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Conserved domains on  [gi|1688987425|gb|TOQ55100|]
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cation transporter [Vibrio parahaemolyticus]

Protein Classification

cation diffusion facilitator family transporter( domain architecture ID 11467717)

cation transporter of the cation diffusion facilitator (CDF) family that facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG3965 COG3965
Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and ...
6-294 7.46e-91

Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and metabolism];


:

Pssm-ID: 443165 [Multi-domain]  Cd Length: 300  Bit Score: 272.09  E-value: 7.46e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425   6 SKNENRILTISALLASGFAAGGMVLGLLVGSIVIVFDGVYSLVSLLLTLLSLAASSYISKPSKSVFPFGKAVLEPIVIAI 85
Cdd:COG3965     1 SRTEQRLLKLSIAGTLLFAVLGIVFGLLSGSQAILFDGVYSLIDAGMTLLSLLVARLIARPDSRRFQFGYWHLEPLVLAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  86 KAAVILVVVCFSLYSAISALMTGGREVDTSIATIFGLVNVIGCGYAWWFMAKKSRRFSSGLIDAEKKQWQMDTLLSVAVT 165
Cdd:COG3965    81 KGLILLLLCLYALVNAVGSLLDGGREIEFGLALVYALVATVGCFGIALYLRRANRRLRSELVRLDAKAWLMDGLLSAALL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 166 VGFIAAWLVSLTPFAHYAVYADPMMMLLMGFYFLKVPFDMLCGALRELLMMTPSKELCQVVGNDVLEIEKVSDHQLKLAG 245
Cdd:COG3965   161 VAFILAYLLQGTGLAWLAPYVDPAILALLSLVFLPVPLRIVRQALREVLLMAPPEELDARVREVMEAIVARYGFLDYRSY 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1688987425 246 ITKVGQELRVNIDLHVDDDM--IELDTLEQTRKQLTTRLSKHRFKLQLNLN 294
Cdd:COG3965   241 VAKVGRKLFIEIYFLVPPDFpaRTIEELDAIRDEIADALGDEGPDRWLTIS 291
 
Name Accession Description Interval E-value
COG3965 COG3965
Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and ...
6-294 7.46e-91

Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and metabolism];


Pssm-ID: 443165 [Multi-domain]  Cd Length: 300  Bit Score: 272.09  E-value: 7.46e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425   6 SKNENRILTISALLASGFAAGGMVLGLLVGSIVIVFDGVYSLVSLLLTLLSLAASSYISKPSKSVFPFGKAVLEPIVIAI 85
Cdd:COG3965     1 SRTEQRLLKLSIAGTLLFAVLGIVFGLLSGSQAILFDGVYSLIDAGMTLLSLLVARLIARPDSRRFQFGYWHLEPLVLAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  86 KAAVILVVVCFSLYSAISALMTGGREVDTSIATIFGLVNVIGCGYAWWFMAKKSRRFSSGLIDAEKKQWQMDTLLSVAVT 165
Cdd:COG3965    81 KGLILLLLCLYALVNAVGSLLDGGREIEFGLALVYALVATVGCFGIALYLRRANRRLRSELVRLDAKAWLMDGLLSAALL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 166 VGFIAAWLVSLTPFAHYAVYADPMMMLLMGFYFLKVPFDMLCGALRELLMMTPSKELCQVVGNDVLEIEKVSDHQLKLAG 245
Cdd:COG3965   161 VAFILAYLLQGTGLAWLAPYVDPAILALLSLVFLPVPLRIVRQALREVLLMAPPEELDARVREVMEAIVARYGFLDYRSY 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1688987425 246 ITKVGQELRVNIDLHVDDDM--IELDTLEQTRKQLTTRLSKHRFKLQLNLN 294
Cdd:COG3965   241 VAKVGRKLFIEIYFLVPPDFpaRTIEELDAIRDEIADALGDEGPDRWLTIS 291
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
22-214 9.61e-28

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 106.20  E-value: 9.61e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  22 GFAAGGMVLGLLVGSIVIVFDGVYSLVSLLLTLLSLAASSYISKPSKSVFPFGKAVLEPIVIAIKAAVILVVVCFSLYSA 101
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 102 ISALMTGGREVDTSIATIFGLVNVIGCGYAWWFMAKKSRRFSSGLIDAEKKQWQMDTLLSVAVTVGFIAAWLVSLTpfah 181
Cdd:pfam01545  81 IQRLLSPGEEIDPGLALILALVSLLVNLFLLLYLRRAARRIRSPALKADALHALSDVLASLGVLISALLIYLGPIT---- 156
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1688987425 182 YAVYADPMMMLLMGFYFLKVPFDMLCGALRELL 214
Cdd:pfam01545 157 GGLLADPLASLLIGLLILYTALRLLKESLSILL 189
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
22-285 1.29e-14

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 72.25  E-value: 1.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  22 GFAAGGMVLGLLVGSIVIVFDGVYSLVSLLLTLLSLAASSYISKPSKSVFPFGKAVLEPIVIAIKAAVILVVVCFSLYSA 101
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 102 ISALMTGGREVDTSIATIFGLVNVIGCGYAWWFMAKKSRRFSSGLIDAEKKQWQMDTLLSVAVTVGFIAAWLvsltpfah 181
Cdd:TIGR01297  81 IERLINPEPEIDGGTMLIVAIVGLIVNLILALYLHRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYF-------- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 182 YAVYADPMMMLLMGFYFLKVPFDMLCGALRELLMMTPSKELCQVVGNDVLEIEKVSD-HQLKLAGITkvgqELRVNIDLH 260
Cdd:TIGR01297 153 GWHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPGVKGvHDLHIWRIG----PGKLFLDVH 228
                         250       260
                  ....*....|....*....|....*..
gi 1688987425 261 --VDDDMIELDTLEQTRKQLTTRLSKH 285
Cdd:TIGR01297 229 vvVDPDLDLKQAHDIALEIEREILKRH 255
 
Name Accession Description Interval E-value
COG3965 COG3965
Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and ...
6-294 7.46e-91

Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and metabolism];


Pssm-ID: 443165 [Multi-domain]  Cd Length: 300  Bit Score: 272.09  E-value: 7.46e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425   6 SKNENRILTISALLASGFAAGGMVLGLLVGSIVIVFDGVYSLVSLLLTLLSLAASSYISKPSKSVFPFGKAVLEPIVIAI 85
Cdd:COG3965     1 SRTEQRLLKLSIAGTLLFAVLGIVFGLLSGSQAILFDGVYSLIDAGMTLLSLLVARLIARPDSRRFQFGYWHLEPLVLAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  86 KAAVILVVVCFSLYSAISALMTGGREVDTSIATIFGLVNVIGCGYAWWFMAKKSRRFSSGLIDAEKKQWQMDTLLSVAVT 165
Cdd:COG3965    81 KGLILLLLCLYALVNAVGSLLDGGREIEFGLALVYALVATVGCFGIALYLRRANRRLRSELVRLDAKAWLMDGLLSAALL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 166 VGFIAAWLVSLTPFAHYAVYADPMMMLLMGFYFLKVPFDMLCGALRELLMMTPSKELCQVVGNDVLEIEKVSDHQLKLAG 245
Cdd:COG3965   161 VAFILAYLLQGTGLAWLAPYVDPAILALLSLVFLPVPLRIVRQALREVLLMAPPEELDARVREVMEAIVARYGFLDYRSY 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1688987425 246 ITKVGQELRVNIDLHVDDDM--IELDTLEQTRKQLTTRLSKHRFKLQLNLN 294
Cdd:COG3965   241 VAKVGRKLFIEIYFLVPPDFpaRTIEELDAIRDEIADALGDEGPDRWLTIS 291
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
22-214 9.61e-28

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 106.20  E-value: 9.61e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  22 GFAAGGMVLGLLVGSIVIVFDGVYSLVSLLLTLLSLAASSYISKPSKSVFPFGKAVLEPIVIAIKAAVILVVVCFSLYSA 101
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 102 ISALMTGGREVDTSIATIFGLVNVIGCGYAWWFMAKKSRRFSSGLIDAEKKQWQMDTLLSVAVTVGFIAAWLVSLTpfah 181
Cdd:pfam01545  81 IQRLLSPGEEIDPGLALILALVSLLVNLFLLLYLRRAARRIRSPALKADALHALSDVLASLGVLISALLIYLGPIT---- 156
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1688987425 182 YAVYADPMMMLLMGFYFLKVPFDMLCGALRELL 214
Cdd:pfam01545 157 GGLLADPLASLLIGLLILYTALRLLKESLSILL 189
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
10-265 2.06e-17

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 80.15  E-value: 2.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  10 NRILTISALLASGFAAGGMVLGLLVGSIVIVFDGVYSLVSLLLTLLSLAASSYISKPSKSVFPFGKAVLEPIVIAIKAAV 89
Cdd:COG0053     2 RRAALASLAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIVAVL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  90 ILVVVCFSLYSAISALMTGGREVDTSIATIFGLVNVIGCGYAWWFMAKKSRRFSSGLIDAEKKQWQMDTLLSVAVTVGFI 169
Cdd:COG0053    82 ILLAGLFILYEAIERLLHPEPVEPSGLGLAVLLISIVVNEALARYLRRVGKKTGSPALKADALHDRSDALTSLGVLIGLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 170 AAWLVSLTpfahyavYADPMMMLLMGFYFLKVPFDMLCGALRELLMMTPSKELCQVVGNDVLEIEKVSD-HQLKlagITK 248
Cdd:COG0053   162 LALLTGWP-------WLDPIAAILIGLLILKVAYKLARESLSLLMDEALDEELVERIRAIILSVPGVIGvHDLR---TRK 231
                         250
                  ....*....|....*..
gi 1688987425 249 VGQELRVNIDLHVDDDM 265
Cdd:COG0053   232 SGPRIFVDLHIEVDPDL 248
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
22-285 1.29e-14

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 72.25  E-value: 1.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  22 GFAAGGMVLGLLVGSIVIVFDGVYSLVSLLLTLLSLAASSYISKPSKSVFPFGKAVLEPIVIAIKAAVILVVVCFSLYSA 101
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 102 ISALMTGGREVDTSIATIFGLVNVIGCGYAWWFMAKKSRRFSSGLIDAEKKQWQMDTLLSVAVTVGFIAAWLvsltpfah 181
Cdd:TIGR01297  81 IERLINPEPEIDGGTMLIVAIVGLIVNLILALYLHRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYF-------- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 182 YAVYADPMMMLLMGFYFLKVPFDMLCGALRELLMMTPSKELCQVVGNDVLEIEKVSD-HQLKLAGITkvgqELRVNIDLH 260
Cdd:TIGR01297 153 GWHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPGVKGvHDLHIWRIG----PGKLFLDVH 228
                         250       260
                  ....*....|....*....|....*..
gi 1688987425 261 --VDDDMIELDTLEQTRKQLTTRLSKH 285
Cdd:TIGR01297 229 vvVDPDLDLKQAHDIALEIEREILKRH 255
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
10-290 5.53e-03

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 37.79  E-value: 5.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  10 NRILTISALLASGFAAGGMVLGLLVGSIVIVFDGVYSLVSLLLTLLSLAASSYISKPSKSVFPFGKAVLEPIVIAIKAAV 89
Cdd:COG1230    17 ERRLLIALALTLGFMVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAEILAALANALL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425  90 ILVVVCFSLYSAISALMTGgREVDTSIATIFGLVNVIGCGYAWWFMAKKSRRF----SSGLIDAEkkqwqmDTLLSVAVt 165
Cdd:COG1230    97 LLVVAGYILYEAIQRLFNP-PPVAGGGMLVVAVIGLVVNLVSAWLLHRGSKHDlnlrGAYLHVLA------DALGSVAV- 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1688987425 166 vgFIAAWLVSLTPFahyaVYADPMMMLLMGFYFLKVPFDMLCGALRELLMMTPSKELCQVVGNDVLEIEKVSD-HQLKla 244
Cdd:COG1230   169 --IVAALVILFTGW----TWLDPLLSLLIALLILRSAWGLLRESLRILLEGVPDGIDLEEVRAALEALPGVADvHDLH-- 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1688987425 245 gITKVGQELRVnIDLHVD-DDMIELDTLeqtRKQLTTRLsKHRFKLQ 290
Cdd:COG1230   241 -VWSLSSGENA-LTAHVVvDDGADADAI---LDEIRELL-AERFGIE 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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