|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
16-377 |
7.83e-79 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 246.79 E-value: 7.83e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 16 TRLLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFAL 95
Cdd:cd17393 4 VAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 96 VNSVASLATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAGFSAFEICMLMAAIV 175
Cdd:cd17393 84 APSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 176 LLCLIFAKRDLLPFASPNEGPA--------FALPKGPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFS 247
Cdd:cd17393 164 LLAALVAIRALLPGTGEAAEDRpdgagkpgFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 248 FSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQAT 327
Cdd:cd17393 244 FSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAGI 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1673034488 328 AIPAVTTFGYLGVLMGPASVGQIAHFSSLASALVVIAMLIALATIFSLFV 377
Cdd:cd17393 324 AVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-378 |
3.05e-56 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 188.91 E-value: 3.05e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 9 KKREVLVTRLLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIF 88
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 89 CLPFFALVNSVASLATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAGFSAF--E 166
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSwhL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 167 ICMLMAAIVLLCLIFAKRDLLPFASPNE--------GPAFALPKGPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNAST 238
Cdd:COG0738 166 PYLILAVLLLLLALLFLRSKLPEIEEEEeeaagsaaSLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 239 GMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAG 318
Cdd:COG0738 246 ATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 319 KQTYMSQATAIPAVTTFGYLGVLMGPASVGQIAHFSSLASALVVIAMLIALATIFSLFVK 378
Cdd:COG0738 326 DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
18-376 |
2.71e-27 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 110.87 E-value: 2.71e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 18 LLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVN 97
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 98 SVASLATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAGFS---AFEICMLMAAI 174
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSwswAYLIIGLIYLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 175 VLLCLIFAKRDLLPFASPNEGPAFALPKGP--------VILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIF 246
Cdd:cd17333 163 LAILILLTLFPELPSARNPQQSVGAFSASAsrllrnpsIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 247 SFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQA 326
Cdd:cd17333 243 GFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKG 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1673034488 327 TAIPAVTTFGYLGVLMGPASVGQIAHFSSLASALVVIAMLIALATIFSLF 376
Cdd:cd17333 323 KGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-378 |
1.69e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 77.23 E-value: 1.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 18 LLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVN 97
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 98 SVASLATLLVIFGLSIGATD-CVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLL-IAGFSA-FEICMLMAAI 174
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWpAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRApFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 175 VLLCLIFAKRDLLPFASPNEGPA--------FALPKGPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIF 246
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRAVSAarlrsglrLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 247 SFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQT-YMSQ 325
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVpPEGR 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1673034488 326 ATAIPAVTTFGYLGVLMGPASVGQIAHFSSLASALVVIAMLIALATIFSLFVK 378
Cdd:cd17325 323 GTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-379 |
4.28e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.99 E-value: 4.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 18 LLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVN 97
Cdd:COG2223 12 LAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 98 SVASLATLLVIFGLSIGAT-DCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAG--FSAFEICMLMAAI 174
Cdd:COG2223 92 SYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFgwRNAFLILGILLLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 175 VLLCLIFAKRDLLPFASPNEGPAFALPKGP-----VILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFSFS 249
Cdd:COG2223 172 VAVLAWLFLRDPPAGAAAAAKASLRDQLEAlrdprFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 250 VTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSM-SFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQ-AT 327
Cdd:COG2223 252 LLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNaGA 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1673034488 328 AIPAVTTFGYLGVLMGPASVGQI-AHFSSLASALVVIAMLIALATIFSLFVKV 379
Cdd:COG2223 332 VYGLVGAAGGLGGFLGPLLFGALlDATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-337 |
8.04e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.93 E-value: 8.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 18 LLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVN 97
Cdd:COG2814 17 LGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 98 SVASLATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAGFS---AFEICMLMAAI 174
Cdd:COG2814 97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGwrwVFLVNAVLALL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 175 VLLCLIFAKRDLLPFASPNEGPAFA--LPKGPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTM 252
Cdd:COG2814 177 ALLLLLRLLPESRPAARARLRGSLRelLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 253 TLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQATAIPAV 332
Cdd:COG2814 257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
|
....*
gi 1673034488 333 TTFGY 337
Cdd:COG2814 337 YNSAF 341
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-378 |
1.19e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 71.44 E-value: 1.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 18 LLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVN 97
Cdd:COG2271 17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 98 SVASLATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAGFSAFEICMLMAAIVLL 177
Cdd:COG2271 97 SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 178 CLIFAkrdllpfaspnegpafalpkgpVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTMTLGRL 257
Cdd:COG2271 177 LALLR----------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 258 FGDRIIAKHGQR--AVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQ-ATAIPAVTT 334
Cdd:COG2271 235 LGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKArGTASGLVNT 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1673034488 335 FGYLGVLMGPASVGQIAHFSSLASALVVIAMLIALATIFSLFVK 378
Cdd:COG2271 315 FGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
32-378 |
4.36e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.93 E-value: 4.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 32 SLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVNSVASLATLLVIFGL 111
Cdd:cd17489 17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 112 SIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAGFS---AFEICMLMAAIVLLCLIFAKRDLLP 188
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGfavLFIVAAVLALLALLLVFLVKDPPPV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 189 FASPNEGPAFALPK---GPVILIGIICFAMFLAEGTVLDWSGIYLidyqnASTGMAALGIFS--FSVTMTLGRLFGDRII 263
Cdd:cd17489 177 AAEEAEAGTRAFRRlveKKVLPPALILFLASIAYGAISTFLPLYA-----AERGISNAGLFFtvYAIALLLSRPFSGKLS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 264 AKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQT-YMSQATAIPAVTTFGYLGVLM 342
Cdd:cd17489 252 DRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVpPHRRGAANGTFFIFFDLGIGL 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 1673034488 343 GPASVGQIAHFSSLASALVVIAMLIALATIFSLFVK 378
Cdd:cd17489 332 GGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-375 |
5.17e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 66.68 E-value: 5.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 18 LLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVN 97
Cdd:cd06174 3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 98 SVASLATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAGFS-----AFEICMLMA 172
Cdd:cd06174 83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgwraVFLIAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 173 AIVLLCLIFAKRDL----------LPFASPNEGPAFALPKGPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAA 242
Cdd:cd06174 163 LLAAILLLLVVPDPpesarakneeASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 243 LGIFSFSVTMTLGRLFGDRIIAKH-GQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQT 321
Cdd:cd06174 243 LLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1673034488 322 Y-MSQATAIPAVTTFGYLGVLMGPASVGQI-AHFSSLASALVVIAMLIALATIFSL 375
Cdd:cd06174 323 PpEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
18-375 |
7.24e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.87 E-value: 7.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 18 LLFLCAGLATAT---WASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFA 94
Cdd:cd17324 3 ALALAAFAIGTTeyvIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 95 LVNSVASLATLLVIFGLSIGA-TDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAgaVAMLLIAGF----SAFEICM 169
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGfWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGR--PLGGLLGQLlgwrAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 170 LMAAIVLLCLIFAKRDLLPFASPNEGPAFALPK----GPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGI 245
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLllrnPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 246 FSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQ 325
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1673034488 326 ATAIPAVTTFGYLGVLMGPASVGQIAHFSSLASALVVIAMLIALATIFSL 375
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
19-376 |
4.23e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.59 E-value: 4.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 19 LFLCAGLATATWASLIPVIKAHI------GIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPF 92
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVrefnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 93 FALVNSVASLATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGaGAVAMLLIAGFSAFEICMLMA 172
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILG-PALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 173 AIVLLCLIFAKRDLlpfaspnegpafalpkGPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTM 252
Cdd:cd17330 160 ALALLNLVLVLFFL----------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 253 TLGRLFGDRIIAKH-GQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMS-QATAIP 330
Cdd:cd17330 224 ILAQLLLIPRLAKRlGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKeQGKAQG 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1673034488 331 AVTTFGYLGVLMGPASVGQIAHFSSLASALVVIAMLIALATIFSLF 376
Cdd:cd17330 304 IIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
18-377 |
4.09e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.49 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 18 LLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVN 97
Cdd:COG2807 25 LVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 98 SVASLATLLVIFGLSIGATDCVMNiqaVLVEER--SKLSLMSGFHGFY-SLGGILGAGAVAMLLIA-----GFSAFEICM 169
Cdd:COG2807 105 SVALLLAGTALIGAGIAVGNVLLP---GLIKRWfpDRVGLMTGLYTAAmGLGAALAAGLTVPLAAAlgwrgALAVWALLA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 170 LMAAIVLLCLIFAKRDLLPFASPNEGPAFALPKGPVILIGIICFAMFLAEGTVLDWSGIYLIDyQNASTGMAALGIFSFS 249
Cdd:COG2807 182 LLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 250 VTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQATA- 328
Cdd:COG2807 261 LAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAa 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1673034488 329 -IPAVTTFGYLGVLMGPASVGQIA-HFSSLASALVVIAMLIALATIFSLFV 377
Cdd:COG2807 341 lSGMAQSVGYLLAALGPLLVGALHdATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
64-377 |
1.16e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 64 PVSGALATKYGCKRVLQLSTMM--IIFCLPFFAlvNSVASLATLLVIFGLSIGA-TDCVMNIQAVLVEERSKLSLMSGFH 140
Cdd:cd17473 53 PLAGWLADRFGRKRLLIAGLLLygIGGVAGLFL--DSLYALLASRALLGIGVAGiMTLATALIGDYFEGEERAKMLGLQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 141 GFYSLGGILGAGAVAMLLIAG----FSAFEICMLMAAIVLLCLIFAKRDLLPFASPNEGPAFALPKGPVILIGIICFAMF 216
Cdd:cd17473 131 AAMSLGGVVFLLLGGALAEIGwrapFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAM 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 217 LAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVAL 296
Cdd:cd17473 211 LLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 297 FGYVLMGIGCANVVP-IMFSAAGKQTYMSQATAIPAVTTFGYLGVLMGPASVGQIAH-FSSLASALVVIAMLIALATIFS 374
Cdd:cd17473 291 LGAILAGLGFGLLLPtLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNlTGGLSGAFLILGVLALVLAIVL 370
|
...
gi 1673034488 375 LFV 377
Cdd:cd17473 371 LLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-344 |
2.85e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 2.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 18 LLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVN 97
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 98 SVASLATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAGFSAFEICMLMAAIVLL 177
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 178 CLIFAKRDLLPFASPNEGPAFALPKG-----------PVILIGIICFAMFLAEGTVLDWSGIYLIDYqNASTGMAALGIF 246
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAEEARLSlivawkallrdPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 247 SFSVTMTLGRLFGDRIIAKHGQRAVLTISGL---VASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYM 323
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGRRRRLLLALLlliLAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK 322
|
330 340
....*....|....*....|..
gi 1673034488 324 S-QATAIPAVTTFGYLGVLMGP 344
Cdd:pfam07690 323 EeRGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-377 |
1.31e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 23 AGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVNSVASL 102
Cdd:cd17474 11 AVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 103 ATLLVIFGLSIGA-TDCVMNIQAVLVEERSKLSLMSGFHGFYSLGG----ILGAGAVAMLLIAGFSAFEICMLMAAIVLL 177
Cdd:cd17474 91 LAGRALQGIGAAGlGPLALTLIGDLFEGGERAKAMGLYEAALGLGIavgpLLGGLLAAISWRYPFFLLAALIPVAFLAIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 178 CLIF--AKRDLLPFASPNEGPAFALPKGPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTMTLG 255
Cdd:cd17474 171 FLLPepKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 256 RLFGDRIIAKH-GQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQT-YMSQATAIPAVT 333
Cdd:cd17474 251 SLFVGRLLKKRfGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELApEEERGTASSLYN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1673034488 334 TFGYLGVLMGPASVGQIAHFSSLASALVVIAMLIALATIFSLFV 377
Cdd:cd17474 331 FVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
7-348 |
3.94e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.51 E-value: 3.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 7 PFKKREVLVTRLLFLCAGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMI 86
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 87 IFCLPFFALVNSVASLATLLVIFGLSIGAtdcVMNIQAVLVEERSKLSLMSGFHGFYSLG---GILGAGAVAMLLIAGF- 162
Cdd:TIGR00895 93 SVFTLLCALATNVTQLLILRFLAGLGLGG---LMPNLNALVSEYAPKRFRGTAVGLMFCGypiGAAVGGFLAGWLIPVFg 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 163 --SAFEICMLMAAIVLLCLIFA----------KRD---------LLPFASPNEGPAFALPKGPVILIGIICFAMF---LA 218
Cdd:TIGR00895 170 wrSLFYVGGIAPLLLLLLLMRFlpesidflvsKRPetvrrivnaIAPQMQAEAQSALPEQKSTQGTKRSVFKALFqgkTA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 219 EGTVLDWSGI---------------YLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGL 283
Cdd:TIGR00895 250 RITVLLWLLYfmllvgvyfltnwlpKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAV 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1673034488 284 IIAIVSMSFYVALFGYVLMGIgCANVVPIMFSAAGKQTYMSQ--ATAIPAVTTFGYLGVLMGPASVG 348
Cdd:TIGR00895 330 LVGSTLFSPTLLLLLGAIAGF-FVNGGQSGLYALMALFYPTAirATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
78-353 |
5.26e-06 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 47.90 E-value: 5.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 78 VLQLSTMMIIFCLPFFALVNSVASLATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAML 157
Cdd:cd17395 64 ALFTSSLLIALVLAVIPFCKDVKVLASVMAIAGLAMGCLDTGANMQIVRMWQKDSAPFLQVLHFSFGFGAFLAPLIADPF 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 158 LIAGFSAFEICMLMAAIVLLCLIFAKRDLLPFASPNEGPAFALPKGPVILIGIICFAMFLAEGTVLDWSGiYLIDYQNAS 237
Cdd:cd17395 144 LSYAYWIMALINLPVPMAVLMLLSKERLLTCCSQRRRKNLRRAPYSFFAIHITGALFLFMYVGLEGAYGA-FVYSYAVEK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 238 TGM----AALGIFSFSVTMTLGRLFGDRI--IAKHGQRAVLTISGLVASlGLIIAIVSMSFYVALFGYVLMGIGCANVVP 311
Cdd:cd17395 223 PGVghkvAAYLPSLFWGTFTLGRLLSIPIssRMKPATMVVLNVVGVVVT-SLVLLLFSKSVVFLWIGTASLGLFLASTFP 301
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1673034488 312 IMFSAAGKQTYMSQATAIPAVTTFGyLGVLMGPASVGQIAHF 353
Cdd:cd17395 302 SMLSYTEDSLQYTGCSTTVLVTGAG-LGEMVLPMLVGSIQPF 342
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-375 |
9.13e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.17 E-value: 9.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 33 LIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVNSVASLATLLVIFGLS 112
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 113 IGATDCVMNIQAVLVEERSKLSLMSgfhgFYSLGGILG------AGAVAMLLIAGFSAFEICMLMAAIVLLCLIFAKRDL 186
Cdd:cd17478 98 SAAFHPEGARLASQAAGGRRGLAMS----IFSVGGNLGfalgplIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 187 LP-----FASPNEGPAFALPKGPVILIGIICFAMFLAEGTVLDWSGIYLIDyQNASTGMAALGIFSFSVTMTLGRLFGDR 261
Cdd:cd17478 174 KPeakkaAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 262 IIAKHGQRAVLTISgLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQATAIPAVTTFGYLGVL 341
Cdd:cd17478 253 LSDRFGRRRVIIAS-LLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGG 331
|
330 340 350
....*....|....*....|....*....|....
gi 1673034488 342 MGPASVGQIAHFSSLASALVVIAMLIALATIFSL 375
Cdd:cd17478 332 IGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
23-298 |
3.24e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.63 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 23 AGLATATWASLIPVIKAHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTMMIIFCLPFFALVNSVASL 102
Cdd:cd17477 8 LGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 103 ATLLVIFGLSIGATDCVMNIQAVLVEERSKLSLMSGFHG-FYSLGGILGAGAVAMLLIAGFSAFEICMLMAAIVLLCLIF 181
Cdd:cd17477 88 FLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYStVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 182 AKRDLLPFASPNEGPAFAL-PKGPVILIGIICFAMFlaEGTVLDWSGIYLIDyQNASTGMAALGIFSFSVTMTLGRLFGD 260
Cdd:cd17477 168 TRRAAPEIEEAESISLRRLlRIAPLALLGAFVAGFL--EGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPLG 244
|
250 260 270
....*....|....*....|....*....|....*...
gi 1673034488 261 RIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFG 298
Cdd:cd17477 245 WLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLV 282
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
196-377 |
4.97e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 4.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 196 PAFALPKGPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTIS 275
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 276 GLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQ-ATAIPAVTTFGYLGVLMGPASVGQIAHFS 354
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|...
gi 1673034488 355 SLASALVVIAMLIALATIFSLFV 377
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
39-180 |
7.34e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.44 E-value: 7.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 39 AHIGIDESTLGLLLLCLGAGAIFAMPVSGALATKYGCKRVLQLSTM-MIIFCLPFFALVNS---VASLATLLVIFGLSIG 114
Cdd:cd17369 257 QTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALlAALFAFPFFWLLDTgstWLIVLAAVVVLGVLHG 336
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 115 ATDCVMNiqAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAM----LLIAGFSAFEICMLMAAIVLLCLI 180
Cdd:cd17369 337 MMYGPQA--AFLAELFPTRVRYTGASLGYQLGAILGGGFAPLiataLVAATGSWWPVALYLAALAVISLV 404
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
83-315 |
5.15e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 5.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 83 TMMIIFCLPFFALVNSVASLATLLVIFGLSIGATDCVMN-IQAVLVEERSKLSLMSGFHGFYSLGGILGAGAVAMLLIAG 161
Cdd:COG2211 94 SFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSaLGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 162 FS---------AFEICMLMAAIVLLCLIFAKRDLLPFASPNEGPAFALPK----GPVILIGIICFAMFLAEGTVLDWSGI 228
Cdd:COG2211 174 FGgdaalgyrlTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKAllknRPFLLLLLAYLLFFLALALVAALLLY 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 229 YLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVS--MSFYVALFGYVLMGIGC 306
Cdd:COG2211 254 YFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGL 333
|
....*....
gi 1673034488 307 ANVVPIMFS 315
Cdd:COG2211 334 GAILVLPWA 342
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
210-378 |
6.93e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.44 E-value: 6.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 210 IICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVS 289
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 290 MSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQATAIPAVTTFGY-LGVLMGPASVGQIAHFSSLASALVVIAMLIA 368
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAInLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLL 165
|
170
....*....|
gi 1673034488 369 LATIFSLFVK 378
Cdd:cd17329 166 AALVLLFLLP 175
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
60-376 |
1.31e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 60 IFAMPVSGALATKYGCKRVLQLST---MMIIFCLPFFALVNSVASLATLLVIFGLSIGAT---DCVMNIQAVLVEERSKL 133
Cdd:cd06173 48 LLFSPFAGVLADRFDRRRLLILADllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAffgPARQALLPELVPKEQLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 134 SLMSGFHGFYSLGGILG--AGAVAMLLIAGFSAFEICMLMAAIVLLCLIFAKRDLLPFASPN---------EGPAFALPK 202
Cdd:cd06173 128 RANALNSLATQLARIIGpaLGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESsslllrdlrEGLRYLRRS 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 203 GPVILIGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLG 282
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 283 LIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQT---YMSQATAIpaVTTFGYLGVLMGPASVGQIAHFSSLASA 359
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVpdeLRGRVFSV--YNALNSGAMPLGALLAGLLADALGLSAV 365
|
330
....*....|....*..
gi 1673034488 360 LVVIAMLIALATIFSLF 376
Cdd:cd06173 366 FLLAGALLLLAALLLLL 382
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
229-379 |
1.50e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 229 YLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCAN 308
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1673034488 309 VVPIMFSAAGKQTYMSQATAIPAVTTFGYLGVLMGPASVGQIAHFS---SLASALVVIAMLIALATIFSLFVKV 379
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWHLPYLILAVLLLLLALLFLRSKL 186
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
208-377 |
3.51e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 208 IGIICFAMFLAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLGLIIAI 287
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 288 VSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQ-ATAIPAVTTFGYLGVLMGPASVGQIAHFSSLASALVVIAML 366
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|.
gi 1673034488 367 IALATIFSLFV 377
Cdd:pfam07690 161 SLLAAVLLLLP 171
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
66-369 |
5.96e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 38.37 E-value: 5.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 66 SGALATKYGCKRVLQLSTMMIIFCLPFFALVNSVASLATLLVIFGLSIGATdcvMNIQAVLV----EERSKLSLMSGFHG 141
Cdd:PRK03699 62 NAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAMFVLGVVSGIT---MSIGTFLIthvyEGKQRGSRLLFTDS 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 142 FYSLGGILGAGAVAMLLIAGFSAFEICMLMAAIVLLCLIFAKRDLLPF----ASPNEGPAFALPKGP-VILIGIICFAMF 216
Cdd:PRK03699 139 FFSMAGMIFPIIAAYLLARSIEWYWVYACIGLVYVAIFILTLFSEFPAlgkhAPKADKPVAKEKWGIgVLFLAIAALLYI 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 217 LAEGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQRAVLTISGLVASLglIIAIVSMSFYVAL 296
Cdd:PRK03699 219 LAQLTFISWVPEYAQKKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLAGLALV--LMYLFVNTDDPSH 296
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1673034488 297 FGYVLMGIG--CANVVPIMFSAAGKQTYMSQATAIPAVTTFGYLGVLMGPASVGQIAHFSSLASALVVIAMLIAL 369
Cdd:PRK03699 297 LLYAILGLGffSSAIYTTIITLGSQQTKVASPKLVNFILTCGTIGTMLTFVVTSPIVAHFGLQAALLTANGLYAV 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
65-377 |
6.07e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.41 E-value: 6.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 65 VSGALATKYGCKRVLQLSTMMIIFCLPFFALVNSVASLATLLVIFGL--SIGATDCVMNIQAVL-VEER-SKLSLMSGFH 140
Cdd:cd17312 57 ISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLfqSMGWPPCVKLLGNWFsKKERgTVYGIWSTSH 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 141 GFYSLGGILGAGAVAMLL--IAGFSAFEICMLMAAIVLLCLIfakRDLLPFaspnegpafalpkgpVILIGIICFAMFLA 218
Cdd:cd17312 137 NFGGILAPILAASLASYYgwRAAFLVPGIVGLVVAIILFFFL---RDSPPY---------------VWVLSLAYAFVYIV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 219 EGTVLDWSGIYLIDYQNASTGMAALGIFSFSVTMTLGRLFGDRIIAKHGQR-----AVLTISGLVASLGLIIAIVSMSFY 293
Cdd:cd17312 199 RYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGrrapiAVIYMLLMTLSLALFWFFPHNKLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 294 VALFGYVlmgIGCANVVPIMF------SAAGKQTYMSQATAIpaVTTFGYLG-VLMGPASVGQIAHFSSLASALVVIAML 366
Cdd:cd17312 279 SIVLLFL---IGFFVGGPINLiggaaaQDIGRKEAAGTATGF--VGLFGYLGaSLAGLPLGYIIDHYGWSTVFYFLISAA 353
|
330
....*....|.
gi 1673034488 367 IALATIFSLFV 377
Cdd:cd17312 354 LLSVLLLLSLW 364
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
265-377 |
8.38e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 37.94 E-value: 8.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673034488 265 KHGQRAVLTISGLVASLGLIIAIVSMSFYVALFGYVLMGIGCANVVPIMFSAAGKQTYMSQATAIPAVTTFGYLGVLMGP 344
Cdd:cd17330 60 RYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGP 139
|
90 100 110
....*....|....*....|....*....|...
gi 1673034488 345 ASVGQIAHFSSLASALVVIAMLIALATIFSLFV 377
Cdd:cd17330 140 ALGGFLSTPYGYALPFLVAAALALLNLVLVLFF 172
|
|
| |
