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Conserved domains on  [gi|1697119541|gb|TQD73079|]
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hypothetical protein C1H46_041381 [Malus baccata]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCAfunc pfam19584
MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a ...
 290-432 1.72e-98

MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a mechanosensitive channel protein MID1-COMPLEMENTING ACTIVITY (MCA). MCAfunc represents the provisionally advocated ARPK domain (Amino-terminal domain of Rice putative Protein Kinases), overlapping with the EF hand-like region at the N-terminus. In MCA proteins, MCAfunc has Ca2+ influx activity and is proposed to be a functional domain of MCAs. MCAfunc is exclusively observed in streptophytes and exists not only in MCA but also in E3 ubiquitin ligase-like proteins, ARO3 like proteins and and protein kinases. In the most basal plant lineage, charophytes, MCAfunc is only found in E3 ubiquitin ligase-like proteins and protein of presently unknown function, while MCA proteins are exclusively found in land plants, from bryophytes to angiosperms.


:

Pssm-ID: 437416  Cd Length: 143  Bit Score: 295.63  E-value: 1.72e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697119541 290 LIGMIVKAASTARMHKKNCRQFAQHLKLIGNLLEQLKISELKRYPETREPLEQLEEALRRSYILVSSCQDRSYLYLLAMG 369
Cdd:pfam19584   1 LIGLIVEAANTARLHKKNCRQFAHHLKLIGNLLEQLKISELKKYPETREPLEQLEDALRRSYLLVNSCQDKSYLYLLAMG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1697119541 370 WNIVYQFRKAQNEIDRYLKLVPLITLVDNARVRERLEYIEMDQCEYTLDEEDRKVQDVILKPD 432
Cdd:pfam19584  81 WNIVNQFRKAQNEIDRYLRIVPLITLVDNARIRERLERIERDQYEYTLDEEDRKVQDAILNQE 143
 
Name Accession Description Interval E-value
MCAfunc pfam19584
MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a ...
 290-432 1.72e-98

MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a mechanosensitive channel protein MID1-COMPLEMENTING ACTIVITY (MCA). MCAfunc represents the provisionally advocated ARPK domain (Amino-terminal domain of Rice putative Protein Kinases), overlapping with the EF hand-like region at the N-terminus. In MCA proteins, MCAfunc has Ca2+ influx activity and is proposed to be a functional domain of MCAs. MCAfunc is exclusively observed in streptophytes and exists not only in MCA but also in E3 ubiquitin ligase-like proteins, ARO3 like proteins and and protein kinases. In the most basal plant lineage, charophytes, MCAfunc is only found in E3 ubiquitin ligase-like proteins and protein of presently unknown function, while MCA proteins are exclusively found in land plants, from bryophytes to angiosperms.


Pssm-ID: 437416  Cd Length: 143  Bit Score: 295.63  E-value: 1.72e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697119541 290 LIGMIVKAASTARMHKKNCRQFAQHLKLIGNLLEQLKISELKRYPETREPLEQLEEALRRSYILVSSCQDRSYLYLLAMG 369
Cdd:pfam19584   1 LIGLIVEAANTARLHKKNCRQFAHHLKLIGNLLEQLKISELKKYPETREPLEQLEDALRRSYLLVNSCQDKSYLYLLAMG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1697119541 370 WNIVYQFRKAQNEIDRYLKLVPLITLVDNARVRERLEYIEMDQCEYTLDEEDRKVQDVILKPD 432
Cdd:pfam19584  81 WNIVNQFRKAQNEIDRYLRIVPLITLVDNARIRERLERIERDQYEYTLDEEDRKVQDAILNQE 143
MLKL_NTD cd21037
N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins; ...
 287-404 1.93e-14

N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins; MLKL is a pseudokinase that does not have protein kinase activity and plays a key role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process. The model corresponds to the MLKL N-terminal region that reveals a four-helix bundle with an additional helix at the top which is likely key for MLKL function. The N-terminal domain binds directly to phospholipids and induces membrane permeabilization.


Pssm-ID: 411030 [Multi-domain]  Cd Length: 138  Bit Score: 70.47  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697119541 287 AVRLIGMIVKAASTARMHKKNCRQFAQHLKLIGNLLEQL-KISELKRYPETREPLEQLEEALRRSYILVSSCQDRSYLYL 365
Cdd:cd21037     3 AAGLALEILEAVETVKSNKEACRRLAERVAELLLALEELlEGKEEDLSPELREALEELERTLEEIKEFVEKISKRSRLKR 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1697119541 366 LAMGWNIVYQFRKAQNEIDRYLKLVPLITLVDNARVRER 404
Cdd:cd21037    83 FLKAKSIAEKLEELNERLDDALQLFQLALQIEIRAWLLE 121
 
Name Accession Description Interval E-value
MCAfunc pfam19584
MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a ...
 290-432 1.72e-98

MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a mechanosensitive channel protein MID1-COMPLEMENTING ACTIVITY (MCA). MCAfunc represents the provisionally advocated ARPK domain (Amino-terminal domain of Rice putative Protein Kinases), overlapping with the EF hand-like region at the N-terminus. In MCA proteins, MCAfunc has Ca2+ influx activity and is proposed to be a functional domain of MCAs. MCAfunc is exclusively observed in streptophytes and exists not only in MCA but also in E3 ubiquitin ligase-like proteins, ARO3 like proteins and and protein kinases. In the most basal plant lineage, charophytes, MCAfunc is only found in E3 ubiquitin ligase-like proteins and protein of presently unknown function, while MCA proteins are exclusively found in land plants, from bryophytes to angiosperms.


Pssm-ID: 437416  Cd Length: 143  Bit Score: 295.63  E-value: 1.72e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697119541 290 LIGMIVKAASTARMHKKNCRQFAQHLKLIGNLLEQLKISELKRYPETREPLEQLEEALRRSYILVSSCQDRSYLYLLAMG 369
Cdd:pfam19584   1 LIGLIVEAANTARLHKKNCRQFAHHLKLIGNLLEQLKISELKKYPETREPLEQLEDALRRSYLLVNSCQDKSYLYLLAMG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1697119541 370 WNIVYQFRKAQNEIDRYLKLVPLITLVDNARVRERLEYIEMDQCEYTLDEEDRKVQDVILKPD 432
Cdd:pfam19584  81 WNIVNQFRKAQNEIDRYLRIVPLITLVDNARIRERLERIERDQYEYTLDEEDRKVQDAILNQE 143
MLKL_NTD cd21037
N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins; ...
 287-404 1.93e-14

N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins; MLKL is a pseudokinase that does not have protein kinase activity and plays a key role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process. The model corresponds to the MLKL N-terminal region that reveals a four-helix bundle with an additional helix at the top which is likely key for MLKL function. The N-terminal domain binds directly to phospholipids and induces membrane permeabilization.


Pssm-ID: 411030 [Multi-domain]  Cd Length: 138  Bit Score: 70.47  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697119541 287 AVRLIGMIVKAASTARMHKKNCRQFAQHLKLIGNLLEQL-KISELKRYPETREPLEQLEEALRRSYILVSSCQDRSYLYL 365
Cdd:cd21037     3 AAGLALEILEAVETVKSNKEACRRLAERVAELLLALEELlEGKEEDLSPELREALEELERTLEEIKEFVEKISKRSRLKR 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1697119541 366 LAMGWNIVYQFRKAQNEIDRYLKLVPLITLVDNARVRER 404
Cdd:cd21037    83 FLKAKSIAEKLEELNERLDDALQLFQLALQIEIRAWLLE 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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