|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
10-377 |
7.54e-89 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 272.97 E-value: 7.54e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 10 LTLQTLSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFF 89
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 90 LGQA-QTPGMLMLSGFFLGVGGAIFSVGVTSVPKYFSKDKVGLANG-IYGMGNIGTAVSSFLAPPIAGII-------GWQ 160
Cdd:cd17341 81 LALAvSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGgIAGAGNMGVAVSQLLAPLIAGAIvfdggfvGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 161 TTVRSYLIIIAIFAILMFIFGDKNEPKVKVPLA--SQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDK 238
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTGKASALEflKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 239 VDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIA-----LFTIGCLTISICAGLGNGLI 313
Cdd:cd17341 241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSgtnlvLFLALFVALGLGAGAGNGSV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1631428180 314 FKLVPSYFAKESGAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFITMGH 377
Cdd:cd17341 321 FRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-382 |
2.03e-74 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 236.32 E-value: 2.03e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 9 QLTLQTLSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIF 88
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 89 FLGQAQTPGMLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIY-GMGNIGTAVSSFLAPPIAGIIGWQTTVRSY 166
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGgGGSFAVGIALVSKWFPPDRRGLALGLAaGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 167 LIIIAIFAILMFIFGDKNEPKVKVPLASQFKKLS---SNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGI 243
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLealRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 244 RSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSH-IALFTIGCLTISICAGLGNGLIFKLVPSYF- 321
Cdd:COG2223 246 LAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFp 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631428180 322 AKESGAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFITMGHLYKKE 382
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
10-340 |
2.74e-43 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 154.00 E-value: 2.74e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 10 LTLQTLSLVVGFMAWSIISPLMPY-ISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIF 88
Cdd:TIGR00886 3 LFFSWFGFFLSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 89 FLGQAQTP-GMLMLSGFFLGVGGAIFSVGVTSVPKYFSKDKVGLANGIY-GMGNIGTAVSSFLAPPIAGIIGWQTTVRSY 166
Cdd:TIGR00886 83 WAGLAVQSySVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAaGWGNMGGGVAQFVMPPIIGSLIFGGGQPAH 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 167 L-----------IIIAIFAILMFIFGDKNEPKVKVPLASQFK---KLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVN 232
Cdd:TIGR00886 163 LawgwafvivpaGILLLPALLIFFVGADTPPGKPATGKLSFKealKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 233 NFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISS----HIALFTIGCLTISICAGL 308
Cdd:TIGR00886 243 QFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLvsdgSLAAFIVLFVALFFFAGA 322
|
330 340 350
....*....|....*....|....*....|..
gi 1631428180 309 GNGLIFKLVPSYFAKESGAANGIVSMMGGLGG 340
Cdd:TIGR00886 323 GNGSTFALVPHIFRRATGAVSGLIGAIGNLGG 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-340 |
1.81e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 113.92 E-value: 1.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQ 94
Cdd:COG2814 17 LGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 95 TPGMLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMG-NIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIAI 172
Cdd:COG2814 97 SLWLLLAARFLQGLGaGALFPAALALIADLVPPERRGRALGLLGAGlGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 173 FAILMFIFGDKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIALA 252
Cdd:COG2814 177 ALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 253 TFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFAKES-GAANGI 331
Cdd:COG2814 257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEArGRASGL 336
|
....*....
gi 1631428180 332 VSMMGGLGG 340
Cdd:COG2814 337 YNSAFFLGG 345
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
22-374 |
7.05e-28 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 113.04 E-value: 7.05e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 22 MAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGMLML 101
Cdd:COG2807 32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 102 SGFFLGVGGAIFSVGVTSVPKYFSKDKVGLANGIYGMG-NIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIAIFAILMFIF 180
Cdd:COG2807 112 GTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAmGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 181 -GDKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNfGIDKVDAGIRSGVFIALATFLRPIG 259
Cdd:COG2807 192 lRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 260 GILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYF--AKESGAANGIVSMMGG 337
Cdd:COG2807 271 PLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALSGMAQSVGY 350
|
330 340 350
....*....|....*....|....*....|....*..
gi 1631428180 338 LGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFIT 374
Cdd:COG2807 351 LLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-381 |
9.96e-28 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 112.27 E-value: 9.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQ 94
Cdd:COG2271 17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 95 TPGMLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMG-NIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIAI 172
Cdd:COG2271 97 SFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGgPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 173 FAILMFIFgdknepkvkvplasqfkklssnyklyyLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIALA 252
Cdd:COG2271 177 LALLRFWL---------------------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 253 TFLRPIGGILGDKFNA--VKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFAKE-SGAAN 329
Cdd:COG2271 230 IVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKaRGTAS 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1631428180 330 GIVSMMGGLGGFFPPLVITYVTGLTGsSHLAFILLAIFGVLAFITMGHLYKK 381
Cdd:COG2271 310 GLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-375 |
3.59e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 102.27 E-value: 3.59e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 14 TLSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQA 93
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 94 QTPGMLMLSGFFLGVGGAIFSVGVTS-VPKYFSKDKVGLANGIYGMGN-IGTAVSSFLAPPIAGIIGWQTTVRSYLIIIA 171
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMAlIADIAPPEERGRAMGIFSSAIgLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 172 IFAILMFIF------GDKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRS 245
Cdd:cd17325 162 LALVLALLLlpeprpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 246 GVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFAKES 325
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1631428180 326 -GAANGIVSMMGGLGGFFPPLVITYVTGLTGSShLAFILLAIFGVLAFITM 375
Cdd:cd17325 322 rGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA-TPFLAAAALLLLAAVLF 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-373 |
1.76e-23 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 99.95 E-value: 1.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 18 VVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPG 97
Cdd:cd17319 13 VINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 98 MLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMGN-IGTAVSSFLAPPIAGIIGWQttvrsyliiiaifai 175
Cdd:cd17319 93 SLYVLRFLLGVAeAGFFPGAIKALAEWFPARERGRATGLFNSGApLGAAIGPPLSGWLLLLFGWR--------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 176 LMFIFgdknEPKVKVPLASQFKKLSsnYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIALATFL 255
Cdd:cd17319 158 WAFII----EGLLGLLLAVLWWFYL--RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 256 RPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHI--ALFTIGCLTIS-ICAGLGNGLIFKLVPSYF-AKESGAANGI 331
Cdd:cd17319 232 MILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTtsPVVAVILLSLAgFGIGAASPVFWSLPADLLpGEAAATAGGL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1631428180 332 VSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFI 373
Cdd:cd17319 312 INSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-381 |
7.77e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 98.77 E-value: 7.77e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 1 MYKTKGGFQLTLQTLSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSF 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 81 VILLFPIFFLGQAQTPGMLMLSGFFLGVGGAIFSVG----VTSVPKYFSKDKVGLANGIYGMGNIGTAVSSFLAPPIAGI 156
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAanpyVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 157 IGWQTTVRSYLIIIAIFAILMFIF---GDKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNN 233
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSklpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 234 FGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLI 313
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631428180 314 FKLVPSYFAKESGAANGIVSMMGGLGGFFPPLVITYVTGLTGsSHLAFILLAIFGVLAFITMGHLYKK 381
Cdd:COG0738 321 FSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLLILLLALALKRK 387
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-344 |
4.03e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 93.25 E-value: 4.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMP-YISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQA 93
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 94 QTPGMLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMG-NIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIA 171
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGfGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 172 IFAILMFIFGDKNEPKVKVPLASQFKKLSSNYKLY------YLSLWYFITFGAFVAFGLFLPNYlVNNFGIDKVDAGIRS 245
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALlrdpvlWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 246 GVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHI---ALFTIGCLTISICAGLGNGLIFKLVPSYFA 322
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTlssLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|...
gi 1631428180 323 KE-SGAANGIVSMMGGLGGFFPP 344
Cdd:pfam07690 322 KEeRGTASGLYNTAGSLGGALGP 344
|
|
| PRK15034 |
PRK15034 |
nitrate/nitrite transport protein NarU; Provisional |
44-367 |
1.72e-18 |
|
nitrate/nitrite transport protein NarU; Provisional
Pssm-ID: 184994 [Multi-domain] Cd Length: 462 Bit Score: 86.86 E-value: 1.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 44 QLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQA----QTP-GMLMLSGFFLGVGGAIFSVGVT 118
Cdd:PRK15034 71 QLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILIIPCVWLGIAvqnpNTPfGIFIVIALLCGFAGANFASSMG 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 119 SVPKYFSKDKVGLANGIY-GMGNIGTAVSSFLAP-----PIAGIIG------------WQTTVRSYLIIIAIFAILMFIF 180
Cdd:PRK15034 151 NISFFFPKAKQGSALGINgGLGNLGVSVMQLVAPlvifvPVFAFLGvngvpqadgsvmSLANAAWIWVPLLAIATIAAWS 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 181 GDKNEPKVKVPLASQFKKLsSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFI-ALAtflRPIG 259
Cdd:PRK15034 231 GMNDIASSRASIADQLPVL-QRLHLWLLSLLYLATFGSFIGFSAGFAMLAKTQFPDVNILRLAFFGPFIgAIA---RSVG 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 260 GILGDKFNAVKVLMIDFIIMIVGAVIL-------GISSHIALFTIgCLTISICAGLGNGLIFKLVPSYFAK--------- 323
Cdd:PRK15034 307 GAISDKFGGVRVTLINFIFMAIFSALLfltlpgtGSGNFIAFYAV-FMGLFLTAGLGSGSTFQMIAVIFRQitiyrvkmk 385
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1631428180 324 -------------ESGAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIF 367
Cdd:PRK15034 386 ggsdeqaqreavtETAAALGFISAIGAVGGFFIPQAFGMSLNMTGSPVGAMKVFLIF 442
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-373 |
1.61e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 83.24 E-value: 1.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 21 FMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGMLM 100
Cdd:cd06174 9 GLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 101 LSGFFLGVGGA-IFSVGVTSVPKYFSKDKVGLANGIYGMG-NIGTAVSSFLAPPIAGII--GWQTTVRSYLIIIAIFAIL 176
Cdd:cd06174 89 LGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFgSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 177 MFIF--------GDKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVF 248
Cdd:cd06174 169 LLLVvpdppesaRAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 249 IALATFLRPIGGILGDKFNAVK-VLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFAKES-G 326
Cdd:cd06174 249 GLAGALGSLLLGLLSDRLIGRKpLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIrG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1631428180 327 AANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFI 373
Cdd:cd06174 329 TAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-373 |
1.99e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 76.82 E-value: 1.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 26 IISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGMLMLSGFF 105
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 106 LGV-GGAIFSVGVTSVPKYFSKDKVGLANGIYGMGN-IGTAVSSFLAPPIAGIIGWQTTVRSYLIIIAIFAILMFIF--G 181
Cdd:cd17324 97 AGLaHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLtLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLlpS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 182 DKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGI 261
Cdd:cd17324 177 LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 262 LGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFAKESGAANGIVS----MMGG 337
Cdd:cd17324 257 LADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLaaynLGGA 336
|
330 340 350
....*....|....*....|....*....|....*.
gi 1631428180 338 LGGFFPPLVITYvtgltGSSHLAFILLAIFGVLAFI 373
Cdd:cd17324 337 LGAALGGLVLDH-----GGWAGVGWVGAALLLLALL 367
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-373 |
4.98e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 75.68 E-value: 4.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 18 VVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPG 97
Cdd:cd17474 9 LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 98 MLMLSGFFLGVGGAIF-SVGVTSVPKYFSKDKVGLANGIYGMGN-IGTAVSSFLAPPIAGiIGWQTTVRSYLIIIAIFAI 175
Cdd:cd17474 89 LLLAGRALQGIGAAGLgPLALTLIGDLFEGGERAKAMGLYEAALgLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 176 LMFIFGDKNEPKVKVPLASQFKKLSSNYK------LYYLSLWYFITFGAFVAfglFLPNYLVNNFGIDKVDAGI---RSG 246
Cdd:cd17474 168 AILFLLPEPKEKAKSSSATKLRDLKKALRgrglltFLVSAFLYFFLYFAFLT---YLPFLLELLYGISPIIIGLlfaGWS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 247 VFIALATFLrpIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFAKES- 325
Cdd:cd17474 245 VLLALGSLF--VGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEEr 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1631428180 326 GAANGIVSMMGGLGGFFPPLVITYVTGLTGsSHLAFILLAIFGVLAFI 373
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAV 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-340 |
1.84e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 71.05 E-value: 1.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQ 94
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 95 TPGMLMLSGFFLGVGGA-IFSVGVTSVPKYFSKDKVGLANGIYGMGnigTAVSSFLAPPIAGIIGWQTTVRSyliiiaif 173
Cdd:cd17321 83 SLAFLIAARALQGIGAAaIMPASLALIAATFPGERRGRALGLWGAV---VGIGAALGPLLGGLLLELFGWRW-------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 174 ailmfIFGdknepkVKVPLASQFKKLSSNYKLYYLSLwyFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIALAT 253
Cdd:cd17321 152 -----IFL------INVPIGLVALLLARTFSGAVLAA--FLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAML 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 254 FLRPIGGILGDKFNAVKVLMIDFIIMIVGAVIL---GISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFAKE-SGAAN 329
Cdd:cd17321 219 VAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLallGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEkAGAAS 298
|
330
....*....|.
gi 1631428180 330 GIVSMMGGLGG 340
Cdd:cd17321 299 GILNTARQLGG 309
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-375 |
4.97e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.55 E-value: 4.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 14 TLSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQA 93
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 94 QTPGMLMLSGFFLGVGGAIFSVGV-TSVPKYFSKDKVGLANGIYGMGnigTAVSSFLAPPIAGIIGWQTTVRS--YLIII 170
Cdd:cd17489 82 TSVALLLVLRLIHGIGWGAFTTAAaTLVADIIPPSRRGEGIGYYGLA---TTLAMALGPALGLFLYQHLGFAVlfIVAAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 171 AIFAILMFIFGDKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGL---FLPNYLVNNFGidkVDAGIRSGV 247
Cdd:cd17489 159 LALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAistFLPLYAAERGI---SNAGLFFTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 248 FIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGcltiSICAGLGNGLIFKLVPSYFAKES-- 325
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA----AVLYGLGFGLLFPALQALAVDLVpp 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1631428180 326 ---GAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLaFILLAIFGVLAFITM 375
Cdd:cd17489 312 hrrGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAM-FLLAAVVVLLALVLY 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-375 |
8.33e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.14 E-value: 8.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 22 MAWSIISPLMPYISQD-VKVNPGQLSIILAIP---VILGSILrvpFGYLTNIIGAKWVFFCSFVILLF----PIFflgqA 93
Cdd:cd17473 13 MAGAAIAPALPAIAQHfVPNSELLVPLLLTLPalfIALFAPL---AGWLADRFGRKRLLIAGLLLYGIggvaGLF----L 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 94 QTPGMLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMGNIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIAI 172
Cdd:cd17473 86 DSLYALLASRALLGIGvAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 173 FAILMFIFGDKNEPKVKVPLASQFKKLSSNYKLyyLSLWYFITFGAFVAF---GLFLPNYLVNNFGIDKVdagiRSGVFI 249
Cdd:cd17473 166 LILVLLFLPEPARKSKSAASPGAATAAALPWKR--VLPIYFLAFLAMLLFyviPIQLPFLLQERGGGSAA----LIGLAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 250 ALATFLRPIGGI----LGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCltisICAGLGNGLIFKLVPSYFAKES 325
Cdd:cd17473 240 AIASLAGAIGALlfgrLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGA----ILAGLGFGLLLPTLNSWAMSLV 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1631428180 326 -----GAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFITM 375
Cdd:cd17473 316 ppelrGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
25-372 |
2.04e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 67.58 E-value: 2.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 25 SIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGMLMLSGF 104
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 105 FLGVGGAIFSVGVTSVPKYFSKDKVGLANGIYG-MGNIGTAVSSFLAPPIAGIIGWQTTVrsYLIIIAIFAILMFIFGDK 183
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSvGGNLGFALGPLIAAALVALFGGLGLL--ILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 184 NEPKVKVPLASQFKKLSSNYKLYYLS---LWYFITFGAFVAFGL--FLPNYLVNNFGiDKVDAGIRSGVFIALATFLRPI 258
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRAlllLLIIVFLRSWVLSSLttFLPFYLVQRGY-SLVFAGLLLSLFLFAGAIGTLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 259 GGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFtIGCLTISICAGLGNGLIFKLVPSYFAKESGAANGIVSMMG-G 337
Cdd:cd17478 250 GGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSY-ILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSfG 328
|
330 340 350
....*....|....*....|....*....|....*..
gi 1631428180 338 LGGFFPPLV--ITYVTGLTGSSHLAFILLAIFGVLAF 372
Cdd:cd17478 329 LGGIGAPVLgaLADAFGLESVLLILALLPLLGALLAF 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
16-375 |
2.58e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.00 E-value: 2.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 16 SLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKW-----------VFFCSFVILL 84
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiligaIPLALSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 85 FPIFFLGQAQTPGMLMLSGFFLGVGGAIFSVGVTS-----VPKYfsKDKVGLANGIYGMGNIGTAVSSFLAPPIAGII-- 157
Cdd:COG2211 99 FTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSAlgaelTPDY--EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFgg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 158 ----GWQTTVRSYLIIIAIFAILMFIF--GDKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLV 231
Cdd:COG2211 177 daalGYRLTALIFAVLGLLAFLLTFFGtkERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 232 NNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIgcLTISICAGLGNG 311
Cdd:COG2211 257 YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLL--LVLAALAGIGLG 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 312 LIFKLVPSYFA------------KESGAANGIVSMMGGLGGFFPPLVITYV--------------TGLTGSSHLAFILLA 365
Cdd:COG2211 335 AILVLPWAMLAdvvdydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLlalfgyvagaaqspSALTGIRLLFFLLPA 414
|
410
....*....|
gi 1631428180 366 IFGVLAFITM 375
Cdd:COG2211 415 VLLLLAALLL 424
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
23-373 |
3.46e-12 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 67.25 E-value: 3.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 23 AWSIISPlmpYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQA-QTPGMLML 101
Cdd:cd17353 21 AWSVFNP---PLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAiSLPLLFLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 102 SGFFLGVG-GAIFSVGVTSVPKYFSkDKVGLANGIYGMGnIGTAvSSFLAPPIAGIIGWQTTVRSYLIIIAIFAILMFIF 180
Cdd:cd17353 98 YGVLGGIGaGIGYITPVSTAVKWFP-DKRGLATGIVIAG-FGLG-SLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 181 G-------DKNEPKVKVPLASQFKKLSSNY--------KLYYLsLWYFITFGAFVAFGLF--LPNYLVNNFGIDKVDAGI 243
Cdd:cd17353 175 AflirdppKGWVPPGVDPLANNAENSPRDYtpremlrtPTFWL-LWLMFFLNATAGLMLIgqAKPIGQEFAGLDAGIAAL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 244 RSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVG-AVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYF- 321
Cdd:cd17353 254 AVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAmFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFg 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1631428180 322 AKESGAANGIVSMMGGLGGFFPPLVITYVTgLTGSSHLAFILLAIFGVLAFI 373
Cdd:cd17353 334 TKNAGTNYGLLYTAKGVGGLIGPIIAAYVL-YTGGYNAAFIIAAALSLVALA 384
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
12-340 |
2.42e-10 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 61.87 E-value: 2.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 12 LQTLSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIIlAIPVILGSIL-RVPFGYLTNIIGAKWVffCSFVILL--FPIF 88
Cdd:PLN00028 40 LSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNA-GIASVSGSIFsRLAMGPVCDLYGPRYG--SAFLLMLtaPAVF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 89 FLGQAQTPGMLMLSGFFLGVGGAIFSVGVTSVPKYFSKDKVGLANGIY-GMGNIGTAVSSFLAPPIAGII---------G 158
Cdd:PLN00028 117 CMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAaGWGNLGGGVTQLLMPLVFPLIkdagapsftA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 159 WQTTVRSYLIIIAIFAILMFIFGD-----------KNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLP 227
Cdd:PLN00028 197 WRIAFFVPGLLHIIMGILVLTLGQdlpdgnyrelkKSGTMPKDSFSKVLRYGVTNYRTWILALTYGYSFGVELTMDNIIA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 228 NYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAV----KVLMIDFIIMIVGA---VILGISSHIALfTIGCL 300
Cdd:PLN00028 277 EYFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARRfgmrGRLWALWIVQTLGGvfcIWLGRANSLGA-AIVVM 355
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1631428180 301 TI-SICAGLGNGLIFKLVPsyFAkeSGAANGIVSMMGGLGG 340
Cdd:PLN00028 356 ILfSIFVQAACGATFGIVP--FV--SRRSLGVISGLTGAGG 392
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
14-375 |
2.08e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 58.40 E-value: 2.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 14 TLSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQA 93
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 94 QTPGMLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMG-NIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIA 171
Cdd:cd17475 82 GSYPVLLVLLFLVGAGyGSVQPGGGRAIMRWFPPRERGLAMGIRQTGvPLGGALAAALLPPLALHYGWRAAFVVAGLVSI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 172 IFAILMFIF-GDKNEPKVKVPLASQFKKLSSNYkLYYLSLWYFITFGAF-----VAFGLFLPNYLVNNFGIDKVDAGIRS 245
Cdd:cd17475 162 LAAVLFWLFyREPPAASAATESASTLLRSLKEV-LRNRDVWLIAIAGALlvapqFALLTFLLLFLHDHLGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 246 GVFIALATFLRPIGGILGDKF---NAVKVLMIDFIIMIVGAVILGI---SSHIALFTIGCLTISICAGLGNGLIFKLVPS 319
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVfggRRRPVLVITAAIAAAALLVLSLlspGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1631428180 320 YFAKE-SGAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFITM 375
Cdd:cd17475 321 SAGPEqAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
213-373 |
4.73e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.29 E-value: 4.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 213 FITFGAFVAFGLFLPnYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHI 292
Cdd:COG2814 20 FLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 293 ALFTIGCLTISICAGLGNGLIFKLVPSYFAKES-GAANGIVSMMGGLGGFFPPLVITYVTGLTGsSHLAFILLAIFGVLA 371
Cdd:COG2814 99 WLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVNAVLALLA 177
|
..
gi 1631428180 372 FI 373
Cdd:COG2814 178 LL 179
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-374 |
5.29e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.28 E-value: 5.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 27 ISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFfcSFVILLFPIFFLGQAQTPGM------LM 100
Cdd:cd17312 22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFM--SAGLLLSALANIFMGFSTSLwffavlWG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 101 LSGFFLGVGgaiFSVGVTSVPKYFSKDKVGlanGIYGMGNIGTAVSSFLAPPIAGII----GWQTTVRSYLIIIAIFAIL 176
Cdd:cd17312 100 LNGLFQSMG---WPPCVKLLGNWFSKKERG---TVYGIWSTSHNFGGILAPILAASLasyyGWRAAFLVPGIVGLVVAII 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 177 MFIFgDKNEPKVkvplasqfkklssnykLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFiALATFLR 256
Cdd:cd17312 174 LFFF-LRDSPPY----------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLY-EVGGIAG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 257 PIG-GILGDKF---NAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLtiSICAGLGNG---LIFKLVPSYFAKE--SGA 327
Cdd:cd17312 236 TILaGLLSDKLfggRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLL--FLIGFFVGGpinLIGGAAAQDIGRKeaAGT 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1631428180 328 ANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLA--FILLAIFGVLAFIT 374
Cdd:cd17312 314 ATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFyfLISAALLSVLLLLS 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
10-375 |
5.73e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.23 E-value: 5.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 10 LTLQTLSLVVGFMAWSIISPLMPYISQDVK--VNPGQLSIILAIPVI---LGSILrvpFGYLTNIIGAKWVFFCSFVILL 84
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLgrpIGALL---FGYLGDRIGRKKALILTLLLFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 85 FPIFFLGQAQTPGMLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMGN-----IGTAVSSFLAPPIAGIIG 158
Cdd:cd17316 78 LATLLIGLLPTPILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWalgalLAALVASLLIPLLSGDWG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 159 WqttvRSYLIIIAIFAILMFIFgdknepkvkvplasqfkklssNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDK 238
Cdd:cd17316 158 W----RILFLIGALPALLALLL---------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 239 VDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGI--SSHIALFTIGCLTISICAGLGNGLIFKL 316
Cdd:cd17316 213 ATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYllSGSPTLLLLLLFILSFFVGGVWGALYAY 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 317 VPSYFAKES-GAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFITM 375
Cdd:cd17316 293 LAELFPTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
213-349 |
7.64e-09 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 56.79 E-value: 7.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 213 FITFGAFVAFGLFLpNYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHI 292
Cdd:cd17352 13 FFTDGILNSFGVLF-VELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSL 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631428180 293 ALFtigCLTISICAGLGNGLIFK----LVPSYFAKESGAANGIVSMMGGLGGFFPPLVITY 349
Cdd:cd17352 92 WQL---YLTYGVLGGLGLGLIYSpaivIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRY 149
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
212-373 |
1.12e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 56.27 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 212 YFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSH 291
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 292 IALFTIGCLTISICAGLGNGLIFKLVPSYFAK-ESGAANGIVSMMGGLGGFFPPLVITYVTGLTGsSHLAFILLAIFGVL 370
Cdd:pfam07690 85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAILSLL 163
|
...
gi 1631428180 371 AFI 373
Cdd:pfam07690 164 AAV 166
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
10-375 |
1.55e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.70 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 10 LTLQTLSLVVGFMAWsiisPLMP-YISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIF 88
Cdd:cd17329 5 LIGSFLNRLGFFMVW----PFMAiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 89 FLGQAQTPGMLMLSGFFLGVGGAIFSVGVTSVPKYFSKDKVGLA--NGIYGMGNIGTAVSSFLAPPIAGIIGWQTTVRSY 166
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRafSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 167 LIIIAIFAILMFIFGDKNEPKVKVPLASQFKKLSS---NYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGI 243
Cdd:cd17329 161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIvlrDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 244 R---SGVFIALATFlrPIGGILGdKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSY 320
Cdd:cd17329 241 LlalNALLIVLLQF--PVARLVE-RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAAL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1631428180 321 FAKES-GAANGIVSMMGGLGGFFPPLVITYVTGLTGSShLAFILLAIFGVLAFITM 375
Cdd:cd17329 318 APPDKrGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG-LPWLILAALGLIAAALL 372
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
15-373 |
3.37e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 54.97 E-value: 3.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQ 94
Cdd:cd17355 10 LILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 95 TPGMLMLSGFFLGVGGAI---FSVGVTSVPKYFSKDKvGLANGIygmGNIGTAVSSFLAPPIAG----IIGWQTTVRSYL 167
Cdd:cd17355 90 SLWQLYLLWGLLGGGGAGtlaAVAFATVAAWWFERRR-GLALGI---LTAGGGLGSLVFLPLGAalieAFGWRTALLVLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 168 IIIAIFAILMFIFGDKNEPKVKVP---------LASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNnFGIDK 238
Cdd:cd17355 166 LLALLVLVPVLLLLRRRPADLALRayddaspasPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 239 VDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCltiSICAGLGNGLIFKLVP 318
Cdd:cd17355 245 AAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLF---AALFGLGWGATVPLTA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 319 -----SYFAKESGAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFI 373
Cdd:cd17355 322 alaarYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
26-375 |
4.71e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.13 E-value: 4.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 26 IISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGMLMLSGFF 105
Cdd:cd17365 17 VMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 106 LGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMG-NIGTAVSSFLAPPIAGIIGWQTtvrsyliiiaifailMFIFGDK 183
Cdd:cd17365 97 TGLGlGAAMPNAITLVSEYAPARRRSLAVTLMFCGyPLGAALGGFLAAALIPAFGWRS---------------VFLLGGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 184 nEPKVKVPLASQfkklssnyklyYLSLW--YFITFGAFVAFGLFLPnYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGI 261
Cdd:cd17365 162 -PPLILLPLLRG-----------TLLLWvtFFMGLLLVYLLNSWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGW 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 262 LGDKFNAVKVLMIDFIIMIVGAVILGISSH------IALFTIGCLTISICAGLgNGLIFKLVPSYF-AKESGAANGIvsm 334
Cdd:cd17365 229 LADRFGPKRVLALFFALGAVSLALLGVSPAslvllyVLVFLAGACVNGAQVGL-YALAARFYPTEVrATGVGWALGV--- 304
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1631428180 335 mGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFITM 375
Cdd:cd17365 305 -GRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAV 344
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
12-373 |
5.88e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.12 E-value: 5.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 12 LQTLSLVVGFMAwSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLG 91
Cdd:cd17504 1 LALAALAVMLVE-TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 92 QAQTPGMLMLSGFFLGVGGAIFSVGVTSVPKYFSKDKVGLANGIY-GMGNIGTAVSSFLAPPIAGIIGWQTTvrsYLIII 170
Cdd:cd17504 80 FAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILsATFGIGAGIGLPLGGWIVQHLGWRWI---FWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 171 AIFAILMFIFgdknePKVKVPLASQFKKLSSNyklyylSLWYFITFGAFVAFGLfLPNYLVNN----FGIDKVDAGIRSG 246
Cdd:cd17504 157 PVAVLLAALV-----PLIDLRLLRRRNVLLAN------ITALLAGFGMFMVFQL-LPQLLQLPtptgFGLGITEAGLLLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 247 VFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGIsSHIALFTIGCLTISICAGLGN---GLIFKLVPSYFAK 323
Cdd:cd17504 225 PGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLAL-LHSSLWALVVALLLIGIGLGLafaSLPNIVVESVPPD 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1631428180 324 ESGAANGIVSMMGGLGGFFPPLVITYVtgLTGSS--------------HLAFILLAIFGVLAFI 373
Cdd:cd17504 304 RTGIATGMNTVLRTIGSAIGPAIAGAI--LTTYTvsitsggvptegayVLAFLIGAALALAALL 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
15-160 |
8.46e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.28 E-value: 8.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQ 94
Cdd:COG0477 21 LGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631428180 95 TPGMLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMGN-IGTAVSSFLAPPIAGIIGWQ 160
Cdd:COG0477 101 SPELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIgLGLALGPLLGGLLVAALGWR 168
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
25-369 |
9.34e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.35 E-value: 9.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 25 SIISPLMPYISQDVKVNPGQLSIILAIpVILGSILRVPF-GYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGMLMLSG 103
Cdd:cd17503 13 TIVNVALPTIMGDLGASLDTVQWVITS-YLLALAIMIPLsGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 104 FFLGVGGAI-FSVGVTSVPKYFSKDKVGLANGIYGMgniGTAVSSFLAPPIAGIIGWQTTVRSYLIIIAIFAILMFIFGd 182
Cdd:cd17503 92 ILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGL---VILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 183 knePKVKVPLasqFKklssNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGIL 262
Cdd:cd17503 168 ---PLLDLRL---FK----DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 263 GDKFNAVKVLMIDFIIMIVGAVILG-ISSHIALFTIGCLTISICAGLG------NGLIFKLVPsyfAKESGAANGIVSMM 335
Cdd:cd17503 238 LDKFGPRLLLLAGLLLLALGTLLLAfLTPDTSLWLIILPLFIRGLGMGlvfmplNTLALNSLP---PEQIGDATALFNTI 314
|
330 340 350
....*....|....*....|....*....|....*
gi 1631428180 336 GGLGGFF-PPLVITYVTGLTGSSHLAFILLAIFGV 369
Cdd:cd17503 315 RQLGGSIgTALLATLLTNRTQFHHSRLSELLAQQV 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-180 |
2.15e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.19 E-value: 2.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMP-YISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQA 93
Cdd:cd17325 206 LAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 94 QTPGMLMLSGFFLGVGGAIFSVGVTS-VPKYFSKDKVGLANGIYGM-GNIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIA 171
Cdd:cd17325 286 TSFWLLLLLLALLGLGLGLVFPATLAlLADIVPPEGRGTAMGLFNTaFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLL 365
|
....*....
gi 1631428180 172 IFAILMFIF 180
Cdd:cd17325 366 LAAVLFLLL 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-376 |
3.31e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.81 E-value: 3.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMPYISQDVKvNPGQLSIILAIPVILGSILRVPF----GYLTNIIGAKWVFFCSFVILLFPIFFL 90
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFN-KLGASGYYVGLLQSSYSLGQFLAsplwGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 91 GQAQTPGMLMLSGFFLGVGGaifsvGVTSVPKYFSKDKVGLANGIYGMGNIGTA--VSSFLAPPIAGIIGWQTTVRSYLI 168
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLTG-----GNVSVAQAYIADITDEEERAKAFGIISAAfgLGFILGPALGGFLSTPYGYALPFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 169 IIAIFAILMFIFGDKNEPKVKVPLasqfkklssnyklyylsLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVF 248
Cdd:cd17330 157 VAAALALLNLVLVLFFLPPLRRLL-----------------LVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 249 -IALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYF-AKESG 326
Cdd:cd17330 220 gIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVpSKEQG 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1631428180 327 AANGIVSMMGGLGGFFPPLVITYVTGLTGsSHLAFILLAIFGVLAFITMG 376
Cdd:cd17330 300 KAQGIIQSLQSLARIIGPLLAGPLYSFLG-PGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
23-373 |
5.58e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.17 E-value: 5.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 23 AWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRvpfGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGMLMLS 102
Cdd:cd17333 14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLA---GFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 103 GFFLGVG-GAIFSVGVTSVPKYFSKD---KVGLANGIYGMGnigtavsSFLAPPIAGIIGWQTTVRSYL-----IIIAIF 173
Cdd:cd17333 91 MFLAGLGaGILDTGANTFVGALFEESsatRLNVLHGFFGLG-------ALIGPLIATSLLTSELSWSWAyliigLIYLLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 174 AILMFIFGDKNEPKVKVPLASQ------FKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGV 247
Cdd:cd17333 164 AILILLTLFPELPSARNPQQSVgafsasASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 248 FIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFAKESGA 327
Cdd:cd17333 244 FWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGK 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1631428180 328 ANGIVSMMGGLGGFFPPLVITYVtGLTGSSHLAFILLAIFGVLAFI 373
Cdd:cd17333 324 GTSVLLAAGSIGGAIIPFIMGFI-AEAVGIQTAMLLITILYAIIFV 368
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-355 |
8.53e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 50.45 E-value: 8.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 30 LMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFC----SFVILLFPIFFLGQAQTPGMLMLSGFF 105
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIglilCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 106 LGVGgaiFSVGVTSVPKYFSKDKVGLANGIYgmgNIGTAVSSFLAPPIAGII-----GWQTTVRSYLIIIAIFAILMFIF 180
Cdd:TIGR00881 97 QGMG---WPPCGRTVTKWFSRSERGTWVSFW---NCSHNVGGGLLPPLVLFGiaelySWHWVFIVPGIIAIIVSLICFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 181 G-----------------------DKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGID 237
Cdd:TIGR00881 171 LrdspqscglppaeempneepdgdAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 238 KVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIA----LFTIGCLTISICAGLGNGLI 313
Cdd:TIGR00881 251 KEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPaanpLMDLICLFALGFLVYGPQML 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1631428180 314 FKLVPSYFA--KESGAANGIVSMMGGLGGFFPPLVITYVTGLTG 355
Cdd:TIGR00881 331 IGVIASELApkKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
17-379 |
2.07e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.14 E-value: 2.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 17 LVVGFMAWSIISPLMPYIS---QDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVF-FCSFVILLFPIFFLGQ 92
Cdd:cd17490 2 LIIVFLFWFSQYVYVPFLSpyaESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFiIIGLLFTVLASLIMIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 93 AQTPGMLMLSGFFLGVGGAIFSVGVTSVPKYFSKDKVGLANGIYGM-GNIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIA 171
Cdd:cd17490 82 FPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLvNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 172 IFAILMFIFGDKNEPKVKV-PLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIA 250
Cdd:cd17490 162 LGFILSLFIKEERREKKPVlTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 251 LATFLRPIGGIL-GDKFNAVKVLMIDFIIMivGAVILGISSHIALFTIGCLtiSICAGLGNGLIFKLVPSyFAKESGAAN 329
Cdd:cd17490 242 PNALASLLSGTLfYKKLGERNTIIIGFLLL--GAYCFLIPFAPNLTLLYLL--QALNGFGTGILFPLLMS-LSIEGVPAE 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1631428180 330 GIVSMMG------GLGGFFPPLVITYVTGLTGSShLAFILLAIFGVLAFITMGHLY 379
Cdd:cd17490 317 QRSTAMGffqaiyALGMFLGPVLVGIISEAFGLQ-TGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
214-373 |
2.31e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 49.15 E-value: 2.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 214 ITFGAFVAFGLFLPnYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIA 293
Cdd:cd17353 14 LILGYQYAWSVFNP-PLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 294 LFtigCLTISICAGLGNGLIF----KLVPSYFAKESGAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGV 369
Cdd:cd17353 93 LL---FLGYGVLGGIGAGIGYitpvSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLI 169
|
....
gi 1631428180 370 LAFI 373
Cdd:cd17353 170 IIVI 173
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
27-374 |
5.61e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 47.96 E-value: 5.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 27 ISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGmLMLSGFFL 106
Cdd:cd17339 18 VGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIAL-LFLGTALA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 107 GVGGAIFSVGVTSVPKYFSKDKVGLANGIYGMG-NIGTAVSSFLAPPIAGI--IGWQTTVRSYLIIIAIFAILMFIFGDK 183
Cdd:cd17339 97 GAGIAVGNVLLPSLIKRDFPRRVGLMTGLYTTSmNLGAALASGLSVPLAQAlgGGWRGALAIWALPALLALLIWLPQLRR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 184 NEPKVKVPLASQFKKLSSNYKLYYLSLWY-FITFGAFVAFGlFLPNYLVNNfGIDKVDAGIRSGVF---IALATFLRPig 259
Cdd:cd17339 177 RKRAAAAAAPLTKISVWRSPLAWQVTLFMgLQSLLFYTLMA-WLPTILIDA-GLSAATAGWLLSLFqlvGIPASLLVP-- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 260 gILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLV------PSYFAKESGAANGIVS 333
Cdd:cd17339 253 -ILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLGLGGGAAFSLALTLIslrssdPAEAAALSGMAQSVGY 331
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1631428180 334 MMGGLGgffpPLVITYVTGLTGSSHLAFILLAIFGVLAFIT 374
Cdd:cd17339 332 LLAALG----PLLFGVLHDLTGSWTAPLVLLLALTVLQLVA 368
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
98-373 |
5.79e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.93 E-value: 5.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 98 MLMLS-GFFLGVG-GAIFSVGVTSVPKYFSKdKVGLANGIYGMGN-IGTAVSSFLAPPIAGIIGWQTTVRSYLIIIAIFA 174
Cdd:cd17352 93 QLYLTyGVLGGLGlGLIYSPAIVIVGQYFEK-KRGLATGIAVAGSgVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLC 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 175 ILMFIFgdknepkvkvplasqfkKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLvNNFGIDKVDAGIRSGVFIALATF 254
Cdd:cd17352 172 VCGLLL-----------------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIV 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 255 LRPIGGILGDK--FNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFAKES-GAANGI 331
Cdd:cd17352 234 GRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKlSNAYGL 313
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1631428180 332 VSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFI 373
Cdd:cd17352 314 VLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGV 355
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
213-375 |
7.29e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 47.52 E-value: 7.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 213 FITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAV----ILGI 288
Cdd:cd17369 238 LAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFpffwLLDT 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 289 SSHIALFtigcLTISICAGLGNGLIFKLVPSYFA-------KESGAANGIvSMMGGLGGFFPPLVITYVTGLTGSSHLAF 361
Cdd:cd17369 318 GSTWLIV----LAAVVVLGVLHGMMYGPQAAFLAelfptrvRYTGASLGY-QLGAILGGGFAPLIATALVAATGSWWPVA 392
|
170
....*....|....
gi 1631428180 362 ILLAIFGVLAFITM 375
Cdd:cd17369 393 LYLAALAVISLVAA 406
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-373 |
8.84e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 8.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 18 VVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCS-----FVILLFPIFFLGQ 92
Cdd:cd06173 9 LLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 93 AQTPGMLMLSGFFLGVGGAIFSVGVTS-VPKYFSKDKVGLANGIYGMgniGTAVSSFLAPPIAGII--GWQTTVRSYLII 169
Cdd:cd06173 89 SLSLWLLLVLAFLLGIASAFFGPARQAlLPELVPKEQLVRANALNSL---ATQLARIIGPALGGLLvaLLGPGGAFAINA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 170 IAIFAILMFIFGDKNEPKVKVPLASQ---------FKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVD 240
Cdd:cd06173 166 LSFLLSALLLLFIRRPPPAAPGESSSlllrdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 241 AGIRSGVF---IALATFlrpIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAGLGNGLIFKLV 317
Cdd:cd06173 246 YGLLLAAFgvgALLGAL---LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLL 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1631428180 318 PSYFAKES-GAANGIVSMMGGLGGFFPPLVITYVTGLTGSShLAFILLAIFGVLAFI 373
Cdd:cd06173 323 QLRVPDELrGRVFSVYNALNSGAMPLGALLAGLLADALGLS-AVFLLAGALLLLAAL 378
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
136-375 |
2.55e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.06 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 136 YGMGNIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIA------IFAILMFIFG------DKNEPKVKVPLASQFKKLSSNY 203
Cdd:cd17332 142 MFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALiigiigIILLLICFFGtrervvPPEEEKSKLPLLKSLKALLKNR 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 204 KLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIRSGVFIALATFLrPIGGILGDKFNAVKVLMIDFIIMIVGA 283
Cdd:cd17332 222 PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLAL-LPWPPLKKRFGKKKAFFIGLLLAILGL 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 284 VILGISSHIALFTIgcLTISICAGLGNGLIFKLVPS-------YFAKESG--------------------AANGIVSMMG 336
Cdd:cd17332 301 LLLFFLPPGNLVLI--LVLAVLAGIGYGGANLLPWAmladvidYGELKTGkrregifysvmtffrklglaLAGALVGLIL 378
|
250 260 270
....*....|....*....|....*....|....*....
gi 1631428180 337 GLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFITM 375
Cdd:cd17332 379 SLAGYVANAAAQSASALNGIRLLIAVLPAVLLLLALILM 417
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
19-375 |
2.59e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.03 E-value: 2.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 19 VGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGM 98
Cdd:cd17320 10 LGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 99 LMLSGFFLGVGGAIFSVGVTSVPK-YFSKDKvglANGIYGMGNIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIAIFAILM 177
Cdd:cd17320 90 LLIARFLQGLGAAAGSVVARAIVRdLYSGAE---LAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 178 FIFG---------DKNEPKVKVPLASQFKKLSSNYKLYYLSLWYFITFGAFVAFGLFLPNYLVNNFGIDKVDAGIrSGVF 248
Cdd:cd17320 167 LLLVllflpetlpEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGL-LFAL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 249 IALATFLRP-IGGILGDKFNAVKVLMIDFIIMIVGAV-----ILGISSHIALFTIGCLTISICAGLGNGLIFKLVPSYFA 322
Cdd:cd17320 246 NAIALILGSlLNGRLVRRFGPRRLLRLGLLLLLAAALvlllaALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1631428180 323 KESGAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFITM 375
Cdd:cd17320 326 HVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
258-375 |
4.50e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.14 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 258 IGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAG----LGNGLIFKLVPsyfAKESGAANGIVS 333
Cdd:COG2270 293 LFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGgiqaLSRSLLARLIP---PGREAEFFGLYA 369
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1631428180 334 MMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFITM 375
Cdd:COG2270 370 LSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLL 411
|
|
| tppB |
PRK09584 |
dipeptide/tripeptide permease DtpA; |
196-319 |
6.99e-05 |
|
dipeptide/tripeptide permease DtpA;
Pssm-ID: 181969 Cd Length: 500 Bit Score: 44.75 E-value: 6.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 196 FKKLSSNYKLYYLSLWYfiTFGAFVAFGLfLPNYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVK-VLMI 274
Cdd:PRK09584 17 FKQPKAFYLIFSIELWE--RFGYYGLQGI-MAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKrVIML 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1631428180 275 DFIIMIVGAVILGISSH-IALFTIGCLTISIcaglGNGLiFKLVPS 319
Cdd:PRK09584 94 GAIVLAIGYALVAWSGHdAGIVYMGMATIAV----GNGL-FKANPS 134
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
208-378 |
7.81e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.03 E-value: 7.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 208 LSLWYFITFGAFVAFGLFLPnYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILG 287
Cdd:COG0477 19 LALGTFLEGLDFTIVNVALP-SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 288 ISSHIALFTIGCLTISICAGLGNGLIFKLVPSYF-AKESGAANGIVSMMGGLGGFFPPLVITYVTGLTGsSHLAFILLAI 366
Cdd:COG0477 98 LAPSPELLIAARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-WRWIFLINAP 176
|
170
....*....|..
gi 1631428180 367 FGVLAFITMGHL 378
Cdd:COG0477 177 LGLLALVLRLRL 188
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
225-370 |
2.24e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 42.75 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 225 FLPNYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISI 304
Cdd:TIGR00881 16 LAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGI 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1631428180 305 CAGLGNGLIFKLVPSYFAK-ESGAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVL 370
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFSRsERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAII 162
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-163 |
2.37e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.97 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMPYISQDV-KVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFV--ILLFPIFFLG 91
Cdd:COG2211 235 LAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLlaALGLLLLFFL 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 92 QAQTPGMLMLSGFFLGVGGAIFSVGVTSV--------PKYFSKDKVGLANGIYGMGN-IGTAVSSFLAPPIAGIIGWQTT 162
Cdd:COG2211 315 GPGNLWLLLVLAALAGIGLGAILVLPWAMladvvdydEWKTGRRREGLYFGIFTFAIkLGQALAGALAGLLLALFGYVAG 394
|
.
gi 1631428180 163 V 163
Cdd:COG2211 395 A 395
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
205-380 |
3.32e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 42.56 E-value: 3.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 205 LYYLSL----WYFITFGAFVAFGLFLPNYLvnNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKF-NAVKVLMIDFIIM 279
Cdd:cd17346 4 LYTLFFtemwERFSYYGMRAILILYLTAQL--GDGFSEADAASIYGAYTALVYLTPIIGGWLADKVlGARRTVFIGGILM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 280 IVGAVILGISSHIA-LFTIGCLTISICAGLGNGLIFKLVPSYFAKESG---AANGIVSMMGGLGGFFPPLVITYVtGLTG 355
Cdd:cd17346 82 ALGYLLLALSPFSVsMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPrrdSGFSIFYMGINLGAFLAPLLCGTL-GDNY 160
|
170 180
....*....|....*....|....*...
gi 1631428180 356 SSHLAFILLAI---FGVLAFITMGHLYK 380
Cdd:cd17346 161 GYHYGFGLAAVgmlLGLLIFLLGRKKLL 188
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
18-158 |
3.40e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.18 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 18 VVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPG 97
Cdd:cd17323 9 FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631428180 98 MLMLSGFFLGVGGAIF-SVGVTSVPKYFSKDKVGLANGIYGMgniGTAVSSFLAPPIAGIIG 158
Cdd:cd17323 89 MLIILRFLQGFFGSSPlAIGAGTIADLFTPEERGKAMGVYSL---GPLLGPALGPIIGGFIT 147
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
17-157 |
6.12e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 6.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 17 LVVGFMAWSIIS-PLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQT 95
Cdd:cd17370 207 LAVALFALGNFSfAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSS 286
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1631428180 96 PGMLMLSGFFLGVG-GAIFSVGVTSVPKYFSKDKVGLANGIYgmgNIGTAVSSFLAPPIAGII 157
Cdd:cd17370 287 LWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLF---NTVVGIGWLLASLIAGYL 346
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
208-375 |
8.64e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 8.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 208 LSLWYFITFGAFVAFGLFLPNYLVNnFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILG 287
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 288 ISSHIALFTIGCLTISICAGLGNGLIFKLVPSYF-AKESGAANGIVSMMGGLGGFFPPLVITY-VTGLTGSSHLAFILLA 365
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGIlASSLGFGWRAVFLIAA 159
|
170
....*....|
gi 1631428180 366 IFGVLAFITM 375
Cdd:cd06174 160 ALALLAAILL 169
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
74-374 |
9.52e-04 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 41.05 E-value: 9.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 74 WVFFCSFVILLFPIFFLGQAQTPGMLMLSG-----FFLGVGGAIFSVGVTSVPKYFSKdkVGLANGIYGMGNigTAVSSF 148
Cdd:cd17394 91 GLFLIALFVLASGLALLQTAANPYVTVLGPeetaaRRLNLAQAFNSLGSTIAPLFGSY--LILSGIPSTATA--LAAMSA 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 149 LAPPIAGIIGWQTTVRSYLIIIAIFAILMFIFGDKNEPKVKVPLASQFKKLSS--------NYKLYYLSLwyFITFGAFV 220
Cdd:cd17394 167 AELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAEALGSKGTllrllknpHLRLGVLAI--FFYVGAEV 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 221 AFGLFLPNYLV-NNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIV-GAVILGISSHIALFTIg 298
Cdd:cd17394 245 AIWSFLINYLMeYIAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLlLLGAIFTGGMVALYAL- 323
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1631428180 299 cLTISICAGLGNGLIFKLVPSYFAKESGAANGIVsMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAI-FGVLAFIT 374
Cdd:cd17394 324 -VLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLL-VMAIVGGAVVPLIQGAVADDAAGLRIAFLVPLLcFAYILFYG 398
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
8-160 |
1.22e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 40.66 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 8 FQLTLQTLSLV-VGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFP 86
Cdd:PRK11652 7 VNLLFMLVLLVaVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILG 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1631428180 87 IFFLGQAQTPGMLMLSGFFLGVGGAIFSVGVTSVPK-YFSKDKVGLANGIYGMGNIgtaVSSFLAPPIAGII----GWQ 160
Cdd:PRK11652 87 TLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRdLYEGTQLRHANSLLNMGIL---VSPLLAPLIGGLLttlfGWR 162
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
57-342 |
2.24e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.89 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 57 SILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQTPGMLMLSGFFLGvGGAIFSVGVTSVPKYFSKDKVGLANGIY 136
Cdd:cd17472 46 AIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLADLTREENRTKAMALI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 137 GMGN-IGTAVSSFLAPPIAGIIG-----WQTTVRSyliIIAIFAILMFIFGDKNEPKVKVPLASQFKKLSSNYKLYYLSL 210
Cdd:cd17472 125 GASIgIAFAISMVLGPLLAAHLGvsglfLITAILS---LVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 211 WYFITFGAFVAFGLFLPNYLVNnFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVK-VLMIDFIIMIVGAVILGIS 289
Cdd:cd17472 202 SIFILHFVLMAFFYILPLLLTQ-LGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKqVFVSSILLIAVGFLLLLFA 280
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1631428180 290 SHIALFTIGCLTI-----SICAGLGNGLIFKLVPsyfAKESGAANGIVSMMGGLGGFF 342
Cdd:cd17472 281 ATSLWLLIIGLIIffigfNLLEALLPSLVSKIAP---KEYRGTAMGIYNTSQFLGSFL 335
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
212-297 |
4.06e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 38.75 E-value: 4.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 212 YFITFGAFVAFGLFLP--NYLVNNFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGIS 289
Cdd:cd17390 2 YLVGFLDLFGVSMILPllSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81
|
....*...
gi 1631428180 290 SHIALFTI 297
Cdd:cd17390 82 TSLALLFL 89
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
32-161 |
4.59e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.88 E-value: 4.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 32 PYISQDVKVNPGQLSIILA---IPVILGSILrvpFGYLTNIIGAKWVFFCSfvILLFPIFFL--GQAQTPGMLMLSGFFL 106
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFLFSaglIGMAFGALF---FGPLADRIGRRRVLLWS--ILLFSVFTLlcALATNVTQLLILRFLA 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1631428180 107 GVG-GAIFSVGVTSVPKYFSKDKVGLANGIYGMG-NIGTAVSSFLAPPIAGIIGWQT 161
Cdd:TIGR00895 116 GLGlGGLMPNLNALVSEYAPKRFRGTAVGLMFCGyPIGAAVGGFLAGWLIPVFGWRS 172
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
234-371 |
6.38e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.37 E-value: 6.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 234 FGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFtigcLTISICAGLGNGLI 313
Cdd:cd17328 29 FLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQL----LLFRALVGIGEASY 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1631428180 314 FKLVPS----YFAKES-GAANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLA 371
Cdd:cd17328 105 SPIAPTiiadLFPKEKrTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLL 167
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-374 |
6.78e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.31 E-value: 6.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 15 LSLVVGFMAWSIISPLMPYISQDVKVNPGQLSIILAIPVILGSILRVPFGYLTNIIGAKWVFFCSFVILLFPIFFLGQAQ 94
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 95 TPGMLMLSGFFLGVGGAIFSVGVTSVPKYFSKDKV-GLANGIYGMGN-IGTAVSSFLAPpIAGIIGWQTTVRSylIIIAI 172
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENrGRVLGLYSTVLgLGFALGPLLLA-LVGTAGALPFLIA--AVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 173 FAILMFIFGDKNEPKVKVPLASQFKKLssnYKLYYLSLWYFITFGAFV-AFGLFLPNYLVNNfGIDKVDAGIRSGVFIAL 251
Cdd:cd17477 160 LALVPLLLTRRAAPEIEEAESISLRRL---LRIAPLALLGAFVAGFLEgAFYSLLPLYGLRL-GLSVAQAALLLAAFVLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 252 ATFLRPIGGILGDKFNAVKVLMIDFIIMIVGAVILGISSHIALFTIGCLTISICAG-----LGNGLIFKLVPSyfaKESG 326
Cdd:cd17477 236 GLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAgplytLALALAGDRLPG---DELV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1631428180 327 AANGIVSMMGGLGGFFPPLVITYVTGLTGSSHLAFILLAIFGVLAFIT 374
Cdd:cd17477 313 AANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
69-374 |
7.64e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.37 E-value: 7.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 69 IIGAKWVffcSFVILLFPIFFLGqAQTPGMLMLSGFFLGVGGAIFS---VGVtsVPKYFSKDKVGLANGIYGMGNI---- 141
Cdd:PRK08633 80 IRIVKLF---EVGLTLLIVLAYY-LGWFWLAFAVTFLLGAQSAIYSpakYGI--IPELVGKENLSRANGLLEAFTIvail 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 142 -GTAVSSFLA----PPIAGIIGWQTTVRSYLIIIAIFAILMFIFGDKNEPKVKVPLASQFKKLSSNYKLYYLS------- 209
Cdd:PRK08633 154 aGTALFSFLFesvnGNTPSEILGRIAPAGLVLLAVAVLGLIFAYRLPKVPAAAPEVFDKKKYLFPKLLWRNLKllrsdrv 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 210 LW-------YFITFGAFVAfgLFLPNYLVNNFGIDKVDAgirSGVFIALATFLRPIGGILGDKFNAVKV----LMIDFII 278
Cdd:PRK08633 234 LWlaiiglsYFWFISQLAQ--ANFPAYAKEVLGLDNTFQ---VQYLLAASAIGIGIGSLLAGRLSGRHIelglVPLGALG 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631428180 279 MIVGAVILGISSHIALFTIGCLTISICAGLG----NGLIfklvpSYFAKESG-----AANGIVSMMGGLGGffppLVITY 349
Cdd:PRK08633 309 LALSLFLLPTAPSLASVLVLFFLFGFSAGLFivplNALI-----QFRAPEKElgkvlAANNFLQNVGMLLF----LALTT 379
|
330 340
....*....|....*....|....*
gi 1631428180 350 VTgltgsSHLAFILLAIFGVLAFIT 374
Cdd:PRK08633 380 LF-----SGLGLSPAGLFYLIALVT 399
|
|
| |
