|
Name |
Accession |
Description |
Interval |
E-value |
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
5-810 |
0e+00 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 1061.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 5 TERIREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSS 84
Cdd:COG0188 7 AERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 85 IYGALVHLSQDWKMREPLIEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFP 164
Cdd:COG0188 87 VYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 165 NLLVNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRS 244
Cdd:COG0188 167 NLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 245 KTSIQDIKAGRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDETDRHGLSIVIELKKGADSQNILNYLFKSTD 324
Cdd:COG0188 247 KAEIEELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQ 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 325 LQVSYSFNMVAIDHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASKNKAD 404
Cdd:COG0188 327 LQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEVIAIIRASKDPDE 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 405 AKNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKKEFGSDRRT 484
Cdd:COG0188 407 AKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEERLLKIIKEELLEIKKKYGDERRT 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 485 KISSktAKIEIDEKALVAEEDVRVLVSRDGYLKRSSLRSFQSTDDSENGLPDF-----DKVVFEKTMSTLTNLYLFTNKG 559
Cdd:COG0188 487 EIEE--AEGEIDIEDLIPDEDVVVTLSHKGYIKRTPLDTYRAQRRGGKGVSGMgtkeeDFVEHLFVASTHDTLLFFTNKG 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 560 NVIFRPVHELVEAKWKEPGQHLSQELGLDTDEQIVSVFELAKLDEKLNFVLATNDGYIKQLALADIQPTRtykSRAMIAM 639
Cdd:COG0188 565 RVYRLKVYELPEGSRTAKGKPIVNLLPLEPGEKITAVLPVKEFDEDKYLLFATKKGTVKKTPLSDFSNIR---KNGIIAI 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 640 KLKQDtSRVIHVEGVvpDTKKEITLFTNQAYAVRYDISEIPTSGARAAGVKSVNLKDDDYVVDYVTVDPKylnlMKLGII 719
Cdd:COG0188 642 NLKEG-DELVGVALT--DGDDDVLLATSNGKAIRFPESDVRPMGRTARGVRGIRLKEGDEVVGMAVVDEE----DDLLTV 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 720 TQRGAFKEFKYELINKVSRAKRGVLVLRELKKNPHrISGVALFGQNHELIIETSSARTMTIKTNDFPLGDRYSNGSFVID 799
Cdd:COG0188 715 TENGYGKRTPLSEYRLQGRGGKGVITIKLTEKNGK-LVGALVVNDDDELMLITSSGQLIRTPVSDIRVTGRNTQGVRLIR 793
|
810
....*....|.
gi 1713617601 800 PVGDGEPTSLT 810
Cdd:COG0188 794 LDEGDKVVSVA 804
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
1-755 |
0e+00 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 1027.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 1 MAQKTERIREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPH 80
Cdd:PRK05561 3 DMSMLEGIEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 81 GDSSIYGALVHLSQDWKMREPLIEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLP 160
Cdd:PRK05561 83 GDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 161 AQFPNLLVNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGA-IVLGDKGIKEAYETGRGR 239
Cdd:PRK05561 163 ARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGeIITGRDGIRKAYETGRGS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 240 IQVRSKTSIQDIKAGRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDETDR-HGLSIVIELKKG-ADSQNILN 317
Cdd:PRK05561 243 IRVRARWEIEDLAGGRWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDReNPVRIVIEPKSNrVDPEALMN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 318 YLFKSTDLQVSYSFNMVAID-HMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTI 396
Cdd:PRK05561 323 HLFATTDLESSYRVNMNAIGlDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAFLNIDEVIRII 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 397 RASKnkaDAKNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKK 476
Cdd:PRK05561 403 RESD---EPKANLMARFDLSEIQAEAILELRLRRLAKLEEIEIRKEQDELRKEIAELEAILASERKLRKLIKKELKADAK 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 477 EFGSDRRTKISSKTAKIEIDEKALVAEEDVRVLVSRDGYLKRSSLRSFqstDDSENGLPDFDKVVFEKTMSTLTNLYLFT 556
Cdd:PRK05561 480 KFGDPRRTPIEEAEEAIAIDEEALIPDEPVTVVLSKKGWVRRAKGHSI---DASGLSFKEGDSLLFAFEARTTDKLLLFT 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 557 NKGNVIFRPVHELVEAkwKEPGQHLSQELGLDTDEQIVSVFElakLDEKLNFVLATNDGYIKQLALADiQPTRTYKSRAM 636
Cdd:PRK05561 557 STGRVYSLPVHELPSA--RGDGEPLTGLVDLAPGEEIVHVLA---FDPDQKLLLASSAGYGFVVTLED-LVARTRAGKAV 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 637 IAMKlkqDTSRVIHVEGVvpDTKKEITLFTNQAYAVRYDISEIPTSGaRAAGVKSVNLK-DDDYVVDYVTVDPKYLnlmk 715
Cdd:PRK05561 631 INLK---DGDEVLPPVPV--EDDDHLAAITSNGRLLVFPLSELPELG-KGKGVKLINLPkDDDGLVDLRVLNPEDG---- 700
|
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 1713617601 716 LGIITQRGAFKEFKYELINK--VSRAKRGVLVLRELKKNPHR 755
Cdd:PRK05561 701 LVLLTAGKRKLKLKPSELEKyrGKRARRGRLLPRGLKRVPRF 742
|
|
| parC_Gpos |
TIGR01061 |
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ... |
8-754 |
0e+00 |
|
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273422 [Multi-domain] Cd Length: 738 Bit Score: 890.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 8 IREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYG 87
Cdd:TIGR01061 1 IFNKPLEEVFGESFGKYAKYIIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 88 ALVHLSQDWKMREPLIEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNLL 167
Cdd:TIGR01061 81 AMVRMSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 168 VNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRSKTS 247
Cdd:TIGR01061 161 INGATGIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 248 IQDIKAGRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDETDRHGLSIVIELKKGADSQNILNYLFKSTDLQV 327
Cdd:TIGR01061 241 IEVNKNGLNQIVITEIPYETNKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 328 SYSFNMVAIDHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASKNKADAKN 407
Cdd:TIGR01061 321 NYNFNMVAIANRTPIQVGLLSYLDAYIKHCHEVIINRSKYELEKASKRLEIVEGLIKAISIIDEIIKLIRSSEDKSDAKE 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 408 NIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKKEFGSDRRTKIS 487
Cdd:TIGR01061 401 NLIDNFKFTENQAEAIVSLRLYRLTNTDIFELKEEQNELEKKIISLEQIIASEKARNKLLKKQLEEYKKQFAQQRRSQIE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 488 SKTAKIEIDEKALVAEEDVRVLVSRDGYLKRSSLRSFQSTDDSENGLPDFDKVVFEKTMSTLTNLYLFTNKGNVIFRPVH 567
Cdd:TIGR01061 481 DFINQIKINESELIENEDYYVLITKAGYIKRTSNRSFASSKYTDFGSKDDDILFAQTIANTTDQILIFTSLGNIINIPVH 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 568 ELVEAKWKEPGQHLSQELGLDTDEQIVSVFELAKLD-EKLNFVLATNDGYIKQLALADIQPTRTykSRAMIAMKLKQDTS 646
Cdd:TIGR01061 561 KLADIRWKDLGEHLSNKITFDENETIVFVGTMNEFDvDQPILVLASKLGMVKRIELTELNIKRN--SKATLCIKLKDKDH 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 647 RvihVEGVVPDTKKEITLFTNQAYAVRYDISEIPTSGARAAGVKSVNLKDDDYVVDYVTVDPKYLNLMklgiITQRGAFK 726
Cdd:TIGR01061 639 L---ISAFLQQKDKLICLVSDLGYALVFHTNEIPVVGAKAAGVKGMKLKEDDQVKSGVIFEANESLVL----LTQRGSVK 711
|
730 740
....*....|....*....|....*...
gi 1713617601 727 EFKYELINKVSRAKRGVlVLRELKKNPH 754
Cdd:TIGR01061 712 RLSISELVVTSRAATGK-KLLPLKKKPH 738
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
30-474 |
0e+00 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 621.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 30 QERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYGALVHLSQDWKMREPLIEMHGNN 109
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 110 GSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNLLVNGATGISAGYATEIPPHNLAE 189
Cdd:cd00187 81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 190 VIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRSKTSIQDIKaGRQQIVVTEIPFGVNK 269
Cdd:cd00187 161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDDE-GRNTIEITELPYQVNK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 270 AFLVKKIDEIRLNKEIDGISEVRDETDRHGLSIVIELKKGADSQNILNYLFKSTDLQVSYSFNMVAIDHM-TPVQVGLKR 348
Cdd:cd00187 240 AKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDPNgRPKKLNLKE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 349 ILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASknkADAKNNIIEKF---SFTPRQAEAIVS 425
Cdd:cd00187 320 ILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVINLIRSS---DEAKKALIEELeklGFSEIQADAILD 396
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1713617601 426 LQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAV 474
Cdd:cd00187 397 MRLRRLTKLEREKLLKELKELEAEIEDLEKILASEERPKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
32-472 |
0e+00 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 589.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 32 RALPDIRDGLKPVQRRILYAMYlDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYGALVHLSQDWKMREPLIEMHGNNGS 111
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMF-ELLNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 112 -MDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNLLVNGATGISAGYATEIPPHNLAEV 190
Cdd:pfam00521 80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 191 IDATIYLLKHPDASLadLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRSKTSIQDikagRQQIVVTEIPFGVNKA 270
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 271 FLVKKIDEIRLNKEIDGISEVRDETDRhGLSIVIELKKGADSQNILNYLFKSTDLQVSYSFNMVAIDHMTPVQVGLKRIL 350
Cdd:pfam00521 234 DLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEIL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 351 SSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASKNKADAKNNIIEKfsFTPRQAEAIVSLQLYR 430
Cdd:pfam00521 313 KEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVIEIIRGSIDRKKAKKNLIEE--LSEIQADYLLDMRLRR 390
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1713617601 431 LTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELN 472
Cdd:pfam00521 391 LTKEEVDKLLEEIDELEKEIAELEKLLASEKKLNDLWIEELD 432
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
11-464 |
0e+00 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 558.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 11 MPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYGALV 90
Cdd:smart00434 1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 91 HLSQDWKMREPLIEMHGNNGSM-DGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNLLVN 169
Cdd:smart00434 81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 170 GATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLgdkgikeayetGRGRIQVRSKTSIQ 249
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIV-----------GPGKYVVRGKIEIE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 250 DikagRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDET-DRHGLSIVIELKKGADSQNILNYLFKSTDLQVS 328
Cdd:smart00434 230 D----DNTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 329 YSFNMVAI-DHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAK-ARLEIIEGLIHALDILDDVIKTIRASKNKA-DA 405
Cdd:smart00434 306 FSINMLALfDNGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIALSIIDEIIVLIRSSKDLAkEA 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1713617601 406 KNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLE 464
Cdd:smart00434 386 KEKLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEEWLN 444
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
5-810 |
0e+00 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 1061.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 5 TERIREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSS 84
Cdd:COG0188 7 AERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 85 IYGALVHLSQDWKMREPLIEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFP 164
Cdd:COG0188 87 VYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 165 NLLVNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRS 244
Cdd:COG0188 167 NLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 245 KTSIQDIKAGRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDETDRHGLSIVIELKKGADSQNILNYLFKSTD 324
Cdd:COG0188 247 KAEIEELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQ 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 325 LQVSYSFNMVAIDHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASKNKAD 404
Cdd:COG0188 327 LQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEVIAIIRASKDPDE 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 405 AKNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKKEFGSDRRT 484
Cdd:COG0188 407 AKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEERLLKIIKEELLEIKKKYGDERRT 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 485 KISSktAKIEIDEKALVAEEDVRVLVSRDGYLKRSSLRSFQSTDDSENGLPDF-----DKVVFEKTMSTLTNLYLFTNKG 559
Cdd:COG0188 487 EIEE--AEGEIDIEDLIPDEDVVVTLSHKGYIKRTPLDTYRAQRRGGKGVSGMgtkeeDFVEHLFVASTHDTLLFFTNKG 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 560 NVIFRPVHELVEAKWKEPGQHLSQELGLDTDEQIVSVFELAKLDEKLNFVLATNDGYIKQLALADIQPTRtykSRAMIAM 639
Cdd:COG0188 565 RVYRLKVYELPEGSRTAKGKPIVNLLPLEPGEKITAVLPVKEFDEDKYLLFATKKGTVKKTPLSDFSNIR---KNGIIAI 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 640 KLKQDtSRVIHVEGVvpDTKKEITLFTNQAYAVRYDISEIPTSGARAAGVKSVNLKDDDYVVDYVTVDPKylnlMKLGII 719
Cdd:COG0188 642 NLKEG-DELVGVALT--DGDDDVLLATSNGKAIRFPESDVRPMGRTARGVRGIRLKEGDEVVGMAVVDEE----DDLLTV 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 720 TQRGAFKEFKYELINKVSRAKRGVLVLRELKKNPHrISGVALFGQNHELIIETSSARTMTIKTNDFPLGDRYSNGSFVID 799
Cdd:COG0188 715 TENGYGKRTPLSEYRLQGRGGKGVITIKLTEKNGK-LVGALVVNDDDELMLITSSGQLIRTPVSDIRVTGRNTQGVRLIR 793
|
810
....*....|.
gi 1713617601 800 PVGDGEPTSLT 810
Cdd:COG0188 794 LDEGDKVVSVA 804
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
1-755 |
0e+00 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 1027.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 1 MAQKTERIREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPH 80
Cdd:PRK05561 3 DMSMLEGIEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 81 GDSSIYGALVHLSQDWKMREPLIEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLP 160
Cdd:PRK05561 83 GDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 161 AQFPNLLVNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGA-IVLGDKGIKEAYETGRGR 239
Cdd:PRK05561 163 ARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGeIITGRDGIRKAYETGRGS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 240 IQVRSKTSIQDIKAGRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDETDR-HGLSIVIELKKG-ADSQNILN 317
Cdd:PRK05561 243 IRVRARWEIEDLAGGRWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDReNPVRIVIEPKSNrVDPEALMN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 318 YLFKSTDLQVSYSFNMVAID-HMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTI 396
Cdd:PRK05561 323 HLFATTDLESSYRVNMNAIGlDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAFLNIDEVIRII 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 397 RASKnkaDAKNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKK 476
Cdd:PRK05561 403 RESD---EPKANLMARFDLSEIQAEAILELRLRRLAKLEEIEIRKEQDELRKEIAELEAILASERKLRKLIKKELKADAK 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 477 EFGSDRRTKISSKTAKIEIDEKALVAEEDVRVLVSRDGYLKRSSLRSFqstDDSENGLPDFDKVVFEKTMSTLTNLYLFT 556
Cdd:PRK05561 480 KFGDPRRTPIEEAEEAIAIDEEALIPDEPVTVVLSKKGWVRRAKGHSI---DASGLSFKEGDSLLFAFEARTTDKLLLFT 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 557 NKGNVIFRPVHELVEAkwKEPGQHLSQELGLDTDEQIVSVFElakLDEKLNFVLATNDGYIKQLALADiQPTRTYKSRAM 636
Cdd:PRK05561 557 STGRVYSLPVHELPSA--RGDGEPLTGLVDLAPGEEIVHVLA---FDPDQKLLLASSAGYGFVVTLED-LVARTRAGKAV 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 637 IAMKlkqDTSRVIHVEGVvpDTKKEITLFTNQAYAVRYDISEIPTSGaRAAGVKSVNLK-DDDYVVDYVTVDPKYLnlmk 715
Cdd:PRK05561 631 INLK---DGDEVLPPVPV--EDDDHLAAITSNGRLLVFPLSELPELG-KGKGVKLINLPkDDDGLVDLRVLNPEDG---- 700
|
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 1713617601 716 LGIITQRGAFKEFKYELINK--VSRAKRGVLVLRELKKNPHR 755
Cdd:PRK05561 701 LVLLTAGKRKLKLKPSELEKyrGKRARRGRLLPRGLKRVPRF 742
|
|
| parC_Gpos |
TIGR01061 |
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ... |
8-754 |
0e+00 |
|
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273422 [Multi-domain] Cd Length: 738 Bit Score: 890.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 8 IREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYG 87
Cdd:TIGR01061 1 IFNKPLEEVFGESFGKYAKYIIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 88 ALVHLSQDWKMREPLIEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNLL 167
Cdd:TIGR01061 81 AMVRMSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 168 VNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRSKTS 247
Cdd:TIGR01061 161 INGATGIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 248 IQDIKAGRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDETDRHGLSIVIELKKGADSQNILNYLFKSTDLQV 327
Cdd:TIGR01061 241 IEVNKNGLNQIVITEIPYETNKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 328 SYSFNMVAIDHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASKNKADAKN 407
Cdd:TIGR01061 321 NYNFNMVAIANRTPIQVGLLSYLDAYIKHCHEVIINRSKYELEKASKRLEIVEGLIKAISIIDEIIKLIRSSEDKSDAKE 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 408 NIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKKEFGSDRRTKIS 487
Cdd:TIGR01061 401 NLIDNFKFTENQAEAIVSLRLYRLTNTDIFELKEEQNELEKKIISLEQIIASEKARNKLLKKQLEEYKKQFAQQRRSQIE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 488 SKTAKIEIDEKALVAEEDVRVLVSRDGYLKRSSLRSFQSTDDSENGLPDFDKVVFEKTMSTLTNLYLFTNKGNVIFRPVH 567
Cdd:TIGR01061 481 DFINQIKINESELIENEDYYVLITKAGYIKRTSNRSFASSKYTDFGSKDDDILFAQTIANTTDQILIFTSLGNIINIPVH 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 568 ELVEAKWKEPGQHLSQELGLDTDEQIVSVFELAKLD-EKLNFVLATNDGYIKQLALADIQPTRTykSRAMIAMKLKQDTS 646
Cdd:TIGR01061 561 KLADIRWKDLGEHLSNKITFDENETIVFVGTMNEFDvDQPILVLASKLGMVKRIELTELNIKRN--SKATLCIKLKDKDH 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 647 RvihVEGVVPDTKKEITLFTNQAYAVRYDISEIPTSGARAAGVKSVNLKDDDYVVDYVTVDPKYLNLMklgiITQRGAFK 726
Cdd:TIGR01061 639 L---ISAFLQQKDKLICLVSDLGYALVFHTNEIPVVGAKAAGVKGMKLKEDDQVKSGVIFEANESLVL----LTQRGSVK 711
|
730 740
....*....|....*....|....*...
gi 1713617601 727 EFKYELINKVSRAKRGVlVLRELKKNPH 754
Cdd:TIGR01061 712 RLSISELVVTSRAATGK-KLLPLKKKPH 738
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
6-786 |
0e+00 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 840.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 6 ERIREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSI 85
Cdd:PRK05560 3 DRIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 86 YGALVHLSQDWKMREPLIEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPN 165
Cdd:PRK05560 83 YDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 166 LLVNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRSK 245
Cdd:PRK05560 163 LLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 246 TSIQDIKaGRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDETDRHGLSIVIELKKGADSQNILNYLFKSTDL 325
Cdd:PRK05560 243 AEIEEIK-GREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 326 QVSYSFNMVAIDHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASKNKADA 405
Cdd:PRK05560 322 QTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIALDNIDEVIALIRASPTPAEA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 406 KNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKKEFGSDRRTK 485
Cdd:PRK05560 402 KEGLMERFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIADLKDILASPERLLEIIKEELLEIKEKFGDPRRTE 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 486 ISSKTAKIEIDEkaLVAEEDVRVLVSRDGYLKRSSLRSFQST-------------DDsenglpDFDKVVFekTMSTLTNL 552
Cdd:PRK05560 482 IIEGEGDIDDED--LIPEEDVVVTLTHGGYIKRTPLDEYRAQrrggkgvsgaktkED------DFVEHLF--VASTHDTL 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 553 YLFTNKGNVIFRPVHELVE----AKwkepGQHLSQELGLDTDEQIVSVFELAKLDEKLNFVLATNDGYIKQLALADIQPT 628
Cdd:PRK05560 552 LFFTNRGRVYRLKVYEIPEasrtAR----GRPIVNLLPLEPGEKITAILPVREFDDDKYLFFATKNGTVKKTSLSEFSNI 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 629 RtykSRAMIAMKLKQDtSRVIHVEGVvpDTKKEITLFTNQAYAVRYDISEIPTSGARAAGVKSVNLKDDDYVVDYVTVDP 708
Cdd:PRK05560 628 R---SNGIIAINLDEG-DELIGVRLT--DGDDDILLATKNGKAIRFPESDVRPMGRTARGVRGIKLREGDEVVSMDVVRE 701
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1713617601 709 KYLNLMklgIITQRGAFKEFKYELINKVSRAKRGVLVLRELKKNpHRISGVALFGQNHELIIETSSARTMTIKTNDFP 786
Cdd:PRK05560 702 DSQEIL---TVTENGYGKRTPVSEYRLQGRGGKGVITIKITEKN-GKLVGALPVDDDDEIMLITDSGKLIRTRVSEIS 775
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
8-784 |
0e+00 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 757.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 8 IREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYG 87
Cdd:TIGR01063 1 IVPVNIEEEMKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 88 ALVHLSQDWKMREPLIEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNLL 167
Cdd:TIGR01063 81 TLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 168 VNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRSKTS 247
Cdd:TIGR01063 161 VNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 248 IQDIKAGRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDETDRHGLSIVIELKKGADSQNILNYLFKSTDLQV 327
Cdd:TIGR01063 241 IEEDSKGREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 328 SYSFNMVAIDHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASKNKADAKN 407
Cdd:TIGR01063 321 SFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIALDNIDEVIALIRASQNTEEAKT 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 408 NIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKKEFGSDRRTKIS 487
Cdd:TIGR01063 401 RLVERFSLSEIQAQAILDMRLQRLTGLEREKLQEEYKELLELIADLEDILASEERVLEIIREELEEIKEQFGDPRRTEIV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 488 SKTAKIeIDEKALVAEEDVRVLVSRDGYLKRSSLRSFQSTDDSENGLP-------DFDKVVFekTMSTLTNLYLFTNKGN 560
Cdd:TIGR01063 481 YDESED-IDIEDLIARENVVVTLSHNGYVKRVPVSAYRLQKRGGKGVSgadmkddDFIEQLL--VASTHDYLLFFTNRGK 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 561 VIFRPVHELVEAKWKEPGQHLSQELGLDTDEQIVSVFELAKLDEKLNFVLATNDGYIKQLALADIQPTRtykSRAMIAMK 640
Cdd:TIGR01063 558 VYWLKVYQIPEASRTAKGKPIVNLLPLQPDERITAILSVKEFDDGLYLFFATKNGVVKKTSLTEFSNIR---SNGIIAIK 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 641 LKqDTSRVIHVEGVvpDTKKEITLFTNQAYAVRYDISEIPTSGARAAGVKSVNLKDDDYVVDYVTV--DPKYLnlmklgI 718
Cdd:TIGR01063 635 LD-DGDELISVRLT--SGEDEVMLGSKNGKAVRFPEEDVRPMGRAARGVRGIKLKNEDFVVSLLVVseESYLL------I 705
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1713617601 719 ITQRGAFKEFKYELINKVSRAKRGVLVLRELKKNPHRISGVALFGqNHELIIETSSARTMTIKTND 784
Cdd:TIGR01063 706 VTENGYGKRTSIEEYRETSRGGKGVKSIKITDRNGQVVGAIAVDD-DDELMLITSAGKLIRTSVQD 770
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
1-720 |
0e+00 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 642.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 1 MAQKTE-----RIREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMG 75
Cdd:PRK13979 1 MAKKIVipkdnNIIKIPLEEAMPENYLPYAVEVAKDRALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 76 NFHPHGDSSIYGALVHLSQDWKMREPLIEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYE 155
Cdd:PRK13979 81 KYHPHGDSSVYDAMVILAQDFTTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 156 PTVLPAQFPNLLVNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKGIKEAYET 235
Cdd:PRK13979 161 PEVLPARYPNLLVNGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 236 GRGRIQVRSKTSIQDIKAGRQQIVVTEIPFGVNKAFLVKKIDEI----RLNKEIDGISEVRDETDRHGLSIVIELKKGAD 311
Cdd:PRK13979 241 GEGKVTLRAKTKIEKLENGRLGIVITEFPYRRNKAKLLQTISEMtadkKHSKALENISDIRDESDRNGIRAVIEFKKSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 312 ---SQNILNYLFKSTDLQVSYSFNMVAIDHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDI 388
Cdd:PRK13979 321 edvAEKVLKYLYKKTDLQCNISFNMVALADGKPETMGLKTMLKHYVEHQKEVVTRRTKKELEIAEKRFHIVEGFIKAIGI 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 389 LDDVIKTIRASKNKADAKNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQII 468
Cdd:PRK13979 401 MDEIIKTIRSSKSKKDASENLIEKFGFTDEQAEAILELMLYRLTGLEIVAFEKEYKELEKLIKKLTKILSSEKELLKVIK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 469 KELNAVKKEFGSDRRTKISSKTAKIEIDEKALVAEEDVRVLVSRDGYLKRSSL----RSFQSTDDSENGLPDFDKVVFEK 544
Cdd:PRK13979 481 KELKEVKEKYGDERRTSIIEDDEKAKIDVEELIVVEDVVITLSNEGFIKRIPLksynRSNSNVEDIEYREGDFNKFLIQS 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 545 tmSTLTNLYLFTNKGNVIFRPVHELVEAKWKEPGQHLSQEL-GLD-TDEQIVSVFELAKLDEKLNFVLATNDGYIKQLAL 622
Cdd:PRK13979 561 --NTKDTLLIFTDKGNMYQIKGINIPEFKWKEKGERLDEIIkGIDlESEKIIEAYSIEDFTPQKDFIFITDSGGIKKTSL 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 623 ADIQptrTYKSRAMiAMKLKQDtSRVIHVEgVVPDTKKE--ITLFTNQAYAVRYDISEIPTSGARAAGVKSVNLKDDDYV 700
Cdd:PRK13979 639 DKFV---TNYTKLM-ALKLKKG-EKLIKVK-LVDRTREEkfIKIKTKKGLSFTVEEPELEPVDRNIIGYQLFDLLPNDSI 712
|
730 740
....*....|....*....|....*.
gi 1713617601 701 --VDYVTvDPKY----LNLMKLGIIT 720
Cdd:PRK13979 713 kkVDFCD-NYEYkefyVNINKKGIIK 737
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
30-474 |
0e+00 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 621.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 30 QERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYGALVHLSQDWKMREPLIEMHGNN 109
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 110 GSMDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNLLVNGATGISAGYATEIPPHNLAE 189
Cdd:cd00187 81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 190 VIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRSKTSIQDIKaGRQQIVVTEIPFGVNK 269
Cdd:cd00187 161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDDE-GRNTIEITELPYQVNK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 270 AFLVKKIDEIRLNKEIDGISEVRDETDRHGLSIVIELKKGADSQNILNYLFKSTDLQVSYSFNMVAIDHM-TPVQVGLKR 348
Cdd:cd00187 240 AKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDPNgRPKKLNLKE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 349 ILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASknkADAKNNIIEKF---SFTPRQAEAIVS 425
Cdd:cd00187 320 ILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVINLIRSS---DEAKKALIEELeklGFSEIQADAILD 396
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1713617601 426 LQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAV 474
Cdd:cd00187 397 MRLRRLTKLEREKLLKELKELEAEIEDLEKILASEERPKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
32-472 |
0e+00 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 589.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 32 RALPDIRDGLKPVQRRILYAMYlDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYGALVHLSQDWKMREPLIEMHGNNGS 111
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMF-ELLNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 112 -MDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNLLVNGATGISAGYATEIPPHNLAEV 190
Cdd:pfam00521 80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 191 IDATIYLLKHPDASLadLMQFVKGPDFPTGAIVLGDKGIKEAYETGRGRIQVRSKTSIQDikagRQQIVVTEIPFGVNKA 270
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 271 FLVKKIDEIRLNKEIDGISEVRDETDRhGLSIVIELKKGADSQNILNYLFKSTDLQVSYSFNMVAIDHMTPVQVGLKRIL 350
Cdd:pfam00521 234 DLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEIL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 351 SSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRASKNKADAKNNIIEKfsFTPRQAEAIVSLQLYR 430
Cdd:pfam00521 313 KEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVIEIIRGSIDRKKAKKNLIEE--LSEIQADYLLDMRLRR 390
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1713617601 431 LTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELN 472
Cdd:pfam00521 391 LTKEEVDKLLEEIDELEKEIAELEKLLASEKKLNDLWIEELD 432
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
11-464 |
0e+00 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 558.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 11 MPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYGALV 90
Cdd:smart00434 1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 91 HLSQDWKMREPLIEMHGNNGSM-DGDSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNLLVN 169
Cdd:smart00434 81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 170 GATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLgdkgikeayetGRGRIQVRSKTSIQ 249
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIV-----------GPGKYVVRGKIEIE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 250 DikagRQQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDET-DRHGLSIVIELKKGADSQNILNYLFKSTDLQVS 328
Cdd:smart00434 230 D----DNTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 329 YSFNMVAI-DHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAK-ARLEIIEGLIHALDILDDVIKTIRASKNKA-DA 405
Cdd:smart00434 306 FSINMLALfDNGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIALSIIDEIIVLIRSSKDLAkEA 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1713617601 406 KNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLE 464
Cdd:smart00434 386 KEKLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEEWLN 444
|
|
| parC_Gneg |
TIGR01062 |
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ... |
8-517 |
5.18e-143 |
|
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130134 [Multi-domain] Cd Length: 735 Bit Score: 439.73 E-value: 5.18e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 8 IREMPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNNTYDKPFKKAAKAVGNIMGNFHPHGDSSIYG 87
Cdd:TIGR01062 1 IENIDLGNFTEEAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 88 ALVHLSQDWKMREPLIEMHGNNGSMDG-DSPAAMRYTESRLSKISNHLLADIDKDTVNMVLNFDDTEYEPTVLPAQFPNL 166
Cdd:TIGR01062 81 AMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 167 LVNGATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLADLMQFVKGPDFPTGAIVLGDKG-IKEAYETGRGRIQVRSK 245
Cdd:TIGR01062 161 LLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEAEIIDKAEeIRKIYETGRGSFRMRAR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 246 TSIQDIkagrqQIVVTEIPFGVNKAFLVKKIDEIRLNKEIDGISEVRDETDRHG-LSIVIELK-KGADSQNILNYLFKST 323
Cdd:TIGR01062 241 WKKEDG-----QIVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDHENpIRVVIVPRsNRVDPDIVMEHLFATT 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 324 DLQVSY--SFNMVAIDHMtPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIIEGLIHALDILDDVIKTIRaskN 401
Cdd:TIGR01062 316 DLEKSYrlNMNMIGLDNV-PAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLHILEGLRIAFLNIDEVIEIIR---E 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 402 KADAKNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKKEFGSD 481
Cdd:TIGR01062 392 EDEPKTILMERFKLSAIQAEAILNLRLRHLAKLEEHAIIDEQSELEKERAILEKILKSERELNQLVKKEIQADATKYGLA 471
|
490 500 510
....*....|....*....|....*....|....*.
gi 1713617601 482 RRTKISSKTAKIEIDEKALVAEEDVRVLVSRDGYLK 517
Cdd:TIGR01062 472 RRSSLEEREEAKQVSEIDMIPKEPVTIILSKMGWVR 507
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
11-513 |
1.54e-65 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 230.75 E-value: 1.54e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 11 MPLEQVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYAMYldnNTYDKPFKKAAKAVGNIMgNFHPHGDSSIYGALV 90
Cdd:PRK09631 2 MDIKTLFKDNFLQYASYVIKDRAIPDVIDGLKPVQRRILHSLF---EMHDGKFHKVANVVGNTM-KYHPHGDASIYEALV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 91 HLSQdwkmREPLIEMHGNNGSM-DGDSPAAMRYTESRLSKISNHLLadIDKDTVNMVLNFDDTEYEPTVLPAQFPNLLVN 169
Cdd:PRK09631 78 NLAN----KDLFIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVL--YNKEITEYEPSYDGRNNEPLCLPAKIPVILIQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 170 GATGISAGYATEIPPHNLAEVIDATIYLLKHPDASLAdlmqfvkgPDFPTGAIVlgDkgiKEAYETGRGRIQVRSKTSIQ 249
Cdd:PRK09631 152 GAEGIAVGMATKILPHNFNEILQAVKSELLGESFALY--------PDFPTGGIV--D---VSEYADGNGKVLVRAKIETK 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 250 DIKAgrqqIVVTEIPFGVNKAFLVKKIDE-IRLNK-EIDGISEVRDETdrhgLSIVIELKKGADSQNILNYLFKSTDLQV 327
Cdd:PRK09631 219 DEKT----IVIREIPFGTTTESLIASIEKaARKGKiKISSINDYTAEN----VEIEIKLPRGVYASEVIEALYAYTDCEV 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 328 SYSFNMVAIDHMTPVQVGLKRILSSYLEHDEAVITKRTQYDLKKAKARleIIEGLIHALDILDDVIKTIRASKNKADAKN 407
Cdd:PRK09631 291 SISVNLLVIKDRYPVIYTVTDIIKFHAEHLQKVLKMELELERAKLLEK--IFAKTLEQIFIEERIYKRIETISSEEDVIS 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 408 NIIEKF---------SFTPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDrkvLEKQIIKELNAVKKEF 478
Cdd:PRK09631 369 IVLSELkpfkeelsrDVTEEDIENLLKIPIRRISLFDIDKNQKEIRILNKELKSVEKNLKS---IKGYAINFIDKLLAKY 445
|
490 500 510
....*....|....*....|....*....|....*..
gi 1713617601 479 GSD--RRTKISsktakieidekaLVAEEDVRVLVSRD 513
Cdd:PRK09631 446 SKEypRKTEIS------------LIKSVDVREIATKN 470
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
24-486 |
1.28e-54 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 203.31 E-value: 1.28e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 24 YSKYIIQERALPDIRDGLKPVQRRILYAMY-LDNNTYDKpfkkAAKAVGNIMgNFHPHGDSSIYGALVHLSQdwkmREPL 102
Cdd:PRK12758 34 YASYVILERAVPHIEDGLKPVQRRILHSMKeMDDGRYNK----VANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 103 IEMHGNNGS-MDGDSPAAMRYTESRLSKISNHLLadIDKDTVNMVLNFDDTEYEPTVLPAQFPNLLVNGATGISAGYATE 181
Cdd:PRK12758 105 IDTQGNWGNiLTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 182 IPPHNLAEVIDATIYLLKHPDASLAdlmqfvkgPDFPTGAIVlgDKGikeAYETGR--GRIQVRSKTSIQDIKAgrqqIV 259
Cdd:PRK12758 183 ILPHNFNELIDASIAYLKGKEFKLY--------PDFPTGGII--DVS---NYNDGErgGRVRVRAKIEKLDKKT----LV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 260 VTEIPFGVNKAFLVKKIDEIRLNKEIDgISEVRDETDRHgLSIVIELKKGADSQNILNYLFKSTDLQVSYSFNMVAIDHM 339
Cdd:PRK12758 246 ITEIPYGTTTSSLIDSILKANDKGKIK-IKKVEDNTAAD-VEILVHLAPGVSPDKTIDALYAFTDCEVSISPNACVIIDN 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 340 TPVQVGLKRILSSYlehdeaviTKRTQYDLKKA-KARLEIIEGLIHALD-----ILDDVIKTIRASKNKADAKNNIIEKF 413
Cdd:PRK12758 324 KPHFLGVSDILRRS--------TDHTVSLLKQElEIRLSELEEQWHFASlekifIEERIYKEIEEAETWEAVIEAIDKGL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 414 S-FTPRQAEAIVSLQLYRLTNT--------DVNALQAEKSDLEEKIA--NYNLL-LTDRKVlekQIIKELnavKKEFGSD 481
Cdd:PRK12758 396 EpFKKQFIREVTEDDIVRLTEIkikriskfDSDKADELIARLEAEIAevKHHLAhLTDYAI---AYFTNL---KKKYGKG 469
|
....*..
gi 1713617601 482 --RRTKI 486
Cdd:PRK12758 470 reRKTEI 476
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
21-501 |
2.79e-47 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 175.47 E-value: 2.79e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 21 FGRYSKYIIQERALPDIRDGLKPVQRRILYAMYLDNntyDKPFKKAAKAVGNIMGnFHPHGDSSIYGALVHLSQdwkmRE 100
Cdd:PRK09630 12 FMHYASYVILERAIPHILDGLKPVQRRLLWTLFRMD---DGKMHKVANIAGRTMA-LHPHGDAPIVEALVVLAN----KG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 101 PLIEMHGNNGS-MDGDSPAAMRYTESRLSKISNHLLadIDKDTVNMVLNFDDTEYEPTVLPAQFPNLLVNGATGISAGYA 179
Cdd:PRK09630 84 YLIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 180 TEIPPHNLAEVIDATIYLLKHPDASLAdlmqfvkgPDFPTGaivlgdkGIKEA--YETGRGRIQVRSKTSIQDIKAgrqq 257
Cdd:PRK09630 162 TKIFPHNFCELLEAQIAILNDQPFTLL--------PDFPSG-------GTMDAseYQDGLGSITLRASIDIINDKT---- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 258 IVVTEIPFGVNKAFLVKKIDEI--RLNKEIDGISEVrdETDRHglSIVIELKKGADSQNILNYLFKSTDLQVSYSFNMVA 335
Cdd:PRK09630 223 LLIKEICPSTTTETLIRSIENAakRGIIKIDSIQDF--STDLP--HIEIKLPKGIYAKDLLRPLFTHTECQVILTSRPTA 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 336 IDHMTPVQVGLKRILSSYLEHDEAVITKRTQYdLKKAKAR------LEIIeGLIHAL-DILDDVIKTIRASKNKADAKNN 408
Cdd:PRK09630 299 IYQNKPVETSISEILRLHTETLQGYLKKELLI-LEDSLSRehyhktLEYI-FIKHKLyDTVREMLSKRKTSPSSSDLHNA 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 409 IIEKFS------FTPRQAEA---IVSLQLYRLTNTDVNALQAEKSDLEEKIANYNLLLTDRKVLEKQIIKELNAVKKEFG 479
Cdd:PRK09630 377 VLEALTpfldtlPTPVDKQAtaqLASLTIKKILCFNENSYTKELACIEKKQAAVQKDLSQLKKYTVKYLKGLLETYGQLG 456
|
490 500
....*....|....*....|....
gi 1713617601 480 sDRRTKISS-KTAKIEI-DEKALV 501
Cdd:PRK09630 457 -HRKTQIAKfKAKKLSAlKQQELF 479
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
24-476 |
4.26e-39 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 150.98 E-value: 4.26e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 24 YSKYIIQERALPDIRDGLKPVQRRILY-AMYLDNNTYDKPFKKAAKAVGNIMGNFHpHGDSSIYGALVHLSQDWKMREPL 102
Cdd:PHA02592 19 YAMYTVEERAIPNLIDGLKPVQRFVIHrALEYAKGNKEKFDKVAAIAGGVADLGYH-HGETSAQDAGALMANTWNNNIPL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 103 IEMHGNNGSMDGDSPAAMRYTESRLSKISNHLLADIDkdtvnmvLNFDDTEYEpTVLPAQF----PNLLVNGATGISAGY 178
Cdd:PHA02592 98 LDGQGNFGSRLVQKAAAARYIFARVHDNFRKIYKDED-------LAPVHEDPE-HIPPAFYlpiiPMVLLNGVSGIATGY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 179 ATEIPPHNLAEVIDATIYLLKHPDASLADlmqfVKGPDFpTGAIVlgdkgikeayETGRGRIQVRSKTSIQdikaGRQQI 258
Cdd:PHA02592 170 ATNILPHSPKSVIKAVLAALNGKDITEPK----VQFPEF-KGEVV----------EIEPGSYEIRGTYELN----GKTKL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 259 VVTEIPFGVNKAFLVKKIDEIrlnKEIDGISEVRDETDrHGLSIVIELKKGADSQNILNYLFKSTDLQVSYSFNMVAIDH 338
Cdd:PHA02592 231 HITEIPVKYDRETYVAVLDPL---EEKGKIVSYDDCTE-DGFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVINE 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 339 MTPVQV--GLKRILSSYLEHDEAVITKRTQYDLKKAKARLEIiegLIHALDILDDVIKTIRASKNKADA-KNNIIEKFSF 415
Cdd:PHA02592 307 NGKLKVyeNAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDL---ALAKAEFIKRVIAGEIVLQGKTRSeLTEELSDNKD 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1713617601 416 TPRQAEAIVSLQLYRLTNTDVNALQAEKSDLEEKIaNYNLLLTDrkvlEKQIIKELNAVKK 476
Cdd:PHA02592 384 FGEYADKLVAMNIYSMTSDEREKLQKEAEELEKEH-EYWKKTTA----KKEYIKDLEELKK 439
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
24-453 |
1.83e-21 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 100.55 E-value: 1.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 24 YSKYIIqERALPDIRDGLKPVQRRILYAMYLDNntydkpFKKAAKaVGNIMG-----NFHPHGDSSIYGALVHLSQDW-- 96
Cdd:PLN03128 666 FSQADL-ARSIPSMVDGLKPSQRKVLFACFKRN------LKSEIK-VAQLSGyvaehSAYHHGEASLASTIIGMAQDFvg 737
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 97 KMREPLIEMHGNNGS--MDGDSPAAMRYTESRLSKISNHLLADIDKDTVNMvLNFDDTEYEPTVLPAQFPNLLVNGATGI 174
Cdd:PLN03128 738 SNNINLLTPSGQFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNY-LNEDGQSIEPEWYCPIIPMVLVNGSEGI 816
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 175 SAGYATEIPPHNLAEVIDatiYLLKHPDASLADLMQ-FVKGpdFpTGAIVLGDKGIKEAYETGrGRIQVRSKTSiqdika 253
Cdd:PLN03128 817 GTGWSTFIPNYNPRDIIA---NIRRLLRGEELEPMHpWYRG--F-KGTITEVSTSRSGSYTVT-GIIEQIGDTT------ 883
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 254 grqqIVVTEIPFGV----NKAFLVK-KIDEIRLNKEIDGISEVRDETDrhgLSIVIELKKG----ADSQNILNYLFKSTD 324
Cdd:PLN03128 884 ----IRITELPVRKwtqdYKEFLEAlLTGTKKKEPEIKDFKENHTDTT---VHFTVTLSEEkmarALAEGLEKKFKLSTT 956
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 325 LQVSysfNMVAIDHM-------TPVQvglkrILSSYLEH-------DEAVITKRTQYDLKKAKARLEIIEGLIH------ 384
Cdd:PLN03128 957 ISTS---NMHLFDKDgkikkydSPED-----ILEEFFHLrldlyvkRKEVLLENLEYELKKLDNKARFILAVVKgeivvn 1028
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 385 ---ALDIL--------DDVIKTIRASKN----KADAKNNIIEKFSFTPRQA--EAIVSLQLYRLTNTDVNALQAEKSDLE 447
Cdd:PLN03128 1029 nrkRAELLaeleekgfDKFPKTAKISETnvvgDRDGEASEEEEASDNELAKsyDYLLGMPISSLTLEKVDELRAERAKKE 1108
|
....*.
gi 1713617601 448 EKIANY 453
Cdd:PLN03128 1109 TEVEEL 1114
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
31-614 |
1.56e-18 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 91.26 E-value: 1.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 31 ERALPDIRDGLKPVQRRILYAMYLDNNtydkpfKKAAKaVGNIMG------NFHpHGDSSIYGALVHLSQDWKMRE--PL 102
Cdd:PTZ00108 679 ERSIPSLVDGLKPGQRKILFACFKRNL------KNEIK-VAQLSGyvsehsAYH-HGEQSLQQTIVGMAQNFVGSNniNL 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 103 IEMHGNNGS--MDGDSPAAMRYTESRLSKISNHLLADIDkDTVNMVLNFDDTEYEPTVLPAQFPNLLVNGATGISAGYAT 180
Cdd:PTZ00108 751 LYPCGQFGSrlQGGKDHAAARYIFTKLSKITRYIFPEED-DPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFST 829
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 181 EIPPHNLAEVIDATIYLLKHPDasLADLMQFVKGpdFpTGAIVLGDKGikeAYETgRGRIQVRSKTSIQdikagrqqivV 260
Cdd:PTZ00108 830 SIPNYNPLDIIDNLRRRLNGEE--VRPLVPWYRG--F-KGTIERNPKG---KFIS-KGIYEKVPDGTVE----------I 890
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 261 TEIPFGV-NKAFlvKKIDEIRLNKEIDGISEVRDETDRHGLSIVIELKKGADSQNILNYLFKSTDLQVSYSF-NMVAIDH 338
Cdd:PTZ00108 891 TELPIGKwTEDY--KEFLESETLKEKDVIVDYRDYSTANTVHFTVKLNDGVLEQWEEEGIEKVFKLKSTISTtNMVLFDE 968
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 339 MTPVQvglkrilssyLEHDEAVI------------TKRTQY---DLKKAKARLE--------IIEGlihALDIL----DD 391
Cdd:PTZ00108 969 NGKIK----------KYSDALDIlkefylvrldlyKKRKEYllgKLERELARLSnkvrfikhVING---ELVITnakkKD 1035
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 392 VIKT--------------IRASKNKA----------DAKNNIIEKFSFTPRQAEAIVSLQLYRLTNTDVNALQAEksdLE 447
Cdd:PTZ00108 1036 LVKElkklgyvrfkdiikKKSEKITAeeeegaeeddEADDEDDEEELGAAVSYDYLLSMPIWSLTKEKVEKLNAE---LE 1112
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 448 EKIANYNLL---------LTDRKVLEKQIIKELNAVKKEFGSDRR-TKISSKTAKIEIDEKALVAEEDVRvlvSRDGYLK 517
Cdd:PTZ00108 1113 KKEKELEKLknttpkdmwLEDLDKFEEALEEQEEVEEKEIAKEQRlKSKTKGKASKLRKPKLKKKEKKKK---KSSADKS 1189
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 518 RSSLRSFQSTDDSENGLPDFDKvvfeKTMSTLTNLYLFTNKGNVIFRPVHELVEAKWKEPGQHLSQELGLDTDEQIVSVF 597
Cdd:PTZ00108 1190 KKASVVGNSKRVDSDEKRKLDD----KPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDL 1265
|
650
....*....|....*...
gi 1713617601 598 EL-AKLDEKLNFVLATND 614
Cdd:PTZ00108 1266 SKeGKPKNAPKRVSAVQY 1283
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
23-477 |
1.20e-12 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 72.20 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 23 RYSKYIIQE----------RALPDIRDGLKPVQRRILYAmyldnnTYDKPFKKAAKA---VGNI--MGNFHpHGDSSIYG 87
Cdd:PLN03237 679 KYSDFVNKElilfsmadlqRSIPSMVDGLKPGQRKILFC------SFKRNFVKEAKVaqlSGYVseHSAYH-HGEQSLAS 751
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 88 ALVHLSQDW--KMREPLIEMHGNNG--SMDGDSPAAMRYTESRLSKISNHLLADiDKDTVNMVLNFDDTEYEPTVLPAQF 163
Cdd:PLN03237 752 TIIGMAQDFvgSNNINLLLPNGQFGtrLQGGKDHASARYIFTRLSPITRFLFPK-DDDILLDYLNEDGQSIEPTWYMPII 830
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 164 PNLLVNGATGISAGYATEIPPHNLAEVIDATIYLLKhpDASLADLMQFVKGpdFpTGAIVLGDKGIKEAYETGRGRIQVR 243
Cdd:PLN03237 831 PTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLN--GESMEPMHPWYRG--F-KGTIEKTASKEGGCTYTITGLYEEV 905
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 244 SKTSiqdikagrqqIVVTEIPF----GVNKAFLVKKIDEIRLNKE--IDGISEVRDETDRHGLSIVIELKKGADSQNILN 317
Cdd:PLN03237 906 DETT----------LRITELPIrrwtDDYKEFLESLKTDNNKNKDpfIKDVKAYNDDTTVHFEVILSEENMLAAKQEGLL 975
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 318 YLFKSTDlQVSYSfNMVAID-------HMTPVQVgLKRILSSYLEHDE---AVITKRTQYDLKKA--KARL-------EI 378
Cdd:PLN03237 976 KKFKLTT-TISTS-NMHLFDskgvikkYDTPEQI-LEEFFHLRLEYYEkrkEVLLKNLEFELLKLenKVRFilavvdgEI 1052
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713617601 379 IEGLIHALDILDD---------------VIKTIRASKNKADAKNNIIEKFSFTPRQA---EAIVSLQLYRLTNTDVNALQ 440
Cdd:PLN03237 1053 IVNNRKKADLVEElrqkgftpfpkkaksVEAAVAGATDDAAEEEEEIDVSSSSGVRGsdyDYLLSMAIGTLTLEKVQELC 1132
|
490 500 510
....*....|....*....|....*....|....*...
gi 1713617601 441 AEKSDLEEKIANYnllltdRKVLEKQI-IKELNAVKKE 477
Cdd:PLN03237 1133 ADRDKLNIEVEDL------KKTTPKSLwLKDLDALEKE 1164
|
|
| DNA_gyraseA_C |
pfam03989 |
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ... |
660-702 |
2.63e-06 |
|
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.
Pssm-ID: 427633 [Multi-domain] Cd Length: 48 Bit Score: 44.79 E-value: 2.63e-06
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1713617601 660 KEITLFTNQAYAVRYDISEIPTSGARAAGVKSVNLKDDDYVVD 702
Cdd:pfam03989 1 DELLLITSKGYVKRTPLSEIREQGRGAKGVKGINLKEGDKVVS 43
|
|
| |
