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Conserved domains on  [gi|1625595224|gb|TIC46517|]
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cyclin-like protein [Wallemia mellicola]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 28-184 1.09e-43

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410228  Cd Length: 150  Bit Score: 148.13  E-value: 1.09e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  28 HDSSQHRHWRYT-PAELADKRRIANEKAIAltrtgwdKEKELNPNSEMStsITPPSVEEENDLIVYYLSQVKPICNLFQF 106
Cdd:cd20524     1 HTSTQRKHWIFSsEEELAELRAEANEKARE-------KLKESLKEEDAE--PKFLTPEEELLLVRYYEKKLLEFCRAFKL 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625595224 107 PEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIGKGKISKESILDIEFLISQNLRFE 184
Cdd:cd20524    72 PDSVLATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEKTAEIILEYELLLLQGLNFH 149
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 188-309 1.09e-28

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410229  Cd Length: 126  Bit Score: 108.15  E-value: 1.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 188 HPAHRAVWGIYLDMQTMPNRQNQQVLDGIFAEARQTARLSRLTNAEFIYTPSQIALGCYVMVN---KTLVEEYIEWKKQE 264
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRLPDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAAseaGIDVEEYLSEKLPG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1625595224 265 FHaeapSFEAIDGVVALIN-----IQKSKGGLKKETVQDIDKRLKLWQDP 309
Cdd:cd20525    81 SE----ESEELEKLLEIIReikklVKKYEGPPDKEEVKALDKKLKKCRNP 126
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 28-184 1.09e-43

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 148.13  E-value: 1.09e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  28 HDSSQHRHWRYT-PAELADKRRIANEKAIAltrtgwdKEKELNPNSEMStsITPPSVEEENDLIVYYLSQVKPICNLFQF 106
Cdd:cd20524     1 HTSTQRKHWIFSsEEELAELRAEANEKARE-------KLKESLKEEDAE--PKFLTPEEELLLVRYYEKKLLEFCRAFKL 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625595224 107 PEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIGKGKISKESILDIEFLISQNLRFE 184
Cdd:cd20524    72 PDSVLATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEKTAEIILEYELLLLQGLNFH 149
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 27-335 6.60e-40

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 143.44  E-value: 6.60e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  27 YHDSSQHRHWRYTPAE-LADKRRIANEKAIaltrtgwdkEKELNPNSEMSTSITPPSVEEENDLIVYYLSQVKPICNLFQ 105
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEEqLQEKRADANAKFR---------EAHEEEEKVLEAKPIFLTPEEELDLVKYYEKRLLDFCSAFK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 106 --FPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIGKGKISK-ESILDIEFLISQNLR 182
Cdd:TIGR00569  72 ptMPTSVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETPLKAlEQVLEYELLLIQQLN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 183 FEYATHPAHRAVWGIYLDMQT-MPNRQNQQVLDGIfAEARQTARLsrLTNAEFIYTPSQIALGCYVMVNKTLVEE----Y 257
Cdd:TIGR00569 152 FHLIVHNPYRPLEGFLIDIKTrLPGLENPEYLRKH-ADKFLNRTL--LTDAYLLYTPSQIALAAILHTASRAGLNmesyL 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625595224 258 IEWKKQEFHAEAPSfEAIDGVVALINIQKSKGGLKKETVQDIDKRLKLWQDPSKVEGTAMYKRKQEEADKEDLEKRNK 335
Cdd:TIGR00569 229 TEQLSVPGNREELP-QLIDIMRELRILVKKYEEPRSEKVAALKKKLDECHSIEENLSSVKIRKRKGYEDDTYISKKAK 305
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 188-309 1.09e-28

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 108.15  E-value: 1.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 188 HPAHRAVWGIYLDMQTMPNRQNQQVLDGIFAEARQTARLSRLTNAEFIYTPSQIALGCYVMVN---KTLVEEYIEWKKQE 264
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRLPDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAAseaGIDVEEYLSEKLPG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1625595224 265 FHaeapSFEAIDGVVALIN-----IQKSKGGLKKETVQDIDKRLKLWQDP 309
Cdd:cd20525    81 SE----ESEELEKLLEIIReikklVKKYEGPPDKEEVKALDKKLKKCRNP 126
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 50-327 3.10e-21

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 92.49  E-value: 3.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  50 ANEKAIALTRTG-WDKEKELNPNSEMSTSITPPSV--EEENDLIVYYLSQVKPICNLFQFPEIVEATAVSYIKRFYLFNS 126
Cdd:COG5333     2 ANALESNLVSSRpLLSFDSSQNAIELDLLVLEPELtlEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 127 VIDLHPKRVMLTSLFLSTKTVNTPISISdFAHYIGKG------KISKESILDIEFLISQNLRFEYATHPAHRAVWGIYLD 200
Cdd:COG5333    82 VEEISLYSVVTTCVYLACKVEDTPRDIS-IESFEARDlwseepKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 201 MQtmpNRQNQQVLDgiFAEARQTArlSRLTNAEFIYTPSQIALGCYVMVNKTLVEEYIEWKKQefhaeaPSFEAIDGVVA 280
Cdd:COG5333   161 LQ---EKDKYKLLQ--IAWKIIND--ALRTDLCLLYPPHIIALAALLIACEVLGMPIIKLLDF------VSYETKEEVIA 227

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1625595224 281 LinIQKSKGGLKKETVQDIDKRLKLWQDPSKV-EGTAMYKRKQ---EEADK 327
Cdd:COG5333   228 L--NYKSIVKNKIKTFKAEHLSRDLPFTLQNIaEPQFALDKKPkseEEADK 276
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 188-283 3.45e-12

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 62.17  E-value: 3.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 188 HPaHRAVWGIYLDMQTMPNRQNQQVldgifAEARQTAR----LSRLTNAEFIYTPSQIALGCYVMVNKTLVEEYIEWKkq 263
Cdd:pfam16899   1 HP-FRPLEGFLLDLKTRPPLLEDRI-----ESLYKRAReilkSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEK-- 72

                          90       100
                  ....*....|....*....|
gi 1625595224 264 eFHAEAPSFEAIDGVVALIN 283
Cdd:pfam16899  73 -FGLPEDRETKLEKLLDTIE 91
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 100-177 4.63e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.07  E-value: 4.63e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625595224  100 ICNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIgkGKISKESILDIEFLI 177
Cdd:smart00385   6 VCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYT--GYFTEEEILRMERLL 81
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 90-184 1.57e-05

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 44.04  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  90 IVYYLSQVkpiCNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNT-PISISDFAhYIGKGKISKE 168
Cdd:pfam00134  34 LIDWLVEV---HEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIyPPTVEDLV-YITDNAYTRE 109

                          90
                  ....*....|....*.
gi 1625595224 169 SILDIEFLISQNLRFE 184
Cdd:pfam00134 110 EILRMERLILETLNFD 125
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 28-184 1.09e-43

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 148.13  E-value: 1.09e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  28 HDSSQHRHWRYT-PAELADKRRIANEKAIAltrtgwdKEKELNPNSEMStsITPPSVEEENDLIVYYLSQVKPICNLFQF 106
Cdd:cd20524     1 HTSTQRKHWIFSsEEELAELRAEANEKARE-------KLKESLKEEDAE--PKFLTPEEELLLVRYYEKKLLEFCRAFKL 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625595224 107 PEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIGKGKISKESILDIEFLISQNLRFE 184
Cdd:cd20524    72 PDSVLATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEKTAEIILEYELLLLQGLNFH 149
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 27-335 6.60e-40

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 143.44  E-value: 6.60e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  27 YHDSSQHRHWRYTPAE-LADKRRIANEKAIaltrtgwdkEKELNPNSEMSTSITPPSVEEENDLIVYYLSQVKPICNLFQ 105
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEEqLQEKRADANAKFR---------EAHEEEEKVLEAKPIFLTPEEELDLVKYYEKRLLDFCSAFK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 106 --FPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIGKGKISK-ESILDIEFLISQNLR 182
Cdd:TIGR00569  72 ptMPTSVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETPLKAlEQVLEYELLLIQQLN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 183 FEYATHPAHRAVWGIYLDMQT-MPNRQNQQVLDGIfAEARQTARLsrLTNAEFIYTPSQIALGCYVMVNKTLVEE----Y 257
Cdd:TIGR00569 152 FHLIVHNPYRPLEGFLIDIKTrLPGLENPEYLRKH-ADKFLNRTL--LTDAYLLYTPSQIALAAILHTASRAGLNmesyL 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625595224 258 IEWKKQEFHAEAPSfEAIDGVVALINIQKSKGGLKKETVQDIDKRLKLWQDPSKVEGTAMYKRKQEEADKEDLEKRNK 335
Cdd:TIGR00569 229 TEQLSVPGNREELP-QLIDIMRELRILVKKYEEPRSEKVAALKKKLDECHSIEENLSSVKIRKRKGYEDDTYISKKAK 305
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 188-309 1.09e-28

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 108.15  E-value: 1.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 188 HPAHRAVWGIYLDMQTMPNRQNQQVLDGIFAEARQTARLSRLTNAEFIYTPSQIALGCYVMVN---KTLVEEYIEWKKQE 264
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRLPDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAAseaGIDVEEYLSEKLPG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1625595224 265 FHaeapSFEAIDGVVALIN-----IQKSKGGLKKETVQDIDKRLKLWQDP 309
Cdd:cd20525    81 SE----ESEELEKLLEIIReikklVKKYEGPPDKEEVKALDKKLKKCRNP 126
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 30-184 4.39e-23

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 94.51  E-value: 4.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  30 SSQHRHWRYTPAELADKRRIANEKAI-AL-----TRTGWDKEKELNPNSEMSTSIT-------PPSVEEENDLIVYYLSQ 96
Cdd:cd20585     5 STHRQRWIFTPQDLTEKREAANQRAVdALqqcgaTRVEAQAAGSLGGGAEVGGSNGkaaklpePLSADEELLMLKYYEQK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  97 VKPICNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDfahyIGKG-KISKESILDIEF 175
Cdd:cd20585    85 IQEVCRALRLPNKIQATALLYFKRFYLQWSVMEHDPKRIMLTCIYLACKVEEYHVSAEE----LGKGiQQDHQLILKNEL 160


                  ....*....
gi 1625595224 176 LISQNLRFE 184
Cdd:cd20585   161 ALLQGLNFD 169
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 50-327 3.10e-21

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 92.49  E-value: 3.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  50 ANEKAIALTRTG-WDKEKELNPNSEMSTSITPPSV--EEENDLIVYYLSQVKPICNLFQFPEIVEATAVSYIKRFYLFNS 126
Cdd:COG5333     2 ANALESNLVSSRpLLSFDSSQNAIELDLLVLEPELtlEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 127 VIDLHPKRVMLTSLFLSTKTVNTPISISdFAHYIGKG------KISKESILDIEFLISQNLRFEYATHPAHRAVWGIYLD 200
Cdd:COG5333    82 VEEISLYSVVTTCVYLACKVEDTPRDIS-IESFEARDlwseepKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 201 MQtmpNRQNQQVLDgiFAEARQTArlSRLTNAEFIYTPSQIALGCYVMVNKTLVEEYIEWKKQefhaeaPSFEAIDGVVA 280
Cdd:COG5333   161 LQ---EKDKYKLLQ--IAWKIIND--ALRTDLCLLYPPHIIALAALLIACEVLGMPIIKLLDF------VSYETKEEVIA 227

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1625595224 281 LinIQKSKGGLKKETVQDIDKRLKLWQDPSKV-EGTAMYKRKQ---EEADK 327
Cdd:COG5333   228 L--NYKSIVKNKIKTFKAEHLSRDLPFTLQNIaEPQFALDKKPkseEEADK 276
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 188-283 3.45e-12

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 62.17  E-value: 3.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 188 HPaHRAVWGIYLDMQTMPNRQNQQVldgifAEARQTAR----LSRLTNAEFIYTPSQIALGCYVMVNKTLVEEYIEWKkq 263
Cdd:pfam16899   1 HP-FRPLEGFLLDLKTRPPLLEDRI-----ESLYKRAReilkSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEK-- 72

                          90       100
                  ....*....|....*....|
gi 1625595224 264 eFHAEAPSFEAIDGVVALIN 283
Cdd:pfam16899  73 -FGLPEDRETKLEKLLDTIE 91
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 100-177 4.63e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.07  E-value: 4.63e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625595224  100 ICNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIgkGKISKESILDIEFLI 177
Cdd:smart00385   6 VCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYT--GYFTEEEILRMERLL 81
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 100-174 1.91e-09

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 53.95  E-value: 1.91e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1625595224 100 ICNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIGkgkISKESILDIE 174
Cdd:cd00043     9 LCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSG---VSEKELRKAE 80
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 89-179 3.76e-09

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 53.75  E-value: 3.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  89 LIVYYLSQVKPICNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIgKGKISKE 168
Cdd:cd20513     1 LHIFFANFIQALGERLKLRQRVIATAIVYFKRFYARNSFKDIDPRLVAPTCLYLASKVEECPSHARLIVAEA-KVLKTKF 79

                          90       100
                  ....*....|....*....|.
gi 1625595224 169 S---------ILDIEF-LISQ 179
Cdd:cd20513    80 SyefpyrvndILECEFyLLEA 100
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 93-185 6.28e-06

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 44.64  E-value: 6.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  93 YLSQVkpiCNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDF--AHYIGK--GKIS-- 166
Cdd:cd20547     8 FISQL---CKKLKFPRRTLGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKIEDTQKKSKDIlaASYNLRhpDKISvd 84

                          90       100
                  ....*....|....*....|....*.
gi 1625595224 167 -------KESILDIEFLISQNLRFEY 185
Cdd:cd20547    85 dqmleefRKAILGLERLLLETICFDF 110
CYCLIN_AcCycH_rpt2 cd20586
second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; ...
 188-309 8.32e-06

second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410289 [Multi-domain]  Cd Length: 132  Bit Score: 44.73  E-value: 8.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 188 HPAHRAVWGIYLDMQTMPNRQNQ---QVLDgifaEARQTA-----RLsRLTNAEFIYTPSQIALGCYVMVNKTL----VE 255
Cdd:cd20586     1 YAPYRALEGFVQDLEEFLAAGSGpdsQGLQ----ELRKAAlaavdKL-MLTDAPLLYPPGQLALAALRSANKAKggvdFD 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1625595224 256 EYIEW--KKQEFHAEAPSFEAIDGVVALINIQKSKGG-LKKETVQDIDKRLKLWQDP 309
Cdd:cd20586    76 RYLERvaARAASKMPDDPAAALTAVLDEIEYLVSEGArPEVAEVKEIDRKLKECRAP 132
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 90-184 1.57e-05

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 44.04  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224  90 IVYYLSQVkpiCNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNT-PISISDFAhYIGKGKISKE 168
Cdd:pfam00134  34 LIDWLVEV---HEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIyPPTVEDLV-YITDNAYTRE 109

                          90
                  ....*....|....*.
gi 1625595224 169 SILDIEFLISQNLRFE 184
Cdd:pfam00134 110 EILRMERLILETLNFD 125
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 101-184 1.84e-05

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 43.31  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 101 CNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDF---AHYI-----GKGKIS------ 166
Cdd:cd20534    13 GLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRRLRDIinvSYRIlhpdkPPLELDdeywel 92

                          90
                  ....*....|....*...
gi 1625595224 167 KESILDIEFLISQNLRFE 184
Cdd:cd20534    93 RDSIVNCELLLLRILKFD 110
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 107-146 1.05e-04

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 41.26  E-value: 1.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1625595224 107 PEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKT 146
Cdd:cd20545    22 PQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKV 61
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 112-184 1.61e-03

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 37.98  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625595224 112 ATAVSYIKRFYLFNSVIDlHPKRVMLTS-LFLSTKTVNTP-------------ISISDFAHyigKGKISKESILDIEFLI 177
Cdd:cd20530    33 ATGIVYFHRFYMFHSFKD-FDRYVTAACcLFLAGKVEETPkkckdiiktarslLNDKQFAQ---FGDDPKEEVMVLERIL 108


                  ....*..
gi 1625595224 178 SQNLRFE 184
Cdd:cd20530   109 LQTIKFD 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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