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Conserved domains on  [gi|1609718361|gb|TGF94986|]
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ketose-bisphosphate aldolase [Escherichia coli]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 1-277 9.14e-136

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member TIGR00167:

Pssm-ID: 473867  Cd Length: 288  Bit Score: 384.75  E-value: 9.14e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361   1 MLADIRYWENDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTS-FEDFSHMMVSMAQKA--TVPVI 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAgLGAISAMVKAMSEAYpyGVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  78 THWDHGRSMEIIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNETVY-EEALAGYHYTDPD 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGvSVADESALYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 157 QAAEFVERTGCDSLAVAIGNQHGVYTSEPQ-LNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQ 235
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQI 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1609718361 236 AAMVAVK----ENQDQ--PFLHLeREVRKAVKERALEKIKLFGSDGKA 277
Cdd:TIGR00167 242 AFAAAVRnyyaENKDYydPRVWL-RPGEKAMKEVVLEKIKLFGSANKA 288
 
Name Accession Description Interval E-value
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-277 9.14e-136

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 384.75  E-value: 9.14e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361   1 MLADIRYWENDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTS-FEDFSHMMVSMAQKA--TVPVI 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAgLGAISAMVKAMSEAYpyGVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  78 THWDHGRSMEIIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNETVY-EEALAGYHYTDPD 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGvSVADESALYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 157 QAAEFVERTGCDSLAVAIGNQHGVYTSEPQ-LNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQ 235
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQI 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1609718361 236 AAMVAVK----ENQDQ--PFLHLeREVRKAVKERALEKIKLFGSDGKA 277
Cdd:TIGR00167 242 AFAAAVRnyyaENKDYydPRVWL-RPGEKAMKEVVLEKIKLFGSANKA 288
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-277 8.30e-122

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 349.00  E-value: 8.30e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361   1 MLADIRYWENDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHW 80
Cdd:COG0191     1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  81 DHGRSMEIIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNETVYEEAL-AGYHYTDPDQAA 159
Cdd:COG0191    81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDdAEALYTDPEEAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 160 EFVERTGCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMV 239
Cdd:COG0191   161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1609718361 240 AVKEN-QDQP----FLHLEREVRKAVKERALEKIKLFGSDGKA 277
Cdd:COG0191   241 AVREYlAENPdkydPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
10-276 8.83e-113

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 325.91  E-value: 8.83e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  10 NDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTS--FEDFSHMMVSMAQKATVPVITHWDHGRSME 87
Cdd:pfam01116   8 KKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAggAEALAALVRAAAEAAGVPVALHLDHGASFE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  88 IIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNE---TVYEEALagyhYTDPDQAAEFVER 164
Cdd:pfam01116  88 LIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEedgVVVDEKL----YTDPEEAAEFVEA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 165 TGCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKEN 244
Cdd:pfam01116 164 TGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAAVREY 243

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1609718361 245 QDQP-FLHLEREVRKAVKERALEKIKLFGSDGK 276
Cdd:pfam01116 244 PPNKdPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 10-275 6.59e-100

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 293.28  E-value: 6.59e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  10 NDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRSMEII 89
Cdd:cd00947     6 KKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGSSFELI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  90 HNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNEtvyEEALAGYH--YTDPDQAAEFVERTGC 167
Cdd:cd00947    86 KRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGE---EDGVVGDEglLTDPEEAEEFVEETGV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 168 DSLAVAIGNQHGVYTS-EPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKEN-- 244
Cdd:cd00947   163 DALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALREYla 242

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1609718361 245 ---QDQPFLHLEREVRKAVKERALEKIKLFGSDG 275
Cdd:cd00947   243 enpKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 10-277 1.77e-83

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 251.97  E-value: 1.77e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  10 NDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRSMEII 89
Cdd:PRK09195   11 NNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALHLDHHEKFDDI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  90 HNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNEtvyEEAL----AGYHYTDPDQAAEFVERT 165
Cdd:PRK09195   91 AQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQ---EDDLqvdeADALYTDPAQAREFVEAT 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 166 GCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKEnq 245
Cdd:PRK09195  168 GIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFSQALKN-- 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1609718361 246 dqpFLHLEREV---RK-------AVKERALEKIKLFGSDGKA 277
Cdd:PRK09195  246 ---YLTEHPEAndpRHylqpaksAMKDVVSKVIADCGCEGKA 284
Fbpase2_Halo NF041368
class II fructose-bisphosphate aldolase;
19-231 3.00e-42

class II fructose-bisphosphate aldolase;


Pssm-ID: 469259  Cd Length: 333  Bit Score: 147.48  E-value: 3.00e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  19 IAHFNVwnaemLMGVIDAAEEAKSPVIISFGTG---FVGN----TSFEDFSHMMVSMAQKATVPVITHWDH---GRSMEI 88
Cdd:NF041368   28 VTEPDI-----LVGLLRGAERADSDLVLQVSRGaaaFAGNgdpaAGLRAFGAYLEALAERYDVGVFLNVDHvtlPDDEDF 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  89 IHNAWTHGM-NSLMRDASAFDFEENIRLTKEAVDFFHPLG--IPVEAELGHVG---NETVYEEALagyhYTDPDQAAEFV 162
Cdd:NF041368  103 LDAAVESGIpSSVMVDASAEPFEENVERTREVVEMVDAADedVLVEAELGRIAgveDGIETDEAF----YTDPEQAVEFV 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1609718361 163 ERTGCDSLAVAIGNQHGVYTS-----EPQLNFEVVKRVRDA-VSVPLVLHGASGISDADIKTAISLGIAKINIHT 231
Cdd:NF041368  179 DRTGCDLLAVSVGTQHGVAKGrdldlRPDLAREIRDALRDHgLDTPLVVHGSSGLSPEQVRELLDAGVCKVNKNT 253
 
Name Accession Description Interval E-value
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-277 9.14e-136

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 384.75  E-value: 9.14e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361   1 MLADIRYWENDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTS-FEDFSHMMVSMAQKA--TVPVI 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAgLGAISAMVKAMSEAYpyGVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  78 THWDHGRSMEIIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNETVY-EEALAGYHYTDPD 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGvSVADESALYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 157 QAAEFVERTGCDSLAVAIGNQHGVYTSEPQ-LNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQ 235
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQI 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1609718361 236 AAMVAVK----ENQDQ--PFLHLeREVRKAVKERALEKIKLFGSDGKA 277
Cdd:TIGR00167 242 AFAAAVRnyyaENKDYydPRVWL-RPGEKAMKEVVLEKIKLFGSANKA 288
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-277 8.30e-122

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 349.00  E-value: 8.30e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361   1 MLADIRYWENDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHW 80
Cdd:COG0191     1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  81 DHGRSMEIIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNETVYEEAL-AGYHYTDPDQAA 159
Cdd:COG0191    81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDdAEALYTDPEEAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 160 EFVERTGCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMV 239
Cdd:COG0191   161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1609718361 240 AVKEN-QDQP----FLHLEREVRKAVKERALEKIKLFGSDGKA 277
Cdd:COG0191   241 AVREYlAENPdkydPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
10-276 8.83e-113

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 325.91  E-value: 8.83e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  10 NDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTS--FEDFSHMMVSMAQKATVPVITHWDHGRSME 87
Cdd:pfam01116   8 KKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAggAEALAALVRAAAEAAGVPVALHLDHGASFE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  88 IIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNE---TVYEEALagyhYTDPDQAAEFVER 164
Cdd:pfam01116  88 LIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEedgVVVDEKL----YTDPEEAAEFVEA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 165 TGCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKEN 244
Cdd:pfam01116 164 TGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAAVREY 243

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1609718361 245 QDQP-FLHLEREVRKAVKERALEKIKLFGSDGK 276
Cdd:pfam01116 244 PPNKdPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 10-275 6.59e-100

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 293.28  E-value: 6.59e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  10 NDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRSMEII 89
Cdd:cd00947     6 KKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGSSFELI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  90 HNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNEtvyEEALAGYH--YTDPDQAAEFVERTGC 167
Cdd:cd00947    86 KRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGE---EDGVVGDEglLTDPEEAEEFVEETGV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 168 DSLAVAIGNQHGVYTS-EPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKEN-- 244
Cdd:cd00947   163 DALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALREYla 242

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1609718361 245 ---QDQPFLHLEREVRKAVKERALEKIKLFGSDG 275
Cdd:cd00947   243 enpKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 10-277 1.77e-83

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 251.97  E-value: 1.77e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  10 NDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRSMEII 89
Cdd:PRK09195   11 NNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALHLDHHEKFDDI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  90 HNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNEtvyEEAL----AGYHYTDPDQAAEFVERT 165
Cdd:PRK09195   91 AQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQ---EDDLqvdeADALYTDPAQAREFVEAT 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 166 GCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKEnq 245
Cdd:PRK09195  168 GIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFSQALKN-- 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1609718361 246 dqpFLHLEREV---RK-------AVKERALEKIKLFGSDGKA 277
Cdd:PRK09195  246 ---YLTEHPEAndpRHylqpaksAMKDVVSKVIADCGCEGKA 284
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 10-277 1.26e-81

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 247.28  E-value: 1.26e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  10 NDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTS-FEDFSHMMVSMAQKAT-VPVITHWDHGRSME 87
Cdd:TIGR01859   9 QKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGgYKMAVAMVKTLIERMSiVPVALHLDHGSSYE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  88 IIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNEtvyEEALAGY--HYTDPDQAAEFVERT 165
Cdd:TIGR01859  89 SCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGI---EDGVDEKeaELADPDEAEQFVKET 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 166 GCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTElCQAAMVA----- 240
Cdd:TIGR01859 166 GVDYLAAAIGTSHGKYKGEPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTD-CRIAFTAairkv 244

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1609718361 241 VKENQDQ--PFLHLeREVRKAVKERALEKIKLFGSDGKA 277
Cdd:TIGR01859 245 LTEKKDEydPRKIL-GPAREAIKETVKEKMRLFGSAGKA 282
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
11-277 4.19e-80

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 243.45  E-value: 4.19e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  11 DATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRSMEIIH 90
Cdd:PRK12737   12 KAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDYIVAIAEVAARKYNIPLALHLDHHEDLDDIK 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  91 NAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVG---NETVYEEALAgyHYTDPDQAAEFVERTGC 167
Cdd:PRK12737   92 KKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGgqeDDLVVDEKDA--MYTNPDAAAEFVERTGI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 168 DSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVK----E 243
Cdd:PRK12737  170 DSLAVAIGTAHGLYKGEPKLDFERLAEIREKVSIPLVLHGASGVPDEDVKKAISLGICKVNVATELKIAFSDAVKkyfyE 249

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1609718361 244 NQD--QPfLHLEREVRKAVKERALEKIKLFGSDGKA 277
Cdd:PRK12737  250 NPKanDP-RKYMTPGKAAMKEVVREKIKVCGSEGKL 284
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
17-277 6.49e-78

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 237.70  E-value: 6.49e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  17 YAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRSMEIIHNAWTHG 96
Cdd:PRK12857   18 YAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASVPVALHLDHGTDFEQVMKCIRNG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  97 MNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVG----NETVYE-EALagyhYTDPDQAAEFVERTGCDSLA 171
Cdd:PRK12857   98 FTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGgtedDITVDErEAA----MTDPEEARRFVEETGVDALA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 172 VAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKEN-QDQPFL 250
Cdd:PRK12857  174 IAIGTAHGPYKGEPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIREAFVARLREVlEKNPDE 253

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1609718361 251 HLEREV----RKAVKERALEKIKLFGSDGKA 277
Cdd:PRK12857  254 IDPRKIlgpaREAAKEVIREKIRLFGSAGKA 284
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
12-277 1.83e-74

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 228.87  E-value: 1.83e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  12 ATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRSMEIIHN 91
Cdd:PRK06801   13 ARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISLESLVEAVKFEAARHDIPVVLNLDHGLHFEAVVR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  92 AWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNE---TVYEEALAGYhYTDPDQAAEFVERTGCD 168
Cdd:PRK06801   93 ALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDeggALYGEADSAK-FTDPQLARDFVDRTGID 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 169 SLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAV------K 242
Cdd:PRK06801  172 ALAVAIGNAHGKYKGEPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAALAAVeqrmthR 251

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1609718361 243 ENQDQPFLHLEREVRKAVKERALEKIKLFGSDGKA 277
Cdd:PRK06801  252 HAIYDEFAELLLGIEEAISDTVAQQMRIFGSAGQA 286
PRK06806 PRK06806
class II aldolase;
12-277 2.16e-74

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 228.49  E-value: 2.16e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  12 ATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRSMEIIHN 91
Cdd:PRK06806   13 ANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHLIGPLMVAAAKQAKVPVAVHFDHGMTFEKIKE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  92 AWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVG-NETVYEEAlaGYHYTDPDQAAEFVERTGCDSL 170
Cdd:PRK06806   93 ALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGgSEDGSEDI--EMLLTSTTEAKRFAEETDVDAL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 171 AVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKE----NQD 246
Cdd:PRK06806  171 AVAIGNAHGMYNGDPNLRFDRLQEINDVVHIPLVLHGGSGISPEDFKKCIQHGIRKINVATATFNSVITAVNNlvlnTPY 250

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1609718361 247 QPFLHLEREVRKAVKERALEKIKLFGSDGKA 277
Cdd:PRK06806  251 SDYFTYHQDVIKAAYENVKKHMQIFGSENKA 281
PRK08185 PRK08185
hypothetical protein; Provisional
 12-278 7.27e-74

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 227.30  E-value: 7.27e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  12 ATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTG---FVGNtsfeDFSHMMVSMAQKATVPVITHWDHGRSMEI 88
Cdd:PRK08185    8 AKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNeldFLGD----NFFAYVRERAKRSPVPFVIHLDHGATIED 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  89 IHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVG-NETVYEEALAGYHYTDPDQAAEFVERTGC 167
Cdd:PRK08185   84 VMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGnTGTSIEGGVSEIIYTDPEQAEDFVSRTGV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 168 DSLAVAIGNQHGVYTS--EPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKEN- 244
Cdd:PRK08185  164 DTLAVAIGTAHGIYPKdkKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKYAFFKKVREIl 243

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1609718361 245 QDQPFLH----LEREVRKAVKERALEKIKLFGSDGKAE 278
Cdd:PRK08185  244 SDNPSLYepnqIYPSAIEAAKEVVRHKMDLFNSTGKAD 281
gatY PRK07998
class II aldolase;
12-273 6.58e-67

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 209.62  E-value: 6.58e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  12 ATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRSMEIIHN 91
Cdd:PRK07998   13 IQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRHADKMDVPVSLHLDHGKTFEDVKQ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  92 AWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHV-GNETvyEEALAGYHYTDPDQAAEFVERTGCDSL 170
Cdd:PRK07998   93 AVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAIlGKED--DHVSEADCKTEPEKVKDFVERTGCDML 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 171 AVAIGNQHGVYTSePQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAV----KENQD 246
Cdd:PRK07998  171 AVSIGNVHGLEDI-PRIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVNYKVAKVNIASDLRKAFITTVgkayVNNHN 249

                         250       260
                  ....*....|....*....|....*...
gi 1609718361 247 QPFL-HLEREVRKAVKERALEKIKLFGS 273
Cdd:PRK07998  250 EANLaRVMAKAKQAVEEDVYSKIKMMNS 277
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 10-277 3.69e-65

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 205.29  E-value: 3.69e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  10 NDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGN-TSFEDFSHMMVSMAQKA--TVPVITHWDHGRSM 86
Cdd:PRK07709   11 NKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHmTGFKTVVAMVKALIEEMniTVPVAIHLDHGSSF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  87 EIIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNETvyEEALA-GYHYTDPDQAAEFVERT 165
Cdd:PRK07709   91 EKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQE--DDVIAeGVIYADPAECKHLVEAT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 166 GCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKE-- 243
Cdd:PRK07709  169 GIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEFTKAVREvl 248

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1609718361 244 NQDQPFLHLEREV---RKAVKERALEKIKLFGSDGKA 277
Cdd:PRK07709  249 NKDQEVYDPRKFIgpgRDAIKATVIGKIREFGSNGKA 285
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 10-278 6.57e-64

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 202.14  E-value: 6.57e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  10 NDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTG---FVGntSFEDFSHMMVSMAQ--KATVPVITHWDHGR 84
Cdd:PRK08610   11 IDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGaarYMS--GFYTVVKMVEGLMHdlNITIPVAIHLDHGS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  85 SMEIIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNETvyEEALA-GYHYTDPDQAAEFVE 163
Cdd:PRK08610   89 SFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQE--DDVVAdGIIYADPKECQELVE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 164 RTGCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKE 243
Cdd:PRK08610  167 KTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIASAKAVRD 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1609718361 244 NQD-QPFLHLERE----VRKAVKERALEKIKLFGSDGKAE 278
Cdd:PRK08610  247 VLNnDKEVYDPRKylgpAREAIKETVKGKIKEFGTSNRAK 286
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
6-276 5.83e-63

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 199.49  E-value: 5.83e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361   6 RYWENDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQKATVPVITHWDHGRS 85
Cdd:PRK12738    7 KYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHES 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  86 MEIIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVG----NETVYEEALagyHYTDPDQAAEF 161
Cdd:PRK12738   87 LDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGgvedDMSVDAESA---FLTDPQEAKRF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 162 VERTGCDSLAVAIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAV 241
Cdd:PRK12738  164 VELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAV 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1609718361 242 K----ENQD--QPFLHLeREVRKAVKERALEKIKLFGSDGK 276
Cdd:PRK12738  244 KawfaENPQgnDPRYYM-RVGMDAMKEVVRNKINVCGSANR 283
PLN02858 PLN02858
fructose-bisphosphate aldolase
 11-277 9.97e-52

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 181.97  E-value: 9.97e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361   11 DATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFShMMVSMAQKATVPVITHWDHGRSMEIIH 90
Cdd:PLN02858  1108 NAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGIPLVS-CCIAAAEQASVPITVHFDHGTSKHELL 1186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361   91 NAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHV-GNE---TVYE-EAlagyHYTDPDQAAEFVERT 165
Cdd:PLN02858  1187 EALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLsGTEdglTVEEyEA----KLTDVDQAKEFIDET 1262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  166 GCDSLAVAIGNQHGVY-TSEPQLNFEVVKRVRDAVS---VPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAV 241
Cdd:PLN02858  1263 GIDALAVCIGNVHGKYpASGPNLRLDLLKELRALSSkkgVLLVLHGASGLPESLIKECIENGVRKFNVNTEVRTAYMEAL 1342

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1609718361  242 KENQDQPFLHLEREVRKAVKERALEKIKLFGSDGKA 277
Cdd:PLN02858  1343 SSPKKTDLIDVMSAAKEAMKAVVAEKLRLFGSAGKA 1378
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
12-276 2.88e-49

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 165.15  E-value: 2.88e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  12 ATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEdfshMMVSMAQKAT-----VPVITHWDHGRSM 86
Cdd:PRK05835   12 AHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGID----MAVGMVKIMCeryphIPVALHLDHGTTF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  87 EIIHNAWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHV----GNETVYEEALAgyhYTDPDQAAEFV 162
Cdd:PRK05835   88 ESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLmgieDNISVDEKDAV---LVNPKEAEQFV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 163 ERTGCDSLAVAIGNQHGV--YTSEPQLNFEVVKRVRDAVSVPLVLHGASGISD----------ADIK-----------TA 219
Cdd:PRK05835  165 KESQVDYLAPAIGTSHGAfkFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDdvrksyldagGDLKgskgvpfeflqES 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1609718361 220 ISLGIAKINIHTELCQAAMVAVKE--NQDQPFLHLER---EVRKAVKERALEKIKLFGSDGK 276
Cdd:PRK05835  245 VKGGINKVNTDTDLRIAFIAEVRKvaNEDKSQFDLRKffsPAQLALKNVVKERMKLLGSANK 306
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
17-277 1.30e-43

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 150.65  E-value: 1.30e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  17 YAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTG---FVGNTSFEDFSHMMVSMAQK--ATVPVITHWDHGRSMEIIHN 91
Cdd:PRK07084   24 YAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGarkYANATLLRYMAQGAVEYAKElgCPIPIVLHLDHGDSFELCKD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  92 AWTHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELG---HVGNETVYEEalagYHYTDPDQAAEFVERTGCD 168
Cdd:PRK07084  104 CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGvlaGVEDEVSAEH----HTYTQPEEVEDFVKKTGVD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 169 SLAVAIGNQHGVYT-----SEPQLNFEVVKRVRDAV-SVPLVLHGAS---------------------GISDADIKTAIS 221
Cdd:PRK07084  180 SLAISIGTSHGAYKfkpgqCPPPLRFDILEEIEKRIpGFPIVLHGSSsvpqeyvktineyggklkdaiGIPEEQLRKAAK 259

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1609718361 222 LGIAKINIHTELCQAAMVAVKENQDQ------PFLHLeREVRKAVKERALEKIK-LFGSDGKA 277
Cdd:PRK07084  260 SAVCKINIDSDGRLAMTAAIRKVFDEkpeefdPRKYL-GPARDELKKLYKHKIInVLGSNGKA 321
Fbpase2_Halo NF041368
class II fructose-bisphosphate aldolase;
19-231 3.00e-42

class II fructose-bisphosphate aldolase;


Pssm-ID: 469259  Cd Length: 333  Bit Score: 147.48  E-value: 3.00e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  19 IAHFNVwnaemLMGVIDAAEEAKSPVIISFGTG---FVGN----TSFEDFSHMMVSMAQKATVPVITHWDH---GRSMEI 88
Cdd:NF041368   28 VTEPDI-----LVGLLRGAERADSDLVLQVSRGaaaFAGNgdpaAGLRAFGAYLEALAERYDVGVFLNVDHvtlPDDEDF 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  89 IHNAWTHGM-NSLMRDASAFDFEENIRLTKEAVDFFHPLG--IPVEAELGHVG---NETVYEEALagyhYTDPDQAAEFV 162
Cdd:NF041368  103 LDAAVESGIpSSVMVDASAEPFEENVERTREVVEMVDAADedVLVEAELGRIAgveDGIETDEAF----YTDPEQAVEFV 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1609718361 163 ERTGCDSLAVAIGNQHGVYTS-----EPQLNFEVVKRVRDA-VSVPLVLHGASGISDADIKTAISLGIAKINIHT 231
Cdd:NF041368  179 DRTGCDLLAVSVGTQHGVAKGrdldlRPDLAREIRDALRDHgLDTPLVVHGSSGLSPEQVRELLDAGVCKVNKNT 253
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 5-242 5.39e-41

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 144.56  E-value: 5.39e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361   5 IRYWENDATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISF---GTGFV-------------GNTSFEDFSHMMVSM 68
Cdd:cd00453     1 VQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFsngGASFIagkgvksdvpqgaAILGAISGAHHVHQM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  69 AQKATVPVITHWDH--GRSMEII---------HNAWTHG--MNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELG 135
Cdd:cd00453    81 AEHYGVPVILHTDHcaKKLLPWIdglldagekHFAATGKplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 136 HVG-------NETVYEEALagyhYTDPDQAAEFVERTGC----DSLAVAIGNQHGVYT-SEPQLNFEVVKRVRDAVS--- 200
Cdd:cd00453   161 CTGgeedgvdNSHMDASAL----YTQPEDVDYAYTELSKisprFTIAASFGNVHGVYKkGNVVLTPTILRDSQEYVSkkh 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1609718361 201 ------VPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVK 242
Cdd:cd00453   237 nlphnsLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVL 284
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 12-277 1.18e-39

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 139.64  E-value: 1.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  12 ATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTG---FVGNTSFED--FSHMMVSMAqkATVPVITHWDHGR-- 84
Cdd:PRK07315   13 ARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGaakYMGGYKVCKnlIENLVESMG--ITVPVAIHLDHGHye 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  85 -SMEIIHNAWThgmnSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGNEtvyEEALAGYHYTDPDQAAEFVE 163
Cdd:PRK07315   91 dALECIEVGYT----SIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGE---EDGIIGKGELAPIEDAKAMV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 164 RTGCDSLAVAIGNQHGVYTSEPQ-LNFEVVKRVRDAVS-VPLVLHGASGISDADIKTAISLGIAKINIHTElCQAAMVAV 241
Cdd:PRK07315  164 ETGIDFLAAGIGNIHGPYPENWEgLDLDHLEKLTEAVPgFPIVLHGGSGIPDDQIQEAIKLGVAKVNVNTE-CQIAFANA 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1609718361 242 KENQDQPFLHLEREVRK---------------AVKERALEKIKLFGSDGKA 277
Cdd:PRK07315  243 TRKFARDYEANEAEYDKkklfdprkflapgvkAIQASVEERIDVFGSANKA 293
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
17-277 2.25e-38

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 137.78  E-value: 2.25e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  17 YAIAHFNVWNAEMLMGVIDAAEEAKSPVII--SFGTGFVGNTSFedFSHMMVSMAQK-ATVPVITHWDHGRSMEIIHNAW 93
Cdd:PRK09196   18 YGVPAFNVNNLEQVQAIMEAADETDSPVILqaSAGARKYAGEPF--LRHLILAAVEEyPHIPVVMHQDHGNSPATCQRAI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  94 THGMNSLMRDAS-------AFDFEENIRLTKEAVDFFHPLGIPVEAELGHVGN-ETVYEEALAGY----------HYTDP 155
Cdd:PRK09196   96 QLGFTSVMMDGSlkadgktPASYEYNVDVTRKVVEMAHACGVSVEGELGCLGSlETGMGGEEDGHgaegklshdqLLTDP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 156 DQAAEFVERTGCDSLAVAIGNQHGVY--TSEPQ---LNFEVVKRVRDAV-SVPLVLHGAS-------------------- 209
Cdd:PRK09196  176 EEAADFVKKTQVDALAIAIGTSHGAYkfTRKPTgdvLAIDRIKEIHARLpNTHLVMHGSSsvpqelldiineyggdmpet 255

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1609718361 210 -GISDADIKTAISLGIAKINIHTELCQAAMVAVK----ENQDQ--P--FLhleREVRKAVKERALEKIKLFGSDGKA 277
Cdd:PRK09196  256 yGVPVEEIQEGIKHGVRKVNIDTDLRLAMTGAIRrflaENPSEfdPrkYL---KPAMEAMKKICKARYEAFGTAGQA 329
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
12-277 3.38e-33

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 124.12  E-value: 3.38e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  12 ATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTGFVGNTSFEDFSHMMVSMAQK-ATVPVITHWDHGRSMEIIH 90
Cdd:PRK13399   13 AAENGYGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGDAMLRHMVLAAAEMyPDIPICLHQDHGNSPATCQ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  91 NAWTHGMNSLMRDASAF-------DFEENIRLTKEAVDFFHPLGIPVEAELGHVGN-ETVYEEALAGYHY---------- 152
Cdd:PRK13399   93 SAIRSGFTSVMMDGSLLadgktpaSYDYNVDVTRRVTEMAHAVGVSVEGELGCLGSlETGEAGEEDGVGAegklshdqml 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 153 TDPDQAAEFVERTGCDSLAVAIGNQHGVY--TSEPQ---LNFEVVKRVRDAV-SVPLVLHGAS----------------- 209
Cdd:PRK13399  173 TDPDQAVDFVQRTGVDALAIAIGTSHGAYkfTRKPDgdiLAIDRIEEIHARLpNTHLVMHGSSsvpqelqeiinayggkm 252

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1609718361 210 ----GISDADIKTAISLGIAKINIHTElCQAAMVAV--KENQDQPFLHLEREVRKAVKERA----LEKIKLFGSDGKA 277
Cdd:PRK13399  253 ketyGVPVEEIQRGIKHGVRKVNIDTD-IRLAMTGAirKVLAEHPSEFDPRKALKPAMKAMtalcKQRFEAFGTAGQA 329
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 12-231 1.05e-23

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 98.33  E-value: 1.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  12 ATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTG---F---------------VGNTSFEDFSHMMvsmAQKAT 73
Cdd:PRK09197   16 AKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNGgaaFiagkgvkddgqgaavLGAIAGAKHVHEV---AEHYG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  74 VPVITHWDHGRS---------MEIIHNAWTHGMNSL----MRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVG-- 138
Cdd:PRK09197   93 VPVILHTDHCAKkllpwidglLDAGEKHFAAGGKPLfsshMIDLSEEPLEENIEICSKYLERMAKAGMTLEIELGVTGge 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 139 -----NETVYEEALagyhYTDPDQAAEFVERTGCDS----LAVAIGNQHGVYtsEP---QLNFEVVKRVRDAVS------ 200
Cdd:PRK09197  173 edgvdNSHEDNSKL----YTQPEDVLYAYEALGKISgrftIAASFGNVHGVY--KPgnvKLRPEILKDSQEYVSkkfglp 246

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1609718361 201 ---VPLVLHGASGISDADIKTAISLGIAKINIHT 231
Cdd:PRK09197  247 akpFDFVFHGGSGSTLEEIREAVSYGVVKMNIDT 280
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 12-243 8.83e-23

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 95.90  E-value: 8.83e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  12 ATNKHYAIAHFNVWNAEMLMGVIDAAEEAKSPVIISFGTG---FVGNTSFED------------FSHMMVSMAQKATVPV 76
Cdd:cd00946    11 AKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGgaaFYAGKGLKNekqkasiagaiaAAHHVRSMAEHYGVPV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361  77 ITHWDHGRSMEIihnAWTHGM----------------NSLMRDASAFDFEENIRLTKEAVDFFHPLGIPVEAELGHVG-- 138
Cdd:cd00946    91 VLHTDHCAKKLL---PWFDGLleadeeyfkqhgeplfSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGITGge 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 139 -----NETVYEEALagyhYTDPDQAAEFVERTGCDS----LAVAIGNQHGVYTS-----EPQLNFEVVKRVR------DA 198
Cdd:cd00946   168 edgvdNSGVDNAEL----YTQPEDVWYVYEALSKISpnfsIAAAFGNVHGVYKPgnvklQPEILGEHQDYVReklglaDD 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1609718361 199 VSVPLVLHGASGISDADIKTAISLGIAKINIHTELCQAAMVAVKE 243
Cdd:cd00946   244 KPLYFVFHGGSGSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRN 288
PRK12331 PRK12331
oxaloacetate decarboxylase subunit alpha;
157-221 4.44e-04

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 183446 [Multi-domain]  Cd Length: 448  Bit Score: 41.23  E-value: 4.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1609718361 157 QAAEFVERTGCDSlaVAIGNQHGVYTsePQLNFEVVKRVRDAVSVPLVLHG--ASGISD----------ADI-KTAIS 221
Cdd:PRK12331  158 KLAKEMQEMGADS--ICIKDMAGILT--PYVAYELVKRIKEAVTVPLEVHThaTSGIAEmtylkaieagADIiDTAIS 231
NMO pfam03060
Nitronate monooxygenase; Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane ...
 158-244 1.18e-03

Nitronate monooxygenase; Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane dioxygenase (NPD) (EC:1.13.11.32), is an FMN-dependent enzyme that uses molecular oxygen to oxidize (anionic) alkyl nitronates and, in the case of the enzyme from Neurospora crassa, (neutral) nitroalkanes to the corresponding carbonyl compounds and nitrite. Previously classified as 2-nitropropane dioxygenase, but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. One atom of oxygen is incorporated into the carbonyl group of the aldehyde product. The reaction appears to involve the formation of an enzyme-bound nitronate radical and an a-peroxynitroethane species, which then decomposes, either in the active site of the enzyme or after release, to acetaldehyde and nitrite.


Pssm-ID: 367316 [Multi-domain]  Cd Length: 331  Bit Score: 39.80  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 158 AAEFVERTGCDSLAV---AIGNQHGVYTSEPQLNFEVVKRVRDAVSVPLVlhGASGISDA-DIKTAISLGIAKINIHTel 233
Cdd:pfam03060 148 EARIAEARGADALIVqgpEAGGHQGTPEYGDKGLFRLVPQVPDAVDIPVI--AAGGIWDRrGVAAALALGASGVQMGT-- 223

                          90
                  ....*....|.
gi 1609718361 234 cqaAMVAVKEN 244
Cdd:pfam03060 224 ---RFLLTKES 231
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
159-224 5.49e-03

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 37.99  E-value: 5.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1609718361 159 AEFVERTGCDSLAvaIGNQHGVYTsePQLNFEVVKRVRDAVSVPLVL--HGASGISDADIKTAISLGI 224
Cdd:PRK14040  161 AKQLEDMGVDSLC--IKDMAGLLK--PYAAYELVSRIKKRVDVPLHLhcHATTGLSTATLLKAIEAGI 224
HisA cd04732
HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase ...
 138-262 6.54e-03

HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-ribosyl)-4-imidazolecarboxamide). In bacteria and archaea, ProFAR isomerase is encoded by the HisA gene.


Pssm-ID: 240083  Cd Length: 234  Bit Score: 37.07  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609718361 138 GNETVYeealagyhYTDP-DQAAEFVERtGCDSLavaignqH-----GVYTSEPQlNFEVVKRVRDAVSVPLVLHGasGI 211
Cdd:cd04732    22 DKKTVY--------SDDPvEVAKKWEEA-GAKWL-------HvvdldGAKGGEPV-NLELIEEIVKAVGIPVQVGG--GI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1609718361 212 -SDADIKTAISLGIAKINIHTelcqaamVAVKENQdqpflhlerEVRKAVKE 262
Cdd:cd04732    83 rSLEDIERLLDLGVSRVIIGT-------AAVKNPE---------LVKELLKE 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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