEERgrAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLL-LPEPRPPPNKRAVSAARLRSgl 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 211 ---ARSAPFLALMVSFALAALASYAVIVnLVPLMVQR--GFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLI 285
Cdd:cd17325 193 rllLRDRRLLALFLAIFVLAFAFGALEP-FLPLYAAElgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 286 MAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLL 365
Cdd:cd17325 272 LLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
32-372 |
2.34e-13 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 70.90 E-value: 2.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 32 YAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPN-YACFVAAW 110
Cdd:cd17314 20 LSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNsFPLSYACF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 111 ILAGVAMsGVFYAPAFAALTRYFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAHLFG 190
Cdd:cd17314 100 VFIGAGT-GILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 191 LRRPWPPVQHHHNVEAPTRTA----RSAPFLALMVSFALAALASYAVIVNLVPLMVQ-RGFSTSAAAVALGLGGAGQVLG 265
Cdd:cd17314 179 FKEPPDNQARLHVQKKKTQTMgeifRDKVFWILFIAIFLVLIGGFLFIANMASLVRSlQLDAPSFVTKLMSIYGLFNAFG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 266 RLGYQTMARRIGVVPRT---VLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGM 342
Cdd:cd17314 259 RLLWGIVADFFGGRLSTlsiLLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGI 338
|
330 340 350
....*....|....*....|....*....|
gi 1583667162 343 LMAPIMITTALGPFVGAALASLLDGYDAMF 372
Cdd:cd17314 339 LLFAPAIGSILGPMLGAKFYDRTPSYISAV 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-372 |
8.38e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 66.30 E-value: 8.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 26 SWGVLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYAC 105
Cdd:cd06174 7 LTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 106 FVAAWILAGVAMSGVFYAPAFAALTRYFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHL--SWRQTYLVLAALLAVIT 183
Cdd:cd06174 87 LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 184 IPAHLFGLRRPWPPVQ------HHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQRG-FSTSAAAVALG 256
Cdd:cd06174 167 ILLLLVVPDPPESARAkneeasSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGgLSVAVAGLLLS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 257 LGGAGQVLGR-LGYQTMARRIGVVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTH 335
Cdd:cd06174 247 LFGLAGALGSlLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI 326
|
330 340 350
....*....|....*....|....*....|....*..
gi 1583667162 336 YGHLSGMLMAPIMITTALGPFVGAALASLLDGYDAMF 372
Cdd:cd06174 327 RGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
64-377 |
2.23e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 64.90 E-value: 2.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 64 ALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVFYApAFAALTRYF-APNAVRALT 142
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTL-ATALIGDYFeGEERAKMLG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 143 VLTLVAGLSSTVFAPLTAALGShLSWRQTYLVLaaLLAVITIPAHLFGLRRPwPPVQHHHNVEAPTRTARSAPFLALMVS 222
Cdd:cd17473 128 LQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVY--LLALPVLILVLLFLPEP-ARKSKSAASPGAATAAALPWKRVLPIY 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 223 FA--LAALASYAVIVNLVPLMVQRG-FSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGVF 299
Cdd:cd17473 204 FLafLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA 283
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1583667162 300 TTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLLDGYDAMFLVLGV 377
Cdd:cd17473 284 SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGV 361
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
26-312 |
2.94e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.49 E-value: 2.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 26 SWGVLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYAC 105
Cdd:COG0738 19 LWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 106 FVAAWILAGVAMsGVFYAPAFAALTRYFAPNAVRALTVLTLVAGLSSTVFAPLTAAL---GSHLSWRQTYLVLAALLAVI 182
Cdd:COG0738 99 LLLALFLLGLGL-GLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYLILAVLLLLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 183 TIPAHLFGLRRPWPPVQHHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQ--RGFSTSAAAVALGLGGA 260
Cdd:COG0738 178 ALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKdvLGLSEATAALGLSLFWG 257
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1583667162 261 GQVLGRLGYQTMARRIGVVpRTVLIMAAVAVTTALLGVFTTLAALVAASIVA 312
Cdd:COG0738 258 GMTIGRFLGGFLLKRFGPV-RLLRLSALLAAVGLLLALLAPGPWLALIGLAL 308
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-315 |
2.88e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 61.42 E-value: 2.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 46 GWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAmSGVFYAPA 125
Cdd:cd17478 27 GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG-SAAFHPEG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 126 FAALTRYFAPNAVRALTVLTlVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPahLFGLRRPWPPVQHHHNVE 205
Cdd:cd17478 106 ARLASQAAGGRRGLAMSIFS-VGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVAL--LLLRLRPLKKPEAKKAAA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 206 APTRTARSA----PFLALMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAVALGL----GGAGQVLGrlGYqtMARRIG 277
Cdd:cd17478 183 KSSARSTLKgvwrALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLflfaGAIGTLIG--GP--LSDRFG 258
|
250 260 270
....*....|....*....|....*....|....*....
gi 1583667162 278 vvPRTVLIMAAVAVTTALLG-VFTTLAALVAASIVAGMA 315
Cdd:cd17478 259 --RRRVIIASLLLAAPFLLLfLLTPGIWSYILLVLAGFL 295
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
41-361 |
1.08e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.49 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 41 ISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGV 120
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 121 FyAPAFAALTRYFAPNAV-RALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAHLFGLRRPWPPVQ 199
Cdd:cd17324 105 W-AIAAAYAADLVPPEKRgRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 200 HHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQR-GFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGV 278
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 279 VPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRwGTTHYGHLSGMLMAPIMITTALGPFVG 358
Cdd:cd17324 264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALG 342
|
...
gi 1583667162 359 AAL 361
Cdd:cd17324 343 GLV 345
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
24-372 |
4.85e-09 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 57.79 E-value: 4.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 24 ITSWGVLYYAFTVLSASISSDTGWSApavtgafSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPN- 102
Cdd:cd17423 19 LRSFGVFFVEFVEYFEESAQRVSWIT-------SIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSl 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 103 YACFVAAWILAGVAMSGVFyAPAFAALTRYFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAAL-LAV 181
Cdd:cd17423 92 LHLYLCIGLLSGLGWALVF-APTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALsLHL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 182 ITIPAHLFGLRRPWPPVQHHHNVEAPTRTA--RSAPFLALMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGG 259
Cdd:cd17423 171 VPCGALLRPLALPGDPPAPPRSLSAAFGLSllTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 260 AGQVLGRL--GYQTMARRIGVVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYG 337
Cdd:cd17423 251 VADAVGRLfsGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPELVGVERVL 330
|
330 340 350
....*....|....*....|....*....|....*
gi 1583667162 338 HLSGMLMAPIMITTALGPFVGAALASLLDGYDAMF 372
Cdd:cd17423 331 NATGLLQMIESVGGLLGPPLSGWLRDITGDYTASF 365
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-368 |
6.35e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 57.25 E-value: 6.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 36 VLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGV 115
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 116 AMSGVfYAPAFAALTRYFAPNAvRAL------TVLTLVAGLSSTVFAPltaaLGSHLSWRQTYLVLAALLAVITIPAHLF 189
Cdd:cd17475 97 GYGSV-QPGGGRAIMRWFPPRE-RGLamgirqTGVPLGGALAAALLPP----LALHYGWRAAFVVAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 190 gLRRPWPPVQHHHNVEAPTRTA----RSAPFLALMVSFALAALASYAVIVNLVP-LMVQRGFSTSAAAVALGLGGAGQVL 264
Cdd:cd17475 171 -YREPPAASAATESASTLLRSLkevlRNRDVWLIAIAGALLVAPQFALLTFLLLfLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 265 GRLGYQTMA------RRIGVVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGH 338
Cdd:cd17475 250 GRIGLGRVSdrvfggRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGT 329
|
330 340 350
....*....|....*....|....*....|
gi 1583667162 339 LSGMLMAPIMITTALGPFVGAALASLLDGY 368
Cdd:cd17475 330 ALGLANTINFIGIAIGPPLFGLLVDATHSY 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
48-370 |
8.35e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.22 E-value: 8.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 48 SAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRW-----------IMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVA 116
Cdd:COG2211 44 SAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiligaIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 117 MSgVFYAPAFAALTRYFAPNAVRAL------TVLTLVAGLSSTVFAPLTAALG--SHLSWRQTYLVLAALLAVITIPAHL 188
Cdd:COG2211 124 YT-LVNIPYSALGAELTPDYEERTRlsswrfAFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFF 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 189 FGLRRPWPPVQHHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQR-GFSTSAAAVALGLGGAGQVLGRL 267
Cdd:COG2211 203 GTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAP 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 268 GYQTMARRIGvvPRTVLIMAAVAVTTALLGVF----TTLAALVAASIVAGMARGIMTLLQATAVTD-------RWGTTHY 336
Cdd:COG2211 283 LWPRLAKRFG--KKKAFIIGLLLAALGLLLLFflgpGNLWLLLVLAALAGIGLGAILVLPWAMLADvvdydewKTGRRRE 360
|
330 340 350
....*....|....*....|....*....|....
gi 1583667162 337 GHLSGMLMAPIMITTALGPFVGAALASLLdGYDA 370
Cdd:COG2211 361 GLYFGIFTFAIKLGQALAGALAGLLLALF-GYVA 393
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
48-365 |
5.08e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.54 E-value: 5.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 48 SAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGV---FYAP 124
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIasaFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 125 AFAALTRYFAPNA--VRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLV-----LAALLAVITIPAHLFGLRRPWPP 197
Cdd:cd06173 112 ARQALLPELVPKEqlVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAInalsfLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 198 VQHHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQR-GFSTSAAAVALGLGGAGQVLGRLGYQTMARRI 276
Cdd:cd06173 192 LLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 277 GVVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPF 356
Cdd:cd06173 272 RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL 351
|
....*....
gi 1583667162 357 VGAALASLL 365
Cdd:cd06173 352 LAGLLADAL 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
51-372 |
6.50e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.06 E-value: 6.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 51 AVTGAFSaglVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSgvFYAPAFAALT 130
Cdd:cd17489 35 LVVGLFT---LAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWG--AFTTAAATLV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 131 RYFAPNAVRAlTVLTLvAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAHLFGLRRPWPPVQHHHNVEAPTRT 210
Cdd:cd17489 110 ADIIPPSRRG-EGIGY-YGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 211 ARSAPFLALMVSFALAALAS--YAVIVNLVPL-MVQRGFstSAAAVALGLGGAGQVLGRLGYQTMARRIGvvPRTVLI-- 285
Cdd:cd17489 188 FRRLVEKKVLPPALILFLASiaYGAISTFLPLyAAERGI--SNAGLFFTVYAIALLLSRPFSGKLSDRKG--PKTVIIpg 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 286 MAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLL 365
Cdd:cd17489 264 LLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF 343
|
....*..
gi 1583667162 366 dGYDAMF 372
Cdd:cd17489 344 -GYRAMF 349
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
36-326 |
7.65e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.66 E-value: 7.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 36 VLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGV 115
Cdd:cd17365 20 FVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 116 AMSGVFyaPAFAALTRYFAPNAVRALTVLTLVAGLSstvfapltaaLGShlswrqtylVLAALLAVITIPAHlfglrrPW 195
Cdd:cd17365 100 GLGAAM--PNAITLVSEYAPARRRSLAVTLMFCGYP----------LGA---------ALGGFLAAALIPAF------GW 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 196 PPVQHHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARR 275
Cdd:cd17365 153 RSVFLLGGVPPLILLPLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADR 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1583667162 276 IGVVPRTVLIMAAVAVTTALLGVFTT-LAALVAASIVAGMA-RGIMTLLQATA 326
Cdd:cd17365 233 FGPKRVLALFFALGAVSLALLGVSPAsLVLLYVLVFLAGACvNGAQVGLYALA 285
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
56-319 |
1.11e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.43 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 56 FSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVFyaPAFAALTRYFAP 135
Cdd:TIGR00895 58 FSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLM--PNLNALVSEYAP 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 136 NAVRALTVLTLVAG--LSSTVFAPLTAALGSHLSWRQTYLV---LAALLAVITI-----PAHLFGLRRP----------W 195
Cdd:TIGR00895 136 KRFRGTAVGLMFCGypIGAAVGGFLAGWLIPVFGWRSLFYVggiAPLLLLLLLMrflpeSIDFLVSKRPetvrrivnaiA 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 196 PPVQHHHNVEAPTRTA----------------RSAPFLALMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGG 259
Cdd:TIGR00895 216 PQMQAEAQSALPEQKStqgtkrsvfkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFN 295
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 260 AGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIM 319
Cdd:TIGR00895 296 FGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGG 355
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
206-366 |
1.47e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.97 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 206 APTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLI 285
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 286 MAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLL 365
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
.
gi 1583667162 366 D 366
Cdd:COG2814 162 G 162
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-296 |
1.64e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.42 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 1 MTPPSLSAGPGLRWVLITLCVTEITSWgVLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPR 80
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEG-LDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 81 WIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVfYAPAFAALTRYFAPNA-VRALTVLTLVAGLSSTVFAPLT 159
Cdd:COG0477 80 RVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL-MPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 160 AALGSHLSWRQTYLVLAALLAVITIPAHLFGLRRPWPPVQHHHNVEAPTRTARSAPFLALMVSFALAALASYAVIVNLVP 239
Cdd:COG0477 159 GLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1583667162 240 LMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALL 296
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
36-315 |
2.55e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.11 E-value: 2.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 36 VLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGV 115
Cdd:cd17319 24 VAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 116 AMSGvFYAPAFAALTRYFAPNA-VRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIpAHLFGLRRp 194
Cdd:cd17319 104 AEAG-FFPGAIKALAEWFPARErGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAV-LWWFYLRQ- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 195 wppvqhhhnveaptrtarsapFLALMVSFALAALASYAVIVNLVPLMVQ-RGFSTSAAAVALGLGGAGQVLGRLGYQTMA 273
Cdd:cd17319 181 ---------------------VWGLALGYFGINYALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGRLS 239
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1583667162 274 RRIGVVPRTVLIMAAVAVTTALLGVFTTLAALVAASIVAGMA 315
Cdd:cd17319 240 DRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA 281
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
52-368 |
2.75e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.11 E-value: 2.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 52 VTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVfyAPAFAALTR 131
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV--SVAQAYIAD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 132 YFAP-NAVRALTVLTLVAGLsSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAHLFGLRRPWPPVqhhhnveaptrt 210
Cdd:cd17330 114 ITDEeERAKAFGIISAAFGL-GFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRLL------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 211 arsapFLALMVSFALAALasYAVIVNLvpLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTM-ARRIGVVPRTVLIMAAV 289
Cdd:cd17330 181 -----LVYFLIALAFAGL--ESVFSLF--LKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRlAKRLGERKLLRLGLLLA 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1583667162 290 AVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLLDGY 368
Cdd:cd17330 252 IIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG 330
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
41-365 |
4.62e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.38 E-value: 4.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 41 ISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMsGV 120
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGG-GL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 121 FYAPAFAALTRYFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIpAHLFGLRRPWPPVQH 200
Cdd:cd17329 105 FEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAAL-VLLFLLPETRPKRRA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 201 HHNVE---APTRTARSAPFLALMVSFALAALAsYAVIVNLVPLMVQR--GFSTSAAAVALGLGGAGQVLGRLgyqTMARR 275
Cdd:cd17329 184 AEKTEilrGYKIVLRDRAFLLFLLASFLISLI-YFQLESTLPVYVVEilGLGESLLGLLLALNALLIVLLQF---PVARL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 276 IGVVPRTVLIMAAV---AVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTA 352
Cdd:cd17329 260 VERFRLRKILMIGIllfAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRA 339
|
330
....*....|...
gi 1583667162 353 LGPFVGAALASLL 365
Cdd:cd17329 340 IGPLVGGLLLDLL 352
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-329 |
1.36e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.80 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 35 TVLSAS---ISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWI 111
Cdd:cd17503 13 TIVNVAlptIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 112 LAGVAmSGVFYAPAFAALTRYFAPNA-VRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAHLFG 190
Cdd:cd17503 93 LQGFG-GGVLIPLAQTILLRIYPPEKrGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLD 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 191 LrrpwppvqhhhnveaptRTARSAPFLALMVSFALAALASYAVIVnLVPLMVQ--RGFSTSAAAVALGLGGAGQVLGRLG 268
Cdd:cd17503 172 L-----------------RLFKDRNFTLGLLLSFLLGLGLFGAMF-LLPLYLQnvLGYSAFESGLVLAPGGLASAILSPL 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1583667162 269 YQTMARRIGvvPRTVLI--MAAVAVTTALLGVF---TTLAALVAASIVAGMARG-IMTLLQATAVTD 329
Cdd:cd17503 234 VGRLLDKFG--PRLLLLagLLLLALGTLLLAFLtpdTSLWLIILPLFIRGLGMGlVFMPLNTLALNS 298
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
56-372 |
1.62e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.79 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 56 FSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGvFYAPAFAALTRYFAP 135
Cdd:cd17474 40 ITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG-LGPLALTLIGDLFEG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 136 NA-VRALTVLTLVAGLSSTVFAPLTAALGSHlSWRQTYLVLAALLAVITIpAHLFGLRRPWPPVQH--HHNVEAPTRTAR 212
Cdd:cd17474 119 GErAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFL-AILFLLPEPKEKAKSssATKLRDLKKALR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 213 SAPFLALMVSFALAALASYAVIVnLVPLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQT---MARRIGVVPRTVLIMAAV 289
Cdd:cd17474 197 GRGLLTFLVSAFLYFFLYFAFLT-YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVgrlLKKRFGARRILVIGLLLY 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 290 AVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLLdGYD 369
Cdd:cd17474 276 ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF-GLS 354
|
...
gi 1583667162 370 AMF 372
Cdd:cd17474 355 APF 357
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-189 |
2.34e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.03 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 12 LRWVLITLCVTEITSWGVLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGV 91
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 92 VAVLAVVVAPNYACFVAAWILAGVAMSgvFYAPAFAALTRYFAPNAVRALT--VLTLVAGLSSTVFAPLTAALGSHLSWR 169
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLG--LVFPATLALLADIVPPEGRGTAmgLFNTAFSLGMVLGPLLGGFLYDAFGFA 354
|
170 180
....*....|....*....|
gi 1583667162 170 QTYLVLAALLAVITIPAHLF 189
Cdd:cd17325 355 TPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
60-320 |
3.47e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 45.62 E-value: 3.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 60 LVTSALMGIVV----GRWLDRYGPR-WIMTIGSVLGVVAVLAVVVAPNYACFVAAWI----LAGVAMSGVFyAPAFAALT 130
Cdd:cd17471 38 MTLSALSGIVVsqwlGRLSDRGGDRkPLILLALLAGALGYLLFAFLRNYWVLLLVGVvllsLGAAAFPQLF-ALAREYAD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 131 RYFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAhLFGLRRPWPPVQHHHNVEAPTRT 210
Cdd:cd17471 117 RSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLV-LFLLPSVKPPAQKATPASSLVKA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 211 ARSAPFLALMVSFALAALASYAVIVNLVPLMVQR-GFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVvpRTVLIMAAV 289
Cdd:cd17471 196 PVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNElGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGK--RRLLLAGFL 273
|
250 260 270
....*....|....*....|....*....|...
gi 1583667162 290 AVTT--ALLGVFTTLAALVAASIVAGMARGIMT 320
Cdd:cd17471 274 AGVLfyLGLALATSLWQLIALQLLNAIFIGITA 306
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
142-370 |
6.40e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 6.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 142 TVLTLVAGLSSTVFAPLTAALGshLSWRQTYLVLAaLLAVITIPAHLFGLRRpwppvQHHHNVEAPTRTA----RSAPFL 217
Cdd:cd17339 128 TSMNLGAALASGLSVPLAQALG--GGWRGALAIWA-LPALLALLIWLPQLRR-----RKRAAAAAAPLTKisvwRSPLAW 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 218 ALMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGvVPRTVLIMAAVAVTTALLG 297
Cdd:cd17339 200 QVTLFMGLQSLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLK-NQRPIVVLLAVLFIIGVLG 278
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1583667162 298 -VFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTH-YGHLSGMLMAPIMITTALGPFVGAALASLLDGYDA 370
Cdd:cd17339 279 lLFAPTALALLWAVLLGLGGGAAFSLALTLISLRSSDPAeAAALSGMAQSVGYLLAALGPLLFGVLHDLTGSWTA 353
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-363 |
8.50e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.49 E-value: 8.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 41 ISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGV 120
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 121 fyAPAFAALTRYFAPNAVR-ALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAHLFglrrpwppvq 199
Cdd:cd17504 102 --PLAFALVREEFPPERVPvAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI---------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 200 hhhnveaPTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQR-----GFSTSAAAVALGLGGAGQVLGRLGYQTMAR 274
Cdd:cd17504 170 -------DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPtptgfGLGITEAGLLLLPGALVMLIAGPLAGRLIA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 275 RIGvvPRTVLIMAAVAVTTALLGVF---TTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITT 351
Cdd:cd17504 243 RVG--PRRVLLIGLVISAVGLLLLAllhSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGS 320
|
330
....*....|..
gi 1583667162 352 ALGPFVGAALAS 363
Cdd:cd17504 321 AIGPAIAGAILT 332
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
47-365 |
1.36e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 47 WSAPAVTGAFSAGLVtsaLMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVFYapAF 126
Cdd:cd17477 31 ALIGLVASAYYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV--VS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 127 AALTRYFAPNAVRA--LTVLTLVAGLSSTVfAPLTAALGSHLSWrQTYLVLAALLAVITIPahlFGLRRPWPPVQHHHNV 204
Cdd:cd17477 106 ESWLNALATNENRGrvLGLYSTVLGLGFAL-GPLLLALVGTAGA-LPFLIAAVLLLLALVP---LLLTRRAAPEIEEAES 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 205 EAPTRTARSAPfLALMVSFALAALAsyAVIVNLVPL-MVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGvvPRTV 283
Cdd:cd17477 181 ISLRRLLRIAP-LALLGAFVAGFLE--GAFYSLLPLyGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD--RRRV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 284 LIMAAVAVTTALLG---VFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAA 360
Cdd:cd17477 256 LLGCALLGALAALLlplVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGA 335
|
....*
gi 1583667162 361 LASLL 365
Cdd:cd17477 336 LMDAF 340
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-189 |
1.48e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 10 PGLRWVLITLCVteitsWGVLYYAFTVLSASISSDTGWSAPAVTGAFSAGL-VTSALMGIVVGRWLDRYGPRWIMTIGSV 88
Cdd:cd06173 208 PLLRLLLLALAL-----FALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFgVGALLGALLLGRLSKRRRRGRLLLIGAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 89 LGVVAVLAVVVAPNYACFVAAWILAGVAMsGVFYAPAFAALTRYFAPN-AVRALTVLTLVAGLSSTVFAPLTAALGSHLS 167
Cdd:cd06173 283 LLGLALLVLGLSPSLWLLLAALFLLGLAG-GLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALG 361
|
170 180
....*....|....*....|..
gi 1583667162 168 WRQTYLVLAALLAVITIPAHLF 189
Cdd:cd06173 362 LSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
55-314 |
1.66e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.41 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 55 AFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVFyaPAFAALTRYFA 134
Cdd:PRK11551 55 AFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGAL--PNLIALTSEAV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 135 PNAVRALTVLTLVAGL--SSTVFAPLTAALGSHLSWRQTYLV------LAALLAVITIPAHLFGLRRPWPPVQHHHNVEA 206
Cdd:PRK11551 133 GPRLRGTAVSLMYCGVpfGGALASVIGVLAAGDAAWRHIFYVggvgplLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 207 PTRTARSAPFLALMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIM 286
Cdd:PRK11551 213 LFGEGRATATLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIY 292
|
250 260
....*....|....*....|....*...
gi 1583667162 287 AAVAVTTALLGVFTTLAALVAASIVAGM 314
Cdd:PRK11551 293 AGILASLAALAAAPSFAGMLLAGFAAGL 320
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
26-201 |
2.84e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.00 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 26 SWGVLYYAFTVLSA---SISSDTGwSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPN 102
Cdd:cd06179 6 AYFAQLFGVTLPAAvlpFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 103 YACFVAAWILAGVAMSGVFYAPAFAAltrYFAPNAVRALTVLTL-VAGLSSTVFAPLTA---ALGSHLSWRQTYLVLAAL 178
Cdd:cd06179 85 VNMLIGGQALIGIGAGTQGLGAAVAS---ELVPNKYRGLVQGVVnLVASPGSALGPLIAgalVEANAAGWRWIFYINAIF 161
|
170 180
....*....|....*....|...
gi 1583667162 179 LAVITIpaHLFGLRRPWPPVQHH 201
Cdd:cd06179 162 NALALI--LLFFFYHPPPRPQLH 182
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
219-367 |
1.46e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.49 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 219 LMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGV 298
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1583667162 299 FTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLLDG 367
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF 149
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
52-193 |
2.36e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.87 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 52 VTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVFYApAFAALTR 131
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTV-GFVLGME 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1583667162 132 YFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHlsWRQTYLVLaALLAVITIPAHLFGLRR 193
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD--WRWLQLAI-SLPGLLFLLLLWWLPRR 164
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
219-365 |
2.50e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 219 LMVSFALAALASYAVIVNLVPLMVQ-RGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLG 297
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEdLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1583667162 298 VFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLL 365
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
67-371 |
4.10e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.23 E-value: 4.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 67 GIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMsGVFYAPAFAALTRYFAPNAVRALTVLTL 146
Cdd:cd17333 48 SLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA-GILDTGANTFVGALFEESSATRLNVLHG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 147 VAGLSSTVFAPLTAALG-SHLSWRQTYLVLAA---LLAVITIPAHLFGLRRPWPPVQHHHNVEAPTRTARSAPFLALMVS 222
Cdd:cd17333 127 FFGLGALIGPLIATSLLtSELSWSWAYLIIGLiylLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGAL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 223 FALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGG--AGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGVFT 300
Cdd:cd17333 207 ALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGfwVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAP 286
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1583667162 301 TLAALVAASIVAGMARGIMtLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLLDGYDAM 371
Cdd:cd17333 287 TLVVGLVATALLGLFMAAL-FPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAM 356
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
60-372 |
4.25e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.21 E-value: 4.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 60 LVTSALMGIVVGRWldryGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVFYAPAFAALTRYFAPNAVR 139
Cdd:cd06180 48 LVGALLASFLRRRG----RARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGH 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 140 ALTVLTLVAGLSSTVFAPLTAA-LGSHLSWRQTYLVLAALLAVITIPAHLFGLRRPWPPVQHHHNVEAPTRTArsaPFLA 218
Cdd:cd06180 124 LIGLLFAGVGLGIALSGLLVPAgLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNR---PLWR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 219 LMVSFALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGV 298
Cdd:cd06180 201 LALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLL 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1583667162 299 FTTLAALVAASIVAGMARGIMTLLQATAVTDRWgtthyGHLSGMLMAPIMITTALGPFVGAALASLLDGYDAMF 372
Cdd:cd06180 281 SPGPAGLVLSAVLFGGTFMAITALVMALARELA-----PPAAPRALALMTASFGVGQILGPLLAGWLADATGGF 349
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
41-257 |
4.42e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 38.85 E-value: 4.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 41 ISSDTGWSAPAVTGAFS---AGLVTSALMGivvGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAm 117
Cdd:PRK10473 29 IAADLNASEAQLHIAFSvylAGMAAAMLFA---GKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIG- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 118 SGVFYAPAFAALtRYFAPNAVRAlTVLTLVAGLSST--VFAPLTAAL-GSHLSWrQTYLVLAALLAVITIPAHLFGLRRP 194
Cdd:PRK10473 105 AGCCYVVAFAIL-RDTLDDRRRA-KVLSLLNGITCIipVLAPVLGHLiMLKFPW-QSLFYTMAAMGILVLLLSLFILKET 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1583667162 195 WpPVQHHHNVEAPTRTARS--APFLALMVSFALAALASYAVIVNLVP--LMVQRGFSTSAAAVALGL 257
Cdd:PRK10473 182 R-PARAPAASSKPRENSESllNRFFLSRLVITTLSVTVILTFVNTSPvlLMEQMGFSRGEYAIIMAL 247
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-184 |
5.24e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 5.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 29 VLYYAFTVLSASISSDTGWSAPAVTG-AFSAGLVTSALMGIVVGRWLD-RYGPRWIMTIGSVLGVVAVLAVVVAPNYACF 106
Cdd:cd17474 212 FLYFAFLTYLPFLLELLYGISPIIIGlLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 107 VAAWILAGVAMSGVFyaPAFAALTRYFAPNAVR--ALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITI 184
Cdd:cd17474 292 LIAIVLFGLGLGLNL--PLLTTLVTELAPEEERgtASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
224-379 |
5.91e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 38.71 E-value: 5.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 224 ALAALASYAVIVNLVPLMVQR-GFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVPRTVLIMAAVAVTTALLGVFTTL 302
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAESlGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1583667162 303 AALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALASLLdGYDAMFLVLGVVA 379
Cdd:cd17325 85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALA 160
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-372 |
6.40e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 6.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 31 YYAFTVLSASISSDTGW--SAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVA 108
Cdd:cd17316 15 FFLIGFVAPVLAAEFSLglSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 109 AWILAGVAMSGVFyaPAFAALTRYFAPNAVRALTVLTLVAG------LSSTVFAPLTAALGSHLSWRqTYLVLAALLAVI 182
Cdd:cd17316 95 LRFLQGIGIGGEY--PGASTYVAEFAPSKRRGFALGLLQSGwalgalLAALVASLLIPLLSGDWGWR-ILFLIGALPALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 183 TIPahlfgLRRpwppvqhhhnveaptrtarsaPFLALMVSFALAALASYAVIVNLVPLMVQ-RGFSTSAAAVALGLGGAG 261
Cdd:cd17316 172 ALL-----LRR---------------------RTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 262 QVLGRLGYQTMARRIGVVPRTV--LIMAAVAVTTALLGVFTTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHL 339
Cdd:cd17316 226 ALVGALIAGLLSDRIGRKKTLVigLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATG 305
|
330 340 350
....*....|....*....|....*....|...
gi 1583667162 340 SGMLMAPIMITTALGPFVGAALASLLDGYDAMF 372
Cdd:cd17316 306 VGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
64-309 |
6.93e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.37 E-value: 6.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 64 ALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVFyAPAFAALTRYFAPNAV-RALT 142
Cdd:cd17328 48 MVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYS-PIAPTIIADLFPKEKRtRALG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 143 VLTLVAGLSSTVFAPLTAALGSH-LSWRQTYLVlAALLAVITIPAHLFGLRRPWPPVQHHHNVEAPTRT---------AR 212
Cdd:cd17328 127 VFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRV-TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATsfladlkalAK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 213 SAPFLALMVSFALAALASYAVIVNlVPLMVQRGFS---TSAAAVALGLGG---AGQVLGRLGYQTMARRIGVVPRTVLIM 286
Cdd:cd17328 206 NPSFILSTLGFTAVSFVTGALAFW-APTFFLRAFGvgdLSSADVGLIFGAitcIAGVLGVLLGGILADRLRRKTPRADPL 284
|
250 260
....*....|....*....|...
gi 1583667162 287 AAvAVTTALLGVFTTLAALVAAS 309
Cdd:cd17328 285 VC-AVGLLAAAPFLFLALVLALS 306
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
162-372 |
7.50e-03 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 38.35 E-value: 7.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 162 LGSHLSWRQTYLVLAALLAVITIpAHLFGLrrPWPPVQHHHNVEAPTRTARSAPFLAL----MVSFALAALASY----AV 233
Cdd:cd17486 150 LADSLSWSAVYLIMAALMGPGIL-ATLFAP--EPPRTDPPANSLSETVVAFFAPFKDFfgqpGALLILAFILLYklgdAM 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 234 IVNLV-PLMVQRGFSTSA-AAVALGLGGAGQVLGRLGYQTMARRIGVVpRTVLIMAAVAVTTALLGV--------FTTLA 303
Cdd:cd17486 227 LGAMAtPFLLDLGFTKTEiGAVYKTVGLIATIVGGLLGGFLMSRLGLK-RSLWLFGILQALSNLGFIylahagpnLTLLV 305
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 304 ALVAA-SIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGMLMAPIMITTALGPFVGAALaslldGYDAMF 372
Cdd:cd17486 306 AAVAVeNFGGGLGTTAFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEAL-----GWTGFF 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
40-377 |
8.98e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 37.92 E-value: 8.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 40 SISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSG 119
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 120 VFyAPAFAALTRYFAPNA-VRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLAALLAVITIPAHLFglrrpwppv 198
Cdd:cd17321 101 IM-PASLALIAATFPGERrGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTF--------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 199 qhhhnveaptrtaRSAPFLALMVSFALAALASYAVIVnlvpLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGV 278
Cdd:cd17321 171 -------------SGAVLAAFLLGAALGGLLFLLPLY----LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583667162 279 VPRTVLIMAAVAVTTALLGVF---TTLAALVAASIVAGMARGIMTLLQATAVTDRWGTTHYGHLSGML------------ 343
Cdd:cd17321 234 RLVLVAGLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILntarqlggalgv 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1583667162 344 ----------MAPIMITTALGPFVGAALASLLDGYDAMFLVLGV 377
Cdd:cd17321 314 allgalltagLSANLGDSGVAALLSAAAAAFAAGFHLAFLVAAA 357
|
|
| |
