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Conserved domains on  [gi|1605580743|gb|TFL88121|]
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ArsR family transcriptional regulator [Escherichia coli]

Protein Classification

FaeA/PapI family transcriptional regulator( domain architecture ID 10520199)

FaeA/PapI family transcriptional regulator is a fimbrial/pilus regulatory protein, similar to Escherichia coli PapI, a key regulator of the pap pili phase variation, and to Salmonella enterica plasmid-encoded fimbriae rgulatory protein PefI

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FaeA pfam04703
FaeA-like protein; This family represents a number of fimbrial protein transcription ...
 11-71 1.81e-34

FaeA-like protein; This family represents a number of fimbrial protein transcription regulators found in Gram-negative bacteria. These proteins are thought to facilitate binding of the leucine-rich regulatory protein to regulatory elements, possibly by inhibiting deoxyadenosine methylation of these elements by deoxyadenosine methylase.


:

Pssm-ID: 398397  Cd Length: 61  Bit Score: 112.18  E-value: 1.81e-34
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1605580743 11 RKNDILSYFGEINAPCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSPVRRGASTLWEIS 71
Cdd:pfam04703  1 MKESILTFINSIGAPCKTREIADALGLSAYQARYYLMQLEKEGKIKRSPLRRGASTLWELL 61
 
Name Accession Description Interval E-value
FaeA pfam04703
FaeA-like protein; This family represents a number of fimbrial protein transcription ...
 11-71 1.81e-34

FaeA-like protein; This family represents a number of fimbrial protein transcription regulators found in Gram-negative bacteria. These proteins are thought to facilitate binding of the leucine-rich regulatory protein to regulatory elements, possibly by inhibiting deoxyadenosine methylation of these elements by deoxyadenosine methylase.


Pssm-ID: 398397  Cd Length: 61  Bit Score: 112.18  E-value: 1.81e-34
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1605580743 11 RKNDILSYFGEINAPCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSPVRRGASTLWEIS 71
Cdd:pfam04703  1 MKESILTFINSIGAPCKTREIADALGLSAYQARYYLMQLEKEGKIKRSPLRRGASTLWELL 61
PHA02943 PHA02943
hypothetical protein; Provisional
 7-72 4.41e-05

hypothetical protein; Provisional


Pssm-ID: 165253  Cd Length: 165  Bit Score: 39.46  E-value: 4.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1605580743   7 TLNERKNDILSYfgeINAPCRT-SEVAEHLGVSAYQARHYLQCLEKEGKIKRspVRRGASTLWEISD 72
Cdd:PHA02943    8 TVHTRMIKTLRL---LADGCKTtSRIANKLGVSHSMARNALYQLAKEGMVLK--VEIGRAAIWCLDE 69
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
25-72 6.72e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 6.72e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1605580743  25 PCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSPVRRGA---STLWEISD 72
Cdd:COG2345    27 PVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRGRgrpAKLYRLTE 77
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
10-59 6.80e-04

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 35.25  E-value: 6.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1605580743  10 ERKNDILSYFGEINAPCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSP 59
Cdd:smart00346  5 ERGLAVLRALAEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDG 54
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 25-75 8.27e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 31.89  E-value: 8.27e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 1605580743 25 PCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRspVRRGASTLWEISDVTE 75
Cdd:cd00090   20 PLTVSELAERLGLSQSTVSRHLKKLEEAGLVES--RREGRRVYYSLTDAER 68
 
Name Accession Description Interval E-value
FaeA pfam04703
FaeA-like protein; This family represents a number of fimbrial protein transcription ...
 11-71 1.81e-34

FaeA-like protein; This family represents a number of fimbrial protein transcription regulators found in Gram-negative bacteria. These proteins are thought to facilitate binding of the leucine-rich regulatory protein to regulatory elements, possibly by inhibiting deoxyadenosine methylation of these elements by deoxyadenosine methylase.


Pssm-ID: 398397  Cd Length: 61  Bit Score: 112.18  E-value: 1.81e-34
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1605580743 11 RKNDILSYFGEINAPCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSPVRRGASTLWEIS 71
Cdd:pfam04703  1 MKESILTFINSIGAPCKTREIADALGLSAYQARYYLMQLEKEGKIKRSPLRRGASTLWELL 61
PHA02943 PHA02943
hypothetical protein; Provisional
 7-72 4.41e-05

hypothetical protein; Provisional


Pssm-ID: 165253  Cd Length: 165  Bit Score: 39.46  E-value: 4.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1605580743   7 TLNERKNDILSYfgeINAPCRT-SEVAEHLGVSAYQARHYLQCLEKEGKIKRspVRRGASTLWEISD 72
Cdd:PHA02943    8 TVHTRMIKTLRL---LADGCKTtSRIANKLGVSHSMARNALYQLAKEGMVLK--VEIGRAAIWCLDE 69
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
25-72 6.72e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 6.72e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1605580743  25 PCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSPVRRGA---STLWEISD 72
Cdd:COG2345    27 PVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRGRgrpAKLYRLTE 77
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
14-63 8.85e-05

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 38.65  E-value: 8.85e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1605580743  14 DILSYFGEINAPCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSPVRRG 63
Cdd:COG1414    13 AILEALAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGR 62
HTH_IclR pfam09339
IclR helix-turn-helix domain;
14-59 9.59e-05

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 36.23  E-value: 9.59e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1605580743 14 DILSYFGEINAPCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSP 59
Cdd:pfam09339  7 AILDALAEAPGPLTLTEIARRTGLPKSTAHRLLQTLVELGYVEQDP 52
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
10-59 6.80e-04

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 35.25  E-value: 6.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1605580743  10 ERKNDILSYFGEINAPCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSP 59
Cdd:smart00346  5 ERGLAVLRALAEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDG 54
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 9-64 1.26e-03

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 35.50  E-value: 1.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1605580743   9 NERKNDILSY---FGEInapcRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRspVRRGA 64
Cdd:COG1349     4 EERRQKILELlreRGRV----SVEELAERLGVSEETIRRDLAELEEQGLLRR--VHGGA 56
MerR pfam00376
MerR family regulatory protein;
27-65 2.49e-03

MerR family regulatory protein;


Pssm-ID: 425647 [Multi-domain]  Cd Length: 38  Bit Score: 32.39  E-value: 2.49e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 1605580743 27 RTSEVAEHLGVSAYQARHYlqclEKEGKIKrsPVRRGAS 65
Cdd:pfam00376  1 TIGEVAKLLGVSPRTLRYY----EKIGLLP--PPERTEG 33
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
26-57 5.32e-03

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 31.81  E-value: 5.32e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1605580743  26 CRTSEVAEHLGVSAYQARHYLQCLEKEGKIKR 57
Cdd:smart00420 15 VSVEELAELLGVSEMTIRRDLNKLEEQGLLTR 46
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-72 5.40e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 32.18  E-value: 5.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1605580743  25 PCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRspVRRGASTLWEISD 72
Cdd:smart00418 10 ELCVCELAEILGLSQSTVSHHLKKLREAGLVES--RREGKRVYYSLTD 55
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
2-62 7.48e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 33.31  E-value: 7.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1605580743   2 KINKLTLNERKNDILSYFGEiNAPCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRSPVRR 62
Cdd:COG3398    13 TRKNVLDNDTRRRIYEYIRE-NPGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGG 72
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 9-53 7.83e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 31.26  E-value: 7.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1605580743  9 NERKNDILSYFgeINAPCRTSEVAEHLGVSAYQARHYLQCLEKEG 53
Cdd:pfam01022  1 DPTRLKILKLL--AEGELCVCELAEELGLSQSTVSHHLKKLREAG 43
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 25-75 8.27e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 31.89  E-value: 8.27e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 1605580743 25 PCRTSEVAEHLGVSAYQARHYLQCLEKEGKIKRspVRRGASTLWEISDVTE 75
Cdd:cd00090   20 PLTVSELAERLGLSQSTVSRHLKKLEEAGLVES--RREGRRVYYSLTDAER 68
PRK14165 PRK14165
winged helix-turn-helix domain-containing protein/riboflavin kinase; Provisional
 28-63 8.96e-03

winged helix-turn-helix domain-containing protein/riboflavin kinase; Provisional


Pssm-ID: 184548 [Multi-domain]  Cd Length: 217  Bit Score: 33.11  E-value: 8.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1605580743  28 TSEVAEHLGVSAYQARHYLQCLEKEGKIKRSPVRRG 63
Cdd:PRK14165   24 SSEFANHTGTSSKTAARILKQLEDEGYITRTIVPRG 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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