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Conserved domains on  [gi|1589111042|gb|TCT75028|]
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siderophore synthetase component [Vibrio crassostreae]

Protein Classification

IucA/IucC family siderophore biosynthesis protein( domain architecture ID 1004190)

IucA/IucC family siderophore biosynthesis protein similar to Klebsiella pneumoniae Aerobactin Synthetase IucA that catalyzes the condensation of citrate and hydroxylamine, serving as a surrogate nucleophile, to produce the corresponding citryl hydroxamate, PPi, and AMP

Gene Ontology:  GO:0019290

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
IucA super family cl34746
Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];
8-583 1.50e-54

Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG4264:

Pssm-ID: 443406 [Multi-domain]  Cd Length: 590  Bit Score: 195.16  E-value: 1.50e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042   8 LTQRLVDTCLREDLFGLVSQSQFKSQLPSALKLSsyprnqiwavFAGSDFTLYLPVTPSYYMQRWVYgqtdgsKGDGWLI 87
Cdd:COG4264    13 LLRKLLNELLRERLLAPEPEGELEDDGGGVYRLP----------LPAGGVEYRFPARRRSAFGRHRF------DPGSIYR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042  88 ERNGVVEAQqHYQDWIELLKvSAHESSHSLLDGYLQELECaekhkglcdsafSQHSEALMLpiSQLERWEQKLLLAdqiA 167
Cdd:COG4264    77 TEDGAWRPL-DALQLLALLL-EELGIDDETLAELLEELLN------------SLANDALAL--AHRRLSAADLAAA---L 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 168 SYLD--------HPYYPTARAKFGLSDHDLEQFAPEFAQSFELRWLAIEKSLVTLTSPQ-------------PECW---- 222
Cdd:COG4264   138 DFIEleqaltegHPLHPAPKSRIGFSAEDYRRYAPEFGGPFRLHWLAVHRDLARFGSAEgldydellaeelgPDTLarfa 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 223 PTMAQVGLPADfalSHELFPAHPL----TLQSLeslpdcvIEAPVA-----CL-----EVTPTLSVRTVV-VNTAPQVHI 287
Cdd:COG4264   218 AELAALGLDPD---DYVLLPVHPWqwenLLAPL-------FAAEIArgrlvPLgeggdEYLPTQSIRTLYnASRPSKPYV 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 288 KVPLIMRSLGTknIRLIKPSTLYDGHWFERLLTHLEQTDKDLRGTLFH-CNE------KHGGHVGDD-----KTFAYIVR 355
Cdd:COG4264   288 KLSLSVLNTNS--VRGLSPKELERGPAISRWLAELLAQDPYLRDPGFTiLREpagigyRHPDYEEGAgyqyrEMLGAIWR 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 356 EYPLSYFQ-DKALVPVAALASPMPDERLFLEHLAEQYYQQN-TLTWFKDYVDLLCKVHLTLWIRYGIALESNQQNAIIAF 433
Cdd:COG4264   366 ENPFPLLEpGERAIPMAALLHDDPDGRPLLAALIERSGLREaAEAWFRRYLDVVLPPLLHLLYRYGIALEAHGQNSVLVL 445

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 434 NEQGKMTLAMKDNDAARIWPERFqtfeQQSPVKCDHLLDQRI--TVDNELALgQMFTTITLQLDIAAIVEAMATKGIATS 511
Cdd:COG4264   446 DDGVPVRLLLRDFQGVRLSEPRL----PELGEALPDLVERRVllTVPDEELR-LRIFYYLFVNNLRELIAALAEHGLLDE 520

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1589111042 512 AYLYEMVANSLSQQLSQLDkqGHNTKLANEMLFeSPNLYAKYLLSSGSLLSKEASGASDINKFYGlSAPNFL 583
Cdd:COG4264   521 ERFWRLVREVLEAYQARHP--ELAERFARFLLF-APTLPRKCLLRTRLRNNGELDDLAPSLAVYG-TLPNPL 588
 
Name Accession Description Interval E-value
IucA COG4264
Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];
8-583 1.50e-54

Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];


Pssm-ID: 443406 [Multi-domain]  Cd Length: 590  Bit Score: 195.16  E-value: 1.50e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042   8 LTQRLVDTCLREDLFGLVSQSQFKSQLPSALKLSsyprnqiwavFAGSDFTLYLPVTPSYYMQRWVYgqtdgsKGDGWLI 87
Cdd:COG4264    13 LLRKLLNELLRERLLAPEPEGELEDDGGGVYRLP----------LPAGGVEYRFPARRRSAFGRHRF------DPGSIYR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042  88 ERNGVVEAQqHYQDWIELLKvSAHESSHSLLDGYLQELECaekhkglcdsafSQHSEALMLpiSQLERWEQKLLLAdqiA 167
Cdd:COG4264    77 TEDGAWRPL-DALQLLALLL-EELGIDDETLAELLEELLN------------SLANDALAL--AHRRLSAADLAAA---L 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 168 SYLD--------HPYYPTARAKFGLSDHDLEQFAPEFAQSFELRWLAIEKSLVTLTSPQ-------------PECW---- 222
Cdd:COG4264   138 DFIEleqaltegHPLHPAPKSRIGFSAEDYRRYAPEFGGPFRLHWLAVHRDLARFGSAEgldydellaeelgPDTLarfa 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 223 PTMAQVGLPADfalSHELFPAHPL----TLQSLeslpdcvIEAPVA-----CL-----EVTPTLSVRTVV-VNTAPQVHI 287
Cdd:COG4264   218 AELAALGLDPD---DYVLLPVHPWqwenLLAPL-------FAAEIArgrlvPLgeggdEYLPTQSIRTLYnASRPSKPYV 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 288 KVPLIMRSLGTknIRLIKPSTLYDGHWFERLLTHLEQTDKDLRGTLFH-CNE------KHGGHVGDD-----KTFAYIVR 355
Cdd:COG4264   288 KLSLSVLNTNS--VRGLSPKELERGPAISRWLAELLAQDPYLRDPGFTiLREpagigyRHPDYEEGAgyqyrEMLGAIWR 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 356 EYPLSYFQ-DKALVPVAALASPMPDERLFLEHLAEQYYQQN-TLTWFKDYVDLLCKVHLTLWIRYGIALESNQQNAIIAF 433
Cdd:COG4264   366 ENPFPLLEpGERAIPMAALLHDDPDGRPLLAALIERSGLREaAEAWFRRYLDVVLPPLLHLLYRYGIALEAHGQNSVLVL 445

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 434 NEQGKMTLAMKDNDAARIWPERFqtfeQQSPVKCDHLLDQRI--TVDNELALgQMFTTITLQLDIAAIVEAMATKGIATS 511
Cdd:COG4264   446 DDGVPVRLLLRDFQGVRLSEPRL----PELGEALPDLVERRVllTVPDEELR-LRIFYYLFVNNLRELIAALAEHGLLDE 520

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1589111042 512 AYLYEMVANSLSQQLSQLDkqGHNTKLANEMLFeSPNLYAKYLLSSGSLLSKEASGASDINKFYGlSAPNFL 583
Cdd:COG4264   521 ERFWRLVREVLEAYQARHP--ELAERFARFLLF-APTLPRKCLLRTRLRNNGELDDLAPSLAVYG-TLPNPL 588
IucA_IucC pfam04183
IucA / IucC family; IucA and IucC catalyze discrete steps in biosynthesis of the siderophore ...
 155-374 1.14e-26

IucA / IucC family; IucA and IucC catalyze discrete steps in biosynthesis of the siderophore aerobactin from N epsilon-acetyl-N epsilon-hydroxylysine and citrate. This family represents the N-terminal region. The C-terminal region appears to be related to iron transporter proteins.


Pssm-ID: 461213 [Multi-domain]  Cd Length: 210  Bit Score: 107.65  E-value: 1.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 155 RWEQKLLLadqiasylDHPYYPTARAKFGLSDHDLEQFAPEFAQSFELRWLAIEKSLVTLtspqpecwptmaqvglpadf 234
Cdd:pfam04183   4 ELEQSLLE--------GHPFHPAPKSRLGFSEEDYRAYAPEFGGPFPLRWLAVHRDLARV-------------------- 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 235 alsheLFPAHPLTLQSLeslpdcvIEAPVACL--------------EVTPTLSVRTVVVNTAPQV-HIKVPLIMRSLGTk 299
Cdd:pfam04183  56 -----LLPVHPWQWEHL-------LPPLFAAEiaagrlvplgeggdLYLPTQSVRTLYNPDAPYKpHVKLSLSVRNTNS- 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 300 nIRLIKPSTLYDGHWFERLLTHLEQTDKDLRGTLFH-CNEKHGGHVGDD-----------KTFAYIVREYPLSYFQ-DKA 366
Cdd:pfam04183 123 -VRGLSPKELENGPAVSRLLARLLAQDPFLRDPGFVlLREPAGIAYRHPdyealadapykEGLGAIWRENPFALLApGER 201


                  ....*...
gi 1589111042 367 LVPVAALA 374
Cdd:pfam04183 202 AIPLAALL 209
 
Name Accession Description Interval E-value
IucA COG4264
Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];
8-583 1.50e-54

Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];


Pssm-ID: 443406 [Multi-domain]  Cd Length: 590  Bit Score: 195.16  E-value: 1.50e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042   8 LTQRLVDTCLREDLFGLVSQSQFKSQLPSALKLSsyprnqiwavFAGSDFTLYLPVTPSYYMQRWVYgqtdgsKGDGWLI 87
Cdd:COG4264    13 LLRKLLNELLRERLLAPEPEGELEDDGGGVYRLP----------LPAGGVEYRFPARRRSAFGRHRF------DPGSIYR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042  88 ERNGVVEAQqHYQDWIELLKvSAHESSHSLLDGYLQELECaekhkglcdsafSQHSEALMLpiSQLERWEQKLLLAdqiA 167
Cdd:COG4264    77 TEDGAWRPL-DALQLLALLL-EELGIDDETLAELLEELLN------------SLANDALAL--AHRRLSAADLAAA---L 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 168 SYLD--------HPYYPTARAKFGLSDHDLEQFAPEFAQSFELRWLAIEKSLVTLTSPQ-------------PECW---- 222
Cdd:COG4264   138 DFIEleqaltegHPLHPAPKSRIGFSAEDYRRYAPEFGGPFRLHWLAVHRDLARFGSAEgldydellaeelgPDTLarfa 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 223 PTMAQVGLPADfalSHELFPAHPL----TLQSLeslpdcvIEAPVA-----CL-----EVTPTLSVRTVV-VNTAPQVHI 287
Cdd:COG4264   218 AELAALGLDPD---DYVLLPVHPWqwenLLAPL-------FAAEIArgrlvPLgeggdEYLPTQSIRTLYnASRPSKPYV 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 288 KVPLIMRSLGTknIRLIKPSTLYDGHWFERLLTHLEQTDKDLRGTLFH-CNE------KHGGHVGDD-----KTFAYIVR 355
Cdd:COG4264   288 KLSLSVLNTNS--VRGLSPKELERGPAISRWLAELLAQDPYLRDPGFTiLREpagigyRHPDYEEGAgyqyrEMLGAIWR 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 356 EYPLSYFQ-DKALVPVAALASPMPDERLFLEHLAEQYYQQN-TLTWFKDYVDLLCKVHLTLWIRYGIALESNQQNAIIAF 433
Cdd:COG4264   366 ENPFPLLEpGERAIPMAALLHDDPDGRPLLAALIERSGLREaAEAWFRRYLDVVLPPLLHLLYRYGIALEAHGQNSVLVL 445

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 434 NEQGKMTLAMKDNDAARIWPERFqtfeQQSPVKCDHLLDQRI--TVDNELALgQMFTTITLQLDIAAIVEAMATKGIATS 511
Cdd:COG4264   446 DDGVPVRLLLRDFQGVRLSEPRL----PELGEALPDLVERRVllTVPDEELR-LRIFYYLFVNNLRELIAALAEHGLLDE 520

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1589111042 512 AYLYEMVANSLSQQLSQLDkqGHNTKLANEMLFeSPNLYAKYLLSSGSLLSKEASGASDINKFYGlSAPNFL 583
Cdd:COG4264   521 ERFWRLVREVLEAYQARHP--ELAERFARFLLF-APTLPRKCLLRTRLRNNGELDDLAPSLAVYG-TLPNPL 588
IucA_IucC pfam04183
IucA / IucC family; IucA and IucC catalyze discrete steps in biosynthesis of the siderophore ...
 155-374 1.14e-26

IucA / IucC family; IucA and IucC catalyze discrete steps in biosynthesis of the siderophore aerobactin from N epsilon-acetyl-N epsilon-hydroxylysine and citrate. This family represents the N-terminal region. The C-terminal region appears to be related to iron transporter proteins.


Pssm-ID: 461213 [Multi-domain]  Cd Length: 210  Bit Score: 107.65  E-value: 1.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 155 RWEQKLLLadqiasylDHPYYPTARAKFGLSDHDLEQFAPEFAQSFELRWLAIEKSLVTLtspqpecwptmaqvglpadf 234
Cdd:pfam04183   4 ELEQSLLE--------GHPFHPAPKSRLGFSEEDYRAYAPEFGGPFPLRWLAVHRDLARV-------------------- 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 235 alsheLFPAHPLTLQSLeslpdcvIEAPVACL--------------EVTPTLSVRTVVVNTAPQV-HIKVPLIMRSLGTk 299
Cdd:pfam04183  56 -----LLPVHPWQWEHL-------LPPLFAAEiaagrlvplgeggdLYLPTQSVRTLYNPDAPYKpHVKLSLSVRNTNS- 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 300 nIRLIKPSTLYDGHWFERLLTHLEQTDKDLRGTLFH-CNEKHGGHVGDD-----------KTFAYIVREYPLSYFQ-DKA 366
Cdd:pfam04183 123 -VRGLSPKELENGPAVSRLLARLLAQDPFLRDPGFVlLREPAGIAYRHPdyealadapykEGLGAIWRENPFALLApGER 201


                  ....*...
gi 1589111042 367 LVPVAALA 374
Cdd:pfam04183 202 AIPLAALL 209
FhuF pfam06276
Ferric iron reductase FhuF-like transporter; This family consists of several bacterial ferric ...
 399-547 2.50e-08

Ferric iron reductase FhuF-like transporter; This family consists of several bacterial ferric iron reductase protein (FhuF) sequences. FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This family also includes the IucA and IucC proteins.


Pssm-ID: 428860 [Multi-domain]  Cd Length: 163  Bit Score: 53.55  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589111042 399 WFKDYVDLLCKVHLTLWIRYGIALESNQQNAIIAFNEQGKMTLAMKDNDAARIWPERFQTFEQQSPVKCDHLLDQRITVD 478
Cdd:pfam06276   3 WFKRYLGLLLPPLLHLLLRYGIALEAHGQNILLVLDDGLPVRLYLRDFGEGVRLRDELLPELPGLPEEVKRLYTDDPAWL 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1589111042 479 NELALGQMFTTitlqldIAAIVEAMATKGIATSAYLYEMVANSLSQQLSQLDkqGHNTKLANEMLFESP 547
Cdd:pfam06276  83 RFIFYYLFVNH------LRPLIAALAAAGGLSERLLWSNVADVLEWYQAELP--ELADRFAQFLLFAPT 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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