inactive transglutaminase family protein fused to 7 transmembrane helices may be associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family
7 transmembrane helices usually fused to an inactive transglutaminase; A family of seven ...
254-499
1.77e-150
7 transmembrane helices usually fused to an inactive transglutaminase; A family of seven transmembrane helices fused to an inactive transglutaminase domain. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it.
:
Pssm-ID: 433936 Cd Length: 248 Bit Score: 430.04 E-value: 1.77e-150
Inactive transglutaminase fused to 7 transmembrane helices; A family of inactive ...
26-182
2.33e-80
Inactive transglutaminase fused to 7 transmembrane helices; A family of inactive transglutaminases fused to seven transmembrane helices. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighbourhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it.
:
Pssm-ID: 433934 Cd Length: 161 Bit Score: 247.53 E-value: 2.33e-80
7 transmembrane helices usually fused to an inactive transglutaminase; A family of seven ...
254-499
1.77e-150
7 transmembrane helices usually fused to an inactive transglutaminase; A family of seven transmembrane helices fused to an inactive transglutaminase domain. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it.
Pssm-ID: 433936 Cd Length: 248 Bit Score: 430.04 E-value: 1.77e-150
Inactive transglutaminase fused to 7 transmembrane helices; A family of inactive ...
26-182
2.33e-80
Inactive transglutaminase fused to 7 transmembrane helices; A family of inactive transglutaminases fused to seven transmembrane helices. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighbourhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it.
Pssm-ID: 433934 Cd Length: 161 Bit Score: 247.53 E-value: 2.33e-80
7 transmembrane helices usually fused to an inactive transglutaminase; A family of seven ...
254-499
1.77e-150
7 transmembrane helices usually fused to an inactive transglutaminase; A family of seven transmembrane helices fused to an inactive transglutaminase domain. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it.
Pssm-ID: 433936 Cd Length: 248 Bit Score: 430.04 E-value: 1.77e-150
Inactive transglutaminase fused to 7 transmembrane helices; A family of inactive ...
26-182
2.33e-80
Inactive transglutaminase fused to 7 transmembrane helices; A family of inactive transglutaminases fused to seven transmembrane helices. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighbourhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it.
Pssm-ID: 433934 Cd Length: 161 Bit Score: 247.53 E-value: 2.33e-80
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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