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Conserved domains on  [gi|1710873140|gb|TVQ37017|]
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ABC transporter permease subunit [Spirochaetaceae bacterium]

Protein Classification

ABC transporter permease( domain architecture ID 11439530)

ABC transporter permease is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of one or more from a variety of substrates including sugars, ions, amino acids, and peptides, among others

Gene Ontology:  GO:0140359|GO:0042626|GO:0016020
PubMed:  18535149|17723295|25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 5-237 8.48e-34

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


:

Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 122.91  E-value: 8.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140   5 SARASRRPDVVRLALIIALFGLPVIMLLTSSLSARGAAT-----LTLRAWRYLFAERRtFLTALASSLGYGFSAMVVAFA 79
Cdd:COG1177     1 SSRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSWFLTfppegFTLRWYAELFSDPR-LLDALLNSLLIALLSTLLATV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  80 SSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVLSFVSYPYMLRALIASYESIDP 159
Cdd:COG1177    80 LGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLARLQGFDP 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1710873140 160 AYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGIVPAFTSYLVPFIRSADYSIAGALS 237
Cdd:COG1177   160 SLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAGPGVTTLPVYIYSMIRRGISPEINALS 237
 
Name Accession Description Interval E-value
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 5-237 8.48e-34

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 122.91  E-value: 8.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140   5 SARASRRPDVVRLALIIALFGLPVIMLLTSSLSARGAAT-----LTLRAWRYLFAERRtFLTALASSLGYGFSAMVVAFA 79
Cdd:COG1177     1 SSRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSWFLTfppegFTLRWYAELFSDPR-LLDALLNSLLIALLSTLLATV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  80 SSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVLSFVSYPYMLRALIASYESIDP 159
Cdd:COG1177    80 LGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLARLQGFDP 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1710873140 160 AYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGIVPAFTSYLVPFIRSADYSIAGALS 237
Cdd:COG1177   160 SLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAGPGVTTLPVYIYSMIRRGISPEINALS 237
Mo_ABC_porter TIGR01581
NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively ...
 61-213 4.50e-14

NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively weak homology compared to its neighbor clades, the molybdate (TIGR02141) and sulfate (TIGR00969) porters. Neighbor-Joining, PAM-distance phylogenetic trees support the separation of the clades in this way. Included in this group is a gene designated NifC in Clostridium pasturianum. It would be reasonable to presume that NifC acts as a molybdate porter since the most common form of nitrogenase is a molybdoenzyme. Several other sequences falling within the scope of this model are annotated as molybdate porters and one, from Halobacterium, is annotated as a sulfate porter. There is presently no experimental evidence to support annotations with this degree of specificity.


Pssm-ID: 130643  Cd Length: 225  Bit Score: 69.35  E-value: 4.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  61 TALASSLGYGFSAMVVAFASSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTW--------- 131
Cdd:TIGR01581  21 KALRLSLATSLASLLLAVIIGIPTAYVLARVRFPLKKLLDTLLDLPMVLPPLVAGLALLLLFGRNGLLGPYleaagiqvi 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 132 ---IGVLLVLSFVSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFL 208
Cdd:TIGR01581 101 fstLGVVLAQTFVASPYYVRVARSTFKSVDPRYEDVARSLGAGPLETFRKITLPMARPGLLAGLVLAWARALGEFGATLM 180


                  ....*
gi 1710873140 209 IGGGI 213
Cdd:TIGR01581 181 FAGSI 185
modB PRK09421
molybdate ABC transporter permease subunit;
60-191 1.35e-11

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 62.63  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  60 LTALASSLGYGFSAMVVAFASSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVLS 139
Cdd:PRK09421    8 WQAVLLSLKVSSVAVLFSLPFGILVAWLLARCRFPGKSLLDSLLHLPLVLPPVVTGYLLLISMGRRGFIGQWLYEWFGIS 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1710873140 140 F-------------VSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAG 191
Cdd:PRK09421   88 FafswrgaalaaavMAFPLMVRAIRLSLEAVDRKLEQAARTLGASPWRVFFTITLPLTLPGIIAG 152
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 63-221 7.36e-08

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 51.13  E-value: 7.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  63 LASSLGYGFSAMVVAFASSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIG----VLLVL 138
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglpALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 139 SFVSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGIVPAFT 218
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160


                  ...
gi 1710873140 219 SYL 221
Cdd:cd06261   161 TGL 163
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 98-261 3.94e-03

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 37.28  E-value: 3.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  98 VVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVLSFVSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFV 177
Cdd:pfam00528  19 LLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFR 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 178 RVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGivPAFTSYLVPFIRSADYSIAGALSLVFLLVPVVLFVLQDRALTV 257
Cdd:pfam00528  99 KIILPNALPPILTGLALAFGGALGGAVLLEFLGSW--PGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRL 176


                  ....
gi 1710873140 258 LLRR 261
Cdd:pfam00528 177 LDPR 180
 
Name Accession Description Interval E-value
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 5-237 8.48e-34

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 122.91  E-value: 8.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140   5 SARASRRPDVVRLALIIALFGLPVIMLLTSSLSARGAAT-----LTLRAWRYLFAERRtFLTALASSLGYGFSAMVVAFA 79
Cdd:COG1177     1 SSRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSWFLTfppegFTLRWYAELFSDPR-LLDALLNSLLIALLSTLLATV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  80 SSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVLSFVSYPYMLRALIASYESIDP 159
Cdd:COG1177    80 LGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLARLQGFDP 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1710873140 160 AYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGIVPAFTSYLVPFIRSADYSIAGALS 237
Cdd:COG1177   160 SLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAGPGVTTLPVYIYSMIRRGISPEINALS 237
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 17-212 7.92e-24

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 97.14  E-value: 7.92e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  17 LALIIALFGLPVIMLLTSSLSARGAA-----TLTLRAWRYLFAERrTFLTALASSLGYGFSAMVVAFASSVLPAKALARA 91
Cdd:COG1176    19 LLWLLLFFVLPLLLLLVYSFTTRDPYggvvpGFTLENYARLFTDP-LYLKVLLRTLWIALLTTLICLLLGYPIAYFLARA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  92 HGSRIAVVEAILLAPALLPSI--TFAI--------GVHQLFIRAGLVD-------TWIGVLLVLSFVSYPYMLRALIASY 154
Cdd:COG1176    98 PPRWRNLLLLLVILPFWTSFLvrTYAWivllgrngLLNSLLLALGLIDeplrllyTEFAVVIGLVYVYLPFMVLPLYAAL 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1710873140 155 ESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGG 212
Cdd:COG1176   178 EKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALLGGG 235
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
1-213 2.95e-21

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 92.53  E-value: 2.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140   1 MCERSARASRRPDVVRLALIIALFGLPVIMLLTSSLSARGAAtltlrAWRYLFAERrtFLTALASSLGYGFSAMVVAFAS 80
Cdd:COG1178     1 MSTRPRRRPRLLLLLLALLLALLVLLPLLALLLRAFTDGLAN-----FWALLSDPY--LWRALGNTLLLALLVTLLSLLL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  81 SVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWI---------------GVLLVLSFVSYPY 145
Cdd:COG1178    74 GVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPNGLLNTLLralfgleppdiyglgGIILVLVLFNYPY 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1710873140 146 MLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGI 213
Cdd:COG1178   154 VYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVLGGGY 221
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
17-203 2.20e-20

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 90.22  E-value: 2.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  17 LALIIALFGLPVIMLLTSSLSARGAATLTLRAWRYLFAERRTfLTALASSLGYGFSAMVVAFASSVLPAKALARAHGSRI 96
Cdd:COG1178   295 LLLVLLGLLLPLLALLLWSLTKALDDNLTLDNYRFVLLDPSL-LRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLA 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  97 AVVEAILLAPALLPSITFAIGVHQLFIRAGLVD---TWIGVLLVLSFVSYPYMLRALIASYESIDPAYEQCARNLGAGAL 173
Cdd:COG1178   374 RLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPLLlygTLAILVLAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPL 453

                         170       180       190
                  ....*....|....*....|....*....|
gi 1710873140 174 RTFVRVELPFLLPGAVAGGSVVFLVAFSDY 203
Cdd:COG1178   454 RTLRRVTLPLLRPGLLAAALLVFVTSMKEL 483
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 7-236 3.09e-16

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 75.94  E-value: 3.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140   7 RASRRPDVVRLALIIALFGLPVIMLLTSSLSARGAATLTLRAWRYLFAERrtFLTALASSLGYGFSAMVVAFASSVLPAK 86
Cdd:COG0555     2 SRRVLPGFGLTLGLTLLYLSLIVLLPLAALVLKAAGLGWAEFWAVLTSPR--VLAALKLSLGTALIAALINLVFGLPLAW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  87 ALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGL------------VDTWIGVLLVLSFVSYPYMLRALIASY 154
Cdd:COG0555    80 VLVRYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPNGWlgqllaplgikvAFTPLGIVLAQTFVSLPFVVRTVQPVL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 155 ESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGIvpAFTSYLVP---FIRSADYS 231
Cdd:COG0555   160 EELDPELEEAAATLGASRWQTFRRVILPLLLPALLTGFALAFARALGEFGAVIFIAGNL--PMKTEILPlliYLKLEEGD 237


                  ....*
gi 1710873140 232 IAGAL 236
Cdd:COG0555   238 YAGAT 242
YnjC COG4135
ABC-type uncharacterized transport system YnjBCD, permease component [General function ...
 4-218 2.18e-15

ABC-type uncharacterized transport system YnjBCD, permease component [General function prediction only];


Pssm-ID: 443310 [Multi-domain]  Cd Length: 564  Bit Score: 75.29  E-value: 2.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140   4 RSARASRRPDVVRLALIIALFGLPVIMLLTSSLSARGA------ATLTLRAWRYLFAerrTFLTALASSLGYGFSAMVVA 77
Cdd:COG4135   296 LGDPALRRLGLALMLLIALLSLLGLALLLLWSFAGRWRfpdalpSSWTLRFWQRAAP---GLLEPLGNTLLLALASALIA 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  78 FASSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVLSFVSYPYMLRALIASYESI 157
Cdd:COG4135   373 LVLVLACLEAEARRGRRPGRRALWLLYLPLLVPQIAFLFGLQVLLLRLGLDGTWLAVIWAHLVFVLPYVFLSLAGPWRAL 452

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1710873140 158 DPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGIVPAFT 218
Cdd:COG4135   453 DPRYAQVAASLGASPWRVFWRVKLPLLLRPILTAAAVGFAVSVAQYLPTLLIGAGRVATLT 513
Mo_ABC_porter TIGR01581
NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively ...
 61-213 4.50e-14

NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively weak homology compared to its neighbor clades, the molybdate (TIGR02141) and sulfate (TIGR00969) porters. Neighbor-Joining, PAM-distance phylogenetic trees support the separation of the clades in this way. Included in this group is a gene designated NifC in Clostridium pasturianum. It would be reasonable to presume that NifC acts as a molybdate porter since the most common form of nitrogenase is a molybdoenzyme. Several other sequences falling within the scope of this model are annotated as molybdate porters and one, from Halobacterium, is annotated as a sulfate porter. There is presently no experimental evidence to support annotations with this degree of specificity.


Pssm-ID: 130643  Cd Length: 225  Bit Score: 69.35  E-value: 4.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  61 TALASSLGYGFSAMVVAFASSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTW--------- 131
Cdd:TIGR01581  21 KALRLSLATSLASLLLAVIIGIPTAYVLARVRFPLKKLLDTLLDLPMVLPPLVAGLALLLLFGRNGLLGPYleaagiqvi 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 132 ---IGVLLVLSFVSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFL 208
Cdd:TIGR01581 101 fstLGVVLAQTFVASPYYVRVARSTFKSVDPRYEDVARSLGAGPLETFRKITLPMARPGLLAGLVLAWARALGEFGATLM 180


                  ....*
gi 1710873140 209 IGGGI 213
Cdd:TIGR01581 181 FAGSI 185
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 17-209 5.09e-13

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 67.43  E-value: 5.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  17 LALIIALFGLPVIMLLTSSLSARGAA----------TLTLRAWRYLFaERRTFLTALASSLGYGFSAMVVAFASSVLPAK 86
Cdd:COG0395    21 LILLALLFLFPLYWMVVTSFKPPAEIfsgppsllpsEFTLENYRAAF-TDGPFGRYLLNSLIVAVVSTVLSLLLSSLAAY 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  87 ALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVLSFVSYPYMLRALIASYESIDPAYEQCAR 166
Cdd:COG0395   100 ALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLLRQFFRSIPRELEEAAR 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1710873140 167 NLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLI 209
Cdd:COG0395   180 IDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLIL 222
modB PRK09421
molybdate ABC transporter permease subunit;
60-191 1.35e-11

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 62.63  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  60 LTALASSLGYGFSAMVVAFASSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVLS 139
Cdd:PRK09421    8 WQAVLLSLKVSSVAVLFSLPFGILVAWLLARCRFPGKSLLDSLLHLPLVLPPVVTGYLLLISMGRRGFIGQWLYEWFGIS 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1710873140 140 F-------------VSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAG 191
Cdd:PRK09421   88 FafswrgaalaaavMAFPLMVRAIRLSLEAVDRKLEQAARTLGASPWRVFFTITLPLTLPGIIAG 152
potB PRK09497
spermidine/putrescine ABC transporter membrane protein; Reviewed
 127-212 1.17e-09

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 181910  Cd Length: 285  Bit Score: 57.39  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 127 LVDTWIGVLLVLSFVSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLV 206
Cdd:PRK09497  146 IMFTESAVIIGLVYILLPFMVLPLYSSIEKLDKPLLEAARDLGANKLQTFIRIIIPLTMPGIIAGCLLVLLPAMGMFYVS 225


                  ....*.
gi 1710873140 207 FLIGGG 212
Cdd:PRK09497  226 DLLGGA 231
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 17-212 4.17e-09

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 56.61  E-value: 4.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  17 LALIIALFgLPVIMLLTSSLSARGAATLTLRAWRYLFAERrTFLTALASSLGYGFSAMVVAFASSVLPAKALARAHGSRI 96
Cdd:TIGR03262  12 LALLLFLL-LPLLALLTKSVYDSDGDFIGLANFAEYFATP-GLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTRSRIPGK 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  97 AVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTW---------IGVLLVLSFVSYPYMLRALIASYESIDPAYEQCARN 167
Cdd:TIGR03262  90 GAFRLVALLPLLAPSLLPAISLIYLFGNQGLLKGLlggfsiygfWGIVIGEVFYTFPHALMILVTALSLADGRLYEAARA 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1710873140 168 LGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGG 212
Cdd:TIGR03262 170 MGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKVIGGD 214
PRK10971 PRK10971
sulfate/thiosulfate ABC transporter permease CysT;
130-237 1.57e-08

sulfate/thiosulfate ABC transporter permease CysT;


Pssm-ID: 182873  Cd Length: 277  Bit Score: 54.37  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 130 TWIGVLLVLSFVSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLI 209
Cdd:PRK10971  139 TWLGIAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFRKVVLPELSPALLAGVALSFTRSLGEFGAVIFI 218

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1710873140 210 GGGIV-PAFTSYLVPFIR--SADYSIAGALS 237
Cdd:PRK10971  219 AGNIAwKTEVTSLMIFVRlqEFDYPAASAIA 249
cysT CHL00187
sulfate transport protein; Provisional
 127-213 3.56e-08

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 52.71  E-value: 3.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 127 LVDTWIGVLLVLSFVSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLV 206
Cdd:CHL00187  133 IVFTKLGVLLAMIFVSFPFVVRTIQPVLQEIEKELEEAAWSLGASPWQTFWKVIFPPLIPALLTGLALTFSRAIGEYGSI 212


                  ....*..
gi 1710873140 207 FLIGGGI 213
Cdd:CHL00187  213 VIISSNI 219
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 63-221 7.36e-08

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 51.13  E-value: 7.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  63 LASSLGYGFSAMVVAFASSVLPAKALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIG----VLLVL 138
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglpALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 139 SFVSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGIVPAFT 218
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160


                  ...
gi 1710873140 219 SYL 221
Cdd:cd06261   161 TGL 163
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 7-210 1.28e-07

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 51.54  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140   7 RASRRPDVVRLALIIALFGLPVI--MLLTSSLSARGAATLTLRAWRYLFAERRtFLTALASSLGYGFSAMVVAFASSVLP 84
Cdd:PRK15050   18 RRRRLRPLLWLLLPLLVLAPLVVypLVRVVLQSLTGEHGLGLATYRAVLGSPD-FRGALLTTLQIAFASTAGCLVLGVLL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  85 AKALARA--HGSRIA--VVEAILLAPALLpsITFAIGVhqLFIRAGLVDTWI------------------GVLLVLSFVS 142
Cdd:PRK15050   97 ALVLAFVpfPGASLVgrFIDTFVAFPSFL--ITLAFTF--LYGSAGSVNIALqrlfgleappldflyspgGVILAEITFY 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1710873140 143 YPYMLRALIASYESIDPAYEQCARNLGAGALRTFVRVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIG 210
Cdd:PRK15050  173 TPFVVRPLLAAFAQLDARQLEAAASLGASPWRVARRVILPEAWPALAAGGSLCLLLTLNEFGIVLFTG 240
thiP PRK09433
thiamine transporter membrane protein; Reviewed
 12-212 6.18e-05

thiamine transporter membrane protein; Reviewed


Pssm-ID: 181853 [Multi-domain]  Cd Length: 525  Bit Score: 44.06  E-value: 6.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  12 PDVVRLALIIALFGLPVIMLLtssLSARGAATLTLRAWRYLFAERR-TFLTALASSLgygFSamvVAFAssVLPAKALAR 90
Cdd:PRK09433    5 PGVLAAALLVALALLALLALW---LHAPGGDWDAVWQDSYLWHVLRfSFWQAFLSAL---LS---VLPA--IPLARALYR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  91 AHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWI---------------GVLLVLSFVSYPYMLRALIASYE 155
Cdd:PRK09433   74 RRFPGRGLLLRLCAMTLVLPVLVAVFGLLSVYGRSGWLAQLLqalglewpfsiyglqGILLAHVFFNLPLATRLLLQALE 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 156 SIDPAYEQCARNLGAGALRTFVRVELPFL---LPGAvagGSVVFLVAFSDYFLVFLIGGG 212
Cdd:PRK09433  154 SIPAEQRQLAAQLGMRGWQFFRLVEWPYLrrqLPPV---AALIFMLCFTSFATVLTLGGG 210
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 98-261 3.94e-03

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 37.28  E-value: 3.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  98 VVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVLSFVSYPYMLRALIASYESIDPAYEQCARNLGAGALRTFV 177
Cdd:pfam00528  19 LLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFR 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140 178 RVELPFLLPGAVAGGSVVFLVAFSDYFLVFLIGGGivPAFTSYLVPFIRSADYSIAGALSLVFLLVPVVLFVLQDRALTV 257
Cdd:pfam00528  99 KIILPNALPPILTGLALAFGGALGGAVLLEFLGSW--PGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRL 176


                  ....
gi 1710873140 258 LLRR 261
Cdd:pfam00528 177 LDPR 180
thiP PRK09433
thiamine transporter membrane protein; Reviewed
 7-184 6.21e-03

thiamine transporter membrane protein; Reviewed


Pssm-ID: 181853 [Multi-domain]  Cd Length: 525  Bit Score: 37.51  E-value: 6.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140   7 RASRRPDVVRLALIIALFGLPVIMLLTSSLSARGAATLTLRA-WRylfaerrTFLTALASSLGYGFSAMVVAFASSVLPA 85
Cdd:PRK09433  275 LWSRLWDGLLIVLALLLLLPPLLAVVVSGLNASLLRVLAQPAlWQ-------ALWTSLRIALAAALLAVVLTMMLLWSSR 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710873140  86 KALARAHGSRIAVVEAILLAPALLPSITFAIGVHQLFIRAGLVDTWIGVLLVL--SFVSYPYMLRALIASYESIDPAYEQ 163
Cdd:PRK09433  348 ELRLRQRKLAAQALELSGMLILAMPGIVLATGLFLLLRNTTDLPASALGIVILtnALMALPYALRVLEPPMRDIAARYGR 427

                         170       180
                  ....*....|....*....|.
gi 1710873140 164 CARNLGAGALRTFVRVELPFL 184
Cdd:PRK09433  428 LCQSLGIRGWSRLRLIELRAL 448
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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