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Conserved domains on  [gi|1710913895|gb|TVQ74656|]
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sensor histidine kinase [Oceanospirillales bacterium]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
78-337 9.73e-60

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 195.47  E-value: 9.73e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895  78 LAIIAFAILLSCTALVSIFAFALLTNKGWEAQLGVGLFALHNLLIASIVGVIGLQFYLMHLERHQHIAAQSRAELDALQA 157
Cdd:COG3275    87 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKA 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 158 RIRPHFLFNSLNTAAELTQQDPKAAEEALLNLSNLFRAALKAGENS--NLIDELALVDSYLSLEQWRLGNRLIITRQFPD 235
Cdd:COG3275   167 QINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKElvPLEEELEFLENYLELEKLRFGDRLQVEIDIDE 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 236 QLPNVTLPSLTIQPLVENAVRHGVEASSEPSSIHIQILTSDKHLTLLIQNP-IPLKAKTHFEGNGIAIENIRQRLALLYD 314
Cdd:COG3275   247 ELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNgVGIQPKKKKKGSGIGLKNVRERLELLYG 326

                         250       260
                  ....*....|....*....|....
gi 1710913895 315 DRARLTTGEVD-RTYRVKLVIPLN 337
Cdd:COG3275   327 DKYSLEIESTDgGGTKVTLKIPLK 350
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
78-337 9.73e-60

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 195.47  E-value: 9.73e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895  78 LAIIAFAILLSCTALVSIFAFALLTNKGWEAQLGVGLFALHNLLIASIVGVIGLQFYLMHLERHQHIAAQSRAELDALQA 157
Cdd:COG3275    87 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKA 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 158 RIRPHFLFNSLNTAAELTQQDPKAAEEALLNLSNLFRAALKAGENS--NLIDELALVDSYLSLEQWRLGNRLIITRQFPD 235
Cdd:COG3275   167 QINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKElvPLEEELEFLENYLELEKLRFGDRLQVEIDIDE 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 236 QLPNVTLPSLTIQPLVENAVRHGVEASSEPSSIHIQILTSDKHLTLLIQNP-IPLKAKTHFEGNGIAIENIRQRLALLYD 314
Cdd:COG3275   247 ELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNgVGIQPKKKKKGSGIGLKNVRERLELLYG 326

                         250       260
                  ....*....|....*....|....
gi 1710913895 315 DRARLTTGEVD-RTYRVKLVIPLN 337
Cdd:COG3275   327 DKYSLEIESTDgGGTKVTLKIPLK 350
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 150-227 1.47e-24

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 94.82  E-value: 1.47e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1710913895 150 AELDALQARIRPHFLFNSLNTAAELTQQDPKAAEEALLNLSNLFRAALKAGENSNLI-DELALVDSYLSLEQWRLGNRL 227
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLeEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-335 2.22e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 76.33  E-value: 2.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 242 LPSLTIQPLVENAVRHGVEASSEPSSIHIQILTSDKHLTLLIQNP--------IPLKAKTHFEGNGIAIENIRQRLALLY 313
Cdd:cd16924     1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNgrgidpkvLNILGKKPKEGNGIGLYNVHQRLILLF 80

                          90       100
                  ....*....|....*....|...
gi 1710913895 314 DDRARLT-TGEVDRTYRVKLVIP 335
Cdd:cd16924    81 GEDYGIHiASEPDKGTRITFTIP 103
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
78-337 9.73e-60

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 195.47  E-value: 9.73e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895  78 LAIIAFAILLSCTALVSIFAFALLTNKGWEAQLGVGLFALHNLLIASIVGVIGLQFYLMHLERHQHIAAQSRAELDALQA 157
Cdd:COG3275    87 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKA 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 158 RIRPHFLFNSLNTAAELTQQDPKAAEEALLNLSNLFRAALKAGENS--NLIDELALVDSYLSLEQWRLGNRLIITRQFPD 235
Cdd:COG3275   167 QINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKElvPLEEELEFLENYLELEKLRFGDRLQVEIDIDE 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 236 QLPNVTLPSLTIQPLVENAVRHGVEASSEPSSIHIQILTSDKHLTLLIQNP-IPLKAKTHFEGNGIAIENIRQRLALLYD 314
Cdd:COG3275   247 ELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNgVGIQPKKKKKGSGIGLKNVRERLELLYG 326

                         250       260
                  ....*....|....*....|....
gi 1710913895 315 DRARLTTGEVD-RTYRVKLVIPLN 337
Cdd:COG3275   327 DKYSLEIESTDgGGTKVTLKIPLK 350
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
76-337 5.69e-59

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 196.01  E-value: 5.69e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895  76 KQLAIIAFAILLSCTALVSIFAFALLTNKGWEAQLGVGLFALHNLLIASI-----VGVIGLQFYLMHLERHQHIA----- 145
Cdd:COG2972   156 RRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVsgndeIGILARSFNEMVERIKELIEevyel 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 146 --AQSRAELDALQARIRPHFLFNSLNTAAELTQQ-DPKAAEEALLNLSNLFRAALKAGENSNLI-DELALVDSYLSLEQW 221
Cdd:COG2972   236 elEKKEAELKALQAQINPHFLFNTLNSIRWLAELeDPEEAEEMLEALSKLLRYSLSKGDELVTLeEELELIKSYLEIQKL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 222 RLGNRLIITRQFPDQLPNVTLPSLTIQPLVENAVRHGVEASSEPSSIHIQILTSDKHLTLLIQNP-----------IPLK 290
Cdd:COG2972   316 RFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNgvgmpeeklekLLEE 395

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1710913895 291 AKTHFEGNGIAIENIRQRLALLYDDRARLTTG-EVDRTYRVKLVIPLN 337
Cdd:COG2972   396 LSSKGEGRGIGLRNVRERLKLYYGEEYGLEIEsEPGEGTTVTIRIPLE 443
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 150-227 1.47e-24

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 94.82  E-value: 1.47e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1710913895 150 AELDALQARIRPHFLFNSLNTAAELTQQDPKAAEEALLNLSNLFRAALKAGENSNLI-DELALVDSYLSLEQWRLGNRL 227
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLeEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-335 2.22e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 76.33  E-value: 2.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 242 LPSLTIQPLVENAVRHGVEASSEPSSIHIQILTSDKHLTLLIQNP--------IPLKAKTHFEGNGIAIENIRQRLALLY 313
Cdd:cd16924     1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNgrgidpkvLNILGKKPKEGNGIGLYNVHQRLILLF 80

                          90       100
                  ....*....|....*....|...
gi 1710913895 314 DDRARLT-TGEVDRTYRVKLVIP 335
Cdd:cd16924    81 GEDYGIHiASEPDKGTRITFTIP 103
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-335 2.72e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 56.68  E-value: 2.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 242 LPSLTIQPLVENAVRHGVEASSEPSSIHIQILTSDKHLTLLIQN------PIPLKAKTHFEGNGIAIENIRQRLALLY-D 314
Cdd:cd16956     1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDngggmdPDTLARILIRSSNGLGLNLVDKRLRQAFgN 80

                          90       100
                  ....*....|....*....|.
gi 1710913895 315 DRARLTTGEVDRTYRVKLVIP 335
Cdd:cd16956    81 DYGLDIECAPGEGTRITIRLP 101
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-313 1.08e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 52.08  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 242 LPSLTIQPLVENAVRHGVEAS--SEPSSIHIQILT---------------SDKHLTLLIQNPIPlkakthfeGNGIAIEN 304
Cdd:cd16955     1 IPKLMIQPLVENAIVHGIQEKkgKGVVKISVKKQLknrlhiavedngigiSPKVIERVEQDEMP--------GNKIGLLN 72


                  ....*....
gi 1710913895 305 IRQRLALLY 313
Cdd:cd16955    73 VHQRLKLGY 81
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-335 1.19e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 49.35  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 242 LPSLTIQPLVENAVRHGVEASSEPSSIHIQILTSDKHLTLLIQN--------PIPLKAKTHF---EGNGIAIENIRQRLA 310
Cdd:cd16957     1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDngqgipeeRLDLLGKTTVtseKGTGTALENLNRRLI 80

                          90       100
                  ....*....|....*....|....*.
gi 1710913895 311 LLYDDRARL-TTGEVDRTYRVKLVIP 335
Cdd:cd16957    81 GLFGSEACLhIESEVHGGTEVWFVIP 106
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 250-334 5.29e-04

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 38.74  E-value: 5.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1710913895 250 LVENAVrhgvEASS---EPSSIHIQILTSDKHLTLLIQNPI---------PLKAKTHFEGNGIAIENIRqRLALLYDDRA 317
Cdd:pfam14501  13 LLDNAI----EACSkidDNRFIRLKIREKQNFLIIRIENTYegelkfegkLPSTKTKGDGHGIGLKSIR-RIVKKYGGNL 87

                          90
                  ....*....|....*..
gi 1710913895 318 RLTTgeVDRTYRVKLVI 334
Cdd:pfam14501  88 STEI--ENGIFTLSILL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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