GNAT family N-acetyltransferase [Saprospirales bacterium]
Protein Classification
GNAT family protein( domain architecture ID 106742)
GNAT (Gcn5-related N-acetyltransferase) family protein similar to N-acetyltransferases that catalyze the transfer of an acetyl group from acetyl-CoA to a substrate
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| NAT_SF super family | cl17182 | N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of ... |
300-364 | 9.97e-04 | ||
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase which catalyze the transfer of an acetyl group to a substrate. The mechanism is an ordered Bi-Bi ternary complex kinetic mechanism for most GNATs: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and then CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/ph enylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included. The actual alignment was detected with superfamily member pfam13480: Pssm-ID: 473072 [Multi-domain] Cd Length: 143 Bit Score: 39.18 E-value: 9.97e-04
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| Name | Accession | Description | Interval | E-value | ||
| Acetyltransf_6 | pfam13480 | Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ... |
300-364 | 9.97e-04 | ||
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions. Pssm-ID: 433244 [Multi-domain] Cd Length: 143 Bit Score: 39.18 E-value: 9.97e-04
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| Name | Accession | Description | Interval | E-value | ||
| Acetyltransf_6 | pfam13480 | Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ... |
300-364 | 9.97e-04 | ||
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions. Pssm-ID: 433244 [Multi-domain] Cd Length: 143 Bit Score: 39.18 E-value: 9.97e-04
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