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Conserved domains on  [gi|1596904288|gb|TDV60568|]
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TetR family transcriptional regulator [Pseudomonas sp. LP_7_YM]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 10451993)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 66-209 6.94e-53

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


:

Pssm-ID: 433616  Cd Length: 143  Bit Score: 167.04  E-value: 6.94e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596904288  66 YEALVDGFLHPPNGRPPNVEDKRHYLVAILDGMWRYRFLHRDLEHLLDADPELAARYRRFSQHCLIKAMAIYGGFVEAGI 145
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1596904288 146 LNMDKVQIESLTLNAWIILTSWVRFLCtTRENATHLNEDAIRRGVYQVLMLELAYVTPQAQEAV 209
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQR-TQAPEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
23-62 2.00e-06

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 43.55  E-value: 2.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1596904288  23 LFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAEL 62
Cdd:pfam00440   8 LFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 66-209 6.94e-53

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 167.04  E-value: 6.94e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596904288  66 YEALVDGFLHPPNGRPPNVEDKRHYLVAILDGMWRYRFLHRDLEHLLDADPELAARYRRFSQHCLIKAMAIYGGFVEAGI 145
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1596904288 146 LNMDKVQIESLTLNAWIILTSWVRFLCtTRENATHLNEDAIRRGVYQVLMLELAYVTPQAQEAV 209
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQR-TQAPEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-128 1.67e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.08  E-value: 1.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596904288   9 RIKTRERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAELFSEYEALVDGFLHPPNGRPPNVEDKR 88
Cdd:COG1309     4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLR 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1596904288  89 HYLVAILDGMWRYRFLHRDLEHLLDADPELAARYRRFSQH 128
Cdd:COG1309    84 ALLRAYLEFLAENPALARLLLAEAAELPELRAALRALLRR 123
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
23-62 2.00e-06

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 43.55  E-value: 2.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1596904288  23 LFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAEL 62
Cdd:pfam00440   8 LFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 1-65 2.00e-05

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 43.96  E-value: 2.00e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1596904288   1 MAPRIKTLRIKTRERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKqaiiAELFSE 65
Cdd:PRK09975    1 MAKKTKAEALKTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENK----TQLFNE 61
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
10-82 1.01e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 41.81  E-value: 1.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1596904288  10 IKTRERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAELFSEYEALVDGFLHPPNGRPP 82
Cdd:NF041196    5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGGG 77
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 13-66 4.29e-03

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 37.12  E-value: 4.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1596904288  13 RERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAELFSEY 66
Cdd:NF037937    1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEYLVTSF 54
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 66-209 6.94e-53

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 167.04  E-value: 6.94e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596904288  66 YEALVDGFLHPPNGRPPNVEDKRHYLVAILDGMWRYRFLHRDLEHLLDADPELAARYRRFSQHCLIKAMAIYGGFVEAGI 145
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1596904288 146 LNMDKVQIESLTLNAWIILTSWVRFLCtTRENATHLNEDAIRRGVYQVLMLELAYVTPQAQEAV 209
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQR-TQAPEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-128 1.67e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.08  E-value: 1.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596904288   9 RIKTRERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAELFSEYEALVDGFLHPPNGRPPNVEDKR 88
Cdd:COG1309     4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLR 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1596904288  89 HYLVAILDGMWRYRFLHRDLEHLLDADPELAARYRRFSQH 128
Cdd:COG1309    84 ALLRAYLEFLAENPALARLLLAEAAELPELRAALRALLRR 123
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
23-62 2.00e-06

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 43.55  E-value: 2.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1596904288  23 LFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAEL 62
Cdd:pfam00440   8 LFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 1-65 2.00e-05

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 43.96  E-value: 2.00e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1596904288   1 MAPRIKTLRIKTRERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKqaiiAELFSE 65
Cdd:PRK09975    1 MAKKTKAEALKTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENK----TQLFNE 61
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 1-65 4.03e-05

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 43.07  E-value: 4.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1596904288   1 MAPRIKTLRIKTRERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKqaiiAELFSE 65
Cdd:PRK10668    1 MARKTKQQAQETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNK----SDLFSE 61
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
10-82 1.01e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 41.81  E-value: 1.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1596904288  10 IKTRERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAELFSEYEALVDGFLHPPNGRPP 82
Cdd:NF041196    5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGGG 77
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
11-124 1.33e-04

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 41.46  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596904288  11 KTRERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAELFSEY-EALVDGFLHPPNGRPPNVEDKRH 89
Cdd:COG3226     8 ERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLaEREAARLRALLAAADDLEDAAEA 87

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1596904288  90 YLVAILDGMWRYRFLHR-DLEHLLDA--DPELAARYRR 124
Cdd:COG3226    88 LADLLAELLPADRDRLLaRYELYLEAlrDPELRALLRR 125
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 13-66 4.29e-03

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 37.12  E-value: 4.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1596904288  13 RERIVQNSLGLFNLQGERSVSTNHIAAHMEISPGNLYYHFPNKQAIIAELFSEY 66
Cdd:NF037937    1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEYLVTSF 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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