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Conserved domains on  [gi|1672994345|gb|TMO81391|]
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N-acetyltransferase [Pseudoalteromonas sp. S3776]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 44-135 4.70e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 52.74  E-value: 4.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672994345  44 GCLIVGVSGSvfGNWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLDTLD--FQAKPFYEKRGHVVKYQLNN 121
Cdd:COG0456     1 GFALLGLVDG--GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREdnEAAIALYEKLGFEEVGERPN 78

                          90
                  ....*....|....
gi 1672994345 122 YPHSGtRYFMEKTL 135
Cdd:COG0456    79 YYGDD-ALVMEKEL 91
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 44-135 4.70e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 52.74  E-value: 4.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672994345  44 GCLIVGVSGSvfGNWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLDTLD--FQAKPFYEKRGHVVKYQLNN 121
Cdd:COG0456     1 GFALLGLVDG--GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREdnEAAIALYEKLGFEEVGERPN 78

                          90
                  ....*....|....
gi 1672994345 122 YPHSGtRYFMEKTL 135
Cdd:COG0456    79 YYGDD-ALVMEKEL 91
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 39-112 5.63e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 44.37  E-value: 5.63e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1672994345  39 FVDEKGCLIVG---VSGSVFGNWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLDTlDFQAKPFYEKRG 112
Cdd:pfam13508   6 FVAEDDGKIVGfaaLLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELET-TNRAAAFYEKLG 81
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 39-98 2.40e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.56  E-value: 2.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1672994345  39 FVDEKGCLIVGVSGSVF----GNWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLD 98
Cdd:cd04301     2 LVAEDDGEIVGFASLSPdgsgGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 44-135 4.70e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 52.74  E-value: 4.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672994345  44 GCLIVGVSGSvfGNWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLDTLD--FQAKPFYEKRGHVVKYQLNN 121
Cdd:COG0456     1 GFALLGLVDG--GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREdnEAAIALYEKLGFEEVGERPN 78

                          90
                  ....*....|....
gi 1672994345 122 YPHSGtRYFMEKTL 135
Cdd:COG0456    79 YYGDD-ALVMEKEL 91
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
56-135 6.26e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 50.85  E-value: 6.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672994345  56 GNWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLDTlDFQAKPFYEKRG--HVVKYQLNNYPhsgTRYFMEK 133
Cdd:COG3153    65 GPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLG-DPSLLPFYERFGfrPAGELGLTLGP---DEVFLAK 140


                  ..
gi 1672994345 134 TL 135
Cdd:COG3153   141 EL 142
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 39-135 5.55e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 48.06  E-value: 5.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672994345  39 FVDEKGCLIVGVsGSVFGNWLMINWLWC---SDTARGKGLAGKLLNALELAAIELGANIAQLDTLDfQAKPFYEKRG-HV 114
Cdd:COG1246    31 WVAEEDGEIVGC-AALHPLDEDLAELRSlavHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTS-AAIHFYEKLGfEE 108

                          90       100
                  ....*....|....*....|...
gi 1672994345 115 VKYQLNNYPHSGTRY--FMEKTL 135
Cdd:COG1246   109 IDKEDLPYAKVWQRDsvVMEKDL 131
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 70-135 7.46e-08

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 47.74  E-value: 7.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1672994345  70 ARGKGLAGKLLNALELAAIELGANIAQLDTLDFQ--AKPFYEKRGHVVKYQLNNYPHSGtryfMEKTL 135
Cdd:COG0454    70 YRGKGIGKALLEALLEWARERGCTALELDTLDGNpaAIRFYERLGFKEIERYVAYVGGE----FEKEL 133
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
47-112 1.63e-07

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 46.06  E-value: 1.63e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672994345  47 IVGVSG--SVFGNWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLDTLDFQ--AKPFYEKRG 112
Cdd:COG3393     2 LVAMAGvrAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNpaARRLYERLG 71
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 39-112 5.63e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 44.37  E-value: 5.63e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1672994345  39 FVDEKGCLIVG---VSGSVFGNWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLDTlDFQAKPFYEKRG 112
Cdd:pfam13508   6 FVAEDDGKIVGfaaLLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELET-TNRAAAFYEKLG 81
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
70-135 2.44e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 40.94  E-value: 2.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1672994345  70 ARGKGLAGKLLNALELAAIELGANI----AQLdtldfQAKPFYEKRGHVV---KYQLNNYPHsgtrYFMEKTL 135
Cdd:COG2153    70 YRGQGLGRALMEAAIEEARERGARRivlsAQA-----HAVGFYEKLGFVPvgeEFLEAGIPH----IDMRKPL 133
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 27-112 2.52e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 40.96  E-value: 2.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672994345  27 HFDAQRVPLGYKFVDEKGCLIVG-VSGSVFG---NWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLDTL-- 100
Cdd:pfam00583  24 LEDWDEDASEGFFVAEEDGELVGfASLSIIDdepPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAad 103

                          90
                  ....*....|..
gi 1672994345 101 DFQAKPFYEKRG 112
Cdd:pfam00583 104 NLAAIALYEKLG 115
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
67-112 7.44e-04

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 37.28  E-value: 7.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1672994345  67 SDTARGKGLAGKLLNALELAAIELGANIAQLDTLDF--QAKPFYEKRG 112
Cdd:COG1247    89 DPDARGRGIGRALLEALIERARARGYRRLVAVVLADneASIALYEKLG 136
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 70-112 9.38e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 36.87  E-value: 9.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1672994345  70 ARGKGLAGKLLNALELAAIELGANIAQLdTLDFQ--AKPFYEKRG 112
Cdd:pfam13673  63 YQGQGIGKALLEAVEDYAEKDGIKLSEL-TVNASpyAVPFYEKLG 106
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 39-98 2.40e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.56  E-value: 2.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1672994345  39 FVDEKGCLIVGVSGSVF----GNWLMINWLWCSDTARGKGLAGKLLNALELAAIELGANIAQLD 98
Cdd:cd04301     2 LVAEDDGEIVGFASLSPdgsgGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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