|
Name |
Accession |
Description |
Interval |
E-value |
| HpaX |
TIGR02332 |
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily ... |
28-439 |
0e+00 |
|
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily (pfam07690). Member of this family are found in a number of proteobacterial genomes, but only in the context of having genes for 4-hydroxyphenylacetate (4-HPA) degradation. The protein is characterized by Prieto, et al. ( as 4-hydroxyphenylacetate permease in E. coli, where 3-HPA and 3,4-dihydroxyphenylacetate are shown to competitively inhibit 4-HPA transport and therefore also interact specificially.
Pssm-ID: 131385 [Multi-domain] Cd Length: 412 Bit Score: 773.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 28 VIKKLFRRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIM 107
Cdd:TIGR02332 1 VIKKLFRRLIIFLFILFIFSFLDRINIGFAGLTMGKDLGLSATMFGLAATLFYAAYVICGIPSNIMLAIIGARRWIAGIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 108 VLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDG 187
Cdd:TIGR02332 81 VLWGIASTATMFATGPESLYLLRILVGIAEAGFLPGILLYLTFWFPAYFRARANALFMIAMPVTMALGLILSGYILALDG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 188 VMALKGWQWLFLLEGFPSVLLGVMVWFWLDDSPDKAKWLTKEDKKCLQEMMDNDRLTLVQPEGAISHHAMQQRSMWREIF 267
Cdd:TIGR02332 161 LMALKGWQWLFLLEGFPSVILGVMTWFWLDDSPDKAKWLDEEDKKALKEMIDNDQLTLEQPEGAFAHAAMPQRSMLREIF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 268 TPVVMMYTLAYFCLTNTLSAISIWTPQILQSFNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFA 347
Cdd:TIGR02332 241 TPAIMLYTLAYFCLTNTLSAINIWTPQILQSFNQGSSNIMIGLLAAIPQFCTIFGMIWWSRHSDRLKERKHHTALPYLFA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 348 AAGWLLASATDHNMIQMLGIIMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFN 427
Cdd:TIGR02332 321 AAGWLLASATDHNLIQLLGIIMASMGSFSAMAIFWTTPDQSISLQARAIAIAVINATGNIGSALSPFLIGILKDATGSFN 400
|
410
....*....|..
gi 1630823399 428 SGLWFVAALLVI 439
Cdd:TIGR02332 401 SGLWFVAALLVI 412
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
34-447 |
1.80e-100 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 304.49 E-value: 1.80e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 34 RRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIA 113
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 114 STATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYIlsldgvMALKG 193
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL------LLLFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 194 WQWLFLLEGFPSVLLGVMVWFWLddspdkakwltkedkkclqemmdndrltlvqpegaishhamqqrsmwreiftPVVMM 273
Cdd:cd17319 156 WRWAFIIEGLLGLLLAVLWWFYL----------------------------------------------------RQVWG 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 274 YTLAYFCLTNTLSAISIWTPQILQSfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDR--RQERRHHTALPYLFAAAGW 351
Cdd:cd17319 184 LALGYFGINYALYGLLTWLPTYLKQ-ARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 352 LLASATDHNMIQMLGIIMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGLW 431
Cdd:cd17319 263 LLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFL 342
|
410
....*....|....*.
gi 1630823399 432 FVAALLVIGAGIIWAI 447
Cdd:cd17319 343 FLAAVALLAALLVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
42-445 |
1.68e-81 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 257.27 E-value: 1.68e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 42 VLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFAT 121
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 122 GPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILsldgvmALKGWQWLFLLE 201
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWIL------IHFSWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 202 GFPSVLLGVMVWFWLDDSPDKAKWLTKEDKKCLQEMMDNDRltlvqpEGAISHHAmQQRSMWREIFTPVVMMYTLAYFCL 281
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQ------QGKGPSTP-KKYQIKELLKDRRVWGLALGQFLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 282 TNTLSAISIWTPQILQSFnQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWLLAS----AT 357
Cdd:TIGR00893 228 NIGLGFFLTWFPTYLVQE-RGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSllmfAT 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 358 DHNMIQMLGIIMASTGSFS--AMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGLWFVAA 435
Cdd:TIGR00893 307 NYVNIPYAALALVALGFFGlgAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAA 386
|
410
....*....|
gi 1630823399 436 LLVIGAGIIW 445
Cdd:TIGR00893 387 LALIGALSYL 396
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
26-453 |
1.22e-61 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 204.33 E-value: 1.22e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 26 QAVIKKLFRRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIAT 105
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 106 IMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSL 185
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 186 DgvmalkGWQWLFLLEGFPSVLLGVMvwfwlddspdkakwltkedkkclqemmdndrltlvqpegaishhamqqrsmwre 265
Cdd:COG2271 161 F------GWRAAFLILGLPGLLLALL------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 266 iftpVVMMYTLAYFCLTNTLSAISIWTPQILQSFnQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHT-ALPY 344
Cdd:COG2271 181 ----RFWLLALAYFLVYFALYGFLTWLPTYLVEV-RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVlAIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 345 LFAAAGWLLASATDHNMIQMLGIIMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTG 424
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
410 420
....*....|....*....|....*....
gi 1630823399 425 sFNSGLWFVAALLVIGAGIIWAIPMQSSR 453
Cdd:COG2271 336 -YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
31-415 |
1.10e-54 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 187.46 E-value: 1.10e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 31 KLFRRLIVFLFVLFIFSFLDRINIGFAgLTMG--RDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMV 108
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNA-AVMGmkEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 109 LWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDGV 188
Cdd:cd17327 80 LWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 189 MALKGWQWLFLLEGFPSVLLGVMVWFWLDDSPDKAKWLTKEDKKCLQEMMDNDRltlvqpEGAISHHAmqQRSMWREIFT 268
Cdd:cd17327 160 GGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQ------TGKGDQKF--KWKQIKEAFK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 269 -PVVMMYTLAYFCLTNTLSAISIWTPQILQSFnqGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFA 347
Cdd:cd17327 232 dPRTWLLFLFFFCSQITNNGISNFLPLILKSL--GFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLA 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1630823399 348 AAGWLLASATDHNMIQMLGIIMASTGSFSAMAIFWT-TPDQSISLRARAIGIAVINATGNIGSALSPFM 415
Cdd:cd17327 310 LVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSwISSNCAGYTKRATVLAIMLIFYNVGNIVAPQI 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
34-457 |
6.08e-45 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 161.20 E-value: 6.08e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 34 RRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIA 113
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 114 STATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDgvmalkG 193
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------G 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 194 WQWLFLLEGFPSVLLGVMVWFWLDDSPDKAKWLTKEDKKclqemmdndrltlvqpegaishhamQQRSMWReifTPVVMM 273
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR-------------------------DQLEALR---DPRFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 274 YTLAYFCLTNTLSAISIWTPQILQSfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWLL 353
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVD-QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 354 ASATDH-NMIQMLGIIMASTGSFSAMAIFWTTPDQsISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGLWF 432
Cdd:COG2223 289 ALALGSlWLFLVLFLLLGLALGGGNGAVFALVPDI-FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLV 367
|
410 420
....*....|....*....|....*
gi 1630823399 433 VAALLVIGAGIIWAIPMQSSRPRAT 457
Cdd:COG2223 368 FAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
39-413 |
1.63e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 129.08 E-value: 1.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 39 FLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATM 118
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 119 FATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSldgvmaLKGWQWLF 198
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS------LFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 199 LLEGFPSVLLGVMVWFWLDDSPDKAKWLTKEDKKclqemmdndrltlvqpegaishhamQQRSMWREIFTPVVMMYTLAY 278
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARL-------------------------SLIVAWKALLRDPVLWLLLAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 279 FCLTNTLSAISIWTPQILQSFnqGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERR--HHTALPYLFAAAGWLLASA 356
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVL--GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrlLLALLLLILAALGLLLLSL 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1630823399 357 TDHNMIQMLGIIMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSP 413
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
40-445 |
5.67e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 119.84 E-value: 5.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 40 LFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMF 119
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 120 ATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDGVmalkGWQWLFL 199
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 200 LEGFPSVLLGVMVWFWLDDSPDKAkwltkedkkclqemmdndrltlvQPEGAISHHAMQQRSMWREIFTPVVMMYTLAYF 279
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESA-----------------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 280 CLTNTLSAISIWTPQILQSFNqGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWLLASATDH 359
Cdd:cd06174 214 LVNLAYYSFSTLLPLFLLDLG-GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 360 NMIQMLGIIMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGLWFVAALLVI 439
Cdd:cd06174 293 LLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLL 372
|
....*.
gi 1630823399 440 GAGIIW 445
Cdd:cd06174 373 AAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
34-412 |
1.00e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 113.15 E-value: 1.00e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 34 RRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIA 113
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 114 STATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDgvmalkG 193
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF------G 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 194 WQWLFLLEGFPSVLLGVMVWFWLddspdkakwltkedkkclqemmdndrltlvqPEGAISHHAMQQRSMWREIFTPVVMM 273
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLL-------------------------------PESRPAARARLRGSLRELLRRPRLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 274 YTLAYFCLTNTLSAISIWTPQILQSfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRhHTALPYLFAAAGWLL 353
Cdd:COG2814 212 LLLLAFLLGFGFFALFTYLPLYLQE-VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1630823399 354 ASATDHNMIQMLGIIMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALS 412
Cdd:COG2814 290 LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
60-447 |
3.82e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 98.02 E-value: 3.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 60 TMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAG 139
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 140 FLPGILLYLTFWFPAYfRARANALFMVAMPVTTALGSLVSGYIlsldgvMALKGWQWLFLLEGFPSVLLGVMVWFWLDDS 219
Cdd:COG2807 123 GNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPL------AAALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 220 PdkakwltkedkkclqemmdndrltlvqPEGAISHHAMQQRSMWReifTPVVMMYTLAYFCLTNTLSAISIWTPQILQSf 299
Cdd:COG2807 196 P---------------------------AAAAAAPAAASLRSLWR---SPLAWLLTLFFGLQSLLYYAVVAWLPPILRD- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 300 nQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGW--LLASATDHNMIQMLGIIMASTGSFSA 377
Cdd:COG2807 245 -AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLlgLLLAPGSLPWLWAVLLGLGQGGLFPL 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1630823399 378 MAIFwttpdqsISLRAR-----AIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGLWFVAALLVIGAGIIWAI 447
Cdd:COG2807 324 ALTL-------IGLRARtpaeaAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
40-445 |
1.59e-19 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 89.99 E-value: 1.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 40 LFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNiMLSIVGARRWIATI-MVLWGIASTATM 118
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFG-YLGDRYNRKWILAVgILIWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 119 FATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDGvmalkGWQWLF 198
Cdd:cd17328 83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWRWAF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 199 LLEGFPSVLLGVMVWFWLDDSPDKAkwltkedkkclqemmdndrltlvqpEGAISHHAMQQRSMWREIF----TPVVMMY 274
Cdd:cd17328 158 RVTGVLGVLLAILLLLFVREPPRGA-------------------------AEGGVMAKSTATSFLADLKalakNPSFILS 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 275 TLAYFCLTNTLSAISIWTPQILQ---SFNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTalpYLFAAAGW 351
Cdd:cd17328 213 TLGFTAVSFVTGALAFWAPTFFLrafGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRA---DPLVCAVG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 352 LLASA---------TDHNMiqMLGIIMASTGSFSAMAIFWTTPD---QSISLRARAIGIAVINATGN-IGSALSPFMIGW 418
Cdd:cd17328 290 LLAAApflflalvlALSNL--LLAWVLLFLGEFLLSLNWAPVFAillYVVIPTRRSTASAIQILLSHlLGDAGSPYLIGL 367
|
410 420 430
....*....|....*....|....*....|....*...
gi 1630823399 419 LKDLTG-----------SFNSGLWFVAALLVIGAGIIW 445
Cdd:cd17328 368 ISDLLRqnkdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
54-445 |
1.89e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 89.60 E-value: 1.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 54 IGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILV 133
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 134 GITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVsgyilsLDGVMALKGWQWLFLLEGFPSVLLGVMVW 213
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAAL------LPPLALHYGWRAAFVVAGLVSILAAVLFW 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 214 FWLDDSPDKAkwltkedkkcLQEMMDNDRLTLVQPegaishhAMQQRSMWReIFTPVVMMYTLAYFCLTNTLsaisIWTP 293
Cdd:cd17475 169 LFYREPPAAS----------AATESASTLLRSLKE-------VLRNRDVWL-IAIAGALLVAPQFALLTFLL----LFLH 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 294 QILqsfnqGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWLLAS---ATDHNMIQMLGIIMA 370
Cdd:cd17475 227 DHL-----GLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVlslLSPGTPLWLLVLLLI 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1630823399 371 STGSFS----AMAIFWTTPDQSISLRARAIGIAviNATGNIGSALSPFMIGWLKDLTGSFNSGLWFVAALLVIGAGIIW 445
Cdd:cd17475 302 LLGLFAigwnGLYLTLVAESAGPEQAGTALGLA--NTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
61-445 |
3.32e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 85.68 E-value: 3.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 61 MGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGF 140
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 141 LPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYIlsldgvMALKGWQWLFLLEGFPSVLLGVMVWFWLDDSP 220
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL------GQLLGWRAAFLAIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 221 DKAKwltkedkkclqemmdndrltlvQPEGAIshhamqqRSMWREIFTPVVMMYTLAYFCLTNTLSAISIWTPQILQSFN 300
Cdd:cd17324 179 PKKP----------------------GSLGLL-------SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 301 QGSSNITIGLLAAVpQICTILGMIYWSRHSDRRQeRRHHTALPYLFAAAGWLLASATDHNMIQMLGIIMASTGSFSAMAI 380
Cdd:cd17324 230 GFSSSAIIGLLLLF-GVAGVVGSPLAGRLADRGG-RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1630823399 381 FWTTPdQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGsFNSGLWFVAALLVIGAGIIW 445
Cdd:cd17324 308 LQTRV-LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
35-419 |
7.11e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 85.10 E-value: 7.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 35 RLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIAS 114
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 115 TATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSldgvmaLKGW 194
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIP------VFGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 195 QWLFLLEGFPSVLLGVMVWFWLddsPDKAKWLTKEDKKCLQEMMDNDRLTLVQPEGAISHHAMQQRSMWREIFTPV---- 270
Cdd:TIGR00895 171 RSLFYVGGIAPLLLLLLLMRFL---PESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALfqgk 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 271 ----VMMYTLAYFCLTNTLSAISIWTPQILQsfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRqeRRHHTALPYLF 346
Cdd:TIGR00895 248 tariTVLLWLLYFMLLVGVYFLTNWLPKLMV--ELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL--GPRVTALLLLL 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1630823399 347 AAAGWLLASATDHNMIQMLGII----MASTGSFSAMAifwTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWL 419
Cdd:TIGR00895 324 GAVFAVLVGSTLFSPTLLLLLGaiagFFVNGGQSGLY---ALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
65-448 |
2.61e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 80.31 E-value: 2.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 65 LGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGI 144
Cdd:cd17473 30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 145 LLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLdgvmalkGWQWLFLLEGFpSVLLGVMVWFWLDDSPDKAK 224
Cdd:cd17473 110 TALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-------GWRAPFLVYLL-ALPVLILVLLFLPEPARKSK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 225 wltkedkkclqemmdndrltlvqpEGAISHHAMQQRSMWREIFtpVVMMYTLAYFCLtntLSAISIWTPQILQSFNQGSS 304
Cdd:cd17473 182 ------------------------SAASPGAATAAALPWKRVL--PIYFLAFLAMLL---FYVIPIQLPFLLQERGGGSA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 305 nITIGLLAAVPQICTILGMIYWSRHSDRRQERRhHTALPYLFAAAGWLLASATDHNMIQMLGIIMASTGSFSAM--AIFW 382
Cdd:cd17473 233 -ALIGLALAIASLAGAIGALLFGRLKRRLGKRR-LLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLptLNSW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630823399 383 TTPDQSISLRARAIGIavINATGNIGSALSPFMIGWLKDLTGSFNSGLWFVAALLVIGAGIIWAIP 448
Cdd:cd17473 311 AMSLVPPELRGRAMGI--VTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
37-445 |
3.54e-16 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 79.57 E-value: 3.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 37 IVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMfgLATTLFYAAYVIFGIPSNIMLSIVG---ARRWIATI-MVLWGI 112
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSL--LQTGLLFAAGFLGRPIGALLFGYLGdriGRKKALILtLLLFGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 113 ASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDGvmALK 192
Cdd:cd17316 79 ATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLS--GDW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 193 GWQWLFLLEGFPSVLLGVMVWFwlddspdkakwltkedkkclqemmdndrltlvqpegaishhamqqrsmwreiftpvVM 272
Cdd:cd17316 157 GWRILFLIGALPALLALLLRRR--------------------------------------------------------TL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 273 MYTLAYFCLTNTLSAISIWTPQILQSfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWL 352
Cdd:cd17316 181 LLILLWFFISFGYYGLTTFLPTYLQT-VLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 353 LASATDHNMIQ-MLGIIMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGLW 431
Cdd:cd17316 260 LFYLLSGSPTLlLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL 339
|
410
....*....|....
gi 1630823399 432 FVAALLVIGAGIIW 445
Cdd:cd17316 340 ILALLAIVALIVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
34-214 |
1.27e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 77.16 E-value: 1.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 34 RRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIA 113
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 114 STATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILsldgvmALKG 193
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV------AALG 166
|
170 180
....*....|....*....|.
gi 1630823399 194 WQWLFLLEGFPSVLLGVMVWF 214
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
63-447 |
2.46e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 77.23 E-value: 2.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 63 RDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLP 142
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 143 GILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSldgvmaLKGWQWLFLLEGFPSVLLGVMVWFWLDDSPDK 222
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD------ALGYRAPFLVCAALALLALVLALLLLPEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 223 AKWltkedkkclqemmdndrltlVQPEGAISHHAMQQRSMWREIFTPVVMMyTLAYFCLTNTLSAISIWTPQILqsfnqG 302
Cdd:cd17325 178 PNK--------------------RAVSAARLRSGLRLLLRDRRLLALFLAI-FVLAFAFGALEPFLPLYAAELG-----G 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 303 SSNITIGLLAAVPQICTILGMIYWSRHSDRRqeRRHHTALPYLFAAAGWLLASATDHNMIQMLGIIMASTGSFSAMAIFW 382
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRI--GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630823399 383 TT-PDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDlTGSFNSGLWFVAALLVIGAGIIWAI 447
Cdd:cd17325 310 LAlLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
48-424 |
1.34e-14 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 75.10 E-value: 1.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 48 FLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLY 127
Cdd:TIGR00881 8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 128 VLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLdgvmaLKGWQWLFLLEGFPSVL 207
Cdd:TIGR00881 88 ALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAE-----LYSWHWVFIVPGIIAII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 208 LGvMVWFWLDDSPDKAKWLTKedkkcLQEMM--DNDRLTLVQPEGAIShhamQQRSMWREIFTPVVMMYTLAYFCLTNTL 285
Cdd:TIGR00881 163 VS-LICFLLLRDSPQSCGLPP-----AEEMPneEPDGDAEKKEEELTK----KQIFLQYVLLNKVLWYISLGYVFVYVVR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 286 SAISIWTPQILqSFNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTAL-----PYLFAAAGWLLASATDHN 360
Cdd:TIGR00881 233 TGILDWSPLYL-TQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAvffmaLIIVSLLVYWLNPAANPL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1630823399 361 MIQMLGIIMASTGSFSAMaIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTG 424
Cdd:TIGR00881 312 MDLICLFALGFLVYGPQM-LIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
60-447 |
6.15e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 72.99 E-value: 6.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 60 TMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAG 139
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 140 FLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYIlsldgvmALKGWQWLFLLEGFPSVLLGVMVWFWLDDS 219
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-------AAISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 220 PDKAKWLTKEDKKCLQEMMDNDRLTLVqpegAIShhamqqrsmwreiftpvVMMYTLAYFCLTNTLSaisiwtpqILQSF 299
Cdd:cd17474 177 KEKAKSSSATKLRDLKKALRGRGLLTF----LVS-----------------AFLYFFLYFAFLTYLP--------FLLEL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 300 NQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWLLASATDHNMIQMLGIIMASTGSFSAMA 379
Cdd:cd17474 228 LYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLP 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1630823399 380 IFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSfnSGLWFVAALLVIGAGIIWAI 447
Cdd:cd17474 308 LLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGL--SAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
41-445 |
5.46e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 69.97 E-value: 5.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 41 FVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFA 120
Cdd:cd17341 5 WLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 121 TGP-TSLYVLRILVGITEAGFLPGILlYLTFWFPAYFRARANALF----MVAMPVTTALGSLVSGYILSLDGVMalkGWQ 195
Cdd:cd17341 85 VSSyWGLLVLGFLLGFAGANFASGQP-WASFWFPKEKIGGAAGGIagagNMGVAVSQLLAPLIAGAIVFDGGFV---GWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 196 WLFLLEGFPSVLLGVMVWFWLDDSPDKAKWltkedkkclqemmdndrltlvqpegaishHAMQQRSMWREIFTPVVMMYT 275
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTGKAS-----------------------------ALEFLKVQLAVLKNYRTWILS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 276 LAYFCLTNTLSAISIWTPQILQSfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALpYLFAAAGWLLAS 355
Cdd:cd17341 212 LLYGVTFGSFVGFSNVLPTYFKT-RFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWL-FIVMTIGAALLS 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 356 ATDHNMIQMLG--IIMASTGSFSAMAIFWTTPDQ--SISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGLW 431
Cdd:cd17341 290 LSLPTSGTNLVlfLALFVALGLGAGAGNGSVFRMvpFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFS 369
|
410
....*....|....
gi 1630823399 432 FVAALLVIGAGIIW 445
Cdd:cd17341 370 LFGVLAVACTLLVW 383
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
30-447 |
2.47e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.34 E-value: 2.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 30 KKLFRRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVL 109
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 110 WGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANaLFMVAMPVTTALGSLVSGYILSLDGVM 189
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLN-LLHAFFSLGALLGPLLGGLLILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 190 AlkgWQWLFLLEGFPSVLLGVMVWFWlddspdkakwltkedkkclqemmdndrlTLVQPEGAISHHAMQQRSMWREIFTP 269
Cdd:COG0738 162 S---WHLPYLILAVLLLLLALLFLRS----------------------------KLPEIEEEEEEAAGSAASLKSLLKNP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 270 VVMMYTLAYFCLTNTLSAISIWTPQILQSfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRhhtALPY--LFA 347
Cdd:COG0738 211 RLLLGGLAIFLYVGAEGAIGDWLPLYLKD-VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR---LLRLsaLLA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 348 AAGWLLASATDHNMIQMLGIIMASTGsfsaMAIFWTTpdqSISLRARAIG------IAVINATGNIGSALSPFMIGWLKD 421
Cdd:COG0738 287 AVGLLLALLAPGPWLALIGLALVGLG----LSLMFPT---IFSLALDGLGkrtaaaVSAVLIMGIVGGAIGPPLIGFLAD 359
|
410 420
....*....|....*....|....*.
gi 1630823399 422 LTGsFNSGLWFVAALLVIGAGIIWAI 447
Cdd:COG0738 360 AFG-LRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
41-448 |
7.13e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.48 E-value: 7.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 41 FVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFA 120
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 121 TGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDGvmALKGWQWLFLL 200
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLP--PEIAWRVLFLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 201 EGFPSvLLGVMVWFWLDDSPdkaKWLTKEDKkclqemmdndrltlvqpegaisHHAMQQRSMWREIFTPVVMMYTLAYFC 280
Cdd:cd17371 163 GALPA-LLVLFIRRFVKEPP---QWQAARAA----------------------RRHFADRPSLRELFSPPLLRTTLLASL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 281 LTNTLS----AISIWTPQILQSfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQeRRHHTALPYLFAAAGWLLASA 356
Cdd:cd17371 217 LATGALggyyGITTWLPSYLTG-ERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIG-RRNNFALFALGSAISILLYFF 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 357 TDHNMIQMLGII----MASTGSFSAMAIFWTtpdQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGLWF 432
Cdd:cd17371 295 LPLSPTLILILGfplgFFASGPFSGMGAYLT---ELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVF 371
|
410
....*....|....*.
gi 1630823399 433 VAALLVIGAGIIWAIP 448
Cdd:cd17371 372 AAVYYIAGLVLALLLP 387
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
37-451 |
9.61e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 62.99 E-value: 9.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 37 IVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTA 116
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 117 TMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSldgvmaLKGWQW 196
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIP------AFGWRS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 197 LFLLEGFPSVLLGVMVwfwlddspdkakwltkedkkclqemmdndRLTLVqpegaishhamqqrsMWREIFTPVVMMYtl 276
Cdd:cd17365 155 VFLLGGVPPLILLPLL-----------------------------RGTLL---------------LWVTFFMGLLLVY-- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 277 ayfcLTNTlsaisiWTPQILQSfnQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRqeRRHHTALPYLFAAAGWLLASA 356
Cdd:cd17365 189 ----LLNS------WLPKLMVE--AGYSLSQALTITLLLNIGGVIGSLLLGWLADRF--GPKRVLALFFALGAVSLALLG 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 357 TDHNMIQMLGIIMASTGSF--SAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGLWFVA 434
Cdd:cd17365 255 VSPASLVLLYVLVFLAGACvnGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALA 334
|
410
....*....|....*..
gi 1630823399 435 ALLVIGAGIIWAIPMQS 451
Cdd:cd17365 335 IPAALGALAVLLLRLRR 351
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
64-444 |
4.16e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.07 E-value: 4.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 64 DLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPG 143
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 144 ILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYIlsldgvMALKGWQWLFLLEGFPSVLLGVMVWFWLDDSPDKA 223
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL------YQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 224 KwltkedkkclqemmdndrltlvqpegaishHAMQQRSMWREIFTPVVMMYTLAYFCLTNTLSAISIWTPqiLQSFNQGS 303
Cdd:cd17489 179 E------------------------------EAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLP--LYAAERGI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 304 SNITIGLLAAvpQICTILGMIYWSRHSDRRQERRhhTALP-YLFAAAGWLLASATDHNMIQMLGIIMASTG------SFS 376
Cdd:cd17489 227 SNAGLFFTVY--AIALLLSRPFSGKLSDRKGPKT--VIIPgLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfgllfpALQ 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1630823399 377 AMAIFWTTPDQsislraRAIGIAVINATGNIGSALSPFMIGWLKDLTGSfnSGLWFVAALLVIGAGII 444
Cdd:cd17489 303 ALAVDLVPPHR------RGAANGTFFIFFDLGIGLGGLLLGLVAELFGY--RAMFLLAAVVVLLALVL 362
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
33-447 |
4.56e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 58.05 E-value: 4.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 33 FRRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGI 112
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 113 ASTATMFATGPTSLYVLR-ILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMpvttALGSLVSGYILSLdgVMAL 191
Cdd:cd17355 81 GLVLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGG----GLGSLVFLPLGAA--LIEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 192 KGWQWLFLLEGFPSVLLGVMVW-FWLDDSPDKAKWLTKEDKkclqemmdndrltlVQPEGAISHHAMQQRSMWReiftpv 270
Cdd:cd17355 155 FGWRTALLVLALLALLVLVPVLlLLRRRPADLALRAYDDAS--------------PASPGSTLKEALRSASFWL------ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 271 vmmYTLAYFCLTNTLSAISIWTPQILQSFnqGSSNITIGLLAAVPQICTILGMIYWSRHSDRrQERRHHTALPYLFAAAG 350
Cdd:cd17355 215 ---LALAFFLCGFAVVGLIVHLVPYLADR--GISPAAAAVALALIGLFNIVGRLLSGWLGDR-YSPRRLLAASYALRALG 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 351 WLLASATDHNMIQMLGIIMASTGS-FSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSG 429
Cdd:cd17355 289 LALLLLLPFPPLALLLFAALFGLGwGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAA 368
|
410
....*....|....*...
gi 1630823399 430 LWFVAALLVIGAGIIWAI 447
Cdd:cd17355 369 WALAVALGLIAALLVLPI 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-216 |
6.74e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 6.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 8 IPESIDPANQHKALTAGQQAVIKKLF--RRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVI 85
Cdd:cd17325 171 LPEPRPPPNKRAVSAARLRSGLRLLLrdRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 86 FGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFM 165
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFN 330
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1630823399 166 VAMPVTTALGSLVSGYIlsldgvMALKGWQWLFLLEGFPSVLLGVMVWFWL 216
Cdd:cd17325 331 TAFSLGMVLGPLLGGFL------YDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
37-214 |
1.20e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 56.41 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 37 IVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTA 116
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 117 TMFATGPT--SLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPvttaLGSLVSGYILSLdgVMALKGW 194
Cdd:cd17380 81 TPLLAYSSlpLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSY----LGTLLGGLIGPL--LLEYYGW 154
|
170 180
....*....|....*....|
gi 1630823399 195 QWLFLLEGFPSVLLGVMVWF 214
Cdd:cd17380 155 PSVFYFFGLLGLLWALVWLI 174
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
57-215 |
3.98e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 54.87 E-value: 3.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 57 AGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGIT 136
Cdd:cd17321 18 ALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIG 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1630823399 137 EAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDgvmalkGWQWLFLLegfpSVLLGVMVWFW 215
Cdd:cd17321 98 AAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF------GWRWIFLI----NVPIGLVALLL 166
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
34-220 |
4.73e-08 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 54.72 E-value: 4.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 34 RRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIA 113
Cdd:cd17488 2 IHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 114 STATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYIlsldgvMALKG 193
Cdd:cd17488 82 NILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFA------ALTYG 155
|
170 180
....*....|....*....|....*..
gi 1630823399 194 WQWLFLLEGFPSVLLGVMVWFWLDDSP 220
Cdd:cd17488 156 WRAGMYVPGIIAILMGIVLCWRLRDRP 182
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
35-445 |
4.96e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.59 E-value: 4.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 35 RLIVFLFVLFIFSF--LDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGI 112
Cdd:cd17312 1 RWRIFLGVFLGYAAyyVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 113 ASTatMFATGPTSLY--VLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLdgvma 190
Cdd:cd17312 81 ANI--FMGFSTSLWFfaVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASY----- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 191 lKGWQWLFLLEGFPSVLLGVMVWFWLDDSPdkakwltkedkkclqemmdndrltlvqpegaishhamqqrsmwreiftPV 270
Cdd:cd17312 154 -YGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------------------------------------PY 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 271 VMMYTLAYFCLTNTLSAISIWTPQILQSfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRR-QERRHHTALPYLFAAA 349
Cdd:cd17312 185 VWVLSLAYAFVYIVRYACLDWGPLYLYE-VKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMT 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 350 GWLLASATDHNMIQMLGIIMASTGSFSAMAI-FWTTPDQSISLRARAIGIA--VINATGNIGSALSPFMIGWLKDLTGSF 426
Cdd:cd17312 264 LSLALFWFFPHNKLLSIVLLFLIGFFVGGPInLIGGAAAQDIGRKEAAGTAtgFVGLFGYLGASLAGLPLGYIIDHYGWS 343
|
410
....*....|....*....
gi 1630823399 427 NSGLWFVAALLVIGAGIIW 445
Cdd:cd17312 344 TVFYFLISAALLSVLLLLS 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
32-444 |
3.55e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.23 E-value: 3.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 32 LFRRLIVFLFVLFIFSFLdrinIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWG 111
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMV----WPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 112 IASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDGvmal 191
Cdd:cd17329 77 LGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF---- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 192 kgwQWLFLLEGFPSVLLGVMVWFWLDDSPDKAKwltkedkkclqemmdndrltlvqpegaiSHHAMQQRSMWREIFT-PV 270
Cdd:cd17329 153 ---RLLFLAAAVLFLLAALVLLFLLPETRPKRR----------------------------AAEKTEILRGYKIVLRdRA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 271 VMMYTLAYFCLTNTLSAISIWTPQILQSFNQGSSNItIGLLAAVPQICTILGMIYWSRHSDRRQeRRHHTALPYLFAAAG 350
Cdd:cd17329 202 FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL-LGLLLALNALLIVLLQFPVARLVERFR-LRKILMIGILLFAIG 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 351 WLLASATDHNMIQMLGIIMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFnsGL 430
Cdd:cd17329 280 FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG--LP 357
|
410
....*....|....
gi 1630823399 431 WFVAALLVIGAGII 444
Cdd:cd17329 358 WLILAALGLIAAAL 371
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
61-439 |
4.94e-07 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 51.81 E-value: 4.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 61 MGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLwGIASTATMFATGPTSLYVLRILVGITEAG- 139
Cdd:cd17339 25 IRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLL-LAAGILLRSLGGIALLFLGTALAGAGIAVg 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 140 --FLPGILlyltfwfPAYFRARA---NALFMVAMPVTTALGSLVSGYILSLDGVmalkGWQWLFLLEGFPSvLLGVMVWF 214
Cdd:cd17339 104 nvLLPSLI-------KRDFPRRVglmTGLYTTSMNLGAALASGLSVPLAQALGG----GWRGALAIWALPA-LLALLIWL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 215 WlddspdkakwltkedkkclqemmdndrLTLVQPEGAISHHAMQQRSMWReifTPVVMMYTLaYFCLTNTLSAISI-WTP 293
Cdd:cd17339 172 P---------------------------QLRRRKRAAAAAAPLTKISVWR---SPLAWQVTL-FMGLQSLLFYTLMaWLP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 294 QILQsfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGW--LLASATDHNMIQMLGIIMAS 371
Cdd:cd17339 221 TILI--DAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVLFIIGVlgLLFAPTALALLWAVLLGLGG 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1630823399 372 TGSFS-AMAIF---WTTPDQSISLRARAIGIavinatGNIGSALSPFMIGWLKDLTGSFNSGLWFVAALLVI 439
Cdd:cd17339 299 GAAFSlALTLIslrSSDPAEAAALSGMAQSV------GYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVL 364
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
61-446 |
1.65e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 50.00 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 61 MGRDLGLSATMFGLATTLFYAAYVifgipSNIMLSIVGARRWIATIMVLWG----IASTATM-FATGPTSLYVLRILVGI 135
Cdd:cd06180 25 MLAELGLSYAQAGWIATANYAGYL-----VGALLASFLRRRGRARRLIRGGllltVLLLAAMaLTSGFAALLALRFLAGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 136 TEA-GFLPGILLYLTfWFPAYFRARANALFMVAmpvtTALGSLVSGYILSLDGVMALkGWQWLFLLEGFPSVLLGVMVWF 214
Cdd:cd06180 100 ASAfVFVFGSNLVLH-HATAAGRGHLIGLLFAG----VGLGIALSGLLVPAGLGGGL-SWRAGWLALALLSAVLLLLSFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 215 WLDDSPDKakwltkedkkclqemmdndrltlvQPEGAISHHAMQQRSMWreiftpvvMMYTLAYFCLTNTLSAISIWTPQ 294
Cdd:cd06180 174 LLRRGPSA------------------------PTEASAAESAPGLNRPL--------WRLALAYGLFGFGYIITATFLPL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 295 ILQSfnQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTA----------LPYLFAAAGWLLASAT--DHNMI 362
Cdd:cd06180 222 IARE--TGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAAnllvqavgvlLPLLSPGPAGLVLSAVlfGGTFM 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 363 QMLGIIMASTGSFSAMAifwttpdqsislRARAIGIavINATGNIGSALSPFMIGWLKDLTGSFNSGLWFVAALLVIGAG 442
Cdd:cd06180 300 AITALVMALARELAPPA------------APRALAL--MTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAAL 365
|
....
gi 1630823399 443 IIWA 446
Cdd:cd06180 366 LALL 369
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
64-222 |
2.05e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 49.61 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 64 DLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGP-TSLYVLRILVGITEAGFLP 142
Cdd:TIGR00886 31 DLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSySVLLLIRLFIGIAGGSFAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 143 GILLyLTFWFPAYFRARANALFM----VAMPVTTALGSLVSGYILSLDGVMALKGWQWLFLLEGFPSVLLGVMVWF--WL 216
Cdd:TIGR00886 111 CMPW-ISFFFPKKIQGTALGLAAgwgnMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLPALLIFfvGA 189
|
....*.
gi 1630823399 217 DDSPDK 222
Cdd:TIGR00886 190 DTPPGK 195
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
79-216 |
3.02e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 49.15 E-value: 3.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 79 FYAAYVIFGIPSNIMLSIVGARRwiatiMVLWGIASTA--TMF-----ATGPTSLYVLRILVGITEAGFLPGILLYLTFW 151
Cdd:cd17318 65 FFYGYILTQIPGGYLAEKYGAKR-----VLGYSILITAllTLLtplaaRGGYGALIVLRILQGLAQGVTFPAMHALWAKW 139
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1630823399 152 FPAYFRARANALFMVAMPVTTALGSLVSGYILSldgvmaLKGWQWLFLLEGFPSVLLgVMVWFWL 216
Cdd:cd17318 140 APPLERSRLTSIAYSGSQFGTVIAMPLSGFLCE------SLGWPSIFYIFGGLGLLW-CLLWFFL 197
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
73-219 |
6.30e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 45.72 E-value: 6.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 73 GLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWF 152
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1630823399 153 PAYFRARANALFMVAMPVTTALGSLVSGYILsldgvmALKGWQWLFLLEGFPSVLLGVMVWFWLDDS 219
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLA------QFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
6-214 |
1.99e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 1.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 6 PAIPESIDPANQHKALTAGQQAVIKKLFRRLIVFLFVLFIFSFLDRINIGFAGLTMgRDLGLSATMFGLATTLFYAAYVI 85
Cdd:cd06173 181 PPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAK-EVLGGGAAGYGLLLAAFGVGALL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 86 FGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFM 165
Cdd:cd06173 260 GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1630823399 166 VAMPVTTALGSLVSGYILSLDGVmalkgwQWLFLLEGFPSVLLGVMVWF 214
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALGL------SAVFLLAGALLLLAALLLLL 382
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
5-213 |
2.69e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.27 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 5 SPAIPESIDPANQHKALTAGQQAVIKKlFRRLIVFLFVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYV 84
Cdd:cd06174 175 DPPESARAKNEEASSKSVLKLLKRVLK-NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 85 IFGIPSNIMLSIVGARRWIATI-MVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANAL 163
Cdd:cd06174 254 LGSLLLGLLSDRLIGRKPLLLIgLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGL 333
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1630823399 164 FMVAMPVTTALGSLVSGYILSLDGvmalkGWQWLFLLEGFPSVLLGVMVW 213
Cdd:cd06174 334 LNTFGFLGGAIGPLLAGFLLAATF-----GLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
34-215 |
4.69e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.27 E-value: 4.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 34 RRLIVFLFVLFIFSFLDRINIGFAGLTMgRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIA 113
Cdd:cd17335 198 PRVLAFLLVAFLMGFGHGLIYSFLFWHL-QDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVR 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 114 STATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALF-MVAMPVTTALGSLVSGYIlsldgvMALK 192
Cdd:cd17335 277 WLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLqGLYFGLGGGLGSLIGGYL------YEAF 350
|
170 180
....*....|....*....|...
gi 1630823399 193 GWQWLFLLEGFPSVLLGVMVWFW 215
Cdd:cd17335 351 GARTTFRFFAIAALAGLLAFFLI 373
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
35-444 |
4.91e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 45.31 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 35 RLIVFL--FVLFIFSFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYvifGIPSNIMLSIV---GARRWIATIMVL 109
Cdd:cd17345 1 RWQVFLgiFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAY---GLSKFVMGNLSdrsNPKRFLAIGLIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 110 WGIASTATMFATGPTS----LYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSL 185
Cdd:cd17345 78 SAIINILIGFVPSATSsvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 186 DGVmalKGWQWLFLLEGFPSVLLGVMVWFWLDDSPDKAKWLTKEdkkclqEMMDNdrltlvQPEGAISHHAMQQRSMWRE 265
Cdd:cd17345 158 FGD---GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIE------EYKGD------YPEEADGEEEEQELSAWEI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 266 IFTPVVMMYTLAYFCLTNTLS-----AISIWTPQIL---QSFNQGSSNITIGL--LAAVPqictilGMIYWSRHSDR-RQ 334
Cdd:cd17345 223 FVKYVLKNKLLWYIAIANVFVylvryGILDWAPTYLsevKGFSKAQAMWAFSLfeWAAIP------GTLLAGWLSDKlFK 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 335 ERRHHTALPYLFAAAGWLLASATDHNMIqMLGIIMASTGSFsamaIFwtTPDQSISLraRAIGIAVINATGN-------- 406
Cdd:cd17345 297 GRRAPTGIIFMILVIVALIVYWLAPNVL-VDLIALIALGFL----IY--GPVMLIGL--QALELVPKKAAGTaagltglf 367
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1630823399 407 ---IGSALSPFMIGWLKDLTGsfnsglWFVAALLVIGAGII 444
Cdd:cd17345 368 gylGGSVLATALIGIIVDHFG------WNGGFIVLLASCIL 402
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
67-216 |
5.06e-05 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 45.22 E-value: 5.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 67 LSATMFGLATTLFYAAYVIFGIPSNIMLSIVGaRRWIATIMVLWG-IASTATMFATGPTSLYVLRILVGITEAGFLPGIL 145
Cdd:cd17372 31 LSAWQVALITSVVFAGMMIGSYLWGIVSDKYG-RRKGLIISALWTfYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLAS 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1630823399 146 LYLTFwFPAYFRARanalFMVAMPVTTALGSLVSGYILSLdgVMALKGWQWLFLLEGFPSVLLGVMvWFWL 216
Cdd:cd17372 110 WYLEF-LPAKSRGT----WMVLFSVFWTVGTIFEASLAWL--VMPRLGWRWLLAFSSVPSSLLLVF-YRWT 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-187 |
5.15e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 5.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 8 IPESIDPANQHKALTAGQQAVIK-KLFRRLIVFLFVLFIFSFldrINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIF 86
Cdd:COG2211 204 TKERPVPEEEKVSLKESLKALLKnRPFLLLLLAYLLFFLALA---LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 87 GIPSNIMLSIVGARRWIATIMVLWGIASTATMFA--TGPTSLYVLRILVGITEAGFLPGILLYLTF---WFPAYFRARAN 161
Cdd:COG2211 281 APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADvvdYDEWKTGRRRE 360
|
170 180 190
....*....|....*....|....*....|
gi 1630823399 162 ALFMVAMPVTT----ALGSLVSGYILSLDG 187
Cdd:COG2211 361 GLYFGIFTFAIklgqALAGALAGLLLALFG 390
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
63-445 |
6.83e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.85 E-value: 6.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 63 RDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLP 142
Cdd:cd17478 24 AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 143 GILLYLTFWFPAYfRARANALFMVAMPVTTALGSLVSGYILSLDGvmaLKGWQWLFLLegfPSVLLGVMVWFWLDDSPDK 222
Cdd:cd17478 104 EGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFG---GLGLLILLII---PGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 223 AKWLTKedkkclqemmdndrltlvqpegaishhAMQQRSMWREIFTPVVMMyTLAYFCLTNTLSAISIWTPQILQSfnQG 302
Cdd:cd17478 177 AKKAAA---------------------------KSSARSTLKGVWRALLLL-LIIVFLRSWVLSSLTTFLPFYLVQ--RG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 303 SSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWLLASATDHNMIQMLGIIMASTGSFSAMAIFW 382
Cdd:cd17478 227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVL 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1630823399 383 TtpdQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGsFNSGLWFVAALLVIGAGIIW 445
Cdd:cd17478 307 A---QELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLGALLAF 365
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
63-226 |
8.62e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 44.56 E-value: 8.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 63 RDLGLSATMFGLATTLFYAAYVIFGI---PSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVL----RILVGI 135
Cdd:cd17357 38 YGLNLSDSELDLLWSLIVSIFFIGGAigsFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELlifgRFLVGI 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 136 TEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLvsgyiLSLDGVMALK-GWQWLFLLEGFPsVLLGVMVWF 214
Cdd:cd17357 118 ACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQV-----FGLPSVLGTEtLWPYLLFFPGIP-ALLQLAALP 191
|
170
....*....|..
gi 1630823399 215 WLDDSPdkaKWL 226
Cdd:cd17357 192 FFPESP---KFL 200
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
157-456 |
8.78e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 8.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 157 RARANALFMVAMPVTTALGSLVSGYILSLDGVMALKGWQWLFLLEGFPSVLLGVMVWFWLDDSPDKAKwltkedkkclqe 236
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE------------ 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 237 mmdndrltlvqpegaishHAMQQRSMWREIFT-PVVMMYTLAYFCLTNTLSAISIWTPQILQSFNQGSSNItIGLLAAVP 315
Cdd:COG2211 213 ------------------EKVSLKESLKALLKnRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAAL-VGLLLALY 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 316 QICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWLLASATDHNMIQML-GIIMASTGSFSAMAIFW-----TTPDQSI 389
Cdd:COG2211 274 FLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLvLAALAGIGLGAILVLPWamladVVDYDEW 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 390 SLRARAIGI--AVINATGNIGSALSPFMIGWLKDLTGsFNSG---------------LWFVAALLVIGAGIIWAIPMQSS 452
Cdd:COG2211 354 KTGRRREGLyfGIFTFAIKLGQALAGALAGLLLALFG-YVAGaaqspsaltgirllfFLLPAVLLLLAALLLLFYPLTRE 432
|
....
gi 1630823399 453 RPRA 456
Cdd:COG2211 433 RHAE 436
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
63-221 |
1.31e-04 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 44.15 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 63 RDLGLSATMFGLATtlfyAAYVIFGIPSNIML----SIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEA 138
Cdd:PLN00028 64 DNLNLTKSDIGNAG----IASVSGSIFSRLAMgpvcDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 139 GFLPGillylTFWFPAYFRAR----ANALFM----VAMPVTTALGSLVSGYILSLdGVMALKGWQWLFLLEGFPSVLLGV 210
Cdd:PLN00028 140 TFVSC-----QYWMSTMFNGKivgtANGIAAgwgnLGGGVTQLLMPLVFPLIKDA-GAPSFTAWRIAFFVPGLLHIIMGI 213
|
170
....*....|.
gi 1630823399 211 MVWFWLDDSPD 221
Cdd:PLN00028 214 LVLTLGQDLPD 224
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
41-217 |
2.09e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 43.40 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 41 FVLFIFSFLDRINIG---FAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTAT 117
Cdd:cd17476 1 ATISGAQLLNQAGLGsviVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 118 MFATGPTSLYVLRILVGITEAGFLPGILLYLTFWF-PAYFRARANALFMVAMPVTTALGSLVSGYILsldgvmALKGWQW 196
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFA------QLAWWPW 154
|
170 180
....*....|....*....|.
gi 1630823399 197 LFLLEGFPSVLLGVMVWFWLD 217
Cdd:cd17476 155 IFWFLAILAAIVAVAAIFWTS 175
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
123-445 |
2.91e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.90 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 123 PTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDGVMALKGWQWL--FLL 200
Cdd:cd17369 105 PILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLSDEAFLSWGWRipFLL 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 201 eGFPSVLLGVMVWFWLDDSPDkakwltkedkkcLQEMMDNDRLTLVQPEGAISHHamqqrsmWREIFTPVVMM---YTLA 277
Cdd:cd17369 185 -SAVLVAVGLYIRLRLEETPV------------FRRAKEAGQVVRAPLVEVLRRH-------WRALLLAIGLRlaeNVLF 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 278 YFCLTNTLSAISiwtpqilQSFNQGSSNITIGLLAAVpqICTILGMIYWSRHSDRRQERRHH---TALPYLFAAAGWLLA 354
Cdd:cd17369 245 YLFTTFALSYAT-------QTLGVDRSTVLLAVLIAS--VVAAITIPLFGWLSDRVGRRPVYlagALLAALFAFPFFWLL 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 355 SATDH-----NMIQMLGIIMASTgsFSAMAIFWTtpdQSISLRARAIGIAV-INATGNIGSALSPFMIGWLKDLTGSFNS 428
Cdd:cd17369 316 DTGSTwlivlAAVVVLGVLHGMM--YGPQAAFLA---ELFPTRVRYTGASLgYQLGAILGGGFAPLIATALVAATGSWWP 390
|
330
....*....|....*..
gi 1630823399 429 GLWFVAALLVIGAGIIW 445
Cdd:cd17369 391 VALYLAALAVISLVAAL 407
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
54-234 |
3.60e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.55 E-value: 3.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 54 IGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILV 133
Cdd:cd17359 20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 134 GITEAGFLPGILLYLTFWFPAYFRARANALFMVaMPVTTALGSLVSGYILSL---DGVMALKGWQWLFLLEGFPSVLLGV 210
Cdd:cd17359 100 GLAVGGASALVPMYIAEVAPAEIRGRLVSLNQL-MIVFGQLLAYIVNYLIANaggADWLGAEGWRWMLGLEAIPAILFLL 178
|
170 180
....*....|....*....|....
gi 1630823399 211 MVWFwlddSPDKAKWLTKEDKKCL 234
Cdd:cd17359 179 GMLF----IPESPRWLVSKGKPIL 198
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
72-239 |
3.75e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 42.76 E-value: 3.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 72 FGL----ATTLFYAAYVI--FGipsNIMLSIVGAR--RWIATI--MVLWGIASTATMFATGPTSLYVLRILVGITEAGFL 141
Cdd:PRK03893 50 FGLttvqAASLISAAFISrwFG---GLLLGAMGDRygRRLAMVisIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 142 PGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLdgvmalKGWQWLFLLEgfpsvLLGVMVWFWLDDS-P 220
Cdd:PRK03893 127 GSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPV------WGWRALFFIG-----ILPIIFALWLRKNlP 195
|
170 180
....*....|....*....|
gi 1630823399 221 DKAKWL-TKEDKKCLQEMMD 239
Cdd:PRK03893 196 EAEDWKeKHAGKAPVRTMVD 215
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
30-213 |
4.20e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 4.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 30 KKLFRRLIVFLFVLFIFSFLdRINIGFAGLTMGrDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVL 109
Cdd:cd17370 196 KKLPKAFWLYLLAVALFALG-NFSFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLS 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 110 WGIASTATMFATGPTSLYVLRILVGI---TEAGFLPGILLYLTfwfPAYFRARANALFMVAMPVTTALGSLVSGYILSld 186
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLymgAQESIERAAVADLV---PAELRGTAYGLFNTVVGIGWLLASLIAGYLWD-- 348
|
170 180
....*....|....*....|....*..
gi 1630823399 187 gvmaLKGWQWLFLLEGFPSVLLGVMVW 213
Cdd:cd17370 349 ----LISPSAAFLFSAVLALIALLLLL 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
17-216 |
1.38e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 17 QHKALTAGQQAVIKKLFRRLIVFLFVLFIF--SFLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIML 94
Cdd:COG0738 191 EEEEEAAGSAASLKSLLKNPRLLLGGLAIFlyVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 95 SIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYfRARANALFMVAMPVTTAL 174
Cdd:COG0738 271 KRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAI 349
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1630823399 175 GSLVSGYILSLDGVmalkgwQWLFLLegfPSVLLGVMVWFWL 216
Cdd:COG0738 350 GPPLIGFLADAFGL------RAAFLV---PLVCYLLILLLAL 382
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
64-445 |
1.51e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 64 DLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTS-----LYVLRILVGITEA 138
Cdd:cd06173 28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlslwlLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 139 GFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSLDGVmalkgwQWLFLLEGFPSVLLGVMVWFWldd 218
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP------GGAFAINALSFLLSALLLLFI--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 219 spdkakwltkedkkclqemmdnDRLTLVQPEGAISHHAMQQRSMWREIFTPVVMMYTLAYFCLTNTLSAISIWTPQILQS 298
Cdd:cd06173 179 ----------------------RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 299 FNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWLLAsatdhnMIQMLGIIMASTGSFSAM 378
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG------LSPSLWLLLAALFLLGLA 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1630823399 379 AIFWTTPDQSI-------SLRARAigIAVINATGNIGSALSPFMIGWLKDLTGSfnSGLWFVAALLVIGAGIIW 445
Cdd:cd06173 311 GGLFNVPLNTLlqlrvpdELRGRV--FSVYNALNSGAMPLGALLAGLLADALGL--SAVFLLAGALLLLAALLL 380
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
60-200 |
1.53e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.64 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 60 TMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAG 139
Cdd:cd17503 21 TIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGV 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1630823399 140 FLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYILSldgvmaLKGWQWLFLL 200
Cdd:cd17503 101 LIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTD------NLSWRWIFYI 155
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
76-445 |
1.89e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 40.33 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 76 TTLFYAAYVIFGIPSNIMLSIVGA---RRW-IATIMVLWGIASTATMFATGPTSLYVL---RILVGITEAGFLPGILLYL 148
Cdd:pfam00083 48 SGLIVSIFSVGCFIGSLFAGKLGDrfgRKKsLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMYI 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 149 TFWFPAYFRARANALFMVAMpvttALGSLV---SGYILSLdgVMALKGWQWLFLLEGFPSVLLgVMVWFWLDDSPdkaKW 225
Cdd:pfam00083 128 SEIAPKKLRGALGSLYQLAI----TFGILLayiFGLGLNK--TSNSDGWRIPLGLQLVPALLL-IIGLLFLPESP---RW 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 226 L-----TKEDKKCLQEMMDNDRLTLVQPEGAISHHAMQQRSM--WREIFTPVVMMYTLAYFCLT------NTLSAISIWT 292
Cdd:pfam00083 198 LvekgrLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKasWKELFSTKTRRQRLLIGVMLqifqqlTGINAIFYYS 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 293 PQILQSFNQGSSNITIGLLAAVPQICTILGmIYWSRHSDRRQerrhhtalPYLFAAAG-------------WLLASATDH 359
Cdd:pfam00083 278 TTIFENLGLSDSFLVTIIVGVVNFVFTFIA-IFLVDRFGRRP--------LLLLGAAGmaicfvilgivalLGVSKSDWA 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 360 NMIQMLGI-IMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGSFNSGlWFVAALLV 438
Cdd:pfam00083 349 GIVAIVFIaLFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTF-FIFAGLLV 427
|
....*..
gi 1630823399 439 IGAGIIW 445
Cdd:pfam00083 428 LFIIFVF 434
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
63-441 |
1.95e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 63 RDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATI-MVLWGIASTATMFATGPTSLYVLRILVGITEAGFL 141
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIgLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 142 PGILLYLTFwFPAYFRARANALFMVAMPVTTALGSLVSGYIlsldgvMALKGWQWLFLLeGFPSVLLGVMVWFWLDDSPD 221
Cdd:cd17490 104 SFTVLYASY-FPPDEAAKAMGLINLVNNLGQLIAFLIGGLI------AEHFGMRAPFLL-AALAGVLGFILSLFIKEERR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 222 KAKWLTKEDKKcLQEMMDNDRLTLVQPEGAISHhamqqrsmwreiftpVVMMYTLAYFcltntlsaisiwTPQILqsFNQ 301
Cdd:cd17490 176 EKKPVLTELKE-LLSVLKDKKLLFFSLLAILQQ---------------MITFSTTFGF------------TPLIA--KQL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 302 GSSNITIGLLAAVPQICTILGmIYWSRHSDRRQERRHHTALPYLFAAAGWLLASATDHNMI-----QML-----GIIMAS 371
Cdd:cd17490 226 GASSFQLGLLSIIYLLPNALA-SLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTllyllQALngfgtGILFPL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 372 TGSFSAmaifwttpdQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGsFNSGLWFVAALLVIGA 441
Cdd:cd17490 305 LMSLSI---------EGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAA 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
66-178 |
2.20e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 66 GLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGIL 145
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110
....*....|....*....|....*....|...
gi 1630823399 146 LYLTFWFPAYFRARANALFMVAMPVTTALGSLV 178
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLL 139
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
98-221 |
3.41e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 39.64 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 98 GARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRAranalFMVAMPVTTALGSL 177
Cdd:cd17362 67 GRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRG-----LLVSLKELFIVLGI 141
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1630823399 178 VSGYILSLDGVMALKGWQWLFLLEGFPSVLLGVMVWfWLDDSPD 221
Cdd:cd17362 142 LLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMW-FLPPSPR 184
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
270-445 |
4.80e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 4.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 270 VVMMYTLAYFCLTNTLSAISIWTPQILQSFnqGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAA 349
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADL--GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 350 GWLLASATDHNMIQMLGIIM-ASTGSFSAMAIFWTTpdQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDLTGsFNS 428
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQgLGAGALFPAALALIA--DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRW 165
|
170
....*....|....*..
gi 1630823399 429 GLWFVAALLVIGAGIIW 445
Cdd:COG2814 166 VFLVNAVLALLALLLLL 182
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-216 |
7.74e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.34 E-value: 7.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 62 GRDLGLSATmfGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFL 141
Cdd:cd17489 221 AAERGISNA--GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLF 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1630823399 142 PGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYilsldgVMALKGWQWLFLLEGFPSVLLGVMVWFWL 216
Cdd:cd17489 299 PALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGL------VAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
48-221 |
7.98e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 38.54 E-value: 7.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 48 FLDRINIGFAGLTMGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLY 127
Cdd:PRK11663 36 YFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 128 VLRILVGITEAGFLPGILLYLTFWFPAYFRARANALFMVAMPVTTALGSLVSGYIlsldgvmALK-GWQWLFLLEGFPSV 206
Cdd:PRK11663 116 LLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAI-------ALHyGWRYGMMIAGIIAI 188
|
170
....*....|....*
gi 1630823399 207 LLGVMVWFWLDDSPD 221
Cdd:PRK11663 189 VVGLFLCWRLRDKPQ 203
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
276-445 |
9.56e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.17 E-value: 9.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 276 LAYFCLTNTLSAISIWTPQILQSfNQGSSNITIGLLAAVPQICTILGMIYWSRHSDRRQERRHHTALPYLFAAAGWLLAS 355
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630823399 356 ATDHNMIQMLGIIMASTGSF-----SAMAIFWTTPDQsislraRAIGIAVINATGNIGSALSPFMIGWLKDLTGsFNSGL 430
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGAlfpaaLALIADWFPPEE------RGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAF 154
|
170
....*....|....*
gi 1630823399 431 WFVAALLVIGAGIIW 445
Cdd:pfam07690 155 LILAILSLLAAVLLL 169
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
404-456 |
9.98e-03 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 38.40 E-value: 9.98e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1630823399 404 TGNIGSALSPFMIGWLKDLTGSFNSGLWFVAALLVIGAGIIWAIPMQSSRPRA 456
Cdd:pfam11700 426 TDKGSSWIGPLIVGAIQDRTGNIRSPFVFLAILLVVPLPLLLLVDVERGRREA 478
|
|
| |
