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Conserved domains on  [gi|1586385893|gb|TBX59963|]
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aminodeoxychorismate synthase component I [Bacillus toyonensis]

Protein Classification

anthranilate synthase component I family protein( domain architecture ID 11414943)

anthranilate synthase component I family protein similar to the component I of anthranilate synthase and aminodeoxychorismate synthase, which are part of complexes that catalyze the two-step biosynthesis of anthranilate and 4-amino-4-deoxychorismate (ADC), respectively

CATH:  3.60.120.10
Gene Ontology:  GO:0046872|GO:0009058
PubMed:  16042594|11450855

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 11-456 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


:

Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 623.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  11 IPYQLDFFKQYKFLSqDKPQHILLESGRG----GRYNIVGLNPVAVIQGKGETLHISESGKETIKRGNPLDLMQEYMEKW 86
Cdd:COG0147     9 LLALETPVSLFLKLA-DGPYAFLLESAEGgekwGRYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  87 KTDYNPEYTPFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQeekvlwiithyvdkhaeaeerlhe 166
Cdd:COG0147    88 RLPPLPGLPPFTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFDH------------------------ 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 167 wknlwaaevpevtmpferpeKKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSP 246
Cdd:COG0147   144 --------------------LKGTRSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSP 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 247 YMGYLELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKY 326
Cdd:COG0147   204 YMFYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEP 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 327 GTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYS 406
Cdd:COG0147   284 GSVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFD 363

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1586385893 407 GDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:COG0147   364 GNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRA 413
 
Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 11-456 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 623.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  11 IPYQLDFFKQYKFLSqDKPQHILLESGRG----GRYNIVGLNPVAVIQGKGETLHISESGKETIKRGNPLDLMQEYMEKW 86
Cdd:COG0147     9 LLALETPVSLFLKLA-DGPYAFLLESAEGgekwGRYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  87 KTDYNPEYTPFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQeekvlwiithyvdkhaeaeerlhe 166
Cdd:COG0147    88 RLPPLPGLPPFTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFDH------------------------ 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 167 wknlwaaevpevtmpferpeKKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSP 246
Cdd:COG0147   144 --------------------LKGTRSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSP 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 247 YMGYLELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKY 326
Cdd:COG0147   204 YMFYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEP 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 327 GTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYS 406
Cdd:COG0147   284 GSVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFD 363

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1586385893 407 GDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:COG0147   364 GNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRA 413
trpE_most TIGR00564
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ...
 23-458 0e+00

anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273142 [Multi-domain]  Cd Length: 454  Bit Score: 519.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  23 FLSQDKPQHILLES----GRGGRYNIVGLNPVAVIQGKGETLHISESGKETIKRGNPLDLMQEYMEKWKTDYNPEYT-PF 97
Cdd:TIGR00564  10 YLKLAQPGSFLLESaepgSERGRYSFIGLNPVLTIKTEGGTEYLGADDRRSGIVGNPLDEIRDVMETFAQHSDPELPiPF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  98 QGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIITHY-----VDKHAEAEERLHEWKNL-- 170
Cdd:TIGR00564  90 TGGAVGYLGYDTVRLFEKITLPPPDPLNLPDAYLMLCDDFIIFDHVTDKLYLIHNNrttasRSAKAAADARLEALVADlq 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 171 WAAEvPEVTMPFerPEKKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSPYMGY 250
Cdd:TIGR00564 170 DPLL-PEVPVPY--PAALSFTSNYEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYRVLRIVNPSPYMYY 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 251 LELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVE 330
Cdd:TIGR00564 247 LDFGDFQIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGRNDIGRVCEPGSVE 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 331 VDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTE 410
Cdd:TIGR00564 327 VPEFMKIERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYGGAVGYLSFDGDMD 406

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1586385893 411 LNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRAKE 458
Cdd:TIGR00564 407 TAIAIRTMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 21-465 8.70e-156

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 451.40  E-value: 8.70e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  21 YKFLSQDKPQHILLESGRGG----RYNIVGL-NPVAVIQGKGETLHISESGKETIKRGNPLDLMQEYMEKWKTDYNPEYT 95
Cdd:PRK13571   40 YRKLAANRPGTFLLESAENGrswsRWSFIGVgSPAALTVRDGEAVWLGTPPAGAPTGGDPLAALRATLELLATPRLPGLP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  96 PFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIITHYVD----------KHAEAEERLH 165
Cdd:PRK13571  120 PLTGGMVGFLGYDAVRRLERLPELAVDDLGLPEMLLLLATDLAAVDHHEGTITLIANAVNwngtdervdaAYDDAVARLD 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 166 EWKNLWAAEVPEVTMPFERPEKKNEAvAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPS 245
Cdd:PRK13571  200 VMTAALAQPLPSTVATFSRPVPEFRA-QRTVEEFGAAVEKLVEEIRAGEAFQVVPSQRFEMDTTADPLDVYRVLRVTNPS 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 246 PYMGYLEL------GDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERND 319
Cdd:PRK13571  279 PYMYLLRVpnsdggTDFSIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLVDLGRND 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 320 LGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGS 399
Cdd:PRK13571  359 LGRVCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELIEELEPTRRGLYGGV 438

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586385893 400 IGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRAKESSeETVR 465
Cdd:PRK13571  439 VGYLDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAAVLRAIAAA-ETLR 503
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 197-449 1.08e-129

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 375.74  E-value: 1.08e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 197 EGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQT--HPLEIYTSLRKINPSPYMGYLELGDFQIVSASPELLIKKQGQEV 274
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGdiDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 275 STRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEV 354
Cdd:pfam00425  81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 355 EEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIV 434
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240

                         250
                  ....*....|....*
gi 1586385893 435 IDSNPKNEYKESLKK 449
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
 
Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 11-456 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 623.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  11 IPYQLDFFKQYKFLSqDKPQHILLESGRG----GRYNIVGLNPVAVIQGKGETLHISESGKETIKRGNPLDLMQEYMEKW 86
Cdd:COG0147     9 LLALETPVSLFLKLA-DGPYAFLLESAEGgekwGRYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  87 KTDYNPEYTPFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQeekvlwiithyvdkhaeaeerlhe 166
Cdd:COG0147    88 RLPPLPGLPPFTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFDH------------------------ 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 167 wknlwaaevpevtmpferpeKKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSP 246
Cdd:COG0147   144 --------------------LKGTRSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSP 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 247 YMGYLELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKY 326
Cdd:COG0147   204 YMFYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEP 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 327 GTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYS 406
Cdd:COG0147   284 GSVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFD 363

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1586385893 407 GDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:COG0147   364 GNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRA 413
trpE_most TIGR00564
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ...
 23-458 0e+00

anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273142 [Multi-domain]  Cd Length: 454  Bit Score: 519.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  23 FLSQDKPQHILLES----GRGGRYNIVGLNPVAVIQGKGETLHISESGKETIKRGNPLDLMQEYMEKWKTDYNPEYT-PF 97
Cdd:TIGR00564  10 YLKLAQPGSFLLESaepgSERGRYSFIGLNPVLTIKTEGGTEYLGADDRRSGIVGNPLDEIRDVMETFAQHSDPELPiPF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  98 QGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIITHY-----VDKHAEAEERLHEWKNL-- 170
Cdd:TIGR00564  90 TGGAVGYLGYDTVRLFEKITLPPPDPLNLPDAYLMLCDDFIIFDHVTDKLYLIHNNrttasRSAKAAADARLEALVADlq 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 171 WAAEvPEVTMPFerPEKKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSPYMGY 250
Cdd:TIGR00564 170 DPLL-PEVPVPY--PAALSFTSNYEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYRVLRIVNPSPYMYY 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 251 LELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVE 330
Cdd:TIGR00564 247 LDFGDFQIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGRNDIGRVCEPGSVE 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 331 VDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTE 410
Cdd:TIGR00564 327 VPEFMKIERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYGGAVGYLSFDGDMD 406

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1586385893 411 LNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRAKE 458
Cdd:TIGR00564 407 TAIAIRTMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 21-465 8.70e-156

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 451.40  E-value: 8.70e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  21 YKFLSQDKPQHILLESGRGG----RYNIVGL-NPVAVIQGKGETLHISESGKETIKRGNPLDLMQEYMEKWKTDYNPEYT 95
Cdd:PRK13571   40 YRKLAANRPGTFLLESAENGrswsRWSFIGVgSPAALTVRDGEAVWLGTPPAGAPTGGDPLAALRATLELLATPRLPGLP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  96 PFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIITHYVD----------KHAEAEERLH 165
Cdd:PRK13571  120 PLTGGMVGFLGYDAVRRLERLPELAVDDLGLPEMLLLLATDLAAVDHHEGTITLIANAVNwngtdervdaAYDDAVARLD 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 166 EWKNLWAAEVPEVTMPFERPEKKNEAvAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPS 245
Cdd:PRK13571  200 VMTAALAQPLPSTVATFSRPVPEFRA-QRTVEEFGAAVEKLVEEIRAGEAFQVVPSQRFEMDTTADPLDVYRVLRVTNPS 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 246 PYMGYLEL------GDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERND 319
Cdd:PRK13571  279 PYMYLLRVpnsdggTDFSIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLVDLGRND 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 320 LGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGS 399
Cdd:PRK13571  359 LGRVCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELIEELEPTRRGLYGGV 438

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586385893 400 IGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRAKESSeETVR 465
Cdd:PRK13571  439 VGYLDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAAVLRAIAAA-ETLR 503
TrpE-arch TIGR01820
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of ...
 18-456 2.74e-147

anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273819 [Multi-domain]  Cd Length: 435  Bit Score: 427.17  E-value: 2.74e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  18 FKQYKFLSQDKPQHILLESGRG----GRYNIVGLNPVAV--IQGKGETLHISESGketikrGNPLDLMQEYMEKWKTDYN 91
Cdd:TIGR01820   2 LELYKAIRADGDYAFLLESAEKpskkARYSFIGWDPEFVvrINGKGKSVEGIPED------GDVVDKLRNAFPKLKGINI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  92 PEYTP-FQGGAIGYFSYDCIR-YIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIIThYVDKHAEAEERLhewKN 169
Cdd:TIGR01820  76 PGEDRrFKGGLVGYIAYDAVRdYWEGIVDLKRKAEDWPPAEFFIYPNTIVYDHLEGKVYYVS-TPEPEAELERIV---ER 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 170 LWAAEVPEVtmpfERPEKKNEAVAFTEEgFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSPYMG 249
Cdd:TIGR01820 152 AKRATDPGE----AGVSFEGESLSDREE-FEEAVEEAKEYIFAGDIFQVVLSREYEYRLDGDPFELYYNLREINPSPYMF 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 250 YLELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTV 329
Cdd:TIGR01820 227 LLKFGDRYLVGSSPETLVRVEGRTVETNPIAGTRPRGATPEEDERLAKELLSDEKERAEHVMLVDLARNDVRKVSEPGSV 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 330 EVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDT 409
Cdd:TIGR01820 307 KVPEFMYVEKYSHVQHIESTVIGTLKKDYDAFDALRATFPAGTLSGAPKIRAMEIIDELEKEPRGVYGGGVGYFSWNGDA 386

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1586385893 410 ELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:TIGR01820 387 DFAIAIRTAEIDKDKLRIQAGAGIVADSIPEREFEETENKMKAVLKA 433
PRK05940 PRK05940
anthranilate synthase component I;
89-460 3.71e-143

anthranilate synthase component I;


Pssm-ID: 235651 [Multi-domain]  Cd Length: 463  Bit Score: 417.59  E-value: 3.71e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  89 DYNPEYTPFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIITHYVDKHAEAEERLHEWK 168
Cdd:PRK05940   88 SALPEHLPFTGGWLGWLGYDLAWEIERLPHLNPDPLPFPVAYWYEPESFAILDHQEQILWLAASDPSQLDRLEQQLEQPT 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 169 nlwaaevPEVTMPF-ERPEKKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSPY 247
Cdd:PRK05940  168 -------PEPDLPLdLRTPPSSLIFYTTQQEYEAAVRQAKKYIQAGDIFQANLSLRFQTTTSADSWQIYRRLQQINPSPF 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 248 MGYLELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYG 327
Cdd:PRK05940  241 ASYWRTPWGDVVSCSPERLVQLQGNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLERNDLGRVCQWG 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 328 TVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSG 407
Cdd:PRK05940  321 SVEVDELLTIERYSHVIHLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLFYGSCGYLDQRG 400

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1586385893 408 DTELNIVIRTLL---AKDGQAHV--QAGAGIVIDSNPKNEYKESLKKAIALWRAKESS 460
Cdd:PRK05940  401 NLDLNILIRTLLytpLSRGLSTIwgQVGAGIVADSDPEKEWLESLQKAKAQLAALNLV 458
PabB-clade2 TIGR01824
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ...
 99-453 5.55e-138

aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.


Pssm-ID: 130883  Cd Length: 355  Bit Score: 400.69  E-value: 5.55e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  99 GGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIIThyVDKHAEAEERLHEWKNLWAAEVPEV 178
Cdd:TIGR01824   1 GGRLGWLAYDVARRLEGIPDLGTSDGGWPVAADFRYEAAVARDHQRQIVALAT--VPAETEGEFATSSDQLPAVAAATSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 179 TMPFERPEKKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQE-RTLQT-HPLEIYTSLRKINPSPYMGYLELGDF 256
Cdd:TIGR01824  79 PSPDVGPLPVDLEASIDRAAYETGVRRIKDYIRAGDVFQANLSRRLTaPIAADvDPLQLFLALRAPNPAPYAIYLEEPGV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 257 QIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMV 336
Cdd:TIGR01824 159 DVASASPELFLAREGRVVQTRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRVCATGTVRVPELCA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 337 IEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIR 416
Cdd:TIGR01824 239 VESYSHVHHLVSRVTGRLREGAGLADLIRALFPGGSITGAPKVRAMEIIDELEPQPRGPYTGSVGWIDADGNADLNILIR 318

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1586385893 417 TLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIAL 453
Cdd:TIGR01824 319 TLEGGGAQLHFRTGAGIVADSDPAGEWDETEAKARAL 355
PLN02445 PLN02445
anthranilate synthase component I
 40-463 2.43e-134

anthranilate synthase component I


Pssm-ID: 215244 [Multi-domain]  Cd Length: 523  Bit Score: 397.51  E-value: 2.43e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  40 GRYNIVGLNPVAVIQGKGETLHI--SESGKETIKR-GNPLDLMQEYMEKWK---TDYNPEYtpFQGGAIGYFSYDCIRYI 113
Cdd:PLN02445   57 GRYSVVGAQPAMEIVAKENKVTImdHEKGTRTEEIvEDPMEIPRRISEKWNpqlIDGLPDV--FCGGWVGYFSYDTVRYV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 114 E--KLP--SLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIItHYV--DKHAEAEE-------RLHEW-KNLWAAEVP--- 176
Cdd:PLN02445  135 EkkKLPfsGAPEDDRNLPDIHLGLYDDVIVFDHVEKKAYVI-HWVrlDRYSSVEEayedgmkRLEALvSRLQDINPPkls 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 177 ------EVTMPFERPEKKNeavaFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSPYMGY 250
Cdd:PLN02445  214 pgsvklSTNQFGPSLEKSN----MTSEEYKNAVLQAKEHILAGDIFQIVLSQRFERRTFADPFEVYRALRIVNPSPYMIY 289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 251 LELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVE 330
Cdd:PLN02445  290 LQARGCILVASSPEILTRVKKNKIVNRPLAGTRRRGKTPEEDKALEKDLLADEKQCAEHIMLVDLGRNDVGKVSKAGSVK 369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 331 VDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTE 410
Cdd:PLN02445  370 VEKLMNIERYSHVMHISSTVTGELLDHLTSWDALRAALPVGTVSGAPKVRAMELIDELEVTRRGPYSGGFGGVSFTGDMD 449

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1586385893 411 LNIVIRTLLAKDGQ------------------AHVQAGAGIVIDSNPKNEYKESLKKAIALWRAKESSEET 463
Cdd:PLN02445  450 IALALRTMVFPTAArydtmysykdtnsrrewvAHLQAGAGIVADSDPEDEYRECVNKAAGLARAIDLAESA 520
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 197-449 1.08e-129

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 375.74  E-value: 1.08e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 197 EGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQT--HPLEIYTSLRKINPSPYMGYLELGDFQIVSASPELLIKKQGQEV 274
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGdiDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 275 STRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEV 354
Cdd:pfam00425  81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 355 EEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIV 434
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240

                         250
                  ....*....|....*
gi 1586385893 435 IDSNPKNEYKESLKK 449
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
PRK09070 PRK09070
aminodeoxychorismate synthase component I;
24-456 2.71e-127

aminodeoxychorismate synthase component I;


Pssm-ID: 236371 [Multi-domain]  Cd Length: 447  Bit Score: 376.73  E-value: 2.71e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  24 LSQDKPQH--ILLES-GRG---GRYNIVGLNPvaviqgkGETLHISESGKEtiKRGNPLDLMQEYMEKWKTDYNPEYT-- 95
Cdd:PRK09070   16 LHRLAPERypALLESsASGtaqGRWDVLLLAQ-------GKCLRLDPDGVT--RQLLEGDFLDALDAAWQAERVPHDGes 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  96 --PFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIITHYVDKHA-EAEERLHEWKNLWA 172
Cdd:PRK09070   87 slPFRGGWAVLLDYELAGQVEPILKLPMRTDGLPLALALRAPAAVLRDRHSGRCVLVAEPGREHLlDQIEADLAACAALP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 173 A--EVPEVTMPFERPEKKneavafteegFMKAVERIQEYIGNGDVFQVNLSTRQERTLQT--HPLEIYTSLRKINPSPYM 248
Cdd:PRK09070  167 PlpVWLAPQAVEEDPPER----------FTDGVERVLDYIRAGDVFQVNLSRAWQAQFANavDPAALYARLRAANPAPFS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 249 GYLELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEqEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGT 328
Cdd:PRK09070  237 GLFVAAGRAIVSSSPERLVSVQGGVVQTRPIAGTRPRFAGD-DDAALIRELVGHPKERAEHVMLIDLERNDLGRICAPGS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 329 VEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGD 408
Cdd:PRK09070  316 VEVDELMTVESYAHVHHIVSNVRGRLRDGVTPGEVIRAVFPGGTITGCPKVRCMQIIAELEQTPRGAYTGSFGYLNRDGD 395

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1586385893 409 TELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:PRK09070  396 MDLNILIRTAEVQGNQVRFRTGAGIVVDSDPERELDETRAKARGLLRA 443
PRK13572 PRK13572
anthranilate synthase component I; Provisional
 13-456 4.56e-107

anthranilate synthase component I; Provisional


Pssm-ID: 237432 [Multi-domain]  Cd Length: 435  Bit Score: 324.38  E-value: 4.56e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  13 YQLDF---FKQYKFLSQDKPQHILLESGRGG---RYNIVGLNPVAVIQ-GKGETLhiseSGKETIKRGNPLDLMQEYMEK 85
Cdd:PRK13572    4 KKLDYvnpLKLYSVLRDEGYPFILESAEKGQrkaRYTYISANPEFMVRiGNKTKV----DGETISKESNPFKALKENFKI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  86 wktdyNPEYTPFQGGAIGYFSYDCIR-YIEKlpslaedDLNIPDIFFLlFDDVFVYDQEEKVLWIITHY--VDKHAEAEE 162
Cdd:PRK13572   80 -----TQSGDRFTGGFVGYIAYDAVHnYIGG-------KIEEPSVFGY-YDHVFVYDHVTRKFYFHSLNnnPEELFNAEK 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 163 RLHEWKNlwaAEVPEvtmpferpEKKNEAVAFTE---EGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSL 239
Cdd:PRK13572  147 IVEKAKR---FEIEE--------EDGGSEVLGCDadrEEFVEMVEKAKEYIYSGDVFQVVLSREYRLKTDLSPFQLYRNL 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 240 RKINPSPYMGYLELgDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERND 319
Cdd:PRK13572  216 REINPSPYMFLLEF-DKDVVGASPETMASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARND 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 320 LGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGS 399
Cdd:PRK13572  295 VRKVSKSGSVRLERFFDVVKYSHVQHIESEVVGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGA 374

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1586385893 400 IGWIGYSGDTELNIVIRtLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:PRK13572  375 VGYFSNSGNADLAIAIR-MAEIDKVCRVRAGAGIVADSVPEKEFYETERKMAAVLKA 430
PRK13574 PRK13574
anthranilate synthase component I; Provisional
 18-453 1.49e-106

anthranilate synthase component I; Provisional


Pssm-ID: 184155 [Multi-domain]  Cd Length: 420  Bit Score: 322.54  E-value: 1.49e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  18 FKQYKFLSQDKPQHILLESGRG----GRYNIVGLnpvaviqGKGETLHISesgketikrGNPLDLMQEYMEKWKTDYNPe 93
Cdd:PRK13574   13 FEVFKCIERDFKVAGLLESIGGpqykARYSVIAW-------GTNGYLKIH---------DDPVNILNSYLKDLKLVDIP- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  94 yTPFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEE-KVlwiithYVDkhaeaeerlhewknlwa 172
Cdd:PRK13574   76 -GLFKGGMIGYISYDAVRFWEKIRDLKPAAEDWPYAEFFIPDNIIIYDHNEgKV------YVN----------------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 173 AEVPEVTMPFERPEKK--NEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSPYMGY 250
Cdd:PRK13574  132 GDLSSVGGCGDMGEFKisFYDESLNKNNYEKIVSESLEYIRSGYIFQVVLSRFYRYLFSGDPLRIYYNLRRINPSPYMFY 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 251 LELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVE 330
Cdd:PRK13574  212 LKFDERYLIGSSPELLFRVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVR 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 331 VDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTE 410
Cdd:PRK13574  292 VPELMYVEKYSHVQHIVSKVIGTLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAE 371

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1586385893 411 LNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIAL 453
Cdd:PRK13574  372 FAIAIRTAFLNKDLLRIQAGAGIVYDSNPESEYFETEHKLRAL 414
pabB TIGR00553
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ...
 101-450 5.68e-105

aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]


Pssm-ID: 273133  Cd Length: 328  Bit Score: 315.47  E-value: 5.68e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 101 AIGYFSYDciryieklpslaeddlNIPDIFFLLFDDVFVYD-QEEKVLWIITHyvdkhaeaeERLHEWKNLWAAEVPEVt 179
Cdd:TIGR00553   1 LVGYLSYE----------------AGPDAAFEPYDAALLADhRRTPLLRFLVF---------ERVEAQPRAAVEAEDDA- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 180 mPFERPEKKNEA-VAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSPYMGYLELGDFQI 258
Cdd:TIGR00553  55 -PADRQAPTSDIqSEMTRAEYGEAIDQLQDYIRAGDCYQANLTQQFHATWDGDPLAAFRKLRRRQPAPFSAFLDLGDGAI 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 259 VSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMVIE 338
Cdd:TIGR00553 134 LSLSPELFFSIDGSEIETRPIKGTLPRGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLGRIAEVGSVKVPELFVVE 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 339 KYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTL 418
Cdd:TIGR00553 214 TYPTVHQLVSTITARLREDLTLSDLFRALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIGYLSPEGDMDFNVAIRTL 293

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1586385893 419 LAKDGQAHVQAGAGIVIDSNPKNEYKESLKKA 450
Cdd:TIGR00553 294 TLDGGRAVYGVGGGIVADSDPEAEYRECLLKA 325
pabB PRK15465
aminodeoxychorismate synthase component 1;
4-449 1.43e-101

aminodeoxychorismate synthase component 1;


Pssm-ID: 185362 [Multi-domain]  Cd Length: 453  Bit Score: 311.08  E-value: 1.43e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893   4 RKSLA---LSIPYQLDFFKQYKFLSQDKPQHILLESGRG----GRYNIVGLNPVAVIQGKGETLHISESGKETIKRGNPL 76
Cdd:PRK15465    1 MKTLSpavITLPWRQDAAEFYFSRLSHLPWAMLLHSGYAdhpySRFDIVVADPICTLTTFGKETVVSESEKRTTTTDDPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  77 DLMQEYMEKwkTDYNPEYT---PFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIITHy 153
Cdd:PRK15465   81 QVLQQVLDR--ADIRPTHNedlPFQGGALGLFGYDLGRRFESLPEIAEQDIVLPDMAVGIYDWALIVDHQRQTVSLLSH- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 154 vdkhAEAEERLhEWknlWAAEVPEVTMPFERPE--KKNeavaFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTH 231
Cdd:PRK15465  158 ----NDVNARR-AW---LESQQFSPQEDFTLTSdwQSN----MTREQYGEKFRQVQEYLHSGDCYQVNLAQRFHATYSGD 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 232 PLEIYTSLRKINPSPYMGYLELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVM 311
Cdd:PRK15465  226 EWQAFLQLNQANRAPFSAFLRLEQGAILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLM 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 312 LVDLERNDLGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPV 391
Cdd:PRK15465  306 IVDLMRNDIGRVAVAGSVKVPELFVVEPFPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQ 385

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1586385893 392 RRGIYTGSIGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKK 449
Cdd:PRK15465  386 RRNAWCGSIGYLSFCGNMDTSITIRTLTAINGQIYCSAGGGIVADSQEEAEYQETFDK 443
PRK13564 PRK13564
anthranilate synthase component 1;
3-456 2.51e-96

anthranilate synthase component 1;


Pssm-ID: 237428 [Multi-domain]  Cd Length: 520  Bit Score: 299.83  E-value: 2.51e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893   3 RRKSLALSIPYQLDFFKQYKFLSQDKPQHILLES----------------------GRGGRYNIVGLNP----------- 49
Cdd:PRK13564    7 TLELLTCKAPYREDPTALFHQLCGDRPATLLLESaeidskdnlkslllvdsalritCLGNTVTIQALTDngaallpllde 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  50 ------VAVIQGKGETLHISESGKET-----IKRGNPLDLMQEYMEKWKTDYNPEYTPFQGGAigyFSYDCIRYIEKLPS 118
Cdd:PRK13564   87 alpagvENEQDPNGLVLTFPPVSPLLdedarLKSLSVFDALRLLQKLVNTPKEEREALFLGGL---FAYDLVAGFEPLPQ 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 119 LAEDDlNIPDIFFLLFDDVFVYDQEEKVLWIITH-YVDKHAEA---EERLHEWKNLWAAEVPEVtmPFERPEKKNEAVAF 194
Cdd:PRK13564  164 LPAGN-NCPDYCFYLAETLLVIDHQKKSARLQASlFTPDEEEKqrlAARLAQLKQQLTQPAPPL--PVTSVPDMEVSVNI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 195 TEEGFMKAVERIQEYIGNGDVFQVNLStrqeRTLQT---HPLEIYTSLRKINPSPYMGYLELGDFQIVSASPELLIKkqg 271
Cdd:PRK13564  241 SDEEFCAVVRKLKEHIRAGDIFQVVPS----RRFSLpcpSPLAAYRVLKKSNPSPYMFYMQDEDFTLFGASPESALK--- 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 272 QEVSTR-----PIAGTRSRGANEQE--DEEL-AR---ELIENEKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMVIEKY 340
Cdd:PRK13564  314 YDASSRqveiyPIAGTRPRGRRADGsiDRDLdSRielELRTDHKELAEHLMLVDLARNDLARICQPGSRYVADLLKVDRY 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 341 SHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTLLA 420
Cdd:PRK13564  394 SHVMHLVSRVVGELRHDLDALHAYRACMNMGTLTGAPKVRAMQLIREVEGQRRGSYGGAVGYLTGHGDLDTCIVIRSAFV 473

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1586385893 421 KDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:PRK13564  474 ENGIATVQAGAGVVLDSDPQSEADETRNKAQAVLRA 509
PRK13567 PRK13567
anthranilate synthase component I; Provisional
 24-453 4.95e-89

anthranilate synthase component I; Provisional


Pssm-ID: 184148 [Multi-domain]  Cd Length: 468  Bit Score: 279.34  E-value: 4.95e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  24 LSQDKPQHILLESGR----GGRYNIVGLNPVAVIQGKGETLHISESGKETIKRGNPLDLMQEYMEKWKTDYNPEYT---P 96
Cdd:PRK13567   17 LAQLHSKKIILESTNqqqtKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQITERPYHYLTTKINEDYHNIQDEQLkslP 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  97 FQGGAIGYFSYDCIRY-IEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIIT--HYVDKH-AEAEERL-HEWKNLW 171
Cdd:PRK13567   97 FISGYVGTCSFDLVRHeFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHYKDELYIIAtnQFSNSTkSDLENRVnKSIEDLT 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 172 AAEVPEVTMPFErPEKKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVN----LSTRQERTLQTHPL--EIYTSLRKINPS 245
Cdd:PRK13567  177 KIQPFMPTQDFD-FKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVpsriYKYAHHASQHLNQLsfQLYQNLKRQNPS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 246 PYMGYLELGDFQIVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCK 325
Cdd:PRK13567  256 PYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSK 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 326 YGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGY 405
Cdd:PRK13567  336 IGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINC 415

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1586385893 406 SGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIAL 453
Cdd:PRK13567  416 NHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSL 463
trpE_proteo TIGR00565
anthranilate synthase component I, proteobacterial subset; This enzyme resembles some other ...
 90-456 1.25e-84

anthranilate synthase component I, proteobacterial subset; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. This group includes proteobacteria such as E. coli and Helicobacter pylori but also the gram-positive organism Corynebacterium glutamicum. The second group includes eukaryotes, archaea, and most other bacterial lineages; sequences from the second group may resemble pabB more closely than other trpE from this group. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273143 [Multi-domain]  Cd Length: 498  Bit Score: 268.69  E-value: 1.25e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  90 YNPEYTPFQGGAIGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWIITHYVDKHAEaEERLHEWKN 169
Cdd:TIGR00565 118 KTKPKHPFTLFSGGLFSYDLVAFFEDLPHLKAKNNNCPDFIFYLAENLIIIDHQEKSVEILGACFAERFE-TQIAQALQD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 170 LWAAEVPEVTMPFERPEKKNEAVA--FTEEGFMKAVERIQEYIGNGDVFQVNLStRQERTLQTHPLEIYTSLRKINPSPY 247
Cdd:TIGR00565 197 LKELQKSIKSDFVPKKSKQSREVSanCSDSEFEGRVLSLQEEIKKGEIFQAVPS-RRFSLECPEGLAAYYHLKLTNPSPY 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 248 MGYLELGDFQIVSASPELLIK--KQGQEVSTRPIAGTRSRGANEQE------DEELARELIENEKERAEHVMLVDLERND 319
Cdd:TIGR00565 276 MFYMKDSDFILFGASPESALKynALTRQAEIYPIAGTRPRGKDAQGnidydlDSRMELELRHDHKERAEHLMLVDLARND 355

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 320 LGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGS 399
Cdd:TIGR00565 356 MARVCKSGKRYVAKLLKVDRYSNVMHLVSRVVGELRKGLDALHAYRACMNMGTLSGAPKISAMQLIYQLENQRRGSYGGA 435

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1586385893 400 IGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:TIGR00565 436 VGYLTSEGSMDTCIVIRSAFVKNGRAVVQAGAGIVLDSVPQNEADETRAKAQAVLDA 492
PRK07508 PRK07508
aminodeoxychorismate synthase component I;
103-450 2.99e-83

aminodeoxychorismate synthase component I;


Pssm-ID: 236035 [Multi-domain]  Cd Length: 378  Bit Score: 261.48  E-value: 2.99e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 103 GYFSYDCIRYIE-KLPSLAEDDLNIPDIFFLLFDDvfvyDQEEkvlwiiTHYVDKHAEAEERLHEWKNLWAaevpevtmp 181
Cdd:PRK07508   50 GYLSYEAGYLLEpKLAPLMPEGRETPLLCFGVFDA----PSPE------APAPARPSENAARLRDPVARWD--------- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 182 feRPEkkneavafteegFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTSLRKINPSPYMGYLELGDFQIVSA 261
Cdd:PRK07508  111 --FAD------------YAQRFERLHRHIRAGDCYQANLTFPLDARWGGDPLALFWALAARQPVGYGALVDLGGPVILSR 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 262 SPELLIKKQGQE-VSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMVIEKY 340
Cdd:PRK07508  177 SPELFFRVDGEGwIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPELFDIETY 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 341 SHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTL-L 419
Cdd:PRK07508  257 PTVHQMVSRVRARLLPGLGLADIFAALFPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGRMRFNVAIRTLsL 336

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1586385893 420 AKDGQAHVQAGAGIVIDSNPKNEYKESLKKA 450
Cdd:PRK07508  337 FPGGRAVFNVGGGIVFDSTAEAEYEECLLKA 367
PLN02889 PLN02889
oxo-acid-lyase/anthranilate synthase
 97-452 4.00e-74

oxo-acid-lyase/anthranilate synthase


Pssm-ID: 215481 [Multi-domain]  Cd Length: 918  Bit Score: 250.15  E-value: 4.00e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  97 FQGGAIGYFSYD----CIRYIEKLPSlaeddlNIPDIFFLLFDDVFVYDQEEKVLWIITHYVDKHAE------AEERLHE 166
Cdd:PLN02889  538 FHGGYVGYIGYDlkveCGMASNRHKS------TTPDACFFFADNVVVIDHHYDDVYILSLHEGSTATtqwlddTEQKLLG 611

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 167 WKNLWAAEVPEVTMPF--ERPEKKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTL-QTHPLEIYTSLRKIN 243
Cdd:PLN02889  612 LKASATRKLEVQTSPTatFSPSKAGFLADKSREQYIKDVQKCLKYIKDGESYELCLTTQMRKRIgEIDSLGLYLHLREKN 691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 244 PSPYMGYLELG--DFQIVSASPELLIKKQGQEV-STRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDL 320
Cdd:PLN02889  692 PAPYAAWLNFSneNLCICSSSPERFLKLDRNGMlEAKPIKGTIARGSTPEEDEQLKLQLQYSEKDQAENLMIVDLLRNDL 771

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 321 GRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSI 400
Cdd:PLN02889  772 GRVCEPGSVHVPNLMDVESYTTVHTMVSTIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLRSMELLDSLESSSRGIYSGSI 851

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1586385893 401 GWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIA 452
Cdd:PLN02889  852 GFFSYNQTFDLNIVIRTVVIHEGEASIGAGGAIVALSNPEDEYEEMILKTRA 903
PRK05877 PRK05877
aminodeoxychorismate synthase component I; Provisional
 201-453 1.45e-65

aminodeoxychorismate synthase component I; Provisional


Pssm-ID: 235634 [Multi-domain]  Cd Length: 405  Bit Score: 216.49  E-value: 1.45e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 201 KAVERIQEYIGNGDVFQVNLSTRQERTLQTHPLEIYTS-LRKINPSpYMGYLElGDF-QIVSASPELLIKKQGQEVSTRP 278
Cdd:PRK05877  146 DGVLACLEAIAAGEVYQACVCTQFTGTVTGSPLDFFADgVARTAPA-RAAYLA-GDWgAVASLSPELFLRRRGSVVTSSP 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 279 IAGTRSRGANEqedEELARELieneKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDK 358
Cdd:PRK05877  224 IKGTLPLDADP---SALRASA----KDVAENIMIVDLVRNDLGRVARTGTVTVPELLVVRPAPGVWHLVSTVSAQVPDEL 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 359 DAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTL-LAKDGQAHVQAGAGIVIDS 437
Cdd:PRK05877  297 PMSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASPVAGCELNVAIRTVeFDADGNAVLGVGGGITADS 376

                         250
                  ....*....|....*.
gi 1586385893 438 NPKNEYKESLKKAIAL 453
Cdd:PRK05877  377 DPDAEWQECLHKAAPI 392
PRK13566 PRK13566
anthranilate synthase component I;
100-456 3.01e-60

anthranilate synthase component I;


Pssm-ID: 237429 [Multi-domain]  Cd Length: 720  Bit Score: 209.39  E-value: 3.01e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 100 GAIGY---FSYDCIRYieKLPSLAEDDlnipDIFFLLFDDVFVYDQEEKVLWIITH-YVDKHAEAEerlhewkNLwAAEV 175
Cdd:PRK13566  159 GAFGYdlaFQFEPIEQ--KLPRPDDQR----DLVLYLPDEILVVDHYAARAWVDRYeFAVGGVSTE-------GL-PRET 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 176 PEVtmPFeRPEKKNEAVAFTEEG-FMKAVERIQEYIGNGDVFQV----NLSTRQERTlqthPLEIYTSLRKINPSPYMGY 250
Cdd:PRK13566  225 APS--PY-KPTTARPGFADHAPGeYAALVEKAKESFRRGDLFEVvpgqTFYEPCERS----PSEIFRRLKEINPSPYGFF 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 251 LELGDFQ-IVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTV 329
Cdd:PRK13566  298 INLGDGEyLVGASPEMFVRVEGRRVETCPISGTIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCEPGSV 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 330 EVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFD--LVK--AVfpggTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGY 405
Cdd:PRK13566  378 KVIGRRQIEMYSRLIHTVDHVEGRLRPGFDALDafLTHawAV----TVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGF 453

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1586385893 406 SGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:PRK13566  454 DGDMNTGLTLRTIRIKDGVAEVRVGATLLFDSDPEAEEAETELKASALLQA 504
PabB-fungal TIGR01823
aminodeoxychorismate synthase, fungal clade; This model represents the fungal clade of a ...
 29-450 1.50e-59

aminodeoxychorismate synthase, fungal clade; This model represents the fungal clade of a para-aminobenzoate synthesis enzyme, aminodeoxychorismate synthase, which acts on chorismate in a pathway that yields PABA, a precursor of folate.


Pssm-ID: 273821 [Multi-domain]  Cd Length: 742  Bit Score: 207.84  E-value: 1.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  29 PQHILLESGRGGRYNIVGLnPVAVIQG-------KGETLHI---SESGKETIKRGNPL-----------DLMQEYMEKWK 87
Cdd:TIGR01823 275 PKFVMSSSVITGRYSIIAL-PNSASQVfthygamLKTTVHYwqdTEISYTRLKKCLSGvdsdldksqfwITLGKFMENKK 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  88 TDYNPEYTPFQGGAIGYFSYDCIRYIE-KLPSLAEDDLN----IPDIFFLLFDDVFVYDQEEKVLWIITHYVDKHAEAEE 162
Cdd:TIGR01823 354 IDNPHREIPFIGGLVGILGYEIGSDLStQYIACGRCNDDenslVPDAKLVFINRSIVIDHKQGKLYVQSLDNTFPVALEW 433

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 163 rlheWKNLWAAEV------PEVTMPFERPEKKNEAVAF-TEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQ---THP 232
Cdd:TIGR01823 434 ----SGELRDSFVrkknikQSLSWPFYLPEEIDFVITFpDKEDYAKAFKACQDYLHAGDSYEMCLTTQTKVVPPaviSPD 509

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 233 LEIYTSLRKINPSPYMGYLELGDFQIVSASPELLIKKQGQE-VSTRPIAGTRSRGanEQEDEELARELIENEKERAEHVM 311
Cdd:TIGR01823 510 WEIYQRLRQRNPAPFSGFFRLKHIIFLSTSPEKFLEVGMDThAKLRPIKGTVKKG--PQMNLEKARRILKTPKEMGENLM 587

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 312 LVDLERNDLGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDK------DAFDLVKAVFPGGTITGAPKIRTMEII 385
Cdd:TIGR01823 588 ILDLIRNDLYELVPKNDVHVEELMSVEEHATVYQLVSVVKAHGLTSAskktrySGIDVLKHSLPPGSMTGAPKKRSVQLL 667

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586385893 386 EELEPVRRGIYTGSIGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAG--IVIDSNPKNEYKESLKKA 450
Cdd:TIGR01823 668 QDVEGGARGIYSGVTGYWDVNGNGDFSVNIRCAFSYNGGTSWRIGAGgaVTVLSTPEGELEEMYNKL 734
MenF COG1169
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ...
 195-456 9.25e-59

Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440783 [Multi-domain]  Cd Length: 353  Bit Score: 196.91  E-value: 9.25e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 195 TEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLqTHPLEIYTS---LRKINPSPYMGYLELGDFQI-VSASPELLIKKQ 270
Cdd:COG1169    87 DPAEWREAVAQALEAIRAGELDKVVLARALDLTL-DEPIDPRALlarLRRRNPDCYTFAVELGAGDGfVGASPERLVRRR 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 271 GQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKygTVEVDEFMVIEKYSHVMHIVSNV 350
Cdd:COG1169   166 GGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREALAPLCS--SLDVPEEPELLRLRNVQHLATPI 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 351 RGEVEEDKDAFDLVKAVFP----GGTitgaPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTLLAKDGQAH 426
Cdd:COG1169   244 TGTLDPGVSALDLAAALHPtpavGGT----PREAALALIRELEPFDRGWYAGPVGWVDADGDGEFAVAIRSALIDGNRAR 319

                         250       260       270
                  ....*....|....*....|....*....|
gi 1586385893 427 VQAGAGIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:COG1169   320 LFAGAGIVAGSDPEAEWAETEAKLRTMLRA 349
PRK06404 PRK06404
anthranilate synthase component I; Reviewed
 187-450 7.98e-57

anthranilate synthase component I; Reviewed


Pssm-ID: 102361 [Multi-domain]  Cd Length: 351  Bit Score: 192.01  E-value: 7.98e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 187 KKNEAVAFTEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQthPLEIYTSLRKINPSPYMGYLELGDFQIVSASPELL 266
Cdd:PRK06404   95 TVKLKGNYNDISLSLKIKELIELIRAGEVLQVVISREFEANID--FKEKLSEFINNDRSRYVFYYRFGKYRVVGSSPENV 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 267 IKKQGQEVSTRPIAGTRSrganeqeDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMVIEKYSHVMHI 346
Cdd:PRK06404  173 FTVNGNIINVDPIAGTYD-------DKILSNELLNSEKDKLEHRMLLDLARNDLSKFADIGTLNVDKVMKIEEFSSVKHL 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 347 VSNVRGEVeEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGySGDTELNIVIRTLLAKDGQAH 426
Cdd:PRK06404  246 VSQVTAKF-SNASYRDILASMFPAGTVSGSPKERAIEIINKYEETPRGPYGGAIGIIS-KGYTDMALVIRTAYSHGNGFR 323

                         250       260
                  ....*....|....*....|....
gi 1586385893 427 VQAGAGIVIDSNPKNEYKESLKKA 450
Cdd:PRK06404  324 VRAGAGIVKDSDPEDEVNEIYSKA 347
isochor_syn TIGR00543
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ...
 195-456 4.16e-48

isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273127  Cd Length: 351  Bit Score: 168.70  E-value: 4.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 195 TEEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQT--HPLEIYTSLRKINPSPYMGYLELGDFQI-VSASPELLIKKQG 271
Cdd:TIGR00543  88 DKAAWRTAVEEALENIRQGPLDKVVLARALTLKFADdiDPIAVLANLRQQYPNAYIFLLEPPQGGVfLGATPERLLSREK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 272 QEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKygTVEVDEFMVIEKYSHVMHIVSNVR 351
Cdd:TIGR00543 168 GELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPICT--SLDVSETPELLKLANVQHLYTPIS 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 352 GEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTLLAKDGQAHVQAGA 431
Cdd:TIGR00543 246 ARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLDGEGNGEFAVGIRSALVEDGQVRLYAGA 325

                         250       260
                  ....*....|....*....|....*
gi 1586385893 432 GIVIDSNPKNEYKESLKKAIALWRA 456
Cdd:TIGR00543 326 GIVADSDPESEWEETELKLQTMLRA 350
PRK07093 PRK07093
para-aminobenzoate synthase component I; Validated
 175-449 1.12e-39

para-aminobenzoate synthase component I; Validated


Pssm-ID: 235932 [Multi-domain]  Cd Length: 323  Bit Score: 145.40  E-value: 1.12e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 175 VPEVTMPFERPEKKNEAVAFTEegFMKAVERIQEYIGNGDVFQVNLstrqertlqTHPLEIYT--SLRKI---NPSPYMG 249
Cdd:PRK07093   54 VPSQVRPHKPFELQKEPISFEE--YQQGFELVQEEIQAGNSYLLNL---------TYPTPIETnlSLEEIfqaSKAKYKL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 250 YLElGDFqiVSASPELLIKKQGQEVSTRPIAGTRSrgANEQEDEELareLIENEKERAEHVMLVDLERNDLGRVCKYgtV 329
Cdd:PRK07093  123 LFK-DQF--VCFSPEPFVRIEDNKISTYPMKGTID--ASLPNAEEK---LLNDEKEFAEHATIVDLLRNDLSMVAKN--V 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 330 EVDEFMVIEKYS----HVMHIVSNVRGEVEEDKDAF--DLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWi 403
Cdd:PRK07093  193 RVTRFRYIDKIKtnkgEILQTSSEISGTLPENWQENigDILAKLLPAGSITGAPKEKTVEIIEQAEGYERGFYTGVFGY- 271

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1586385893 404 gYSGDTeLN--IVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKK 449
Cdd:PRK07093  272 -FDGES-LDsaVMIRFIEQENDGLYFKSGGGITIDSDLKDEYNELIQK 317
Anth_synt_I_N pfam04715
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) ...
 26-149 6.22e-35

Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) catalyzes the first step in the biosynthesis of tryptophan. Component I catalyzes the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (pfam00425). This region is involved in feedback inhibition by tryptophan. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).


Pssm-ID: 428082 [Multi-domain]  Cd Length: 140  Bit Score: 127.04  E-value: 6.22e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893  26 QDKPQHILLESGRG--GRYNIVGLNPVAVIQGK-GETLHISESGKETIKRGNPLDLMQEYMEK-WKTDYNPEYTPFQGGA 101
Cdd:pfam04715  13 AGEPHSFLLESAEGgeGRYSFIGINPLLTIKSKnGEVSVSGPDGQELEQEDGPLDALRALLARfRIEDSPPTLPPFSGGL 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1586385893 102 IGYFSYDCIRYIEKLPSLAEDDLNIPDIFFLLFDDVFVYDQEEKVLWI 149
Cdd:pfam04715  93 VGYLGYDLVRYIEKLPRTAPDDLNLPDARLILYEDLIVFDHQENKLYL 140
PRK07054 PRK07054
isochorismate synthase;
201-448 1.23e-34

isochorismate synthase;


Pssm-ID: 235920 [Multi-domain]  Cd Length: 475  Bit Score: 134.89  E-value: 1.23e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 201 KAVERIQEyignGDVFQVNLSTRQERTLqTHPLEIYT---SLRKINPSPYMGYLELGDFQIVSASPELLIKKQGQEVSTR 277
Cdd:PRK07054  203 RAVDAIRG----GAFGKVVLARDVLQQY-ARPVAIGPllrRLRLRDPHAHLFAFRRGNACFLGATPERLVRVAAGDLHTH 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 278 PIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKygTVEVDEFMVIEKYSHVMHIVSNVRGEVEED 357
Cdd:PRK07054  278 ALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDAIRAALAPLSR--ALDIPDQPSLHRLPRLQHLSTPIRATLAPD 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 358 KDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIVIDS 437
Cdd:PRK07054  356 ATLLQVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGWYAAPIGWLDAHGNGDFAVALRSALITGGACRLFAGCGIVADS 435

                         250
                  ....*....|..
gi 1586385893 438 NPKNEYKES-LK 448
Cdd:PRK07054  436 EPASEYRETcLK 447
PRK06923 PRK06923
isochorismate synthase DhbC; Validated
 175-449 3.04e-33

isochorismate synthase DhbC; Validated


Pssm-ID: 235886 [Multi-domain]  Cd Length: 399  Bit Score: 129.47  E-value: 3.04e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 175 VPEVTMPFER-------PEKKNEAVAFT------EEGFMKAVERIQEYIGNGDVFQVNLStrqeRTLQ---THPLEIYTS 238
Cdd:PRK06923   87 VPEYSRISERlqldttnHLEINRNLTFEmtpvpdPEVYMNGVKQGIAKIQDGDLKKIVLS----RSLDvksSEKIDKQKL 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 239 LRKI---NPSPYMGYLELGDFQ------IVSASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEH 309
Cdd:PRK06923  163 LRELaehNKHGYTFAVNLPKDEnensktLIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEH 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 310 VMLVDLERNDLGRVCKygTVEVDEFMVIEKYSHVMHIVSNVRGEVEE-DKDAFDLVKAVFPGGTITGAPKIRTMEIIEEL 388
Cdd:PRK06923  243 AVVVEAVAAALRPYCH--TLHVPEKPSVIHTEAMWHLSTEVKGELKDpNTSSLELAIALHPTPAVCGTPTEEAREAIQQI 320

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1586385893 389 EPVRRGIYTGSIGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKK 449
Cdd:PRK06923  321 EPFDREFFTGMLGWSDLNGDGEWIVTIRCAEVEENTLRLYAGAGVVAESKPEDELAETSAK 381
PRK06772 PRK06772
salicylate synthase;
262-449 1.90e-29

salicylate synthase;


Pssm-ID: 102546 [Multi-domain]  Cd Length: 434  Bit Score: 119.46  E-value: 1.90e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 262 SPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMVIEKYS 341
Cdd:PRK06772  238 SPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCQPGSVVVEDLMSVRQRG 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 342 HVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIgysGDTELN--IVIRTLL 419
Cdd:PRK06772  318 SVQHLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLL---DDTRFDaaLVLRSVF 394

                         170       180       190
                  ....*....|....*....|....*....|
gi 1586385893 420 AKDGQAHVQAGAGIVIDSNPKNEYKESLKK 449
Cdd:PRK06772  395 QDSQRCWIQAGAGIIAQSTPERELTETREK 424
PLN02786 PLN02786
isochorismate synthase
 202-445 8.28e-29

isochorismate synthase


Pssm-ID: 178383 [Multi-domain]  Cd Length: 533  Bit Score: 119.12  E-value: 8.28e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 202 AVERIQEYIGNG--DVFQVNL--STRQERTLQTHPLEIYTSLRKINPSPYMGYLELGDF-QIVSASPELLIKKQGQEVST 276
Cdd:PLN02786  265 AVNKALQIIKRKssPLKKVVLarSSRIITDTDIDPIAWLACLQVEGQNAYQFCLQPPDApAFIGNTPEQLFHRKGLGVCS 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 277 RPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKygTVEVDEFMVIEKYSHVMHIVSNVRGEVEE 356
Cdd:PLN02786  345 EALAATRPRGGSSARDLQIELDLLTSPKDDLEFSIVRENIREKLEAICD--RVVVEPHKAIRKLARVQHLYAQLAGRLRS 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 357 DKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGySGDTELNIVIRTLLAKDGQ-AHVQAGAGIVI 435
Cdd:PLN02786  423 EDDEFDILAALHPTPAVCGHPTEEARLLIAETESFDRGMYAGPVGWFG-GGESEFAVGIRSALVEKGLgALIYAGTGIVE 501

                         250
                  ....*....|
gi 1586385893 436 DSNPKNEYKE 445
Cdd:PLN02786  502 GSNPSSEWNE 511
PRK07912 PRK07912
salicylate synthase;
251-449 3.76e-28

salicylate synthase;


Pssm-ID: 169151 [Multi-domain]  Cd Length: 449  Bit Score: 116.04  E-value: 3.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 251 LELGDFQIVSASPELL--IKKQGQeVSTRPIAGTRS--RGAneqEDEELARE-LIENEKERAEHVMLVDLERNDLGRVCK 325
Cdd:PRK07912  238 LRLGGIRALGYSPELVtaVRADGV-VITEPLAGTRAfgRGA---AIDRLARDdLESNSKEIVEHAISVRSSLAEITEIAE 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 326 YGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGY 405
Cdd:PRK07912  314 PGSAAVIDFMTVRERGSVQHLGSTVRGRLDASSDRMDALEALFPAVTASGIPKAAGVDAIFRLDEAPRGLYSGAVVMLSA 393

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1586385893 406 SGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKESLKK 449
Cdd:PRK07912  394 DGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEK 437
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 175-446 1.73e-25

isochorismate synthase EntC; Provisional


Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 107.65  E-value: 1.73e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 175 VPEVTMPFERPEKKNEAVAFT---------------EEGFMKAVERIQEYIGNGDVFQVNLSTRQERTLQTHP--LEIYT 237
Cdd:PRK15016   90 IPESWQSFSRQEKQRSARRFTrsqslnvverqaipeQTTFEAMVARAAALTATPQVDKVVLSRLIDITTDAAIdsGALLE 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 238 SLRKINPSPYMGYLELGDFQIV-SASPELLIKKQGQEVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDLE 316
Cdd:PRK15016  170 RLIAQNPVSYNFHVPLADGGVLlGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAM 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 317 RNDLG-RVCKYGTVEVDEFMVIEKyshVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGI 395
Cdd:PRK15016  250 KEVLReRSSELHVPSSPQLITTPT---LWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELEPFDREL 326

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1586385893 396 YTGSIGWIGYSGDTELNIVIRTLLAKDGQAHVQAGAGIVIDSNPKNEYKES 446
Cdd:PRK15016  327 FGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRET 377
PRK15012 PRK15012
menaquinone-specific isochorismate synthase; Provisional
 198-453 9.50e-10

menaquinone-specific isochorismate synthase; Provisional


Pssm-ID: 184974 [Multi-domain]  Cd Length: 431  Bit Score: 60.24  E-value: 9.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 198 GFMKAVERIQEYIGNGDVFQVNLSTRQErtLQ-THPLE---IYTSLRKINPSPYMGYLEL-GDFQIVSASPELLIKKQGQ 272
Cdd:PRK15012  171 GWTQLIELATKTIAEGELDKVVLARATD--LHfASPVNaaaMMAASRRLNLNCYHFYMAFdAENAFLGSSPERLWRRRDK 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 273 EVSTRPIAGTRSRGANEQEDEELARELIENEKERAEHVMLVDlernDLGRVCKYGTVEVD----EFMVIEKyshVMHIVS 348
Cdd:PRK15012  249 ALRTEALAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVE----DICQRLQADTQTLDvlppQVLRLRK---VQHLRR 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586385893 349 NVRGEVEEDKDAFDLVKaVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSgDTELNIVIRTLLAKDGQAHVQ 428
Cdd:PRK15012  322 CIWTSLNKADDVICLHQ-LQPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQ-QSEFCVSLRSAKVSGNVVRLY 399

                         250       260
                  ....*....|....*....|....*
gi 1586385893 429 AGAGIVIDSNPKNEYKESLKKAIAL 453
Cdd:PRK15012  400 AGAGIVRGSDPEQEWQEIDNKAAGL 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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